LOCUS       NM_001271366            9880 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus marker of proliferation Ki-67 (Mki67), mRNA.
ACCESSION   NM_001271366 XM_225460
VERSION     NM_001271366.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9880)
  AUTHORS   Dovmark,T.H., Kvist,P.H., Molck,A.M. and Hvid,H.
  TITLE     Quantitative Assessment of Epithelial Proliferation in Rat Mammary
            Gland Using Artificial Intelligence Independent of Choice of
            Proliferation Marker
  JOURNAL   J Histochem Cytochem 70 (3), 237-250 (2022)
   PUBMED   35057663
  REMARK    GeneRIF: Quantitative Assessment of Epithelial Proliferation in Rat
            Mammary Gland Using Artificial Intelligence Independent of Choice
            of Proliferation Marker.
REFERENCE   2  (bases 1 to 9880)
  AUTHORS   Shojaei-Zarghani,S., Yari Khosroushahi,A. and Rafraf,M.
  TITLE     Oncopreventive effects of theanine and theobromine on
            dimethylhydrazine-induced colon cancer model
  JOURNAL   Biomed Pharmacother 134, 111140 (2021)
   PUBMED   33360052
REFERENCE   3  (bases 1 to 9880)
  AUTHORS   Cui,X., Liu,X., Han,Q., Zhu,J., Li,J., Ren,Z., Liu,L., Luo,Y.,
            Wang,Z., Zhang,D., Fan,Y., Zhang,D. and Dong,G.
  TITLE     DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma
            progression by PI3K/Akt/mTOR pathway
  JOURNAL   Cell Death Dis 10 (10), 701 (2019)
   PUBMED   31541079
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9880)
  AUTHORS   Silva-Pena,D., Garcia-Marchena,N., Alen,F., Araos,P., Rivera,P.,
            Vargas,A., Garcia-Fernandez,M.I., Martin-Velasco,A.I.,
            Villanua,M.A., Castilla-Ortega,E., Santin,L., Pavon,F.J.,
            Serrano,A., Rubio,G., Rodriguez de Fonseca,F. and Suarez,J.
  TITLE     Alcohol-induced cognitive deficits are associated with decreased
            circulating levels of the neurotrophin BDNF in humans and rats
  JOURNAL   Addict Biol 24 (5), 1019-1033 (2019)
   PUBMED   30277635
REFERENCE   5  (bases 1 to 9880)
  AUTHORS   Wang,W., Shen,X.B., Jia,W., Huang,D.B., Wang,Y. and Pan,Y.Y.
  TITLE     The p53/miR-193a/EGFR feedback loop function as a driving force for
            non-small cell lung carcinoma tumorigenesis
  JOURNAL   Ther Adv Med Oncol 11, 1758835919850665 (2019)
   PUBMED   31205511
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9880)
  AUTHORS   Ridanpaa,M., Fodde,R. and Kielman,M.
  TITLE     Dynamic expression and nuclear accumulation of beta-catenin during
            the development of hair follicle-derived structures
  JOURNAL   Mech Dev 109 (2), 173-181 (2001)
   PUBMED   11731231
REFERENCE   7  (bases 1 to 9880)
  AUTHORS   Rijken,A.M., Umezawa,A., van Gulik,T.M., Bosma,A., Polak,M.M.,
            Offerhaus,G.J., Obertop,H. and Gouma,D.J.
  TITLE     Prognostic value of cell proliferation (Ki-67 antigen) and nuclear
            DNA content in clinically resectable, distal bile duct carcinoma
  JOURNAL   Ann Surg Oncol 5 (8), 699-705 (1998)
   PUBMED   9869516
REFERENCE   8  (bases 1 to 9880)
  AUTHORS   Liu,R.Y., Matsumoto,K., Kunishio,K., Mizumatsu,S., Tamiya,T.,
            Furuta,T. and Ohmoto,T.
  TITLE     Proliferative potential and apoptosis in rat glioma cell lines
            after hyperthermia
  JOURNAL   Neurol Med Chir (Tokyo) 38 (4), 196-201 (1998)
   PUBMED   9631633
REFERENCE   9  (bases 1 to 9880)
  AUTHORS   Gerlach,C., Sakkab,D.Y., Scholzen,T., Dassler,R., Alison,M.R. and
            Gerdes,J.
