LOCUS       NM_001105979            2342 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Mix paired-like homeobox 1 (Mixl1), mRNA.
ACCESSION   NM_001105979 XM_001061956 XM_222997
VERSION     NM_001105979.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2342)
  AUTHORS   Pereira,L.A., Wong,M.S., Mossman,A.K., Sourris,K., Janes,M.E.,
            Knezevic,K., Hirst,C.E., Lim,S.M., Pimanda,J.E., Stanley,E.G. and
            Elefanty,A.G.
  TITLE     Pdgfralpha and Flk1 are direct target genes of Mixl1 in
            differentiating embryonic stem cells
  JOURNAL   Stem Cell Res 8 (2), 165-179 (2012)
   PUBMED   22265737
REFERENCE   2  (bases 1 to 2342)
  AUTHORS   Pereira,L.A., Wong,M.S., Lim,S.M., Sides,A., Stanley,E.G. and
            Elefanty,A.G.
  TITLE     Brachyury and related Tbx proteins interact with the Mixl1
            homeodomain protein and negatively regulate Mixl1 transcriptional
            activity
  JOURNAL   PLoS One 6 (12), e28394 (2011)
   PUBMED   22164283
REFERENCE   3  (bases 1 to 2342)
  AUTHORS   Zhang,H., Fraser,S.T., Papazoglu,C., Hoatlin,M.E. and Baron,M.H.
  TITLE     Transcriptional activation by the Mixl1 homeodomain protein in
            differentiating mouse embryonic stem cells
  JOURNAL   Stem Cells 27 (12), 2884-2895 (2009)
   PUBMED   19711456
REFERENCE   4  (bases 1 to 2342)
  AUTHORS   Lim,S.M., Pereira,L., Wong,M.S., Hirst,C.E., Van Vranken,B.E.,
            Pick,M., Trounson,A., Elefanty,A.G. and Stanley,E.G.
  TITLE     Enforced expression of Mixl1 during mouse ES cell differentiation
            suppresses hematopoietic mesoderm and promotes endoderm formation
  JOURNAL   Stem Cells 27 (2), 363-374 (2009)
   PUBMED   19038793
REFERENCE   5  (bases 1 to 2342)
  AUTHORS   Tam,P.P., Khoo,P.L., Lewis,S.L., Bildsoe,H., Wong,N., Tsang,T.E.,
            Gad,J.M. and Robb,L.
  TITLE     Sequential allocation and global pattern of movement of the
            definitive endoderm in the mouse embryo during gastrulation
  JOURNAL   Development 134 (2), 251-260 (2007)
   PUBMED   17151016
REFERENCE   6  (bases 1 to 2342)
  AUTHORS   Willey,S., Ayuso-Sacido,A., Zhang,H., Fraser,S.T., Sahr,K.E.,
            Adlam,M.J., Kyba,M., Daley,G.Q., Keller,G. and Baron,M.H.
  TITLE     Acceleration of mesoderm development and expansion of hematopoietic
            progenitors in differentiating ES cells by the mouse Mix-like
            homeodomain transcription factor
  JOURNAL   Blood 107 (8), 3122-3130 (2006)
   PUBMED   16403910
REFERENCE   7  (bases 1 to 2342)
  AUTHORS   Mohn,D., Chen,S.W., Dias,D.C., Weinstein,D.C., Dyer,M.A., Sahr,K.,
            Ducker,C.E., Zahradka,E., Keller,G., Zaret,K.S., Gudas,L.J. and
            Baron,M.H.
  TITLE     Mouse Mix gene is activated early during differentiation of ES and
            F9 stem cells and induces endoderm in frog embryos
  JOURNAL   Dev Dyn 226 (3), 446-459 (2003)
   PUBMED   12619131
REFERENCE   8  (bases 1 to 2342)
  AUTHORS   Hart,A.H., Hartley,L., Sourris,K., Stadler,E.S., Li,R.,
            Stanley,E.G., Tam,P.P., Elefanty,A.G. and Robb,L.
