LOCUS       NM_001173554            3744 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus meiosis regulator for oocyte development (Mios),
            mRNA.
ACCESSION   NM_001173554 XM_001055421 XM_342642
VERSION     NM_001173554.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3744)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
REFERENCE   2  (bases 1 to 3744)
  AUTHORS   Bar-Peled,L. and Sabatini,D.M.
  TITLE     Regulation of mTORC1 by amino acids
  JOURNAL   Trends Cell Biol 24 (7), 400-406 (2014)
   PUBMED   24698685
  REMARK    Review article
REFERENCE   3  (bases 1 to 3744)
  AUTHORS   Bar-Peled,L., Chantranupong,L., Cherniack,A.D., Chen,W.W.,
            Ottina,K.A., Grabiner,B.C., Spear,E.D., Carter,S.L., Meyerson,M.
            and Sabatini,D.M.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   4  (bases 1 to 3744)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_342642.4, XM_001055421.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1543287.1,
                                           SRR26643287.10448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000004.1  37230285-37230495
            212-270             JAXUCZ010000004.1  37232878-37232936
            271-1604            JAXUCZ010000004.1  37236110-37237443
            1605-1703           JAXUCZ010000004.1  37237717-37237815
            1704-1958           JAXUCZ010000004.1  37242227-37242481
            1959-2128           JAXUCZ010000004.1  37244597-37244766
            2129-2194           JAXUCZ010000004.1  37246743-37246808
            2195-2353           JAXUCZ010000004.1  37247727-37247885
            2354-2506           JAXUCZ010000004.1  37251070-37251222
            2507-2711           JAXUCZ010000004.1  37252763-37252967
            2712-2841           JAXUCZ010000004.1  37253932-37254061
            2842-3744           JAXUCZ010000004.1  37254958-37255860
FEATURES             Location/Qualifiers
     source          1..3744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..3744
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /note="meiosis regulator for oocyte development"
                     /db_xref="GeneID:362324"
                     /db_xref="RGD:1308432"
     exon            1..211
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     exon            212..270
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     exon            271..1604
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2938
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /note="WD repeat-containing protein mio; missing oocyte,
                     meiosis regulator, homolog; GATOR complex protein MIOS"
                     /codon_start=1
                     /product="GATOR2 complex protein MIOS"
                     /protein_id="NP_001167025.1"
                     /db_xref="GeneID:362324"
                     /db_xref="RGD:1308432"
                     /translation="MSGTKPDILWAPHQVDRFVVCDSELSLYHVESAVNSELKAGSLR
                     LSEDSAATLLSINSDTPYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKD
                     LIGKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEK
                     VRLSAGEAETTLLVTKPLYELGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQ
                     KMFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWC
                     PTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTS
                     QNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHLYECAEEESDNTLEKDIAT
                     KMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEEMDQKSPGNKGS
                     LVYAGIKSIVKSSLGMVESSRHNWSGLDKQTDIQNLNEERILALQLCGWIKKGTDVDV
                     GPFLNSLVQEGEWERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGYTD
                     EKNSLWREMCSTLRLQLNNPYLCVMFAFLTSEAGAYDGVLYENKVAVRDRVAFACKFL
                     GDAQLNKYIEKLTNEMKEAGNLEGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQG
                     SPLDVLKDERVQYWIENYRNLLDAWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFC
                     GKSISYSCSSVPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLPRCALCLINMGTPVSS
                     CPGGSKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTC
                     KCMQLDTTGNLVPAETLQP"
     exon            1605..1703
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1958
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2128
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2194
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2353
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2506
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2711
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2841
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3744
                     /gene="Mios"
