LOCUS       NM_001168000            4757 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus MIER family member 3 (Mier3), mRNA.
ACCESSION   NM_001168000 XM_001074643 XM_226757
VERSION     NM_001168000.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4757)
  AUTHORS   Huang,W., Chen,J., Liu,X., Liu,X., Duan,S., Chen,L., Liu,X.,
            Lan,J., Zou,Y., Guo,D. and Zhou,J.
  TITLE     MIER3 induces epithelial-mesenchymal transition and promotes breast
            cancer cell aggressiveness via forming a co-repressor complex with
            HDAC1/HDAC2/Snail
  JOURNAL   Exp Cell Res 406 (1), 112722 (2021)
   PUBMED   34242623
REFERENCE   2  (bases 1 to 4757)
  AUTHORS   Zhang,H., Wang,L., Bai,J., Jiao,W. and Wang,M.
  TITLE     MIER3 suppresses the progression of non-small cell lung cancer by
            inhibiting Wnt/beta-Catenin pathway and histone acetyltransferase
            activity
  JOURNAL   Transl Cancer Res 9 (1), 346-357 (2020)
   PUBMED   35117188
  REMARK    Erratum:[Transl Cancer Res. 2020 Nov;9(11):7379-7380. doi:
            10.21037/tcr-2020-005. PMID: 35129549]
REFERENCE   3  (bases 1 to 4757)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4757)
  AUTHORS   denDekker,A.D., Xu,X., Vaughn,M.D., Puckett,A.H., Gardner,L.L.,
            Lambring,C.J., Deschenes,L. and Samuelson,D.J.
  TITLE     Rat Mcs1b is concordant to the genome-wide association-identified
            breast cancer risk locus at human 5q11.2 and MIER3 is a candidate
            cancer susceptibility gene
  JOURNAL   Cancer Res 72 (22), 6002-6012 (2012)
   PUBMED   22993404
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001168000.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JQ013732.1, SRR26643288.8446.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000002.1  45025662-45025807
            147-281             JAXUCZ010000002.1  45030837-45030971
            282-402             JAXUCZ010000002.1  45032079-45032199
            403-488             JAXUCZ010000002.1  45033595-45033680
            489-561             JAXUCZ010000002.1  45035935-45036007
            562-713             JAXUCZ010000002.1  45037656-45037807
            714-795             JAXUCZ010000002.1  45039906-45039987
            796-890             JAXUCZ010000002.1  45042210-45042304
            891-1018            JAXUCZ010000002.1  45045435-45045562
            1019-1161           JAXUCZ010000002.1  45045643-45045785
            1162-4757           JAXUCZ010000002.1  45045864-45049459
FEATURES             Location/Qualifiers
     source          1..4757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..4757
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /note="MIER family member 3"
                     /db_xref="GeneID:310086"
                     /db_xref="RGD:1311241"
     exon            1..146
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1613
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /note="mesoderm induction early response 1, family member
                     3"
                     /codon_start=1
                     /product="mesoderm induction early response protein 3"
                     /protein_id="NP_001161472.1"
                     /db_xref="GeneID:310086"
                     /db_xref="RGD:1311241"
                     /translation="MLVHDYDDERTLEEEELMGDGKNFSSEIEDLEKEGNMPLEDLLA
                     FYGYESTIPTVANSSANSSPSELADELPDMTLDKEEIAKDLLSGDDEETQSSADDLTP
                     SVTSHETSDFFPRPLRSNTTCDGDKESEIEDVETDSGNSPEDLRKEIMIGLQYQAEIP
                     PYLGEYSGDEKAYENEDQLLWRPDVVLESKVKEYLIETSLRTGNEKVLDRISSGTHTR
