LOCUS       NM_001399326            3424 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus mitoguardin 2 (Miga2), transcript variant 1,
            mRNA.
ACCESSION   NM_001399326 XM_006233781
VERSION     NM_001399326.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3424)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3424)
  AUTHORS   Zhang,Y., Liu,X., Bai,J., Tian,X., Zhao,X., Liu,W., Duan,X.,
            Shang,W., Fan,H.Y. and Tong,C.
  TITLE     Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is
            Required for Neuronal Homeostasis
  JOURNAL   Mol Cell 61 (1), 111-124 (2016)
   PUBMED   26711011
REFERENCE   3  (bases 1 to 3424)
  AUTHORS   Bassett,J.H., Gogakos,A., White,J.K., Evans,H., Jacques,R.M., van
            der Spek,A.H., Ramirez-Solis,R., Ryder,E., Sunter,D., Boyde,A.,
            Campbell,M.J., Croucher,P.I. and Williams,G.R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Rapid-throughput skeletal phenotyping of 100 knockout mice
            identifies 9 new genes that determine bone strength
  JOURNAL   PLoS Genet 8 (8), e1002858 (2012)
   PUBMED   22876197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 6, 2022 this sequence version replaced XM_006233781.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231217.1, FQ212119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000003.1  34034044-34034106
            64-299              JAXUCZ010000003.1  34038446-34038681
            300-510             JAXUCZ010000003.1  34040372-34040582
            511-623             JAXUCZ010000003.1  34041771-34041883
            624-741             JAXUCZ010000003.1  34042500-34042617
            742-878             JAXUCZ010000003.1  34042906-34043042
            879-996             JAXUCZ010000003.1  34047735-34047852
            997-1097            JAXUCZ010000003.1  34048547-34048647
            1098-1213           JAXUCZ010000003.1  34049317-34049432
            1214-1286           JAXUCZ010000003.1  34049797-34049869
            1287-1373           JAXUCZ010000003.1  34049999-34050085
            1374-1472           JAXUCZ010000003.1  34052682-34052780
            1473-1607           JAXUCZ010000003.1  34052985-34053119
            1608-1661           JAXUCZ010000003.1  34054144-34054197
            1662-1778           JAXUCZ010000003.1  34054726-34054842
            1779-3424           JAXUCZ010000003.1  34055058-34056703
FEATURES             Location/Qualifiers
     source          1..3424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..3424
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /note="mitoguardin 2"
                     /db_xref="GeneID:296623"
                     /db_xref="RGD:1310887"
     exon            1..63
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            64..299
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1985
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /note="isoform 1 is encoded by transcript variant 1;
                     family with sequence similarity 73, member B"
                     /codon_start=1
                     /product="mitoguardin 2 isoform 1"
                     /protein_id="NP_001386255.1"
                     /db_xref="GeneID:296623"
                     /db_xref="RGD:1310887"
                     /translation="MAFRRTEGMSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGL
                     RKVLFATALGTVALALAAHQLKRRRRKKKQVGPEMGSEQLGTFPMPILMARKVPSVKK
                     GCSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSLASMVMVNSSSPTAACSGSWETR
                     GMEESVPTMDGSAESLYVQGMELFEEALQKWEQALSVGQRGDGGSTPTPGDSLQNPDT
                     SSEALSEPESQRREFAEKLESLLHRAYHLQEEFGSTLPSDNMLLDLERTLMLPLTEGS
                     LCLRADDEDSLTSEDSFFSATELFESLQIGEYPLPLSRPAAAYEEALQLVKEGKVPCR
                     TLRTELLGCYSDQDFLAKLHCVRQAFEGLLEERNNQVFFGEVGRQMVTGLMTKAEKSP
                     KGFLESYEEMLNYALRPETWATTRLELEGRGVACMSFFDIVLDFILMDAFEDLENPPS
                     SVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAF
                     GFLGPKPQLSEVCAFFKHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLG
                     YLGAPVASSTGLNGPLPRENGPLDELQ"
     exon            300..510
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            511..623
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            624..741
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            742..878
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            879..996
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1097
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1213
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1286
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1373