  TITLE     Ki-67 expression during rat liver regeneration after partial
            hepatectomy
  JOURNAL   Hepatology 26 (3), 573-578 (1997)
   PUBMED   9303485
REFERENCE   10 (bases 1 to 9880)
  AUTHORS   Falini,B., Flenghi,L., Fagioli,M., Stein,H., Schwarting,R.,
            Riccardi,C., Manocchio,I., Pileri,S., Pelicci,P.G. and
            Lanfrancone,L.
  TITLE     Evolutionary conservation in various mammalian species of the human
            proliferation-associated epitope recognized by the Ki-67 monoclonal
            antibody
  JOURNAL   J Histochem Cytochem 37 (10), 1471-1478 (1989)
   PUBMED   2476477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 18, 2012 this sequence version replaced XM_225460.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760389, SAMN06680432
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               JAXUCZ010000001.1  199952256-199952593 c
            339-417             JAXUCZ010000001.1  199950401-199950479 c
            418-533             JAXUCZ010000001.1  199950197-199950312 c
            534-597             JAXUCZ010000001.1  199947459-199947522 c
            598-643             JAXUCZ010000001.1  199944583-199944628 c
            644-1606            JAXUCZ010000001.1  199943198-199944160 c
            1607-1782           JAXUCZ010000001.1  199941597-199941772 c
            1783-2044           JAXUCZ010000001.1  199940529-199940790 c
            2045-2163           JAXUCZ010000001.1  199940324-199940442 c
            2164-2335           JAXUCZ010000001.1  199940066-199940237 c
            2336-2491           JAXUCZ010000001.1  199938026-199938181 c
            2492-6511           JAXUCZ010000001.1  199933168-199937187 c
            6512-9129           JAXUCZ010000001.1  199930196-199932813 c
            9130-9540           JAXUCZ010000001.1  199929115-199929525 c
            9541-9880           JAXUCZ010000001.1  199926150-199926489 c
FEATURES             Location/Qualifiers
     source          1..9880
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..9880
                     /gene="Mki67"
                     /note="marker of proliferation Ki-67"
                     /db_xref="GeneID:291234"
                     /db_xref="RGD:1305476"
     exon            1..338
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..9606
                     /gene="Mki67"
                     /note="antigen KI-67; antigen identified by monoclonal
                     antibody Ki-67"
                     /codon_start=1
                     /product="proliferation marker protein Ki-67"
                     /protein_id="NP_001258295.1"
                     /db_xref="GeneID:291234"
                     /db_xref="RGD:1305476"
                     /translation="MASSARLVTIKRSGDDGAHFPLSLSSCLFGRSIECDIRIQLPVV
                     SKKHCKIEVKEQEAILYNFSSANPTQVNGTIINEPVQLKHGDIITIIDRSFRYEDGSH
                     DGSRPTEFPRKSLGKEPARRASRDTISADPDGKDQDTKASKMTASRRSFVYAKGLSAD
