LOCUS       NM_031051                552 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Rattus norvegicus macrophage migration inhibitory factor (Mif),
            mRNA.
ACCESSION   NM_031051
VERSION     NM_031051.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 552)
  AUTHORS   Dong,Z., Yang,P., Ji,Z., Fan,C., Wang,J., Zhu,P., Zhou,F., Gan,M.,
            Wu,X. and Geng,D.
  TITLE     MIF inhibition attenuates intervertebral disc degeneration by
            reducing nucleus pulposus cell apoptosis and inflammation
  JOURNAL   Exp Cell Res 439 (1), 114089 (2024)
   PUBMED   38740166
  REMARK    GeneRIF: MIF inhibition attenuates intervertebral disc degeneration
            by reducing nucleus pulposus cell apoptosis and inflammation.
REFERENCE   2  (bases 1 to 552)
  AUTHORS   Liu,J., Chen,Y., Chen,H., Wang,Y., Li,D., Zhang,Q., Chai,L.,
            Qiu,Y., Zhang,J., Shen,N., Wang,Q., Wang,J. and Li,M.
  TITLE     Macrophage migration inhibitory factor exacerbates asthmatic airway
            remodeling via dynamin-related protein 1-mediated autophagy
            activation
  JOURNAL   Respir Res 24 (1), 216 (2023)
   PUBMED   37674165
  REMARK    GeneRIF: Macrophage migration inhibitory factor exacerbates
            asthmatic airway remodeling via dynamin-related protein 1-mediated
            autophagy activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 552)
  AUTHORS   Li,R., Li,D., Wang,H., Chen,K., Wang,S., Xu,J. and Ji,P.
  TITLE     Exosomes from adipose-derived stem cells regulate M1/M2 macrophage
            phenotypic polarization to promote bone healing via miR-451a/MIF
  JOURNAL   Stem Cell Res Ther 13 (1), 149 (2022)
   PUBMED   35395782
  REMARK    GeneRIF: Exosomes from adipose-derived stem cells regulate M1/M2
            macrophage phenotypic polarization to promote bone healing via
            miR-451a/MIF.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 552)
  AUTHORS   He,Z., Wang,Y., Zhuan,L., Li,Y., Tang,Z.O., Wu,Z. and Ma,Y.
  TITLE     MIF-mediated NF-kappaB signaling pathway regulates the pathogenesis
            of polycystic ovary syndrome in rats
  JOURNAL   Cytokine 146, 155632 (2021)
   PUBMED   34242901
  REMARK    GeneRIF: MIF-mediated NF-kappaB signaling pathway regulates the
            pathogenesis of polycystic ovary syndrome in rats.
REFERENCE   5  (bases 1 to 552)
  AUTHORS   Zhang,Y., Liu,Z., Wang,K., Lu,S., Fan,S., Xu,L. and Cai,B.
  TITLE     Macrophage migration inhibitory factor regulates joint capsule
            fibrosis by promoting TGF-beta1 production in fibroblasts
  JOURNAL   Int J Biol Sci 17 (7), 1837-1850 (2021)
   PUBMED   33994866
  REMARK    GeneRIF: Macrophage migration inhibitory factor regulates joint
            capsule fibrosis by promoting TGF-beta1 production in fibroblasts.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 552)
  AUTHORS   Rossi,A.G., Haslett,C., Hirani,N., Greening,A.P., Rahman,I.,
            Metz,C.N., Bucala,R. and Donnelly,S.C.
  TITLE     Human circulating eosinophils secrete macrophage migration
            inhibitory factor (MIF). Potential role in asthma
  JOURNAL   J Clin Invest 101 (12), 2869-2874 (1998)
   PUBMED   9637721
REFERENCE   7  (bases 1 to 552)
  AUTHORS   Miyazaki,K., Isbel,N.M., Lan,H.Y., Hattori,M., Ito,K., Bacher,M.,
            Bucala,R., Atkins,R.C. and Nikolic-Paterson,D.J.
