LOCUS       XM_006246716            5177 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus misshapen-like kinase 1 (Mink1),
            transcript variant X1, mRNA.
ACCESSION   XM_006246716
VERSION     XM_006246716.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051345.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006246716.5.
            
            On Jan 21, 2021 this sequence version replaced XM_006246716.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5177
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5177
                     /gene="Mink1"
                     /gene_synonym="MEKKK 6"
                     /note="misshapen-like kinase 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 45 ESTs, 3 long SRA reads, 59 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 112 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:303259"
                     /db_xref="RGD:1359135"
     CDS             267..4421
                     /gene="Mink1"
                     /gene_synonym="MEKKK 6"
                     /codon_start=1
                     /product="misshapen-like kinase 1 isoform X1"
                     /protein_id="XP_006246778.1"
                     /db_xref="GeneID:303259"
                     /db_xref="RGD:1359135"
                     /translation="MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRH
                     VKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLW
                     LVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVL
                     LTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWS
                     LGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLS
                     RPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHG
                     EEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLH
                     QRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQE
                     YIRHRLEEEQRQLEILQQQLLQEQALLLEYKRKQLEEQRQSERLQRQLQQEHAYLKSL
                     QQQQQQQQQLQKQQQQQQQQQQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEE
                     RARMNKQQNSPLAKTKPSSAGPEPPIPQASPSPPGPLSQTPPMQRPVEPQEGPHKSLV
                     AHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQN
                     SDPTSEGPGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPR
                     SNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNTSSNPDLRRSDPGWERSDSVLPASHG
                     HLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPASYKRAIGEDFVL
                     LKERTLDEAPKPPKKAMDYSSSSEEVESSEDEEEEGDGEPSEGSRDTPGGRSDGDTDS
                     VSTMVVHDVEEVSGTQPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPT
                     ENSQGQSPPTKDGGGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGE
                     GGRLDQLQFDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGT
                     ENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKI
                     LHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFM
                     AFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQI
                     TPHAIVFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMG
                     WGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNR
