LOCUS       NM_031359               2452 bp    mRNA    linear   ROD 03-FEB-2024
DEFINITION  Rattus norvegicus muskelin 1 (Mkln1), mRNA.
ACCESSION   NM_031359
VERSION     NM_031359.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2452)
  AUTHORS   Lampert,F., Stafa,D., Goga,A., Soste,M.V., Gilberto,S., Olieric,N.,
            Picotti,P., Stoffel,M. and Peter,M.
  TITLE     The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell
            proliferation and targets the transcription factor Hbp1 for
            degradation
  JOURNAL   Elife 7, e35528 (2018)
   PUBMED   29911972
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2452)
  AUTHORS   Delto,C.F., Heisler,F.F., Kuper,J., Sander,B., Kneussel,M. and
            Schindelin,H.
  TITLE     The LisH motif of muskelin is crucial for oligomerization and
            governs intracellular localization
  JOURNAL   Structure 23 (2), 364-373 (2015)
   PUBMED   25579817
REFERENCE   3  (bases 1 to 2452)
  AUTHORS   Debenedittis,P., Harmelink,C., Chen,Y., Wang,Q. and Jiao,K.
  TITLE     Characterization of the novel interaction between muskelin and
            TBX20, a critical cardiogenic transcription factor
  JOURNAL   Biochem Biophys Res Commun 409 (2), 338-343 (2011)
   PUBMED   21586270
REFERENCE   4  (bases 1 to 2452)
  AUTHORS   Valiyaveettil,M., Bentley,A.A., Gursahaney,P., Hussien,R.,
            Chakravarti,R., Kureishy,N., Prag,S. and Adams,J.C.
  TITLE     Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic
            mediator of cell morphology regulation
  JOURNAL   J Cell Biol 182 (4), 727-739 (2008)
   PUBMED   18710924
REFERENCE   5  (bases 1 to 2452)
  AUTHORS   Kobayashi,N., Yang,J., Ueda,A., Suzuki,T., Tomaru,K., Takeno,M.,
            Okuda,K. and Ishigatsubo,Y.
  TITLE     RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat
            proteins ARMC8alpha and ARMC8beta are components of the CTLH
            complex
  JOURNAL   Gene 396 (2), 236-247 (2007)
   PUBMED   17467196
REFERENCE   6  (bases 1 to 2452)
  AUTHORS   Hasegawa,H., Katoh,H., Fujita,H., Mori,K. and Negishi,M.
  TITLE     Receptor isoform-specific interaction of prostaglandin EP3 receptor
            with muskelin
  JOURNAL   Biochem Biophys Res Commun 276 (1), 350-354 (2000)
   PUBMED   11006128
REFERENCE   7  (bases 1 to 2452)
  AUTHORS   Adams,J.C. and Zhang,L.
  TITLE     cDNA cloning of human muskelin and localisation of the muskelin
            (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2
            by physical mapping and FISH
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 19-21 (1999)
   PUBMED   10640805
REFERENCE   8  (bases 1 to 2452)
  AUTHORS   Adams,J.C., Seed,B. and Lawler,J.
  TITLE     Muskelin, a novel intracellular mediator of cell adhesive and
            cytoskeletal responses to thrombospondin-1
  JOURNAL   EMBO J 17 (17), 4964-4974 (1998)
   PUBMED   9724633
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB046442.1.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_031359.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046442.1, SRR8487231.55874.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2452
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2452
                     /gene="Mkln1"
                     /note="muskelin 1"
                     /db_xref="GeneID:83536"
                     /db_xref="RGD:620076"
     CDS             1..2208
                     /gene="Mkln1"
                     /note="muskelin 1, intracellular mediator containing kelch
                     motifs"
                     /codon_start=1
                     /product="muskelin"
                     /protein_id="NP_112649.1"
                     /db_xref="GeneID:83536"
                     /db_xref="RGD:620076"
                     /translation="MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQS
                     SRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELL
                     SSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDI
                     VQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDMHDKLVL
                     KGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQM
                     VIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCID
                     IQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQM
                     CMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGP
                     EDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGM
