LOCUS       NM_001191089            4917 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus melanocyte inducing transcription factor (Mitf),
            transcript variant 1, mRNA.
ACCESSION   NM_001191089 XM_001065759
VERSION     NM_001191089.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4917)
  AUTHORS   George,A., Zand,D.J., Hufnagel,R.B., Sharma,R., Sergeev,Y.V.,
            Legare,J.M., Rice,G.M., Scott Schwoerer,J.A., Rius,M., Tetri,L.,
            Gamm,D.M., Bharti,K. and Brooks,B.P.
  TITLE     Biallelic Mutations in MITF Cause Coloboma, Osteopetrosis,
            Microphthalmia, Macrocephaly, Albinism, and Deafness
  JOURNAL   Am J Hum Genet 99 (6), 1388-1394 (2016)
   PUBMED   27889061
REFERENCE   2  (bases 1 to 4917)
  AUTHORS   Mehta,G., Kumarasamy,S., Wu,J., Walsh,A., Liu,L., Williams,K.,
            Joe,B. and de la Serna,I.L.
  TITLE     MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4
            expression in cardiac hypertrophy
  JOURNAL   J Mol Cell Cardiol 88, 101-110 (2015)
   PUBMED   26388265
  REMARK    GeneRIF: MITF interacts with BRG1 to promote GATA4 expression in
            cardiac hypertrophy.
REFERENCE   3  (bases 1 to 4917)
  AUTHORS   Denecker,G., Vandamme,N., Akay,O., Koludrovic,D., Taminau,J.,
            Lemeire,K., Gheldof,A., De Craene,B., Van Gele,M., Brochez,L.,
            Udupi,G.M., Rafferty,M., Balint,B., Gallagher,W.M., Ghanem,G.,
            Huylebroeck,D., Haigh,J., van den Oord,J., Larue,L., Davidson,I.,
            Marine,J.C. and Berx,G.
  TITLE     Identification of a ZEB2-MITF-ZEB1 transcriptional network that
            controls melanogenesis and melanoma progression
  JOURNAL   Cell Death Differ 21 (8), 1250-1261 (2014)
   PUBMED   24769727
REFERENCE   4  (bases 1 to 4917)
  AUTHORS   Maruyama,K., Uematsu,S., Kondo,T., Takeuchi,O., Martino,M.M.,
            Kawasaki,T. and Akira,S.
  TITLE     Strawberry notch homologue 2 regulates osteoclast fusion by
            enhancing the expression of DC-STAMP
  JOURNAL   J Exp Med 210 (10), 1947-1960 (2013)
   PUBMED   23980096
REFERENCE   5  (bases 1 to 4917)
  AUTHORS   Pogenberg,V., Ogmundsdottir,M.H., Bergsteinsdottir,K., Schepsky,A.,
            Phung,B., Deineko,V., Milewski,M., Steingrimsson,E. and Wilmanns,M.
  TITLE     Restricted leucine zipper dimerization and specificity of DNA
            recognition of the melanocyte master regulator MITF
  JOURNAL   Genes Dev 26 (23), 2647-2658 (2012)
   PUBMED   23207919
REFERENCE   6  (bases 1 to 4917)
  AUTHORS   Weilbaecher,K.N., Hershey,C.L., Takemoto,C.M., Horstmann,M.A.,
            Hemesath,T.J., Tashjian,A.H. and Fisher,D.E.
  TITLE     Age-resolving osteopetrosis: a rat model implicating microphthalmia
            and the related transcription factor TFE3
  JOURNAL   J Exp Med 187 (5), 775-785 (1998)
   PUBMED   9480987
REFERENCE   7  (bases 1 to 4917)
  AUTHORS   Opdecamp,K., Nakayama,A., Nguyen,M.T., Hodgkinson,C.A., Pavan,W.J.
            and Arnheiter,H.
  TITLE     Melanocyte development in vivo and in neural crest cell cultures:
            crucial dependence on the Mitf basic-helix-loop-helix-zipper
            transcription factor
  JOURNAL   Development 124 (12), 2377-2386 (1997)
   PUBMED   9199364
REFERENCE   8  (bases 1 to 4917)
  AUTHORS   Yasumoto,K., Yokoyama,K., Takahashi,K., Tomita,Y. and Shibahara,S.
