LOCUS       NM_001011985            3424 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus MAPK interacting serine/threonine kinase 2
            (Mknk2), mRNA.
ACCESSION   NM_001011985 XM_216852
VERSION     NM_001011985.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3424)
  AUTHORS   Joshi,S., Sharma,B., Kaur,S., Majchrzak,B., Ueda,T., Fukunaga,R.,
            Verma,A.K., Fish,E.N. and Platanias,L.C.
  TITLE     Essential role for Mnk kinases in type II interferon (IFNgamma)
            signaling and its suppressive effects on normal hematopoiesis
  JOURNAL   J Biol Chem 286 (8), 6017-6026 (2011)
   PUBMED   21149447
REFERENCE   2  (bases 1 to 3424)
  AUTHORS   Dolniak,B., Katsoulidis,E., Carayol,N., Altman,J.K., Redig,A.J.,
            Tallman,M.S., Ueda,T., Watanabe-Fukunaga,R., Fukunaga,R. and
            Platanias,L.C.
  TITLE     Regulation of arsenic trioxide-induced cellular responses by Mnk1
            and Mnk2
  JOURNAL   J Biol Chem 283 (18), 12034-12042 (2008)
   PUBMED   18299328
REFERENCE   3  (bases 1 to 3424)
  AUTHORS   Chrestensen,C.A., Eschenroeder,A., Ross,W.G., Ueda,T.,
            Watanabe-Fukunaga,R., Fukunaga,R. and Sturgill,T.W.
  TITLE     Loss of MNK function sensitizes fibroblasts to serum-withdrawal
            induced apoptosis
  JOURNAL   Genes Cells 12 (10), 1133-1140 (2007)
   PUBMED   17903173
REFERENCE   4  (bases 1 to 3424)
  AUTHORS   Gaestel,M.
  TITLE     MAPKAP kinases - MKs - two's company, three's a crowd
  JOURNAL   Nat Rev Mol Cell Biol 7 (2), 120-130 (2006)
   PUBMED   16421520
  REMARK    Review article
REFERENCE   5  (bases 1 to 3424)
  AUTHORS   Knauf,U., Tschopp,C. and Gram,H.
  TITLE     Negative regulation of protein translation by mitogen-activated
            protein kinase-interacting kinases 1 and 2
  JOURNAL   Mol Cell Biol 21 (16), 5500-5511 (2001)
   PUBMED   11463832
REFERENCE   6  (bases 1 to 3424)
  AUTHORS   Waskiewicz,A.J., Flynn,A., Proud,C.G. and Cooper,J.A.
  TITLE     Mitogen-activated protein kinases activate the serine/threonine
            kinases Mnk1 and Mnk2
  JOURNAL   EMBO J 16 (8), 1909-1920 (1997)
   PUBMED   9155017
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001011985.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085941.1, FQ211808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000007.1  9690465-9690549
            86-202              JAXUCZ010000007.1  9690710-9690826
            203-290             JAXUCZ010000007.1  9694761-9694848
            291-392             JAXUCZ010000007.1  9694940-9695041
            393-490             JAXUCZ010000007.1  9695122-9695219
            491-570             JAXUCZ010000007.1  9696735-9696814
            571-644             JAXUCZ010000007.1  9697002-9697075
            645-749             JAXUCZ010000007.1  9697295-9697399
            750-805             JAXUCZ010000007.1  9697482-9697537
            806-901             JAXUCZ010000007.1  9697647-9697742
            902-1096            JAXUCZ010000007.1  9697953-9698147
            1097-1261           JAXUCZ010000007.1  9698586-9698750
            1262-1305           JAXUCZ010000007.1  9699136-9699179
            1306-3424           JAXUCZ010000007.1  9699407-9701525
FEATURES             Location/Qualifiers
     source          1..3424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3424
