LOCUS       NM_145771               1039 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus myo-inositol oxygenase (Miox), mRNA.
ACCESSION   NM_145771 NM_019908
VERSION     NM_145771.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1039)
  AUTHORS   Tominaga,T., Dutta,R.K., Joladarashi,D., Doi,T., Reddy,J.K. and
            Kanwar,Y.S.
  TITLE     Transcriptional and Translational Modulation of myo-Inositol
            Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR
            INJURY INDUCED IN OBESITY AND DIABETES
  JOURNAL   J Biol Chem 291 (3), 1348-1367 (2016)
   PUBMED   26578517
  REMARK    GeneRIF: Data suggest that Miox expression/activity is up-regulated
            in kidneys tubules during oxidative stress (as in obesity and
            diabetic nephropathy); up-regulation of Miox activity is related to
            phosphorylation of serine/threonine residues.
REFERENCE   2  (bases 1 to 1039)
  AUTHORS   Lu,Y., Liu,C., Miao,X., Xu,K., Wu,X. and Liu,C.
  TITLE     Increased expression of myo-inositol oxygenase is involved in the
            tubulointerstitial injury of diabetic nephropathy
  JOURNAL   Exp Clin Endocrinol Diabetes 117 (6), 257-265 (2009)
   PUBMED   19053028
  REMARK    GeneRIF: increased expression of MIOX in diabetic kidneys may
            contribute to tubulointerstitial injury and the development of
            diabetic nephropathy
REFERENCE   3  (bases 1 to 1039)
  AUTHORS   Thorsell,A.G., Persson,C., Voevodskaya,N., Busam,R.D.,
            Hammarstrom,M., Graslund,S., Graslund,A. and Hallberg,B.M.
  TITLE     Structural and biophysical characterization of human myo-inositol
            oxygenase
  JOURNAL   J Biol Chem 283 (22), 15209-15216 (2008)
   PUBMED   18364358
REFERENCE   4  (bases 1 to 1039)
  AUTHORS   Arner,R.J., Prabhu,K.S. and Reddy,C.C.
  TITLE     Molecular cloning, expression, and characterization of myo-inositol
            oxygenase from mouse, rat, and human kidney
  JOURNAL   Biochem Biophys Res Commun 324 (4), 1386-1392 (2004)
   PUBMED   15504367
  REMARK    GeneRIF: Molecular cloning and characterization of myo-inositol
            oxygenase as a 33kDa protein.
REFERENCE   5  (bases 1 to 1039)
  AUTHORS   Arner,R.J., Prabhu,K.S., Thompson,J.T., Hildenbrandt,G.R.,
            Liken,A.D. and Reddy,C.C.
  TITLE     myo-Inositol oxygenase: molecular cloning and expression of a
            unique enzyme that oxidizes myo-inositol and D-chiro-inositol
  JOURNAL   Biochem J 360 (Pt 2), 313-320 (2001)
   PUBMED   11716759
REFERENCE   6  (bases 1 to 1039)
  AUTHORS   Yang,Q., Dixit,B., Wada,J., Tian,Y., Wallner,E.I., Srivastva,S.K.
            and Kanwar,Y.S.
  TITLE     Identification of a renal-specific oxido-reductase in newborn
            diabetic mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 9896-9901 (2000)
   PUBMED   10944187
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078840.1.
            
            On Nov 26, 2004 this sequence version replaced NM_145771.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078840.1, AF197128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1039
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1039
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /note="myo-inositol oxygenase"
                     /db_xref="GeneID:252899"
                     /db_xref="RGD:628739"
     exon            1..21
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..864
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /EC_number="1.13.99.1"
                     /note="MI oxygenase; aldehyde reductase-like 6;
                     kidney-specific protein 32; renal-specific oxidoreductase;
                     renal-specific oxido-reductase; aldehyde reductase (aldose
                     reductase) like 6"
                     /codon_start=1
                     /product="inositol oxygenase"
                     /protein_id="NP_665714.2"
                     /db_xref="GeneID:252899"
                     /db_xref="RGD:628739"
                     /translation="MKVDLGPDPSLVYRPDVDPEMAKSKGSFRNYTSGPLLDRVFTTY
                     KLMHTHQTVDFVMRKRIQFGSFSYKKMTVMEAVDMLDDLVDESDPDVDFPNSFHAFQT
                     AEGIRKAHPDKDWFHLVGLLHDLGKILALWGEPQWAVVGDTFPVGCRPQASVVFCDST
                     FQDNPDLQDPRYSTELGMYQPHCGLENVLMSWGHDEYLYQMMKFNKFSLPSEAFYMVR
                     FHSFYPWHTGGDYRQLCSQQDLDMLPWVQEFNKFDLYTKCPDLPEVKSLRPYYQGLID
                     KYCPGILSW"
     exon            22..102
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            103..183
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            184..346
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            347..414
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            415..524
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            525..592
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            593..642
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            643..755
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1016
                     /gene="Miox"
                     /gene_synonym="Aldrl6; RSOR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaggatga aggtcgactt gggcccagac ccttccctgg tctatcgacc tgatgtggac
       61 ccagagatgg ccaaaagcaa gggcagcttc cgaaactaca cttcaggccc gctgctggat
      121 cgcgtcttta ccacctataa gctgatgcac actcaccaga ccgtggactt cgtcatgcgg
      181 aagcgcatcc agtttggaag cttctcttac aagaagatga cggtcatgga ggctgtagat
      241 atgctggatg atctggtgga cgaatctgac ccagacgtag acttccccaa ctcctttcac
      301 gcgttccaga ccgcggaggg catccgaaaa gcccacccag acaaggactg gttccatctg
      361 gttggacttt tgcatgatct ggggaaaatc ctggccctgt ggggggaacc tcagtgggct
      421 gttgttggag acactttccc cgtgggctgc cgtccccagg cctccgtggt gttctgcgac
      481 tctactttcc aggacaatcc tgacctccag gaccctcgat acagcacaga acttggcatg
      541 taccagcccc actgtggact tgagaatgtc cttatgtcct ggggccatga tgagtaccta
      601 taccagatga tgaagttcaa caagttctcc ctaccttcag aggccttcta catggtccga
      661 ttccattcct tctatccgtg gcacaccggc ggtgactacc ggcagctgtg cagtcagcaa
      721 gacctggata tgctgccttg ggtgcaagag ttcaacaagt ttgacctcta caccaagtgc
      781 cctgacctac cggaagtgaa gagcctgcgg ccctactatc aggggctgat tgacaagtac
      841 tgcccgggca tcctgagctg gtgaatggtt tctaatacct tctctctcac tgctgagggg
      901 caccaaggct ggacaacttc agggacaata atagcccatg ccacctgtcc acagtcccca
      961 cccatcacag ttgaggtcac ttttgcctgg ctatcaataa agcataaaag agattaaaaa
     1021 aaaaaaaaaa aaaaaaaaa
//