                     DNEQALYELLKCNHNVTEAIERYCCNGKASQEGMTAWTEEECRSFEHALMLYGKDFHL
                     IQKNKVRSRTVAECVAFYYMWKKSERYDYFAQQTKFGKKRYNHHPGVTDYMDRLVDET
                     ESLGDTVSSSALTSNRPEPIPDQPLNILSSFTASDLTALTNSVATVCNPTDVSCLDDS
                     FSPLGNAPRGQVNHVPVVTEELLTLPSNGESDCFNLFETGFYHSELNPMCSEESERPA
                     KRLKMGIAVPESFMNEVSVNNLGVDFENHTHHITSAKMAVSVADFGSLSASETNGFIN
                     AHTLHQHAALHSE"
     exon            147..281
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
     exon            282..402
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
     exon            403..488
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
     exon            489..561
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
     exon            562..713
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
     exon            714..795
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
     exon            796..890
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1018
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1161
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..4757
                     /gene="Mier3"
                     /gene_synonym="RGD1311241"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgggtcttt gtcttctgag gatcatgatt ttgaccccac tgctgagatg ctggtccatg
       61 actatgatga tgaaagaact ctagaggaag aggaattgat gggtgacggc aaaaacttca
      121 gttctgaaat tgaagacctg gaaaaggaag gaaatatgcc tctagaagat ctgttggcat
      181 tctacggcta tgaatctaca attccaacgg ttgcaaattc cagtgcaaac agctccccaa
      241 gtgaacttgc agacgaacta ccagatatga ctctagacaa agaagaaata gcaaaagacc
      301 tgttgtcggg cgatgatgag gaaacccagt cttctgcaga tgacctgaca ccgtctgtga
      361 cttcccatga aacttcagac ttcttcccgc ggcctttacg atcaaacaca acatgtgatg
      421 gagataagga atcagagatt gaggacgttg aaacggacag tggtaactca cctgaagatt
      481 tgagaaagga aataatgatt ggtctacagt atcaggcaga aattccccct tatcttggcg
      541 agtacagtgg tgatgagaaa gcttatgaaa atgaagacca gttactgtgg cgtcctgatg
      601 tggttttgga gagcaaagtc aaggagtacc ttattgagac ctcattaaga actggaaatg
      661 aaaaagtcct agacagaatt tcctcaggca cacacaccag ggataacgaa caggcattat
      721 atgaacttct caagtgtaac cacaatgtta cggaggcaat cgaaaggtac tgctgtaatg
      781 gaaaggcgtc tcaagaagga atgacagctt ggactgaaga ggagtgccgg agttttgaac
      841 atgcgctaat gctttatggg aaagattttc atctcattca gaagaataag gtgagatcga
      901 gaactgttgc tgaatgtgta gccttctact acatgtggaa gaagtcagaa cgctacgatt
      961 actttgctca acagacaaaa tttggaaaga aacgctataa ccatcatcct ggcgttacgg
     1021 actatatgga tcgtcttgta gatgaaacag agtctctggg tgatacggtc agttcttcag
     1081 ccttaacttc taaccggcct gagcccattc ctgatcagcc gctgaacatt ctcagctcct
     1141 tcactgccag tgacttgaca gctttgacca acagtgtagc aactgtctgc aaccccacag
     1201 atgtgagttg tctggatgat agcttttctc cactggggaa cgcgccccgt ggacaagtca
     1261 atcatgtgcc tgtcgtaacg gaagagttac tcaccctgcc cagcaatggt gaaagtgatt
     1321 gttttaactt atttgagact ggattttatc actcagagtt aaaccccatg tgcagcgaag
     1381 aatcggaaag accagcaaag agattgaaaa tgggcattgc tgtcccggaa tcctttatga
     1441 atgaggtttc tgttaataac ctgggtgtag actttgaaaa tcacacacat cacatcacca
     1501 gtgccaaaat ggctgtttct gtggctgact ttggcagctt gtctgccagt gagacaaacg
     1561 gattcatcaa tgcccacact ctacatcagc acgcagccct tcattcagag tgacgtgaat
     1621 gagcagccca gagacaatgg gtgtgcagtg ccagtaaact tgaggggagc tatcaggttt
     1681 gcacagtctt tcactggaag tttgaaccgt tctcactatg acatcagtga tgtcagtatg
     1741 tatagaacta tatcttgatt tatcaagagt attttcattt ttcaatccat aaatgtggaa
     1801 atgaactatg atcagcagag ttgggaacta agattgaact ctgtggtgca gctttaagct
     1861 ctgcttctct tcctcatccc ttaatacctc ttcccacgtc ctccttttct gttcctgttg