                     /gene="Mknk2"
                     /note="MAPK interacting serine/threonine kinase 2"
                     /db_xref="GeneID:299618"
                     /db_xref="RGD:1305728"
     exon            1..85
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            86..202
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1531
                     /gene="Mknk2"
                     /EC_number="2.7.11.1"
                     /note="mnk2; MAP kinase signal-integrating kinase 2; MAPK
                     signal-integrating kinase 2; MAP kinase-interacting
                     serine/threonine kinase 2"
                     /codon_start=1
                     /product="MAP kinase-interacting serine/threonine-protein
                     kinase 2"
                     /protein_id="NP_001011985.1"
                     /db_xref="GeneID:299618"
                     /db_xref="RGD:1305728"
                     /translation="MVQKRTAELQGFHRSFKGQNPFELAFTLDPAQHGDSDFSPQCEA
                     RPDMPSSQPIDIPDAKKRGRKKKRCRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCV
                     NLITNQEYAVKIIEKQLGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFE
                     KMRGGSILSHIHRRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQ
                     VSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRC
                     DLWSLGVILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDW
                     SHISFAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPLVLQRNSCAKDL
                     TSFAAEAIAMNRQLAQCEEDAGQDQPVLIRATSRCLQLSPPSQSKLAQRRQRASLSAT
                     PVVLVGDRV"
     exon            203..290
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..392
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..490
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..570
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..644
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..749
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..805
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..901
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1096
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1261
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1305
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..3424
                     /gene="Mknk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctggtggc ggcggaggcg gtggcggtgg ccgtggcggc gctgttcccc gcgcagtcct
       61 cggagcgggg tccgggctgt gtgagggtcg cctccgaagc cgtcccccgg gccccgcgtc
      121 ccctcccccg ctggcggggc ccggactgaa gatggtgcag aagagaacag ccgaacttca
      181 gggcttccac cgttcgttca aggggcagaa tcctttcgag ttggccttca ccttagaccc
      241 cgcccagcac ggggactctg acttcagccc gcagtgtgaa gcccgacctg acatgccttc
      301 cagtcagccc atcgacatcc cagacgccaa gaagagaggc cgcaaaaaga agcgctgtcg
      361 ggctactgac agcttctcag gcagatttga agatgtctac cagctgcagg aggatgtgct
      421 gggggaaggg gcccatgccc gtgtgcagac ctgtgtcaat ctcatcacca accaggaata
      481 tgctgtcaag atcattgaga agcagctggg ccatatccgc agcagggtgt tccgggaggt
      541 ggagatgctg taccagtgcc agggacatag gaatgttcta gaactgattg agttctttga
      601 ggaggaggac cgcttctacc tggtgtttga aaagatgcgt ggtggatcca tcctgagcca
      661 catccacaga aggcgccact ttaatgaact ggaggccagc gtggtggtac aggatgtggc
      721 cagtgccctg gacttcctgc ataacaaagg catcgcccac agggacctaa agccagagaa