                     VPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQ
                     AAKENLSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLC
                     RPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLA
                     SALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL"
     exon            1..98
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            99..168
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..311
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..400
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..510
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..703
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..781
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..847
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..960
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1173
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1395
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1525
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1673
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1788
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1928
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2031
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2086
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2441
                     /gene="Mkln1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggctg gcggggctgt tgctgcggcg cccgagtgcc ggcttctgcc ctacgcgctg
       61 cataagtgga gctccttctc ctccacctac cttcccgaga acattttagt ggataaacca
      121 aatgatcagt cttccagatg gtcttcagag agcaactatc ctccccagta cttgattctg
      181 aagcttgaaa ggcctgctat agttcagaat attacatttg gaaaatatga gaaaactcat
      241 gtctgcaatt tgaagaaatt caaagttttc ggtggaatga atgaagaaaa tatgacagag
      301 ctgctgtcca gcggcttgaa gaatgattat aacaaagaga catttacctt gaaacataaa
      361 attgatgaac agatgttccc ttgtcgattc attaaaattg ttccactttt gtcctggggg
      421 cccagcttta attttagcat ctggtatgtt gaactcagtg gcattgatga tcctgatata
      481 gtgcagccct gtctgaactg gtacagcaag taccgcgaac aggaagccat tcgcctttgt
      541 ctaaaacact tcagacaaca caactataca gaggcttttg aatccctgca gaagaaaacc
      601 aagattgcac tggagcatcc aatgttgaca gatatgcacg acaaattggt gttaaagggt
      661 gactttgatg cttgcgagga gttgattgaa aaagcggtaa atgatggctt gttcaatcag
      721 tatatcagtc aacaggagta taagccacgg tggagtcaga ttattcctaa gagcaccaaa
      781 ggtgatggag aagataaccg tccaggaatg agagggggcc atcagatggt cattgatgtt
      841 cagacagaga ctgtttattt gtttggtggc tgggatggaa cacaagatct tgctgacttc
      901 tgggcataca gtgtgaagga gaaccagtgg acatgtattt ctagagacac tgagaaagag
      961 aatggtccta gtgccagatc atgtcataaa atgtgcattg atattcagcg gagacaaatc
     1021 tacacattgg gccgttactt ggattcctct gtgaggaaca gcaaatctct gaaaagtgat
     1081 ttctaccgtt acgacattga caccaacacc tggatgttac taagtgaaga cactgctgcc
     1141 gacggtggac caaaattggt gtttgatcat cagatgtgta tggactcaga aaagcatatg
     1201 atctatacct ttggtggtag gattttgaca tgtaatggca gtgtagatga cagcagagcc
     1261 agtgaaccac aattcagtgg gctgtttgca ttcaactgcc agtgtcaaac ctggaaactt
     1321 cttcgagagg actcctgtaa cgcaggccct gaggacatcc agtctcggat tggacactgc
     1381 atgctgttcc actcgaaaaa ccgttgttta tacgtgtttg gtggccagag atctaagacc
     1441 tatttgaatg atttttttag ttatgatgtg gactctgatc atgtagacat aatttcagat
     1501 ggcaccaaga aagactctgg aatggttcca atgaccggat tcacacagag agcaactatt
     1561 gatccagaac tgaatgaaat acatgtttta tccggactta gcaaagacaa agaaaagagg
     1621 gaagagaatg tcagaaattc attctggatt tatgacattg tgaggaatag ctggtcttgt
     1681 gtctataaga atgatcaagc tgcaaaagag aatctgagta aaagtcttca ggaagaagaa
     1741 ccatgtccaa ggtttgccca tcagctcgtt tatgatgaat tacacaaggt tcattattta
     1801 tttggtggga atccaggaaa gtcttgctct ccaaagatga gactagatga cttctggtcg
     1861 ctgaagttgt gcagaccttc gaaggactac ttactgaggc attgcaagta cctcatcagg
     1921 aagcacaggt ttgaagaaaa ggcccagatg gatcccctta gtgctctgaa gtatttacag
     1981 aatgatcttt atataactgt ggatcattcg gacccagaag agacaaaaga gtttcaactc
     2041 ctagcctcag ccctgttcaa atctggctca gatttcacag ctttaggctt ttcagacgtg
     2101 gatcacacct atgctcagag aactcagctc tttgacacct tagtgaattt ctttcctgac
     2161 agcatgactc ctcctaaggg caacctggta gacctcatca cactgtaact gggcgtggat
     2221 tgaggagtta ctgggctcag aagtggagac aggaaccgga ggttgctgtt tgtgtgggca
     2281 gaggtgacgt tgcagtgact gaggactgag gactgcatcc gagttttgaa ggatccttac
     2341 tgtcacaagt tttaaccctc ttccttcata cctgacctca atcccctttt ccttatattc
     2401 ctgcattagg ctaataaagt gaaattgata tacttcccat taaaaaaaaa aa
//