                     SPASDDSKDSVTQDSSGHVEQHDRRNLGEPTSGDLFKKFRATRSSYGDLKSSPAQSLS
                     NSNKNESPFEKLYQSMKEELDVKSEKSHRKSEPQFDRAAEESWETERLVSCKARPKSS
                     RSTPVTATSSPKVGKSWTERWRGGVGPVQTPTETAKMKTPVQKAQQLKDEDSRVPGRR
                     NSVNLDESESAQAVHKIVTPGKLVTRNQAAVKVGHVASPANTPEHSSSKKRRSIPADM
                     EVPCAETQKRLSLTQCLAPGEKKSPKDSFSKPEKLGTVAKQTCSGITGLSSIDISNCG
                     DSINKSEGVPLKRRRVSFGGHLRPELFDENLPPNTPLKRGETPTKRKSLGTHSPAGLK
                     KIIKERPPSPGKQESPGVTPPRTNDERRRSGRTSLASSGSKFLYETDIPKKAGRKSGN
                     LPAKRASISRSQHGILQMICSKRRSGASEANLIVAKSWADVVKLGVKQTQMKVVKHVP
                     QKQTRKRQRRPSTPKKPTSSLHDQFTTGHANSPCTIVIGRAQTEKASMPARPYKMLNN
                     LMLNWKMDFSEDLSGLTEMFKTPVKEKQQQMSDVGSILSDSENLSERQLQGTNSEDTP
                     PPTASEILGEKVLLSTQNAAKQQSNKYSASSTLRRQSIKHENTVQTPKNVHNITQIEK
                     KTPASETEPLKTASSMSKLRRSRELRHTLVKSKNEKTEAVLAKSITGRHLRKTFQGQE
                     VDQQVQGSENSSQRCEENSKLSEDSEKTSARRSSARKQKLTKDLVGSQMVTQSADCAE
                     DLLSQEQGTIQNLEESMYTQNTSKSDQGVAKQKVNTVVDATRVKRWSKTPVKMTHPLE
                     GAADFTEHFETPDLKDEPIGDDETKVLCKSPQPKTENLKASAKPRTSTSRRKVDRKEE
                     LSAVTKLIHMSGESRHTPKVLKLEHGDIKALRQSENEMLAATVTGSKRPLEKAKEKAQ
                     PVEDLTGFEELFLSPVPGDKITKMPSKSPHTESVRTPASTKRLSTTGLSKVDVREEPA
                     TLGKRTKSSGRVTGTPAPAQEDNDTTTFMETPKQKLDFTGNSTGHKRRSQASKNRAQP
                     LEDLDGFQELFQTPAAARTPVTVDESAKVSLESVQPQLVITSASTKRLSKTGLSKVDV
                     REEPSTLGKRTKSSDTVTGTPAPVQEENNTMAFMQTPKQKLDFTGNSTGHKRRSRASK
                     NRAQPLEDLDGFQELFQTPAAASDPVTVDESAKVSLESVQPQLVITPASTKRLSKTGL
                     SKVDVREEPSTLGKRTKSSDTVTGTPAPVQEENNTTAFMQTPKQKLDFTGNSTGHKRR
                     SRASKNRAQPLEDLDGFQELFQTPAAASDPVTVDESAKVSLESVQPQLVITPASTKRL
                     SKTGLSKVDVREEPSTLGKRTKSSDTVTGTPAPVQDENNTTAFMQTPKQKLDFTGNST
                     GHKRRSRASKNRAQPLEDLDGFQELFQTPAAASDPVTVDESAKVSLESVQPQLVITPA
                     STKRLSKTGLSKVDVREEPSTLGKRTKSSDTVTGTPAPVQEENNTMAFMQTPKQKLDF
                     TGNSTGHKRRSRASKNRAQPLEDLDGFQELFQTPAAASDPVTVDESAKVSLESVQPQL
                     VITPASTKRLSKTGLSKVDVREEPSTLGKRRKSSDTVTGTPAPVQDENNTMAFMQTPK
                     QKLDFTGNSTGHKRRSRASKNRAQPLEDLDGFQELFQTPAAASDPVTVDESAKVSLES
                     VQPQLVITPASTKRLSKTGLSKVDVREEPSTLGKRTKSSDTVTGTPAPVQDENNTTAF
                     MQTPKQKLDFTGNSTGHKRRSRASKNRAQPLEDLDGFQELFQTPAAASDPVTVDESAK
                     VSLESVQPQLVITPASTKRLSKTGLSKVDVREEPSTLGKRTKSSGRVTGTPAPVQEEN
                     NTTTFMETPKQKLESLGDLTGLRKQSRTPKAKAQYLEDISGFQEGFQTPDHANGPLAV
                     GKTKKMSFISPQPGRPVRTQNNRKSLPKISLRQVDVTGGISVLGKQSPGRALTAPVQA
                     DNGIKAIMETPKETLATAADLTGFTRPQQTPKEKDQPLEDYGGFQELFQTPAGASDSV
                     TVEESKKMPVESLQPQPVRTPASTKRLSKTGLSKVDVREEPSTPGKRTKSSDTVTGTP