  TITLE     Functional analysis of microphthalmia-associated transcription
            factor in pigment cell-specific transcription of the human
            tyrosinase family genes
  JOURNAL   J Biol Chem 272 (1), 503-509 (1997)
   PUBMED   8995290
REFERENCE   9  (bases 1 to 4917)
  AUTHORS   Tassabehji,M., Newton,V.E., Liu,X.Z., Brady,A., Donnai,D.,
            Krajewska-Walasek,M., Murday,V., Norman,A., Obersztyn,E.,
            Reardon,W. et al.
  TITLE     The mutational spectrum in Waardenburg syndrome
  JOURNAL   Hum Mol Genet 4 (11), 2131-2137 (1995)
   PUBMED   8589691
REFERENCE   10 (bases 1 to 4917)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000148.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001191089.5.
            
            On Dec 20, 2021 this sequence version replaced NM_001191089.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JACYVU010000148.1  27739087-27739322
            237-486             JACYVU010000148.1  27868268-27868517
            487-714             JACYVU010000148.1  27916058-27916285
            715-798             JACYVU010000148.1  27917309-27917392
            799-894             JACYVU010000148.1  27919246-27919341
            895-1012            JACYVU010000148.1  27926769-27926886
            1013-1087           JACYVU010000148.1  27928882-27928956
            1088-1163           JACYVU010000148.1  27940024-27940099
            1164-1311           JACYVU010000148.1  27943299-27943446
            1312-4917           JACYVU010000148.1  27947542-27951147
FEATURES             Location/Qualifiers
     source          1..4917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..4917
                     /gene="Mitf"
                     /note="melanocyte inducing transcription factor"
                     /db_xref="GeneID:25094"
                     /db_xref="RGD:3092"
     exon            1..236
                     /gene="Mitf"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1713
                     /gene="Mitf"
                     /note="isoform 1 is encoded by transcript variant 1;
                     microphthalmia-associated transcription factor;
                     melanogenesis associated transcription factor"
                     /codon_start=1
                     /product="microphthalmia-associated transcription factor
                     isoform 1"
                     /protein_id="NP_001178018.1"
                     /db_xref="GeneID:25094"
                     /db_xref="RGD:3092"
                     /translation="MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSSSSAEHSGAS
                     KPPLSSSTMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVAVSQTPAINVSV
                     PTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRHQVKQYLSTTLANKHAGQVLSPPC
                     PNQPGDHAMPPVPGSSAPNSPMAMLTLNSNCEKEAFYKFEEQSRAESECPGMNTHSRA
                     SCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLT
                     ISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKEL
                     GTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHANRHLLLRV
                     QELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQELVQHQADLTCTTTLDL
                     TDGTISFTNNLGTMPESSPAYSIPRKMASNLEDILMDDALSPVGVTDPLLSSVSPGAS
                     KTSSRRSSMSAEETEHAC"
     exon            237..486
                     /gene="Mitf"
                     /inference="alignment:Splign:2.1.0"
     exon            487..714