  TITLE     Mixl1 is required for axial mesendoderm morphogenesis and
            patterning in the murine embryo
  JOURNAL   Development 129 (15), 3597-3608 (2002)
   PUBMED   12117810
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001061956.1, XM_222997.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2342
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..2342
                     /gene="Mixl1"
                     /note="Mix paired-like homeobox 1"
                     /db_xref="GeneID:289311"
                     /db_xref="RGD:1310011"
     exon            1..415
                     /gene="Mixl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..718
                     /gene="Mixl1"
                     /codon_start=1
                     /product="homeobox protein MIXL1"
                     /protein_id="NP_001099449.1"
                     /db_xref="GeneID:289311"
                     /db_xref="RGD:1310011"
                     /translation="MAAAGSQQLQFAEGAAFPTFPAAHPGGQLLPAARPATGLPPAPP
                     DSRAPAATPCFPSRGPRPAAQTPTGLDPPGPSKGSAAPSAPQRRKRTSFSSEQLQLLE
                     LVFRQTMYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLSSRREDFL
                     HRPAPGTEARCLKPQLPLEADVNHVLDSSMAGGGVCTSGSQGFETYSSLSEDIGSKLD
                     SWEEHIFSALGSF"
     exon            416..2342
                     /gene="Mixl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccgggaaa cgtcccggag tgatggccgc agcagggtcc cagcagcttc agttcgcaga
       61 gggcgccgct ttccccacct tcccggccgc gcaccccgga ggacagctgc tcccggccgc
      121 gcgcccagcc actgggctac ccccggcgcc cccggactct cgcgccccag cggccacgcc
      181 atgctttcca agccggggcc ccaggcccgc agcgcagact cccaccggcc tggatccgcc
      241 cggaccctcc aaaggctcgg ccgccccgtc tgcgccgcag cgccgcaagc gcacgtcgtt
      301 cagctccgag cagctgcagt tgctggagct cgtcttccga cagaccatgt accccgacat
      361 ccacttgcgg gagcgtctgg ctgcgctcac gctgctaccc gagtcaagga tccaggtgtg
      421 gttccagaac agacgggcca agtcccggcg tcagagcggg aagtcgtttc agcccttatc
      481 ctcaaggcgg gaagatttcc tccatcgtcc tgctccgggg actgaagcaa ggtgtctgaa
      541 gcctcagttg cctctagagg cggatgtgaa ccacgttctg gattccagta tggctggagg
      601 aggcgtctgt acatctggtt ctcagggttt tgaaacttac tcctctctct ctgaagatat
      661 tggctcaaag ttggactcat gggaggagca catcttttct gccttgggta gcttctgagg
      721 attctgggag agttcaagat gtactcaggg agatctggga gattcgaacc agaccctgtc
      781 tgatctcctg actggccagg tcttggttct ggatcacctc tcatatttag gtttcccttc
      841 tccgacacag cctttactgc tggcttgttc ttggtagcca cccgccctcc cacccgcaag
      901 tcactgtgaa tctccaagac tgcacattat catcggtcta catcccctgg gccttctcac
      961 tagggttatt ctcgttttcc agactgatta ttcaaaattt gctttcctca taggaacctc
     1021 cagctggatt caatttctcc cctttctcgg cagctgccta caacgtgggt tcactctctc
     1081 tcacccaaat ccttatcacc aagacttagt actttttatt gaatcttttt gttttgtttt
     1141 tgaccttgct gtgtaagtaa ggatggcatg aactcctgtc ctcccacctc tatttgccat
     1201 cgtgactgac tggatgttgc tatttttgct taaaattgtg tatgatatta agatatatat
     1261 ccaaatcaag cttaacacat gcatgagatc agtcaccttc cttttttctg cgatgataca
     1321 atctattagc aatttcaagt atatgaaata tcgatactaa ctctagccat taccattgag
     1381 ttcttcagct tctctctcct agctgactga gtatcctagc cacctcccct gccctcactt
     1441 gactggtttc tcgtctggcc tgtcaacttt acactccatc agtaaagatg ctactttcaa
     1501 cctctttcaa gaaccccatg cctcttgttc cccactttct ttctttcttt ttcttttttt
     1561 tttttggttc tttttttttt tcggagctgg ggactgaacc cagggccttg cgcttcctag
     1621 gtaagcgctc taccactgag ctaaatcccc agcccctctt tctttctttt ttaaattact
     1681 ctatttggaa atctgtggca gcatccagtt accaaaccat aagaccctgt caagcacgct
     1741 cctagtcaat gacatcatct ttagcttatg caaactttaa gatcatttac ccacaatgtg
     1801 cttctctgtc tgtctctgtc tgtcattcct ttctagttgg gactcagtga gaaagcttct
     1861 ctttcaaaac agctcaagca caccgctttc tgaagcctga acttttctta actaatcctg
     1921 tttttcgtac ctgttacttt gatgaccatt tttcttagca cttgttctta ttatgtttcc
     1981 tgtacaacat tagtggatta ctaaatgctc ctcactgccg ttttttacat gaatcccatt
     2041 gaaatgagcc ctgttttccc agacctcagc actgggaaag ttggggaata cataatgaat
     2101 gacagaaaac attctgaagg gaactttctg cacacacagt acatcgagaa tttatttgag
     2161 cacgcttatc tgctgggctg ctgagatagc tcagtggagg taaacatgtt gtcaccaagc
     2221 atgacaatct gagtttgatc cccaagaccc acatggtgag aaggagaatg gatttgtctt
     2281 ttagacttcc acatgtgtgc tatggtgtat acccacatac atacacacat acaaaataaa
     2341 ta
//