      781 catcctgtgt gagcacccca accaggtctc gccagtgaag atctgtgact tcgatcttgg
      841 cagtggcatt aaactcaacg gagactgctc ccccatctcc acgccagagc tgctcacccc
      901 gtgtgggtct gcggagtaca tggcacccga ggtggtggaa gcctttagtg aggaggccag
      961 catctatgac aagcgctgcg acctgtggag cctgggtgtc atcctgtaca tcctgctcag
     1021 tggctacccg cccttcgtag gccactgtgg cagcgactgt ggctgggacc gcggggaggc
     1081 ctgccctgcc tgccagaaca tgctgtttga gagcatccag gaagggaagt acgagttccc
     1141 cgacaaggac tggtcccaca tctccttcgc tgccaaagac ctcatctcca agctgctggt
     1201 gcgagatgcc aagcagaggc tgagcgctgc ccaagttctg cagcacccct gggtgcaggg
     1261 gtgtgctcca gagaacacct taccaacacc cttggttctg cagaggaaca gctgtgccaa
     1321 agacctcacg tcctttgcag ctgaggccat cgccatgaac cggcagctgg cccagtgtga
     1381 ggaggacgct gggcaggacc agcctgtgct catccgagct acctcacgct gcctgcagtt
     1441 gtccccgccc tcccagtcca agctggccca gaggcgccag agggccagcc tgtcggccac
     1501 ccctgtggtc ctcgtagggg atcgcgtgtg acccctacta gccccaatgt acatatgccc
     1561 ttcagggcct gaaggctagg gacctggaca ccccacccct tgccatccca ggtaccagct
     1621 cagctgggcc tcgggggtgt agggatctgt tagggggtgt cttcttttct ccctgtcctc
     1681 accctgcccc tgcccctgcc ccttggcttt gttttgtttg tttttctttt gccgctattg
     1741 aaagcaagtg ccccggagga gggcggaggg ttcaggccaa tcagcctgca ccccacgatg
     1801 ctcgcctgtc aactgtgaag gtcctgccac ctgcgccccc acctccactc cagccactct
     1861 gctgtcttcc agggctgggg atcccgcagg gtcagcaccc cacacctcta cccagccctc
     1921 aggattgtca gggacaggcc ctcctggtga gcacagtggt gttttgcctc tccccaccag
     1981 agcacccttg ggtctggggt gggggcgggg ctccctatct tggataaaga cctctagggg
     2041 gcaggtggat ggggacagtg cacttgattg acccctagtc cccatcgccc atctgcagtg
     2101 tcccttggag ggttgacaat cagaaccccc tcccaggctg cttagctcct tgccctggga
     2161 caggcctact gttcccaact ccacttcggg gcagagctgg agggggaccc agccagctcc
     2221 accaaggcag gagaggtgct gggcaaggct cacatcagca aacatggggt ccccacatgt
     2281 ctccccaccc agggcacccg agtgcccctt ctcagggctc agcctgacca aggccacgtc
     2341 ctgcccctgg gactggagtt cttacgctct cctcgctact tctgttaccc agagctgagg
     2401 ccatacccag gggtttctca ccttccctct gcccccaaag ggcaacggct caggtgtgcc
     2461 tgctttcagg aaagggtcga agctgccttg gtctccctct ggacacccaa gggaggctgg
     2521 gaagggatgc ggtggccctg cagtgcccag acctaactgc cccgaggcct gtagactgtt
     2581 cctagccgaa ctactatgca atacgagttc ccattttctc catggccctg ctggtcgggg
     2641 gcggctgcca ggggccaggc cactctgccc tgcaactgct caggtgtcta cagggcagcc
     2701 cctggcctca aaaatccttg gtcaggattg tttgtcaagt ttagtttagg cttttttttt
     2761 ttttttttaa agaaataatt tgacttgctt ccctgttctt gaagagtact tgaatgtcgg
     2821 ggtctggtgg gtgggggcct ggggcaccca ctgcccagca tcctccaccc tcctccctag
     2881 tctcatagga tcgtcacagt ggaggtgaca tgccttctcc agtcctgccc cactgcccca
     2941 cctgcctctg tggacacatt tccaaagaac ccctagaggg tggggggctc ctaggcatct
     3001 gagttctcag ccatcagtat gactcctagg catctgagtt ctcagccatc agtatgactc
     3061 agctgtcctg ttgggcacct gaggactcag cccctccgca ggttcctgaa gcaacctgac
     3121 tgggcagtga gcagcattga ccccaccccc actccccaag cagggctgtg atttcccggg
     3181 tccctccaag cctgacctgg aggacgggtg gtcagacccc ttaactgtga atgagacatg
     3241 atcctggggt ggcttggcca caaaccatgc tgaaatctaa gagacctgtt gtagagtggg
     3301 ggacatgcaa gcactttcaa ctccatcgta ccaggtgaac tgacctccgg actcctttcc
     3361 caccaactgt caacgccagg attttgtatt gttttgtaag gatttaataa aagtcattta
     3421 aaaa
//