                     /gene="Mitf"
                     /inference="alignment:Splign:2.1.0"
     exon            715..798
                     /gene="Mitf"
                     /inference="alignment:Splign:2.1.0"
     exon            799..894
                     /gene="Mitf"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1012
                     /gene="Mitf"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1087
                     /gene="Mitf"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1163
                     /gene="Mitf"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1311
                     /gene="Mitf"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..4917
                     /gene="Mitf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgggctag cgggctgagt ggggcactga gcggggcgcg cgtcttgggg tacccgaggc
       61 cctccccatc tttgtcaggt gcccgggttc tggtccaagt cccaagcagt ggaaggcggg
      121 caagcaggag tcatgcagtc tgaatcggga atcgtggcgg atttcgaagt cggggaggag
      181 tttcacgaag aacccaaaac ctattacgaa ctcaaaagtc aacctctgaa gagcagcagt
      241 tctgcagagc attctggggc ctccaagcct ccgttaagct cctccactat gacatcacgc
      301 atcttgctac gccagcaact catgcgtgag cagatgcagg agcaggagcg cagggagcag
      361 cagcagaagc tgcaggcagc ccagttcatg caacagagag tggccgtgag tcagacacca
      421 gccataaacg tcagcgtgcc caccaccctt ccctctgcca cccaggtgcc gatggaagtc
      481 ctcaaggtgc agacccacct ggaaaacccc accaagtacc acatacagca agcccagagg
      541 caccaggtaa agcagtacct ttctaccact ttagcaaaca aacatgccgg ccaagtcctg
      601 agcccgccat gtccaaacca gcctggcgac catgccatgc ctccagtgcc ggggagcagc
      661 gcacccaaca gccccatggc tatgctcact cttaactcca actgtgaaaa agaggcgttt
      721 tataagtttg aggagcagag cagggcagag agtgagtgcc caggtatgaa cacgcactct
      781 cgagcttcgt gcatgcagat ggatgatgtg attgatgaca tcatcagcct ggaatcaagt
      841 tataatgaag aaattttggg cttgatggat ccggccttgc aaatggcaaa tacgttacct
      901 gtctctggaa acttgatcga cctatacagc aaccagggcc tgccaccccc aggccttacc
      961 atcagcaact cttgtccagc caaccttccc aacataaaaa gagagctcac agcgtgtatt
     1021 ttccccacag agtctgaagc aagagcattg gctaaagaga ggcagaaaaa ggacaatcac
     1081 aacttgattg aacggagaag aagatttaac ataaatgacc gcattaagga actaggtact
     1141 ttgattccca agtcaaacga tccggacatg cgttggaaca aggggaccat cctcaaggcc
     1201 tccgtggact acatccgaaa gttgcaacgg gaacagcagc gagctaagga ccttgaaaac
     1261 cggcagaaga agctggagca tgctaaccgc catctgctgc tcagagtgca ggagctcgag
     1321 atgcaggcta gagcacatgg gctttctctt atcccatcca cgggtctctg ctcgcctgat
     1381 ttggtgaatc ggatcatcaa gcaagaacca gttcttgaga actgcagcca ggaacttgta
     1441 cagcaccagg cagacctgac atgcacaacg actctggatc tcacggacgg taccatctcc
     1501 tttaccaaca acctcggcac aatgcctgag agcagcccgg cctacagcat ccccaggaag
     1561 atggcctcca acttggaaga catcctgatg gacgatgccc tctcacctgt cggcgtcacc
     1621 gacccactgc tgtcatcagt gtccccagga gcttcgaaaa caagcagccg gaggagcagt
     1681 atgagcgcag aagaaacgga gcatgcgtgt tagcgagctt gccttgttct gcctcaacac
     1741 ggactgctcc ctctcttctt cttcagtaga cttcacaatg tacctgaaga ggttttcttg
     1801 ataattttcc tttaatatga atttttcgtg ctttaccagt agcccaggat atattttatt
     1861 tttagaattt tgtgagccag acttgtatat tctattttac aactacaaag gcctcctaag
     1921 tattgtacct tcagcgtgca gtatctgtga actgatttct cgaagcgtga gctttctgag
     1981 caaggggatt tttgcttcag agaagtaagt gtctgtccgt tttcattcag gggaaaactt
     2041 cgtgtgagct ctgtctgtct gtgacctcct ttgaaattaa catgtaaagt ttaattacat
     2101 gaatgtaaag caaccaaaag aagaaaacaa agaagatgat gatgattata gaagaagaag
