LOCUS       NM_001011931            2888 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus MHC I like leukocyte 1 (Mill1), mRNA.
ACCESSION   NM_001011931 XM_039103924 XM_218395
VERSION     NM_001011931.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Ashiru,O., Boutet,P., Fernandez-Messina,L., Aguera-Gonzalez,S.,
            Skepper,J.N., Vales-Gomez,M. and Reyburn,H.T.
  TITLE     Natural killer cell cytotoxicity is suppressed by exposure to the
            human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes
  JOURNAL   Cancer Res 70 (2), 481-489 (2010)
   PUBMED   20068167
REFERENCE   2  (bases 1 to 2888)
  AUTHORS   Waldhauer,I., Goehlsdorf,D., Gieseke,F., Weinschenk,T.,
            Wittenbrink,M., Ludwig,A., Stevanovic,S., Rammensee,H.G. and
            Steinle,A.
  TITLE     Tumor-associated MICA is shed by ADAM proteases
  JOURNAL   Cancer Res 68 (15), 6368-6376 (2008)
   PUBMED   18676862
REFERENCE   3  (bases 1 to 2888)
  AUTHORS   Kajikawa,M., Baba,T., Tomaru,U., Watanabe,Y., Koganei,S.,
            Tsuji-Kawahara,S., Matsumoto,N., Yamamoto,K., Miyazawa,M.,
            Maenaka,K., Ishizu,A. and Kasahara,M.
  TITLE     MHC class I-like MILL molecules are beta2-microglobulin-associated,
            GPI-anchored glycoproteins that do not require TAP for cell surface
            expression
  JOURNAL   J Immunol 177 (5), 3108-3115 (2006)
   PUBMED   16920948
REFERENCE   4  (bases 1 to 2888)
  AUTHORS   Chalupny,N.J., Rein-Weston,A., Dosch,S. and Cosman,D.
  TITLE     Down-regulation of the NKG2D ligand MICA by the human
            cytomegalovirus glycoprotein UL142
  JOURNAL   Biochem Biophys Res Commun 346 (1), 175-181 (2006)
   PUBMED   16750166
REFERENCE   5  (bases 1 to 2888)
  AUTHORS   Gasser,S., Orsulic,S., Brown,E.J. and Raulet,D.H.
  TITLE     The DNA damage pathway regulates innate immune system ligands of
            the NKG2D receptor
  JOURNAL   Nature 436 (7054), 1186-1190 (2005)
   PUBMED   15995699
REFERENCE   6  (bases 1 to 2888)
  AUTHORS   Groh,V., Rhinehart,R., Randolph-Habecker,J., Topp,M.S.,
            Riddell,S.R. and Spies,T.
  TITLE     Costimulation of CD8alphabeta T cells by NKG2D via engagement by
            MIC induced on virus-infected cells
  JOURNAL   Nat Immunol 2 (3), 255-260 (2001)
   PUBMED   11224526
REFERENCE   7  (bases 1 to 2888)
  AUTHORS   Bauer,S., Groh,V., Wu,J., Steinle,A., Phillips,J.H., Lanier,L.L.
            and Spies,T.
  TITLE     Activation of NK cells and T cells by NKG2D, a receptor for
            stress-inducible MICA
  JOURNAL   Science 285 (5428), 727-729 (1999)
   PUBMED   10426993
REFERENCE   8  (bases 1 to 2888)
  AUTHORS   Groh,V., Rhinehart,R., Secrist,H., Bauer,S., Grabstein,K.H. and
            Spies,T.
  TITLE     Broad tumor-associated expression and recognition by tumor-derived
            gamma delta T cells of MICA and MICB
  JOURNAL   Proc Natl Acad Sci U S A 96 (12), 6879-6884 (1999)
   PUBMED   10359807
REFERENCE   9  (bases 1 to 2888)
  AUTHORS   Groh,V., Steinle,A., Bauer,S. and Spies,T.
  TITLE     Recognition of stress-induced MHC molecules by intestinal
            epithelial gammadelta T cells
  JOURNAL   Science 279 (5357), 1737-1740 (1998)
   PUBMED   9497295
REFERENCE   10 (bases 1 to 2888)
  AUTHORS   Groh,V., Bahram,S., Bauer,S., Herman,A., Beauchamp,M. and Spies,T.