     1921 cccttacccc agatttaaaa cctgtagaca gaggccacca gctcaaacca gcacagatgt
     1981 tctgaactga tgtgtggctt cttttcatgt caactccttt tgccgtaatg gatgcagtgg
     2041 aatcacaatg tttacaggta ccaaccccga tccctgctca atgtagcatt tttttttttt
     2101 ttgttttatt ttctttatta ataataaaag caggggtagg tttctttaaa ctgcacaaac
     2161 atgcaaggat tttttaaaaa cggaaacttc tctcatgtta ttcaaccaga gcacttcagt
     2221 ttacaaacag caagaccatc tgtctggaag ccagccgagg gactgtgtgc aaatgacgag
     2281 acgagacgct tggatcctgt tcccatccta gaccagggct accgtacaca gaactgggca
     2341 ctttactgcc gggagacttc tgtgttaaaa atttttttct gactaaaaat ttggcatttg
     2401 aagatgtggt attcatatgg gattttgtcc accattgtca agattgcaat attaaaaatc
     2461 atactggtca ctggtaattt agtttattcc aaggcagttg acttgcagaa gcacagtcta
     2521 caaagcccag gaagttgcca cagtggttta cgttttggga cacctcttaa gtttgaactg
     2581 cagttcaaag tgttaataac gtagtcttgt agatggtatg cacagtgcag agccttgaag
     2641 tatattcaag ctattttgtt tagcttgaat agttggaaag aaaaatgtga gtttctgtct
     2701 gaaataaaat ggtacgttac cacttttaag ttttaagtga gagatgttca caggcatctc
     2761 agacgtgatt ttacttttac tccaaacgtg aataagaagc cattgtcata gctttgccca
     2821 tttttgcttt attagacatg ctcttaagtt ttaaggtgaa tcaaactata caatacagta
     2881 ttaggatata agctttgctt ttatagtaca gttaaaacaa ttactttttg caccgtctta
     2941 attacatttt tttattttac tagttgtgtt gctttgcaaa aaaacttaga acatttgact
     3001 gtgttgctgt tgtgtgagtt gcttcaaggt gtgctgagta ggtaggaggt agtggtctta
     3061 gtgattgaaa gggagggtat ttattataca aactgtgaac tgcaatgaca tccttggttt
     3121 tggatggtgt gcattgtttt tctttgcagc attttaatga agattgcttt gaagtgttta
     3181 cgctgtagca cattaactat aagatttagt ttagcacaga ggacgaaggg tagttaaatt
     3241 aataacttaa aaatcagtct ttaacttata catctaaaat ttagtattcc tgtatgcaca
     3301 cagtaaataa tgggtagcct gggctccatg ttgctttcta atatttttat ccacatggtt
     3361 agcttcttat tgctgtgttg tgctaaactc gaaccttctt ccttcgttcc cttcagtatg
     3421 ctttctttac tgtaggagga cactgggcat gttcttccat tgctgtcact ctttgtcact
     3481 ctgggtttac agtggctggt ctgtataaat aatttacaca aagatgactg aatgctaata
     3541 ccagttgcac ttaagtgaaa atgcccattc tcattagttg acacagttta tctatgcatt
     3601 gctggggtct tgatataaga tagaaacggt gtttcttatc tagagttttg attatcagca
     3661 agttgaatgg acactttagt tatttaaata gatttttgac caaaatccag aaaaatgata
     3721 tgagagaaag ataaattcca gctggtttaa catttttaaa tgctaacagg actttagcct
     3781 cttagagagg ctacctagct gggaacgttt acttttaatt ccttgttaaa atgaggcaat
     3841 aatttgcaag atttttgtat atatgtgtac agtaaattct tttttagacc taattcaata
     3901 ttttctgact gctcctgtca tgtatgatac atttttgtgc atgcctgatg tgacattcat
     3961 aaattgtacc actatgactt tatccatgta aaatagttat ttattgaatt ttctttcaac
     4021 agctggactt tttttttttg tctccattta aacatcttaa cagagaattt gttactgttt
     4081 attaaaagaa ttgagtttga aaacataaat ctgatttgca atcgtatgaa gaaaaacaat
     4141 gcctttatca tcacgtgtta agcacaattc ttaaagcaaa ctgtgataaa ttctttgttt
     4201 ctttcatttg ccgcaatatt ttcatatgaa caaaccaaaa atccatggtg agcagttgca
     4261 gtgtggctga tccaaccttt gtgtacaggg aactggagag gacgtggaca ttcagaagtg
     4321 taacctggtg ctgtgactag agcaatactt cactcttgtt agttgtgctt ggccttgctc
     4381 atgctagcct tttaaatgtt tagttttcct cttgtcatgg tcaactgctg aatttacttg
     4441 aaggatgtag aatactattt aaaaaaaata ctaaagtctg tacaattagg tcaaagaatt
     4501 gtgcaatcgt ttccttttta atttttaaaa ttgaaggtca caaatatttg agatcagacc
     4561 tagtagacta gtagtactat ttaatttaac caaagtctag taaatacttc aactttgaat
     4621 gtaaactaac aaacccgacc accaaggaga ttgtttgccc agagtttcaa agcacattgt
     4681 ctacgaatgg aaattgaaat aatttataaa atattgacat tactatgttt tttaaaaagt
     4741 tcctaatttt ttcacta
//