                     NCIMNW"
ORIGIN      
        1 tgtcggcacc ccgctggagg gggtgcccgg cgcgttcgcg tcacggtccg ctccgcgcgt
       61 gcgcagggca gcgggcggct cgggttgcag gcgcgcgggt cagagcgcct gtcagccgct
      121 gggtcggtcc tcccgctggc cctccccctc cccggccttc ggggcaggcg cggtggagcc
      181 cgcccctcgg gtcccccgat gggggagaag cggcaacggc ggcagcggag tgagcgagcc
      241 ggagcgtgag tggccccgcg gcggccatgg gcgacccagc ccccgcccga agcttggacg
      301 acatcgacct gtctgccctg agggaccctg caggaatctt tgagctggtg gaggtggttg
      361 gcaatggaac ctatggacag gtgtacaagg ggcggcacgt caagactggg cagctggctg
      421 ccattaaggt catggatgtc acagaggatg aggaggaaga aatcaaacag gaaatcaaca
      481 tgttaaagaa gtactctcac catcgcaata ttgccaccta ctacggggcc ttcatcaaga
      541 agagccctcc tgggaacgat gaccagctct ggctggtgat ggagttctgt ggtgctggct
      601 cagtgaccga cctggtaaag aacacgaaag gaaacgcgct gaaagaggat tgcattgcgt
      661 acatctgcag ggagattctc aggggtcttg cccatctcca tgcccacaag gtgatccacc
      721 gagatatcaa gggacaaaat gtgctgctga cagagaatgc tgaagtcaag ctagtggact
      781 ttggggtgag tgctcagctg gaccgcactg tggggaggcg gaacactttc attgggaccc
      841 catactggat ggctccagaa gtcattgcct gtgacgagaa ccccgatgcc acctatgact
      901 acaggagtga catttggtct ctaggaatca cagccattga aatggcagag ggagcccccc
      961 ctctgtgtga catgcaccct atgcgggctc tcttcctcat ccctcggaac cctcccccca
     1021 ggctcaagtc aaagaaatgg tctaagaagt tcactgactt cattgacacg tgtctcatca
     1081 agacttacct gagccgacca ccaacagaac agttactcaa attccccttc atccgagacc
     1141 agcccacgga gcggcaggtc cgcatccagc tcaaggacca cattgaccgc tcccggaaga
     1201 agcgggggga gaaagaggag acagagtatg agtacagtgg cagtgaagag gaagacgaca
     1261 gccatggaga ggaaggcgag ccaagttcca tcatgaatgt gcctggggag tccacactcc
     1321 gccgagaatt cctcagactc caacaggaga ataagagcaa ctcagaggct ttaaagcagc
     1381 agcagcagct gcagcagcag cagcagcggg accctgaggc acacatcaaa cacctgctgc
     1441 accagcggca gcgtcgcata gaggagcaga aggaggagcg gcgacgtgta gaggagcaac
     1501 agcggcgaga gcgagaacag cgcaagctgc aggagaagga gcagcagcgg cggttggaag
     1561 acatgcaagc ccttcgtcga gaggaagaga ggcggcaagc agagcgggaa caggaatata
     1621 ttcgtcacag gctagaggag gagcagcgac agctcgagat ccttcagcaa cagctgctcc
     1681 aggaacaggc cttgctgctg gaatacaagc ggaagcagct ggaggagcag cggcagtcgg
     1741 agcggctcca gagacagctg cagcaggagc atgcctacct caagtccctg cagcagcagc
     1801 agcaacagca gcagcagctc cagaaacaac agcagcagca gcagcagcag cagcagcagc
     1861 agcagcagca gcagatccta cctggagaca ggaaacccct gtatcattat ggtcggggca
     1921 ttaatcctgc tgacaagcca gcatgggccc gagaggtgga agagagagct cggatgaaca
     1981 agcagcagaa ctctcccttg gccaagacaa agccaagcag tgcggggcca gagcccccca
     2041 ttccccaggc ctctcctagc cccccaggac ctctttccca aactcctcct atgcagaggc
     2101 ctgtggagcc tcaggaagga ccacacaaga gcctggtggc acaccgggtc ccactgaagc
     2161 catatgcagc acctgtaccc cgatcccagt ccctgcagga ccaacccact cgaaacttgg
     2221 ctgccttccc agcctcccac gaccctgacc ctgctgctgt ccccacaccc actgccacac
     2281 ccagtgcccg aggagctgtc atccgccaga attcagaccc cacctctgaa gggcctgggc
     2341 ctagccctaa ccctccatcc tgggtccggc ctgataatga agctccaccc aaggttcctc
     2401 agaggacctc gtctattgcc actgccctta acaccagtgg ggctggaggg tcccggccag
     2461 ctcaggctgt ccgtgccaga cctcgcagca actccgcctg gcaaatctat ctgcagaggc
     2521 gggcagagcg aggcaccccc aagcctcctg ggcccccagc tcagccccct ggcccgccca