  TITLE     Cell stress-regulated human major histocompatibility complex class
            I gene expressed in gastrointestinal epithelium
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12445-12450 (1996)
   PUBMED   8901601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000033.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001011931.4.
            
            On or before Mar 18, 2021 this sequence version replaced
            XM_039103924.1, NM_001011931.2.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, BN/SsN and WKAH/Hkm, because no single
            transcript from the same strain was available for the full length
            of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB113962.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JACYVU010000033.1  2249752-2249882
            132-224             JACYVU010000033.1  2259548-2259640
            225-488             JACYVU010000033.1  2267451-2267714
            489-764             JACYVU010000033.1  2267910-2268185
            765-1289            JACYVU010000033.1  2269493-2270017
            1290-2888           JACYVU010000033.1  2274288-2275886
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2888
                     /gene="Mill1"
                     /note="MHC I like leukocyte 1"
                     /db_xref="GeneID:292671"
                     /db_xref="RGD:1311714"
     exon            1..131
                     /gene="Mill1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1255
                     /gene="Mill1"
                     /note="MHC class I-like located near the LRC, 1; MHC class
                     I-like located near the leukocyte receptor complex 1; MHC
                     class I-like protein MILL1"
                     /codon_start=1
                     /product="MHC class I-like protein MILL1 precursor"
                     /protein_id="NP_001011931.1"
                     /db_xref="GeneID:292671"
                     /db_xref="RGD:1311714"
                     /translation="MMLSRDLRAEAAVRLWIMFLLLEDLLGACAVGDYQRRVPSAPNT
                     DIRNTLEKPRVTTQEVAGPHTLRYDLMALSLKLPELPQVLIWRYFDDEPFLHYNESSN
                     RTDSWEPRIKRHWRAMTWARETEDLQEMVEQLKRMLAEVTGQKGQDKGLHILQATLGC
                     ELQRNGSTRGFWHLGYDGRNLLTFDQKTLTWTMDMPFTQQKKTFWEPRAPRADLVKTF
                     LDDTCPAQLQRHLASLRSEPLDTGSPMVIVTFRNYPLGRVTLTCRAFNLYPHMATRGT
                     LAWLQDRKLVKQKAFEPGTILPSGDRTYQIWVSIWVLPGQEPQFTCNLSYHGGNIEKR
                     AVIVNTVSGEKTRQPSTSGVGGRVKKSLWTTMTTAFMVTSWTRKTGGDSTLLLLWWLL
                     FFSTVLAVLTLV"
     exon            132..224
                     /gene="Mill1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..488
                     /gene="Mill1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..764
                     /gene="Mill1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..1289
                     /gene="Mill1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..2888
                     /gene="Mill1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcaaagtg aactcaggag tctcagaaag gcagaagaag atgatgttgt ccagggacct
       61 cagagctgaa gctgcagttc ggctgtggat aatgttcttg ctcctggagg atttactggg
      121 cgcttgtgca gtgggtgact accaaagacg agtgccttct gcccccaaca cagacatcag
      181 gaacactcta gagaagccta gagtaaccac acaggaggta gcaggacccc acactctgcg