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1472
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1607
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1661
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1778
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..3424
                     /gene="Miga2"
                     /gene_synonym="Fam73b; RGD1310887"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtttggt tgtgttgccg cctggaaagg agacgctgcc cttccccagc gatgggatcc
       61 cggctttgtg gaatgacctg ttatgtgtgc ccctgtcctg ctggggagtg gatggtgccc
      121 aggacccagc cagagaccag ctgaagacgt tctcctcgga agctctcacc ccaggaggtc
      181 ccgtcccggg tgctgggcct accatggcat tccgtaggac tgagggtatg tccatgatcc
      241 aggctctggc catgactgtg gctgagatac cagtgttcct gtacacgact tttggtcagt
      301 ctgcgttctc ccaactgcgg ttgaccccag gcctgagaaa ggttcttttt gccacggccc
      361 tcgggactgt ggccttggcc ctggctgccc accagctgaa aaggcgccgt cggaagaaga
      421 aacaggtggg ccccgagatg ggaagtgagc agctgggcac cttccccatg cccatcctca
      481 tggcccgcaa ggtcccttcg gtgaagaaag gctgctccag ccggagggtt cagagcccca
      541 gcagcaagag caacgacact ctgagtggta tctcctccat agagcccagc aagcactcag
      601 gctcctccca cagcctggcc tcgatggtaa tggtcaattc atccagccct acagctgcgt
      661 gctcaggctc atgggaaacc agagggatgg aggagtctgt gcccaccatg gatggcagtg
      721 ctgagagcct ctatgtgcaa ggcatggagc tgtttgagga agccctgcag aaatgggagc
      781 aggcactgag tgtgggtcag agaggggacg gaggcagcac ccccacacca ggtgacagcc
      841 tccagaaccc agacacctca tctgaagcac tgtcagagcc agagtcacaa cgaagggagt
      901 ttgctgagaa gctggagtcc ctgttgcacc gggcctacca tttgcaggaa gagttcggat
      961 ccaccctccc ctctgacaac atgctgctgg accttgagag gaccctaatg ctgcccctga
     1021 ctgagggctc attgtgtctg cgagctgatg atgaggacag cctgacctca gaagactcct
     1081 ttttctcagc cactgagctc tttgagtccc tgcagatcgg agagtacccg cttcctctct
     1141 ccaggcccgc tgctgcctac gaggaggctc tgcagctggt gaaggagggg aaagtacctt
     1201 gtcgaacact caggacagag ctgctaggct gctacagtga ccaagatttc ctggccaagc
     1261 tgcattgtgt acggcaggcc tttgaggggc ttctagaaga aaggaacaac caggtgttct
     1321 tcggggaggt cggccggcag atggtgacag gcctaatgac caaggctgag aagagtccca
     1381 agggcttcct ggagagctac gaggagatgt tgaactacgc cctgcggcct gagacctggg
     1441 ctaccacccg gttggagctg gagggcagag gggtggcatg catgagcttc ttcgacatcg
     1501 tgttggactt catcctcatg gatgcctttg aggacctaga gaaccctcca tcttcggtgc
     1561 ttgctgtcct gcggaaccgt tggctgtctg atagcttcaa ggaaacagcc ctggccaccg
     1621 cgtgctggtc tgtcctgaaa gccaagagga ggcttctgat ggtgcctgat ggcttcatct
     1681 ctcatttcta ctccgtatcg gagcatgtta gccctgtgct ggcctttggc ttcctcggac
     1741 ccaagcccca gctctcagaa gtctgtgctt tcttcaagca ccagattgtg caatacctga
     1801 gggacatgtt cgacctggac aacgtgcgct acacttctgt gccagcccta gcagaagaca
     1861 tcctacagtt gtcccggcgc cgcagcgaga ttctgttggg ctacctgggg gcaccagtgg
     1921 ctagtagcac cgggctgaat gggccactgc ctcgagagaa tgggcccctg gatgagctgc
     1981 aatagtaggg tgcgggctgg aggagagagg tggctgggcc tcagtcacaa gggtgattgc
     2041 tgggagagag aaagctgccc ctcccttcct ttggagtggc atccaagggc cagggtggcc
     2101 aagggccatt gcccctgagc ttgctccact tcctcatctg ggaatcccaa cacccagagg
     2161 acagatttcc atgaagagga accactagga gcactggata gcagctgccc ttggggttcc
     2221 ctgagcagta gaggcaggcc agagtcagca gcagggtctg accaagggca agcagcaaga
     2281 cagaaaggtg gtggagaatg gctttgagca tggaccacag agccctcatc tcctctgccg
     2341 ctggcggagg gcaaggaggt gataggtaag ggatagagcg cacagggcta tgtggtgacc
     2401 ggcacagggt tctgcaatag gagccatgta tagctacaca attcccagca cctgggcttc
     2461 cggccaggat gaaagccaca tctgggccat ccagagcggg gctcgcccca tgtgtgctca
     2521 tgtctgagca gggactcgtc cttcacaaac ccaggacgct gtcctcatat tcccacgccc
     2581 tgccaaagac tcaagtttcc ccacctctgc caccaccaaa gagggaggag gaggcagggc
     2641 tggcccttcc catgccctgg tgagcctgaa gctccttcct gggcagtgct agactccagc
     2701 tgaggactcc agcccgagct cacacaggcc catctcctgt gttgccatct gctgctccaa
     2761 agtgaggacc taggaaccat ggcagggtgg gcagaggtca cacagcaggg cagttcctcc
     2821 ccatcacccc accccacccc acccccgaca agctggactc agcactttgc cttcaactcc
     2881 atgcacatgt gttttggggc agctgccacc cagggtcctg cagcagccct tggcatttgt
     2941 cacggaggct gcaggggttc tggcggcctt ccttttgcct gagctgggaa gcttttattt
     3001 attgccttaa tactttattt ggctgttccg tccctcccag ttgtggcatg caggagaaaa
     3061 gactcctggt ctgcagtgga gcactggctc ctggaacaaa gttcctctcc ctggaaggga
     3121 caagggctcc ctggggtcag caggatgcac tgaagagagg gtagccatgg ctctgggtcc
     3181 tctctgaggc ctgcgctcaa aagggagcag ccctcacgca ctgtcctcac attccattct
     3241 tttgcactta ccttgagctg tgaatgtaac cttgggccaa ggcccactct gatttgctcc
     3301 tgaaccatac agctgtggca tttttatttt gtcctgtttg tgtgtccatg ccccaccctc
     3361 tacactcaac cagcaataga gtgtgagagc aaggcctgtg aatcagataa aggatcgaag
     3421 tgac
//