                     APVPEENDTTPFMQTPKQKLEFTGNSAGHKRRSRTPKTRAQPLEDLDGFQELFQTPAG
                     ASDPVTVDESTKVSLESSQPLPVITPASTKRLSKTPGQNKDLVTLDNLAKMPGSSPPP
                     EPIDTSVISGRQLRTRLRNLYVKNELSEDGMHPKMSGEIVDSSRAPGGEEKVIKARKQ
                     CVKRKLDTAVNLPSSKRQRIAGAEEPQTLEDLPGFQELCQAPCLVMDSVIVDKTTKVP
                     SKSPEPVDTTSEIKPRRRLKRLGVTEEPIPQRTTTRVLRQTRNTHKEPIDSSNGVDEF
                     KESSAQKQDPAISLTGRRNQPRKVKEKTQPLEELTSFQEEIATRMSCKSPQPEEKKTL
                     VGLKKQLRIQLFKVGVEEEPTAQRKQPARETRSRLKEPMGNRINVEELKKSTEQKIDP
                     VASMTVSKRPRRIPKEKAQTVELAGLKGPIQTLGHTEESARDKEPTQMPCNSLQPEQV
                     DSLQPSPRRPRTRHGKVEADKPSAVRKTVPTSRQSVRSRKVTEIDDNGTKASKAPVKQ
                     TLDTVAKETDSKRQLRTRKNGVQPLEVLGDSKEITQISDHSEKLRHDTNILKSTLQQK
                     PDSMKPLRKCRRVLRTSKEDPKEVLMDTSDLAALQSKSNLYLSPPRKSARDGRILKTR
                     TLCSVTPKQEATGEKPVHKKQRAASTKRQVSPEPVKVKHLRSVSHKRESVEEHISTIM
                     QIEEMEAKRENPVTPDQSSRYRKKTEKQPSPKFDASAEKVGIKKNEKTMKISQETEPQ
                     NPDPGTKKSSSLGKVSGKRTCLRSRGQTEIPQPHEAEEKTRKSGAEISIKTQQEKGVS
                     GDPDVRRLRSRQTRVTLDNEPKPRVTRGAKKDAKTLKKDEDIVYTKILRTRSHQKSET
                     V"
     exon            339..417
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            418..533
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            534..597
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            598..643
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            644..1606
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1782
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2044
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2163
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2335
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2491
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..6511
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            6512..9129
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            9130..9540
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
     exon            9541..9880
                     /gene="Mki67"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcggcgg gcggcgggtg tgcgggtcgg ggcggagcga aggccgcggg tggccgtggt
       61 cggacctccg cggctgagga gccgagggtt ctgacgcggg ctgcacccgg tgagccgcgg
      121 gcagagctaa ctttcgctgt cagaaccagc tgaggagcgg ccgggcggcg agacggcgag
      181 cttcacagag gggctactcc gccctcggcc gcagtcactg actccggact gacggccggg
      241 cggaccatgg cgtcctcagc tcgcctggtc accatcaaac ggagcggcga tgacggcgca
      301 cacttcccgc tgagcctcag ctcctgcctg tttggaagga gtattgaatg tgacattcgt
      361 atacagctgc ctgtagtgtc aaaaaaacat tgcaaaattg aagtcaaaga acaagaggca
      421 atattatata atttcagttc cgccaatcca actcaagtaa atggcactat tataaatgag
      481 cctgtgcagc tgaaacatgg agacataata acaatcattg accgctcctt taggtatgaa
      541 gacggaagcc atgatggaag caggccaaca gaattcccga gaaagtcact tggaaaggaa