                     /gene_synonym="RGD1308432"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccaggggc ggtgccgagc gagaggaagg cggggctcgc ggcgaggagg tctgcttccg
       61 aggcggctga agaggtttgg tagtgggccc agcgggtggc ccgggtcacc gcccgctctt
      121 cggcggccat cttgcccgcg cccgtctccc gcggcggggg gggcggcgta caggccggaa
      181 acgtctgtgt ggcgacacgc cacctcctca gggacatagc aagcttctca agacatggtt
      241 aagaagcttc ctttctttgt gagaatctag tgaatggacc tgactggact ttttaagccc
      301 atcaataaac atgagcggta ccaagcctga tattttgtgg gcaccacacc aggttgatag
      361 attcgttgta tgtgactcag agctgagcct ttatcatgtg gaatcggctg tgaattcaga
      421 actcaaagct ggatcattac gtttatctga agactctgca gctacattac tgtcaataaa
      481 ctcagataca ccctatatga aatgtgttgc gtggtatctc aattatgatc ctgagtgtct
      541 cctagcagtt ggacaagcaa atggtcgagt tgtacttaca agtcttggtc aagatcataa
      601 ctctaagttt aaagatttga taggaaaaga atttgttcca aaacatgctc gacaatgcaa
      661 tacgcttgcg tggaatccac tggatagtaa ctggcttgct gctggtctag acaaacacag
      721 agctgacttt tcagttctga tatgggatat ctgcagcaaa tatactcctg atattgttcc
      781 catggaaaaa gtgagacttt cagcaggtga agctgaaaca acattattag taacaaaacc
      841 actgtatgag ttagggcaga atgatgcttg tctatctctt tgttggcttc cacgagacca
      901 gaagcttctt cttgctggca tgcatcgtaa cctagccata tttgatcttc ggaacacaag
      961 ccagaagatg tttgtaaata caaaagctgt tcaaggagtg acagtggacc cttacttcca
     1021 tgatcgtgtt gcttccttct atgaaggtca ggttgcaata tgggatctta gaaaatttga
     1081 gaagccagtt ttgactttga ctgaacaacc aaagccctta acaaaagtag catggtgtcc
     1141 aactaggaca ggcctgcttg ctactttaac aagggatagt aatattatta ggctgtatga
     1201 tatgcagcac acacccactc ccattgggga tgaaactgag cccacaataa ttgaaagaag
     1261 tgtgcaacct tgtgacaatt acattgcttc ctttgcatgg cacccaacga gtcaaaatcg
     1321 aatgatagtt gtgactccca accgaacaat gtctgacttc actgtatttg aaaggatatc
     1381 tcttgcctgg agcccgatta catctttaat gtgggcttgt ggtcgccatt tgtatgagtg
     1441 tgcagaagaa gaaagtgata ataccttaga aaaagatata gcaacaaaaa tgcgccttcg
     1501 ggctttatca aggtatggac ttgataccga acaggtatgg agaaaccaca ttttagctgg
     1561 caatgaagac ccacagctca agtcactctg gtatactctg cactttatga agcagtatac
     1621 agaagagatg gatcaaaaat ctccaggcaa caaaggatca ttggtttatg caggaattaa
     1681 atcaatagta aaatcatcat taggaatggt agaaagcagc agacataatt ggagtggctt
     1741 ggataaacaa actgatattc agaacttaaa tgaagagagg attttagcgt tacagctttg
     1801 tgggtggata aagaaaggaa cggatgtaga tgtggggcca tttttgaact cccttgtaca
     1861 agaaggagaa tgggaaagag ctgctgccgt ggctttgttc aacttggata ttcggcgagc
     1921 aatccaaatc ctgaatgaag gggcatcttc agaaaaagga gatctgaatc tcaatgtggt
     1981 ggcaatggct ttatcagggt atacggacga gaagaactcc ctgtggaggg agatgtgcag
     2041 cacactacgc ttgcagctca acaaccccta tctgtgtgtc atgtttgcat ttctgacaag
     2101 tgaagcaggg gcctatgacg gagttttgta tgaaaacaaa gttgctgtac gggacagagt
     2161 ggcatttgct tgtaaattcc ttggtgatgc tcagttaaat aaatacattg aaaagctgac
     2221 caatgaaatg aaagaggctg ggaatttgga aggcatcttg ctgaccggcc tcactaaaga
     2281 tggagtggac ctgatggaga gttatgtgga cagaactgga gatgtccaaa cagcaagcta
     2341 ctgcatgtta cagggttcac ctttagatgt tctgaaagac gaaagggttc aatattggat
     2401 tgagaattac agaaatttat tagatgcctg gaggttttgg cacaaacggg ctgaatttga
     2461 tattcatagg agtaaattgg atcccagttc caagccttta gcacaggtgt ttgtgagttg
     2521 taatttttgt ggcaaatcaa tctcctacag ctgttcctct gtgcctcatc agggcagagg
     2581 gtttagtcag tatggtgtga gtggctcacc aacaaaatcc aaagtcacaa gctgccctgg
     2641 ctgtcgaaaa ccccttcctc gatgtgcact ttgcctcatt aatatgggaa cacctgtttc
     2701 tagctgtcct ggtggatcca aatcagatga aaaagtggac ttgagcaagg acaaaaagtt
     2761 agctcagttt aacaattggt ttacctggtg tcacaattgt cggcatggtg ggcatgccgg
     2821 acatatgcta agttggttca gggaccatgc agagtgtcct gtatctgcat gcacgtgtaa
     2881 atgtatgcag ttggatacaa caggaaatct ggtgccagca gagactcttc agccatgaaa
     2941 tgttacatct gaagagaaac cttcaagtgt ggagtcttta atagatgtcc ttcatagttc
     3001 aaaaaaatac ctcagaacaa gtcactcatg agtttcctat aatggggaaa taaatcattc
     3061 tatcagttta gcaatttgat attttgagtg attttgacga acttctcaga ggcaaacgcg
     3121 ctgctgatat gaacatcaga gcatgaatat tggtgctgtt cagtagggta aagtttattt
     3181 gaaagaactt tctaggcttt tgtcaaaatt atgtgtacag atggttttag aataaaaaca
     3241 gaccttgtgc ctgtatcttc actctggaat tgataacttt tgataaaaat ctgtacatgt
     3301 ttaaagccaa atgccaattc agtggttcat ctatcaatgt aaacttattc atgcttaaat
     3361 atgctttcag agaaaatgtg aatttttaca ttgagaatta gctcctgacc cacactggag
     3421 aatacatgca catgtgctta tgtgtacaca catatttaac gaatcttcaa cctcatacat
     3481 ttgtatttta atataaaaga ttttgacata gatcattctt gtcttcctca aaaatccaag
     3541 ttaggagcag gctggtgaga tggttcagca tataagaagg gggctggctg ccaccccaga
     3601 agacctaagt gcagtcagtc cttgggaccc atgtgttgga agcagtgatt cagctgaccc
     3661 ccagaagtgt gctgcagcat ggggcaggca gatacgcacg catgcgcatt agaaaataaa
     3721 gaataataaa acaatttaaa acca
//