     2581 acacctctag taaccctgac ctcaggagga gtgaccctgg ctgggagcgt tcagacagtg
     2641 tcctccctgc ctcccacggc cacctccctc aggccggctc cttggagcgg aaccgaaacc
     2701 gtgtgggagc ctccacaaaa ctggacagct ccccagtgct ctcccctggg aacaaggcca
     2761 agcctgaaga ccaccgctca aggccaggcc ggcccgcaag ctataagcga gcgattggtg
     2821 aggatttcgt gttgctcaaa gagcggactc tggatgaggc ccctaagcct cccaagaagg
     2881 ccatggacta ttcctcatcc agtgaggagg tggagagcag tgaagatgag gaggaggaag
     2941 gcgatgggga gccatcagag gggagcagag acactcccgg gggccgcagt gatggtgaca
     3001 cagatagcgt cagcaccatg gtggttcatg atgttgaaga ggtatccggg acccagcctt
     3061 catatggagg aggcaccatg gtggtccagc gtactcctga agaggagcga agcctgctgc
     3121 ttgctgatag caatggctac acaaacctgc cagatgtggt ccagcccagc cactcaccta
     3181 ctgagaacag ccaaggtcaa agccctccaa caaaggatgg aggcggtgat taccagtctc
     3241 gtgggctggt aaaggcccca ggaaagagtt cattcaccat gtttgtggat ctagggatct
     3301 accagcctgg aggcagtggg gataccatcc ccatcacagc cctagtgggc ggagagggtg
     3361 gtcgccttga tcaactgcag ttcgatgtga ggaagggctc tgtggtcaac gtcaatccca
     3421 ccaacactcg agctcatagt gaaactcccg agattcgcaa gtacaagaag cgattcaatt
     3481 ccgagatcct ctgtgcagcc ctctgggggg tcaacctcct agtgggcaca gagaatgggc
     3541 tgatgttgct ggaccgaagt gggcagggca aagtgtatgg acttattggg cgacgacgct
     3601 tccagcaaat ggatgttctg gaagggctca acctgctcat caccatctca gggaaaagga
     3661 acaaactgcg ggtatattac ctgtcctggc ttcggaataa gattctacac aatgacccag
     3721 aggtggaaaa gaagcagggg tggaccaccg tgggggacat ggagggctgc ggccactatc
     3781 gtgttgtgaa atatgaacga attaagttcc tggtcattgc tctgaagaac tctgtggagg
     3841 tgtatgcctg ggcccctaaa ccctaccaca aattcatggc cttcaagtcc tttgctgacc
     3901 tccctcaccg ccctctgctg gtggacctga cagtagagga gggccagcgg ctcaaggtca
     3961 tctatggctc cagtgctggc ttccatgctg tggatgttga ctctgggaac agctatgaca
     4021 tctacatccc tgtacatatc cagagccaaa tcacacccca cgccatcgtc tttctcccca
     4081 acactgacgg catggagatg ctgctttgct atgaagatga gggtgtctac gtcaacactt
     4141 acgggcggat catcaaggac gtggtgctgc agtggggaga gatgcccacc tctgtcgcct
     4201 acatctgctc caaccagata atgggctggg gtgagaaggc catagagatc cgctctgtgg
     4261 agacaggcca cctagatggg gtcttcatgc acaaacgagc ccagaggctc aagttcctgt
     4321 gtgagcggaa tgataaggtg ttttttgcct cagtccgctc tggaggaagc agccaagttt
     4381 actttatgac tctgaaccgt aactgcatca tgaactggtg acgaggcccc tgggctgggg
     4441 ctccccacat ggacccagct ctgtccccac agccagacta cccaggccgc ccctgccctc
     4501 ccacccccct tgggcttttg cttttaatgg tttgattcac tggagcctgc tgggaacgtg
     4561 acctcatatt cctgaagctt ttgtgatcac gtgaccatcc tttctcccga cattctcaaa
     4621 actgcctttc cttaacttct gggggatgac acagcttcct tccccttacc aggaattgag
     4681 tgggacttgc tcctcccttt tctctacaga agagagtgct tggggcttgg accccttacc
     4741 ccattgctgc tgactgagca gggccctgac cccttttttg cacgccaggg gagccggctc
     4801 cccccttgaa tgtaccagac tctggggggg gtattcactg ggccctgggt tggggggggt
     4861 caccagccac tccaggggca gggaccattt cctcatttct gaaagcactt taatgatttc
     4921 ccccctcagt ccccagggaa tggaggaggg accccatagc caaaacattc ccccctttcc
     4981 tccccacccc caccccatct ttcctcttcc cttccctaga gggagagggc tcagagctcc
     5041 caccctctat cctcccttgc ttgcatctgt atatagtgtg agcagcaagt agcccttctc
     5101 cctcctgtat cctttctcaa tgtagtggcc ttggatatcc cctttgttaa taaagacaat
     5161 tcaaccagct tccacca
//