      601 ccagcacggc gagcctcaag agataccatc tctgctgacc ctgatgggaa agatcaagat
      661 accaaagctt caaaaatgac tgcttcaaga agatcttttg tctatgccaa ggggctttct
      721 gcagatagtc ctgcctcaga tgactcaaag gacagtgtta cccaagattc atcagggcat
      781 gtagaacagc acgatcgcag aaacctagga gaacccactt ctggggatct ctttaagaag
      841 ttcagggcta cacggagcag ttacggggac ctgaagtctt ctcctgcaca gagccttagc
      901 aatagcaaca aaaatgaatc tcccttcgag aaactttatc agtcaatgaa ggaagagttg
      961 gatgtaaaat cagagaaatc tcatagaaaa tcagaacccc aatttgaccg tgcagcagaa
     1021 gaatcgtggg agacagagcg attggtgtca tgcaaggcaa gaccaaagtc cagtagaagc
     1081 acccctgtta cagcaacctc ttcacccaaa gtaggaaaga gctggaccga gagatggaga
     1141 ggtggtgtgg ggcctgttca gactcccaca gagacagcta aaatgaagac ccctgtgcag
     1201 aaggcacagc agcttaagga tgaagactct cgtgttcctg gcagaagaaa ttctgtgaat
     1261 ctggatgaaa gtgaaagtgc ccaggcagtt cataaaatag tcactcctgg gaaactggta
     1321 actagaaatc aagctgcagt aaaagttgga catgttgcca gccctgccaa tacaccagaa
     1381 cattcctctt ccaaaaagag aagaagtatt cctgcagaca tggaggttcc atgtgcagag
     1441 acacaaaagc ggctctcttt aacacagtgc cttgctccag gtgaaaagaa aagtcccaag
     1501 gattccttca gcaagcctga gaaactgggc acagtggcca aacagacttg ctctggtata
     1561 actggcctta gttccattga tatcagcaac tgtggtgatt ccattaacaa gagtgaggga
     1621 gtgcctttga agagaagacg tgtatccttt gggggtcatc taagacctga attatttgat
     1681 gaaaacttgc ctcctaatac tccactcaaa agaggagaaa caccaacgaa gaggaagtct
     1741 cttggcactc acagtccagc tggcctaaag aaaatcatca aggaacggcc tccgtctcca
     1801 gggaaacaag agtctcctgg agtaactcca ccaaggacaa atgatgaaag acgaagatca
     1861 ggcaggactt cacttgcttc cagcggaagc aaattcttat atgagacaga cattcccaag
     1921 aaagcaggca ggaagagtgg caacctgcct gcgaagagag catccatcag ccgaagtcag
     1981 catggcattc tacagatgat ttgctccaaa agaagaagtg gtgcttctga agccaacctg
     2041 attgttgcaa aatcatgggc tgatgttgta aaacttggcg tgaaacaaac gcaaatgaaa
     2101 gttgtgaaac atgtccctca aaagcagaca agaaaaagac aaagaagacc cagtactcca
     2161 aagaaaccta caagcagcct tcacgatcaa tttactacag gccatgcaaa ctcaccctgt
     2221 accattgtaa tagggagagc acagactgaa aaggcaagca tgcctgcccg accctacaaa
     2281 atgctgaaca acttgatgct aaactggaaa atggacttca gtgaagatct gtcaggacta
     2341 actgaaatgt tcaagactcc agtgaaggag aagcagcagc agatgagtga cgtgggctcc
     2401 attctgtctg attcagagaa tttgtctgaa agacagttgc aaggaaccaa ctcagaagac
     2461 acacccccac ccaccgcctc agagattttg ggagaaaaag tgctcctcag tactcagaat
     2521 gcagcaaagc agcaatccaa taaatattct gcaagttcta ccttaagacg gcagagcatc
     2581 aaacatgaaa acacagtgca aactcctaag aatgtccata acattacgca aattgagaag
     2641 aagactccag cctctgagac agagcctcta aagacagcat caagtatgag caagttaagg
     2701 agatctagag agctcagaca tacccttgtc aaaagtaaga atgaaaaaac agaagcagtc
     2761 cttgccaaga gcatcacagg aagacatcta cggaagacat ttcaaggaca agaagtagac
     2821 caacaagtgc agggcagtga aaactcttca caaagatgcg aggaaaacag taaattaagt
     2881 gaagattcag aaaagacatc cgctaggaga tcaagtgcca ggaagcagaa actaacaaaa
