LOCUS       NM_031052               2393 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus mitochondrial intermediate peptidase (Mipep),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_031052
VERSION     NM_031052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2393)
  AUTHORS   Mossmann,D., Meisinger,C. and Vogtle,F.N.
  TITLE     Processing of mitochondrial presequences
  JOURNAL   Biochim Biophys Acta 1819 (9-10), 1098-1106 (2012)
   PUBMED   22172993
  REMARK    Review article
REFERENCE   2  (bases 1 to 2393)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 2393)
  AUTHORS   Isaya,G., Kalousek,F. and Rosenberg,L.E.
  TITLE     Sequence analysis of rat mitochondrial intermediate peptidase:
            similarity to zinc metallopeptidases and to a putative yeast
            homologue
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 8317-8321 (1992)
   PUBMED   1518864
REFERENCE   4  (bases 1 to 2393)
  AUTHORS   Kalousek,F., Isaya,G. and Rosenberg,L.E.
  TITLE     Rat liver mitochondrial intermediate peptidase (MIP): purification
            and initial characterization
  JOURNAL   EMBO J 11 (8), 2803-2809 (1992)
   PUBMED   1322290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1, FM065705.1, FN806671.1, FM117087.1, FM100741.1,
            FM061883.1 and CR459947.1.
            
            On May 5, 2015 this sequence version replaced NM_031052.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M96633.1, SRR26643299.56985.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 JAXUCZ010000015.1  39102327-39102334
            9-548               FM065705.1         1-540
            549-905             FN806671.1         262-618
            906-1204            FM117087.1         351-649
            1205-1343           JAXUCZ010000015.1  39139585-39139723
            1344-1939           FM100741.1         1-596
            1940-2323           FM061883.1         217-600
            2324-2393           CR459947.1         1-70                c
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..2393
                     /gene="Mipep"
                     /note="mitochondrial intermediate peptidase"
                     /db_xref="GeneID:81684"
                     /db_xref="RGD:621680"
     exon            1..287
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2240
                     /gene="Mipep"
                     /EC_number="3.4.24.59"
                     /note="MIP"
                     /codon_start=1
                     /product="mitochondrial intermediate peptidase precursor"
                     /protein_id="NP_112314.2"
                     /db_xref="GeneID:81684"
                     /db_xref="RGD:621680"
                     /translation="MLLAAGTRYAYRLCGRRAAAALQGHAGRSCARSVSTSWSPVGAA
                     FNVKPQGHLWDLLGERRGLFGVPELSTPEGFQVAQEEALRKTEWLVERACSTPPGPQT
                     VLIFDELSDCLCRVADLADFVKIGHPEQAFREAAQEACRSIGTMVEKLNTNVELYQSL
                     QKLLDDKKLMDSLDAETRRVAELFMFDFEISGIHLDEEKRRRAVDLNVKILDLSSAFL
                     MGTNFPIKIQKHLLPEHIQHHFARDGRHLVIDGLHAEASDDLVREAAYKIFLYPNADQ
                     LKCLEELLSSRDLLANLVGYSTFSHRALQGTIAQTPETVMQFLEKLSEKLCERTRKDF
                     EMMQGMKTKLNPQNSELMPWDPPYYSGVIRAERYNIEPSLYCPFLSLGACMEGLNVLF
                     NRLLGVTLYAEQPFKGEVWCIDVRKLAVVHESEGLLGYIYCDFFQRANKPQQDCHFTI
                     RGGRLKEDGSYQLPVVVLMLNLPHASRDFPTLLTPGMMENLFHEMGHAMHSMLGRTRY
                     QHVTGTRCPTDFAEVPSILMEYFSNDYRVVSQFAKHYQTGQPLPKAMVSRLCESKKVC
                     AAAEMQLQVFYAALDQIYHGQHPLKKSTTDILMETQEQFYGLPYVPDTAWQLRFSHLV
                     GYGAKYYSYLMSRAVASMVWKECFLQDPFNRAAGERYRREMLAHGGGKEPMLMIQGML
                     QKCPSIDDFVDALVSDLNLDFETFFMDSK"
     exon            288..461
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            462..550
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            551..637
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            638..701
