LOCUS       NM_001044267            1935 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus MAPK interacting serine/threonine kinase 1
            (Mknk1), mRNA.
ACCESSION   NM_001044267 XM_001064399 XM_001064462 XM_575887
VERSION     NM_001044267.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Panja,D., Kenney,J.W., D'Andrea,L., Zalfa,F., Vedeler,A.,
            Wibrand,K., Fukunaga,R., Bagni,C., Proud,C.G. and Bramham,C.R.
  TITLE     Two-stage translational control of dentate gyrus LTP consolidation
            is mediated by sustained BDNF-TrkB signaling to MNK
  JOURNAL   Cell Rep 9 (4), 1430-1445 (2014)
   PUBMED   25453757
  REMARK    GeneRIF: Long-term potentiation (LTP) consolidation in the dentate
            gyrus of live rodents requires sustained (hours) BDNF-TrkB
            signaling and from TrkB to MAP-kinase-interacting kinase.
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Niknami,M., Patel,M., Witting,P.K. and Dong,Q.
  TITLE     Molecules in focus: cytosolic phospholipase A2-alpha
  JOURNAL   Int J Biochem Cell Biol 41 (5), 994-997 (2009)
   PUBMED   18761105
  REMARK    Review article
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Chrestensen,C.A., Eschenroeder,A., Ross,W.G., Ueda,T.,
            Watanabe-Fukunaga,R., Fukunaga,R. and Sturgill,T.W.
  TITLE     Loss of MNK function sensitizes fibroblasts to serum-withdrawal
            induced apoptosis
  JOURNAL   Genes Cells 12 (10), 1133-1140 (2007)
   PUBMED   17903173
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Origanti,S. and Shantz,L.M.
  TITLE     Ras transformation of RIE-1 cells activates cap-independent
            translation of ornithine decarboxylase: regulation by the
            Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways
  JOURNAL   Cancer Res 67 (10), 4834-4842 (2007)
   PUBMED   17510413
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   Chen,S., Atkins,C.M., Liu,C.L., Alonso,O.F., Dietrich,W.D. and
            Hu,B.R.
  TITLE     Alterations in mammalian target of rapamycin signaling pathways
            after traumatic brain injury
  JOURNAL   J Cereb Blood Flow Metab 27 (5), 939-949 (2007)
   PUBMED   16955078
REFERENCE   6  (bases 1 to 1935)
  AUTHORS   Chrestensen,C.A., Shuman,J.K., Eschenroeder,A., Worthington,M.,
            Gram,H. and Sturgill,T.W.
  TITLE     MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines
  JOURNAL   J Biol Chem 282 (7), 4243-4252 (2007)
   PUBMED   17130135
REFERENCE   7  (bases 1 to 1935)
  AUTHORS   Gaestel,M.
  TITLE     MAPKAP kinases - MKs - two's company, three's a crowd
  JOURNAL   Nat Rev Mol Cell Biol 7 (2), 120-130 (2006)
   PUBMED   16421520
  REMARK    Review article
REFERENCE   8  (bases 1 to 1935)
  AUTHORS   Fukunaga,R. and Hunter,T.
  TITLE     MNK1, a new MAP kinase-activated protein kinase, isolated by a
            novel expression screening method for identifying protein kinase
            substrates
  JOURNAL   EMBO J 16 (8), 1921-1933 (1997)
   PUBMED   9155018
REFERENCE   9  (bases 1 to 1935)
  AUTHORS   Waskiewicz,A.J., Flynn,A., Proud,C.G. and Cooper,J.A.
  TITLE     Mitogen-activated protein kinases activate the serine/threonine
            kinases Mnk1 and Mnk2
  JOURNAL   EMBO J 16 (8), 1909-1920 (1997)
   PUBMED   9155017
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098754.1.