     2941 gacttagtag gaagtcagat ggtcacccaa tcagcagact gtgctgagga cctacttagt
     3001 caagaacaag gaacaataca aaacctagag gaatccatgt acacgcaaaa cacatcaaaa
     3061 agtgatcaag gagttgcaaa acagaaagtt aacacagtgg tagatgcaac cagagtgaag
     3121 cgctggtcaa agacccctgt caaaatgaca caccctctag aaggtgcagc tgatttcacg
     3181 gagcactttg aaacaccaga tctcaaagat gaacccatag gtgatgatga aactaaagtc
     3241 ctttgcaaat ccccacaacc caaaacagag aacctcaagg caagcgcaaa gccacggacc
     3301 agcacatcta ggaggaaagt agataggaag gaagaactct ctgccgtgac aaagcttata
     3361 catatgtcag gggaaagtag gcatactccc aaagttctaa aacttgagca tggggatatc
     3421 aaagctttga ggcaatctga aaatgaaatg ctggctgcaa cagtaactgg aagcaagagg
     3481 cctttagaaa aagctaagga aaaggctcag cctgtggaag acctgactgg tttcgaggaa
     3541 ctctttctat caccagtccc tggtgacaaa atcacaaaaa tgcccagcaa atctccacac
     3601 acagaatcag tcagaactcc agcaagcaca aagagactgt ccacgacagg tctcagtaag
     3661 gtggatgtga gagaagagcc tgcaaccctt gggaaaagaa caaagtcatc aggcagagtg
     3721 acaggcacac cagcaccagc ccaggaagat aatgatacca caaccttcat ggaaactccc
     3781 aagcagaaac tggatttcac aggaaattca actggacata agagaaggtc acaagcatcc
     3841 aagaacaggg ctcagcccct agaagacctg gatggcttcc aagaactctt ccaaacacca
     3901 gctgctgcta ggacccctgt gactgttgat gaaagtgcaa aggtgtctct ggaatctgta
     3961 caaccacaac tagtcataac ctcagcaagc acaaagagac tgtccaagac aggtctcagt
     4021 aaggtggatg tgagagaaga gccttcgacc ctggggaaac gaacaaagtc atcagacaca
     4081 gtgacaggca caccggcacc agtgcaggaa gaaaataaca ccatggcctt tatgcaaact
     4141 ccaaagcaga aactggattt cacaggaaat tcaactggac ataagagaag gtcacgagca
     4201 tccaagaaca gggctcagcc cctagaagac ctggatggct tccaagaact cttccaaaca
     4261 ccagctgctg ccagtgaccc tgtgactgtt gatgaaagtg caaaggtgtc tctggagtct
     4321 gtacaaccac aactagtcat aaccccagca agcacaaaga gactgtccaa gacaggtctc
     4381 agtaaggtgg atgtgagaga agagccttcg accctgggga aacgaacaaa gtcatcagac
     4441 acagtgacag gtacaccggc accagtgcag gaagaaaata acaccacggc ctttatgcaa
     4501 actccaaagc agaaactgga tttcacagga aattcaactg gacataagag aaggtcacga
     4561 gcatccaaga acagggctca gcccctagaa gacctggatg gcttccaaga actcttccaa
     4621 acaccagctg ctgccagtga ccctgtgact gttgatgaaa gtgcaaaggt gtctctggaa
     4681 tctgtacaac cacaactagt cataacccca gcaagcacaa agagactgtc caagacaggt
     4741 ctcagtaagg tggatgtgag agaagagcct tcgaccctgg ggaaacgaac aaagtcatca
     4801 gacacagtga caggcacacc ggcaccagtg caggatgaaa ataacaccac ggcctttatg
     4861 caaactccaa agcagaaact ggatttcaca ggaaattcaa ctggacataa gagaaggtca
     4921 cgagcatcca agaacagggc tcagccccta gaagacctgg atggcttcca agaactcttc
     4981 caaacaccag ctgctgccag tgaccctgtg actgttgatg aaagtgcaaa ggtgtctctg
     5041 gaatctgtac aaccacaact agtcataacc ccagcaagca caaagagact gtccaagaca
     5101 ggtctcagta aagtggatgt gagagaagag ccttcgaccc tggggaaacg aacaaagtca
     5161 tcagacacag tgacaggcac accggcacca gtgcaggaag aaaataacac catggccttt