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            702..884
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1041
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1090
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1151
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1204
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1358
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1436
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1641
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1751
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1826
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1946
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2068
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2142
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2389
                     /gene="Mipep"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgtgcacc agtcgggtct gcaacgcgag tgcccagcgc aagctgctac cttggaaacg
       61 cagggcgcgc gcttcctgag cgtggcagag ccggggtccc gaggatgctg ctggcagccg
      121 ggacgcggta tgcctaccgg ctgtgcggcc ggcgagccgc ggcggctctg cagggacacg
      181 caggccggag ctgcgcccgg agcgttagca ctagctggtc cccggtgggc gctgccttta
      241 acgtcaagcc ccagggccac ctgtgggacc tgttgggaga gcgacggggt ctttttggag
      301 ttcctgagct cagcacccct gaaggattcc aagttgccca ggaggaagcc ttgaggaaga
      361 cggagtggct ggtagagcga gcatgttcca cacctccagg gccacagaca gtcctcattt
      421 tcgatgagct ctcggattgc ctctgcagag tggctgactt ggcggacttt gtgaaaattg
      481 gacacccaga gcaggcgttc agagaggctg cgcaggaggc ctgcagaagt attggcacca
      541 tggtggaaaa gttgaatacg aatgtggaat tgtatcagag tctgcagaaa ttactagatg
      601 acaagaagct tatggattcc cttgatgcag aaaccaggcg agtagccgaa ctatttatgt
      661 ttgattttga aatcagtgga atccatctag atgaagaaaa gcgcagaaga gccgtggacc
      721 tcaatgttaa gatcttggac ttgagtagtg ctttcctcat gggaaccaac tttcccatca
      781 agatccagaa gcatctctta ccagagcaca ttcagcacca ctttgctcgt gatggaaggc
      841 atttagtcat cgatggtcta catgcggaag cctccgatga cctggttcgg gaggctgctt
      901 ataaaatttt cctttatccc aatgctgatc agttgaagtg tttggaggag ttgctaagca
      961 gccgagatct tctggcaaac ctagtaggct attctacctt ttcccacagg gccctccagg
     1021 gaaccatagc ccagactcca gagactgtca tgcagttcct tgagaagcta tctgaaaagc
     1081 tctgcgaaag aactagaaaa gattttgaga tgatgcaagg aatgaaaaca aaactaaatc
     1141 ctcaaaattc tgaactaatg ccttgggacc ctccctacta cagtggtgtg attcgtgcag
     1201 agaggtataa tattgagccc agtttatatt gtccattctt atcccttgga gcttgcatgg
     1261 aaggcctgaa tgtcctattt aacagactgt tgggcgtcac cttatatgca gaacagccct
     1321 tcaaaggaga ggtgtggtgt attgatgtcc ggaagctggc tgttgttcat gaatctgaag
     1381 ggttgctggg ctacatttac tgtgattttt tccagcgagc aaacaagcca cagcaggatt
     1441 gccacttcac catccgaggg ggcagattaa aggaagatgg cagctatcag ctcccagttg
     1501 tggttctcat gctgaatctc cctcatgctt ccagggattt ccctacctta ttaactcctg
     1561 ggatgatgga aaatctcttc catgaaatgg ggcatgccat gcactcaatg ctcggacgaa
     1621 ctcggtacca gcatgtcact gggaccaggt gccctactga ctttgctgaa gttccgtcta
     1681 ttctgatgga gtatttttca aatgattacc gagtagtcag ccagtttgcc aagcattatc
     1741 agactggtca gccactgccg aaagctatgg tgtctcgtct ctgtgaatct aagaaggtct
     1801 gtgccgccgc agaaatgcag ctgcaggtct tttatgccgc cctggatcaa atctaccatg
     1861 gccagcatcc cctgaagaag tcaaccacag acatcctcat ggaaacacaa gagcagtttt
     1921 atggcttacc ctatgttcct gacactgcct ggcagctgag gttcagccac ctggtgggat
     1981 atggcgccaa gtattactca tacctcatgt ccagggctgt ggcatccatg gtctggaagg
     2041 agtgcttcct acaggatccc tttaacaggg ccgccgggga gcgctaccgc agagagatgt
     2101 tagcccacgg tgggggcaag gaacctatgc tcatgattca aggcatgctg cagaaatgtc
     2161 cttccatcga tgattttgtg gatgcccttg tgtctgactt gaatctggac tttgaaactt
     2221 tcttcatgga ttctaaatag cagaagcctg gctcacgtgg ataggaaact cgttaccaga
     2281 tcctacagtt atgaagcctt cactccaact tcagtgttca ctgaggaaga aatactttct
     2341 gacaagcctt aaattgacag aattcggaat aaatagtatg ttttaattaa aaa
//