      241 ctatgacctc atggccttgt ctctgaagtt gcctgagttg ccccaggtcc tgatctggag
      301 atactttgat gatgagccct tcctacatta taatgaaagc agcaacagaa cagactcctg
      361 ggaacctagg atcaagagac attggagagc tatgacttgg gcaagagaga ctgaggatct
      421 gcaggaaatg gtggagcaac tcaaaaggat gctagctgag gtcacaggcc agaaaggcca
      481 agataagggc cttcacatcc tccaggcaac cctgggctgt gagcttcaaa gaaatggaag
      541 cactagaggc ttctggcacc tgggctatga cgggcggaac ctcctcacct tcgaccagaa
      601 gactctcaca tggacaatgg atatgccctt cacccagcag aagaagacgt tctgggagcc
      661 acgtgcaccc agggctgacc tagttaagac gttcttggat gacacatgtc ctgctcagct
      721 ccagagacat ctggcttcct tgagaagtga accacttgac acaggttccc cgatggtgat
      781 cgtgaccttc aggaattatc cactgggcag ggtcacactg acatgccggg cttttaatct
      841 gtatccccat atggccacca ggggcaccct ggcctggctt caggatagga agctggtaaa
      901 gcagaaagct tttgaaccag ggaccatctt gcccagtggg gacaggacct accagatctg
      961 ggtgtccatt tgggttcttc ctggacagga accacagttc acctgtaatc tgagttacca
     1021 tggtggcaac atagagaagc gtgctgttat tgtgaacact gtctctggtg agaaaacaag
     1081 acaaccttcc acctcaggtg tgggaggcag ggtcaagaaa agcctgtgga ctacaatgac
     1141 cacagctttt atggtgacct cctggaccag gaaaactggt ggggactcca ctctgcttct
     1201 gctctggtgg cttctgttct tttctacagt gttggcagtt ctgaccctcg tctagagcag
     1261 cacgaacacc caagacagca agaaaccagg ttaccgaact caatgggcaa ggactccggc
     1321 acttcctgca ttcattatgg ctcctgtgct ctgtatggct cctgtactcc atatgattcc
     1381 gaacaacaga ttcacaacag attcacatca ggctccttcc agaaaaagga aggttctcgg
     1441 gtcttgtttt aactagcatg tttgtagtat cactgttatt agtacctaaa gctgcttcca
     1501 tagcgaccca acaagtacaa actgcccatt ttgttaattg gcagatgcca tgcaggagta
     1561 gcagcaatgg tcaagtgagc tccctggaga aggcccacca tcttgtcctc ctgagatgcg
     1621 tgtgctctgg tgaggcattg ccccagagac ttagtcccag ggctgttcct gctactgtgt
     1681 gttttctcat ggttgtcagt accgtgctcc tcattgattt ggcttggtga gagtggactc
     1741 cgggagaccc tcactcactg cctacagact gttgtggtta cttcctggtt gccagccacc
     1801 ctattgggaa aatgtcctgc agatcaacat gaagatgagc tttcgtgaat taatgccgtt
     1861 taggtggttg ttttgccaga aagatgtagt aaagttagaa ctgagaataa attgtgcccc
     1921 ctcctcgtag aatggttaag taagggctgc ataacaagga gtacaatgag ctttcataca
     1981 ttgcactaag aagagaaata ggattaagac agatttgtga tgaaagaaga aaccttcttt
     2041 ctaggtccgg tccaaggaag aagccacagg tgtgcactgt gataaagcaa ggccgtgtgg
     2101 aactgttgct ttgaacttat aacgagctta caaaatgaaa agctgctttg aacttactat
     2161 ccctttggac aacatccttt tgaactcccc ttatatgtaa cattttctct atgaggtaat
     2221 tttataaata attttttaat ctaaaaatgt ataaaaaggc taagaaaaaa gtgtggctgt
     2281 tgaggctctg ccccatccaa caagtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2341 tgtgtgtgtg aatgtatgta ttacaatgtg tctttgtgta tatatgcctg tctgtatgta
     2401 tgtgtacata catacatatg tagatatgta tgtatttata taagtattca tgtgcacttg
     2461 tgaaacaggt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat ctgactttct
     2521 ttatttcctt cgtctgtgaa attgccatca gcttttggcg ccagaacagc aagagagtta
     2581 aaagccagaa gtcattggcc ttcagccttt ggttgtgtcc cacctcagta cctgatccag
     2641 ttgaagctgg cccacagcag ctaatcagct agcttataat ccttctgtag cttctgcctc
     2701 acaggaatgt atagatacaa acctagaagc tgtcttgaat gctttagaaa ctatgtgatt
     2761 gtacctagga gatacagtac aaactgcaca gcatccgtta gttacaggat cctgctgctg
     2821 ttatatgtgt atgttactct tttaagctaa atgaaaatga aataaaattt aaaataactt
     2881 acagggaa
//