     5221 atgcaaactc caaagcagaa actggatttc acaggaaatt caactggaca taagagaagg
     5281 tcacgagcat ccaagaacag ggctcagccc ctagaagacc tggatggctt ccaagaactc
     5341 ttccaaacac cagctgctgc cagtgaccct gtgactgttg atgaaagtgc aaaggtgtct
     5401 ctggaatctg tacaaccaca actagtcata accccagcaa gcacaaagag actgtccaag
     5461 acaggtctca gtaaggtgga tgtgagagaa gagccttcga ccctggggaa acgaagaaag
     5521 tcatcagaca cagtgacagg cacaccggca ccagtgcagg atgaaaataa caccatggcc
     5581 tttatgcaaa ctccaaagca gaaactggat ttcacaggaa attcaactgg acataagaga
     5641 aggtcacgag catccaagaa cagggctcag cccctagaag acctggatgg tttccaagaa
     5701 ctcttccaaa caccagctgc tgccagtgac cctgtgactg ttgatgaaag tgcaaaggtg
     5761 tctctggaat ctgtacaacc acaactagtc ataaccccag caagcacaaa gagactgtcc
     5821 aagacaggtc tcagtaaggt ggatgtgaga gaagagcctt cgaccctggg gaaacgaaca
     5881 aagtcatcag acacagtgac aggcacaccg gcaccagtgc aggatgaaaa taacaccacg
     5941 gcctttatgc aaactccaaa gcagaaactg gatttcacag gaaattcaac tggacataag
     6001 agaaggtcac gagcatccaa gaacagggct cagcccctag aagacctgga tggcttccaa
     6061 gaactcttcc aaacaccagc tgctgccagt gaccctgtga ctgttgatga aagtgcaaag
     6121 gtgtctctgg aatctgtaca accacaacta gtcataaccc cagcaagcac aaagagactg
     6181 tccaagacag gtctcagtaa agtggatgtg agagaagagc cttcgaccct ggggaaacga
     6241 acaaagtcat caggcagagt gacaggcaca ccggcaccag tgcaggaaga aaataacacc
     6301 acaaccttca tggaaactcc aaagcagaaa ctggagtctt taggagattt aacagggctt
     6361 aggaaacagt ccagaacacc taaagcaaaa gcccaatatc tagaggacat atctggtttt
     6421 caggagggtt tccagacacc agaccatgcc aatggcccat tagcagttgg caaaaccaaa
     6481 aaaatgtcct ttatttctcc acaaccagga agaccagtta gaacccaaaa caacagaaag
     6541 agtctgccca agattagcct gagacaagta gatgtgacgg gaggaatttc agttctcggg
     6601 aagcagtcac ctggcagagc cctcacagca ccagtgcagg cggataatgg gatcaaagca
     6661 attatggaga ctccaaagga aacactggca actgcagcag atttaactgg gtttaccaga
     6721 ccacaacaaa cacctaagga aaaagaccag cccctggaag attatggtgg cttccaagaa
     6781 ctcttccaaa caccagctgg tgccagtgac tcagtgactg ttgaggaaag taaaaagatg
     6841 ccagtggaat ctttacaacc acaaccagtc agaaccccag caagcacaaa gagactgtcc
     6901 aagacaggtc tcagtaaggt ggatgtgaga gaagagcctt caacacctgg gaaaagaaca
     6961 aagtcatcag acacagtgac aggcacacct gcaccagtgc cggaagaaaa tgacaccaca
     7021 ccctttatgc aaactccaaa gcagaaactg gaattcacag gaaattcagc aggacataag
     7081 agaaggtcac ggacacctaa gaccagagct cagcccctag aagacctgga tggcttccaa
     7141 gaactcttcc aaacaccagc tggtgccagt gaccctgtga ctgttgatga aagtacaaag
     7201 gtgtctctgg aatcttcaca accactacca gtcataaccc cagcaagcac aaagagactg
     7261 tccaagacac caggacagaa caaggattta gtgacactgg acaatcttgc aaaaatgcca
     7321 ggcagttctc caccaccaga gccaatagat acttcagtaa tctcaggtag acagctcaga
     7381 actcgtctta ggaaccttta tgtgaaaaat gaactgtcag aagacggaat gcatccaaaa
     7441 atgtcagggg aaattgtgga ctcatctaga gcaccaggag gtgaagagaa agtcattaaa
     7501 gcaaggaagc aatgtgtaaa gcggaaattg gacacagcag tcaatttacc tagcagcaag
