LOCUS       NM_001025118            2054 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus MINDY lysine 48 deubiquitinase 1 (Mindy1), mRNA.
ACCESSION   NM_001025118 XM_227441
VERSION     NM_001025118.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Kristariyanto,Y.A., Abdul Rehman,S.A., Weidlich,S., Knebel,A. and
            Kulathu,Y.
  TITLE     A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin
            chains
  JOURNAL   EMBO Rep 18 (3), 392-402 (2017)
   PUBMED   28082312
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Abdul Rehman,S.A., Kristariyanto,Y.A., Choi,S.Y., Nkosi,P.J.,
            Weidlich,S., Labib,K., Hofmann,K. and Kulathu,Y.
  TITLE     MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally
            Distinct New Family of Deubiquitinating Enzymes
  JOURNAL   Mol Cell 63 (1), 146-155 (2016)
   PUBMED   27292798
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091386.1.
            
            On Jul 1, 2005 this sequence version replaced XM_227441.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091386.1, SRR8487231.154491.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2054
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /note="MINDY lysine 48 deubiquitinase 1"
                     /db_xref="GeneID:310665"
                     /db_xref="RGD:1559660"
     exon            1..644
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1598
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /EC_number="3.4.19.12"
                     /note="protein FAM63A; deubiquitinating enzyme MINDY-1;
                     family with sequence similarity 63, member A"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-1"
                     /protein_id="NP_001020289.1"
                     /db_xref="GeneID:310665"
                     /db_xref="RGD:1559660"
                     /translation="MEQPQAECPAPSKTNSAETVESEKHEALSGPEKHPQDKDGADAA
                     PEKHPQDKDGADAHGEAGKQKSGDQTLPPVQDGGNLECPPPEASSSPPGPACGIPSEV
                     ETTEACSRPQQLPQSPRIQQPDLDFYCVKWIPWKGERTPIITQSSNGPCPLLAIMNIL
                     FLQWKVKLPPQKEVITSDELLTHLGNCLLSIKPQEKSEGLQLNFQQNVGDAMTVLPKL
                     ATGLDVNVRFTGVSDFEYTPECSVFDLLGVPLYHGWLVDPQSPEAVSAVGKLSYNQLV
                     EKIIICKHSSDSNLVTEGLIAEQFLETTAAQLTYHGLCELTATAKEDELSVFFRNNHF
                     STMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKSHGAEG
                     GSGSPEKQLQVDQDYLIALSLQQQQQPQGMLGLSDLELAQQLQQEEYQQQQAVQPVRT
                     RAPSSPGRGATSGRPAGERRQRSKTESDCVLL"
     exon            645..702
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /inference="alignment:Splign:2.1.0"
     exon            703..767
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /inference="alignment:Splign:2.1.0"
     exon            768..926
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1029
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1172
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1364
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1517
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..2028
                     /gene="Mindy1"
                     /gene_synonym="Fam63a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctgttca ctttgtcttt tcttgtttcc tttgctctat aattcaatga ccttattggc
       61 caggtccttt tgcacactag aatagcccta ggcaaggtct ctgaggtcac agagcaactt
      121 cattcccctc agctgactct gtacccacta tggaacaacc tcaggctgag tgcccagccc
      181 ccagtaagac caacagtgca gaaactgttg aatctgaaaa gcacgaggcc ctgtctggac
      241 cagaaaagca tcctcaggac aaggacggtg cagatgctgc accagaaaag catcctcagg
      301 acaaggacgg tgcagatgct catggggaag caggaaaaca gaagtcagga gaccaaactt
      361 tgccaccagt ccaggatggg ggaaatcttg agtgtcctcc tcctgaagct agttcaagtc
      421 ctcctgggcc agcttgtggg ataccatctg aggtagagac aacagaggca tgttccaggc
      481 cgcagcagct tccccagtcc cccaggatcc aacagcctga tctagatttc tactgtgtca
      541 agtggatccc ctggaaggga gaacggaccc ccatcatcac ccagagcagc aatggtcctt
      601 gtcctctcct ggccatcatg aacatcctct ttctgcagtg gaaggtaaag ctgccgcctc
      661 agaaggaagt gatcacatca gacgagctcc tgacacatct tggaaactgc cttctgtcca
      721 tcaaacccca agagaagtct gagggccttc aacttaactt tcagcagaat gtgggcgatg
      781 caatgacggt gctccctaaa ctggccacag gtctggacgt caatgtgcga ttcacaggcg
      841 tctcagactt cgagtacaca ccggaatgca gcgtctttga cttgttggga gtacctctat
      901 accatggctg gctcgtggat ccacagagtc ctgaggctgt gagtgctgtt gggaaactga
      961 gttataacca gctagtagag aagatcatca tctgtaaaca ctctagtgac tccaacctcg
     1021 tgacagaagg cttgattgcg gagcagttcc tggagaccac cgcagctcag ctgacttacc
     1081 atggcctgtg cgagctcaca gccactgcca aggaagacga acttagcgtc ttttttcgaa
     1141 acaaccactt tagcacgatg actaagcaca agagtcacct gtacctactg gtcactgacc
     1201 aaggttttct acaggaggag caggtggtgt gggagagctt gcataacgtg gatggggaca
     1261 gctgcttttg tgactctgac ttccacctaa gtcattccct aggcaaaagc catggagcag
     1321 aaggtgggag tggctctcca gagaagcaac tgcaggtaga ccaggactac cttattgcct
     1381 tgtccctgca gcagcagcag cagccacagg gcatgctggg tctcagtgac ctggaactgg
     1441 cccagcaact tcaacaagaa gagtaccagc aacagcaagc agttcaacct gtgcggacca
     1501 gggccccttc atccccgggt agaggagcca catctggacg cccagctggg gagcggaggc
     1561 agaggtcgaa gactgagtca gactgtgttc tgctctgact ccgccccata cagcctgccc
     1621 cgccccttct ttcagaggcc ttgaccggca ggaccccgcc ccacctcaat ccttgaggca
     1681 tacaggataa cctgtatgcg ctattgggga tcagaacagt gggtgccaag atcagacttg
     1741 gtaccgtctt tgcccttgta ctgctatctt ctcttcctct catccagggc cacatgggta
     1801 tgggttgggt gaagatctct ggttcccagt cccctttcct ggattagtca catggatatg
     1861 ccgacccagg ctgctaagtg agacacccat ctcctgtgtc cttgcctgtc tggttgttcc
     1921 tgggcttaac cgcacaggcc tgtctttgtt ttagggtttg gtttgggttt atatctttat
     1981 tatttttaat gccttcctag gggtttggaa ataaaactcc tttcctgaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaa
//