  TITLE     Up-regulation of macrophage colony-stimulating factor (M-CSF) and
            migration inhibitory factor (MIF) expression and monocyte
            recruitment during lipid-induced glomerular injury in the exogenous
            hypercholesterolaemic (ExHC) rat
  JOURNAL   Clin Exp Immunol 108 (2), 318-323 (1997)
   PUBMED   9158105
REFERENCE   8  (bases 1 to 552)
  AUTHORS   Suzuki,M., Sugimoto,H., Nakagawa,A., Tanaka,I., Nishihira,J. and
            Sakai,M.
  TITLE     Crystal structure of the macrophage migration inhibitory factor
            from rat liver
  JOURNAL   Nat Struct Biol 3 (3), 259-266 (1996)
   PUBMED   8605628
REFERENCE   9  (bases 1 to 552)
  AUTHORS   Sakai,M., Nishihira,J., Hibiya,Y., Koyama,Y. and Nishi,S.
  TITLE     Glutathione binding rat liver 13k protein is the homologue of the
            macrophage migration inhibitory factor
  JOURNAL   Biochem Mol Biol Int 33 (3), 439-446 (1994)
   PUBMED   7951062
REFERENCE   10 (bases 1 to 552)
  AUTHORS   Blocki,F.A., Schlievert,P.M. and Wackett,L.P.
  TITLE     Rat liver protein linking chemical and immunological detoxification
            systems
  JOURNAL   Nature 360 (6401), 269-270 (1992)
   PUBMED   1436109
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031051.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U62326.1, AW434062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000020.1  12790357-12790548
            193-365             JAXUCZ010000020.1  12790741-12790913
            366-552             JAXUCZ010000020.1  12791036-12791222
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..552
                     /gene="Mif"
                     /note="macrophage migration inhibitory factor"
                     /db_xref="GeneID:81683"
                     /db_xref="RGD:621163"
     exon            1..192
                     /gene="Mif"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..432
                     /gene="Mif"
                     /EC_number="5.3.3.12"
                     /EC_number="5.3.2.1"
                     /note="L-dopachrome isomerase; L-dopachrome tautomerase;
                     phenylpyruvate tautomerase; glutathione-binding 13 kDa
                     protein; macrophage migration inhibitory factor
                     (glycosylation-inhibiting factor)"
                     /codon_start=1
                     /product="macrophage migration inhibitory factor"
                     /protein_id="NP_112313.1"
                     /db_xref="GeneID:81683"
                     /db_xref="RGD:621163"
                     /translation="MPMFIVNTNVPRASVPEGFLSELTQQLAQATGKPAQYIAVHVVP
                     DQLMTFSGTSDPCALCSLHSIGKIGGAQNRNYSKLLCGLLSDRLHISPDRVYINYYDM
                     NAANVGWNGSTFA"
     exon            193..365
                     /gene="Mif"
                     /inference="alignment:Splign:2.1.0"
     exon            366..552
                     /gene="Mif"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtcacgta gctcaggtcc cagacttggg tcacaccgcg ctttacaccg tcctccggcc
       61 gtcgctcgca gtctctccgc caccatgcct atgttcatcg tgaacaccaa tgttccccgc
      121 gcctccgtgc cagaggggtt tctctccgag ctcacccagc agctggcgca ggccaccggc
      181 aagccggcac agtacatcgc agtgcacgtg gtcccggacc agctcatgac ttttagtggc
      241 acgagcgacc cctgcgccct ctgcagcctg cacagcatcg gcaagatcgg tggcgcccag
      301 aaccgcaact acagcaagct gctgtgcggc ctgctgtccg atcgcctgca catcagcccg
      361 gaccgggtct acatcaacta ttacgacatg aacgcagcca acgtgggctg gaacggttcc
      421 accttcgctt gagcccgggc ctcacttacc tgcaccgctg ttcttcgagt cttgctgcac
      481 gccccgttct gtgtttatcc acccgtaatg atggccacct tccggtcggg agaaataaat
      541 ggtttgagac ca
//