     7561 aggcaaagaa ttgcaggagc agaagagcca cagaccctag aggatctgcc tggcttccaa
     7621 gagctctgcc aagctccatg cttggtaatg gactcagtta ttgttgacaa aaccacaaag
     7681 gtgcccagca aatctccaga acctgtggat acaacttcag agataaagcc aagaagacga
     7741 ctcaagagac tgggtgtgac tgaagagccc ataccacaaa gaacgactac aagagtgtta
     7801 aggcaaacca gaaacacaca caaagagccc atagatagta gtaatggtgt agatgagttt
     7861 aaggagtctt cggcacagaa acaagaccca gccataagtt taaccggcag gaggaatcaa
     7921 ccaagaaagg ttaaggaaaa gacccaaccc ttggaagagc tgactagttt ccaagaggaa
     7981 attgccacaa gaatgtcttg caaatctcca caaccagaag agaagaaaac cttagtaggc
     8041 ttaaagaagc agctcagaat acaactattc aaagtgggtg tggaagagga gcccacagca
     8101 cagagaaagc aaccagccag ggaaaccagg agcagactca aagagcccat gggtaacagg
     8161 ataaatgttg aagagcttaa gaagtctaca gagcagaaaa ttgacccagt agcaagtatg
     8221 actgtcagca agaggccacg gaggataccc aaggaaaagg cacagaccgt agaattggct
     8281 ggtctcaaag gaccaatcca aaccctaggt cacactgagg aatctgcaag ggataaagaa
     8341 cccacacaga tgccctgtaa ttctctacaa ccagagcaag ttgatagcct ccaaccctca
     8401 ccaagacgtc ccaggacaag acatgggaaa gtagaggcag acaagccttc agcagtaagg
     8461 aagacagtgc caacatcaag gcaaagtgtg cgatcccgaa aggtcactga aattgatgac
     8521 aatggtacca aagcttcaaa ggcacctgta aagcagacat tagatacagt agccaaagaa
     8581 actgacagca aaaggcagct aaggacacgt aagaatgggg ttcaacctct tgaagtcctg
     8641 ggtgactcca aagaaataac acaaatatca gatcactctg agaaactaag acatgacact
     8701 aatattctta agagcactct acagcaaaag ccagactcaa tgaaacctct gagaaaatgc
     8761 agaagagtgc tgaggacctc taaagaggac cccaaagaag tgttgatgga taccagtgac
     8821 cttgcagcat tacaaagcaa aagcaacctt tacctgtccc cccccaggaa gtctgcaaga
     8881 gatggaagga ttttgaaaac caggactttg tgctctgtaa ccccaaagca ggaagcaaca
     8941 ggtgagaagc ctgtacataa gaaacaaagg gcagcttcta ccaagaggca ggtgtcacct
     9001 gagccggtga aggtgaaaca cctgagaagt gtgtcacata aacgtgaatc tgtggaggag
     9061 cacattagca ccattatgca aatagaagaa atggaagcca aaagagagaa ccctgtcact
     9121 ccagatcaga gctctaggta ccgaaagaaa actgaaaaac agccaagccc caagtttgat
     9181 gcgtctgcag agaaggttgg gataaagaaa aatgagaaaa caatgaagat ctcccaggag
     9241 acagagccgc agaatccaga tcctggaacc aagaagtctt catctctggg caaagtcagt
     9301 gggaaaagaa catgtttgag gtctagagga cagacggaga ttccccagcc tcatgaagca
     9361 gaagagaaaa caagaaaatc aggtgcagaa atctcgataa agacccagca agagaaagga
     9421 gtctctggag atccagatgt taggcgtttg agatccagac aaactagagt cactttggac
     9481 aatgaaccta agccaagagt aactcgaggg gccaagaaag atgcaaaaac tctgaagaag
     9541 gatgaagaca ttgtatacac caagatatta agaacaagaa gtcaccagaa aagtgaaact
     9601 gtgtagcaaa gacatttaag aaggaaaagt aaatttggtt tagtgataga ttccagtatg
     9661 attttcatct ccagtgtgaa ggtgaactgt aaataatatt gcctgtgctt aaggaaggaa
     9721 gctttgagct ttcctgatca tactctcttc aagctccaat ggagatcatg aagatcacca
     9781 gggatctctc agagcaatag cagtttaaat gtttggtggg taaacaggta gaaatgtggc
     9841 cctctgtcct acccaataaa gctctgtgaa attcactgcc
//