     2161 aagaagaaga agaagaagaa gaagaagaag aagaagaaga agaagaagaa gaagaagaag
     2221 aagaagaaga agaagaagaa gaagagaagc ctttctcact ttataaatgt gtcgattccc
     2281 tggtactgcc ttaaagacac agtgctctct cagcattacc gcgtctttgt actgaaaact
     2341 gcttaaaagc agaatatatt acatacagac aaatctagca gtcattttca tgaggattgt
     2401 ctaactagaa attgtaactt atgctaaccc aaactgaaag aagttattag accaaggcat
     2461 gaagcgtagg acctgacctg ctggctttta ttgggcacag ttatagtttt cctcataata
     2521 agtgtgattc aatttttcat aagatttttt cgaaacggaa atgaatgtcc tctctgaata
     2581 aaaaacatcg aggagcatcg gaagtttgtt tcactttttt tgttttttcc atttttgctt
     2641 ttgataaaga caaccgaact gggcgccttt ctaattggct ttactatttt tatttttaaa
     2701 ttatgtttta gcctttttaa ttgtatagag tctttattat cgtcattttt ttcagtgttt
     2761 gtattaattt ataagaatgt gcatcttaaa atggcgagtt ttccatactt ttacagctca
     2821 ccgatgattc tctgcattct ttgtacaccc aagaaagact acttttaccc aaggtcttgt
     2881 gttcaaagag agctttgcaa atattttgta tattccacta tcacttgaaa ctgtttttca
     2941 acacatttaa ggtgtagtat taggttaata accaggcttt ctagaaaaaa aatacttaca
     3001 tatgcatttc tagggtatga aaataactat attcttgaag cttgatagcc attgcattta
     3061 ccatgcccgt gatggtcatt tgaattggga tttatttcaa caaaactggc tggattcttt
     3121 tttaaagaga gaaacactgt attggcagat tacttgataa cagcattttg tcaacgtggc
     3181 aacattgtaa agttagtttc tgtgcattac ctactcgcat agccctatgc aataactgta
     3241 gttacatgta tcaagtctag ctgttttgtg caggtgatat atactgttcc aagccaggct
     3301 gtctcatgga atttctcagc agcagcccgt ggttgaatag cgagcggcat aaaacttatc
     3361 ctttcagaat gaagtgcctt aaaaatctca gcagtctttt ttggaccagc actgactgaa
     3421 ctgtaaaatg ggagaaagtt tcgagatgga atctggagtg aagaaggacg acgtagcatg
     3481 gtgcctctgt agacattcta agagcttcca atttcccttc agatattttt aatatgaaat
     3541 atattttact gacagtgcca aattctttca tcaggaaacc tttttcagga gggttttttt
     3601 ttaagtgttt aaatgtcaaa tgtgaattgg tgatgggtga tggagagatc caagagcaga
     3661 tgattgtcag atgtatgaat ggatggcctt ggtgagattc gtcaaatgag cggttcccat
     3721 gcatgttggg taatgcaaat ccttggaaac actgatgatg ctatccagtc ttgtagcttt
     3781 attacttaag ggggtaggga aaataagttc ccattctttc aactccctta agtgtgtgac
     3841 tcttttccta gaatagaaat gcaaatgtgc atgaaaagat aattgtacca tagtgttcac
     3901 caatacaatc atagcattgt ctgtttttct cttcatattt atgtgggggg gaggagggct
     3961 gatgcagaag ttgaagattg caatgctatg atgctaggct ttcttagctg actctgacgg
     4021 ttcttttttt tcctttttaa ataattgaac aaggtttcac aaagttgact aacccacggc
     4081 taagcgactc tggtcgaggc agaacaactt tctaggaagc tttgttgaga gaaagtatgg
     4141 catattgcac cactaccctg gcttgtagcc cctgggcctg ccatcgctgg ctcccctggt
     4201 atcttcctca taaggtacag ctgctgggag aggcaggcga gcaatccaga ggcgggcagc
     4261 atgggggtgg ttttatttat ttcttttgtg ccagcgagaa tgtggatcct ttcagggacc
     4321 ggttaagcca agaggaagtg tttttgctca ctgtttttaa ggagagaatg tttctagcca
     4381 ctccccgacc cctgggtgca gaattgtgtc tcagggttgg acctccgttt cgagtgctca
     4441 aaataccaaa attctccacc agcctctggg taaggcaatg gaaataccaa accttctgac
     4501 tttgccaaaa actatacaag caatctggtc atacccagag catgacacag ttcagtctgg
     4561 ttgtttgtaa acaataaagc aataagaaca aacacaatgc acaggacatt aaaagataca
     4621 aacacaaagc acaaaggaat gtaacttgtt aatatttttg gaaaaaaatg cactgggaag
     4681 aagttgttgt tgataatagt ataaacaaat acccaacttc ttgacaaaga tgacagatga
     4741 ctgtctcttg cggacacttg ctactgtaat gtcagtaaca gcccctgctg ttgggtacag
     4801 caatacattc tgtatggtcc acagcactgt atattatgat tgatattaat gtatccaatg
     4861 aaataattga actgttgttc ttcatagcct cattaaagca tttggttttt cacattg
//