            
            On or before Aug 24, 2006 this sequence version replaced
            XM_575887.2, XM_001064399.1, XM_001064462.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1935
                     /gene="Mknk1"
                     /note="MAPK interacting serine/threonine kinase 1"
                     /db_xref="GeneID:500526"
                     /db_xref="RGD:1559603"
     exon            1..45
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            46..147
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1289
                     /gene="Mknk1"
                     /EC_number="2.7.11.1"
                     /note="mnk1; MAP kinase signal-integrating kinase 1; MAPK
                     signal-integrating kinase 1; MAP kinase-interacting
                     serine/threonine kinase 1"
                     /codon_start=1
                     /product="MAP kinase-interacting serine/threonine-protein
                     kinase 1"
                     /protein_id="NP_001037732.1"
                     /db_xref="GeneID:500526"
                     /db_xref="RGD:1559603"
                     /translation="MGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLG
                     EGAYAKVQGAVSLQSGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNRNILELIEFF
                     EDDTRFYLVFEKLQGGSILAHIQKRKHFNELEASRVVRDVATALDFLHTKGIAHRDLK
                     PENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVF
                     RDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQ
                     EGKYEFPDKDWAHISTEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPERGLPTPQ
                     VLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEHEALAEGLCSMKLSPPSKSRLA
                     RRRALAHAGREANSCSTPAGL"
     exon            148..245
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            246..325
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..399
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..504
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..560
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..656
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..851
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1016
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1060
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1911
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcaggtggg ggtgcgcgcg gccgttcccg cggtggtcaa ctaagagatg ggcagcagtg
       61 agccccttcc catcgtggat agtgacaaga ggagaaagaa gaagcgtaag acccgggcca
      121 ccgactctct gccagggaag tttgaagacg tgtaccagct gacctcagaa ttgctgggag
      181 aaggagccta tgccaaagtc cagggtgccg tgagcctgca gagtggcaaa gagtatgcag
      241 tcaaaatcat cgagaagcaa gcaggacaca gtcgaagccg agtattccgt gaggtggaga
      301 cgttgtacca gtgtcaagga aacaggaaca ttttggagct gattgaattc tttgaagatg
      361 acacacgatt ttacttggtc tttgagaaat tgcaaggagg ctccatccta gcacacatcc
      421 agaagcggaa gcacttcaat gagctagaag ccagcagagt ggtgcgggat gtcgccactg
      481 cccttgattt cctgcatact aaaggcattg ctcaccgtga tctgaagcca gaaaacatat
      541 tgtgcgaatc tccagaaaag gtgtctccgg tgaaaatttg tgactttgac ttgggcagtg
      601 gagtaaaatt gaacaactcc tgcactccca taaccacacc agagctgacc actccatgcg
      661 gctctgcaga gtatatggca cctgaggtgg tggaggtctt tagggacgag gctactttct
      721 atgacaagcg ctgtgacctg tggagcctgg gtgtggtcct ctacatcatg ctgagtggct
      781 accccccctt tgtaggtcac tgtggggctg actgcggctg ggaccgggga gaggtatgca
      841 ggatgtgcca gaacaagctg ttcgaaagca tccaggaagg caaatacgag tttcccgaca
      901 aagactgggc tcacatctcc accgaggcca aagacctcat ctctaagctc ctggttcgag
      961 atgcgaagca gagactcagc gctgcccaag ttctgcagca tccatgggtg caagggcaag
     1021 ctccagaaag gggactcccc acgccgcaag tccttcagag aaacagcagc accatggact
     1081 tgacactctt cgcagctgag gccattgccc tcaaccgcca gctgtctcag catgaagaga
     1141 atgaactggc tgaggaacac gaggccctag ccgagggcct ctgctccatg aagctgtccc
     1201 ctccatccaa atctcgcctg gcacgaaggc gagccctggc ccacgctggc cgagaagcaa
     1261 actcttgttc cacacccgca gggctctgaa ctgatatgca ggcacacctt gtcggtgccc
     1321 cctgacaacc tacgaggtca aagtgtgaag ctagccgagg gacctgccct gcagccccag
     1381 caggccttta ccatccacaa aggctcctgg gttcccaccc atcccccatt tcccttgggt
     1441 cctcaaagga aaaagctttt tccaaagggg ttgtctttga aaaggaaggc aatcacttgt
     1501 cactttgcat aatagcctgc agcaggaaca tctctctgcc cggctccaac tgctcccagt
     1561 gtgcagatcc cggatccagc ttttggtggg ggctgctggg gctgcagcct tcagggagcc
     1621 ggcttccagg agctgacaga agctgacaga cacgcctctt ctcccctgca ctgtcacctt
     1681 ctcccacctt cctctgtcct acagacgtcc tctctgcctg tcttctcccc ggctgagcaa
     1741 agccatcccc tcaattcagg aagggcaggg aaccaaccag atcagtcttc cagtctgtag
     1801 cacggagaag cacataatct ttctttgcct tgaccgagat gtcttcctca tttatcatcc
     1861 tcttccgtgt ttcggattgt tgctaaagtc agtattattc ctttttaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaa
//
