LOCUS       NM_001398845            2657 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus mitochondrial elongation factor 2 (Mief2),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001398845 XM_006246545
VERSION     NM_001398845.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Bartsakoulia,M., Pyle,A., Troncoso-Chandia,D., Vial-Brizzi,J.,
            Paz-Fiblas,M.V., Duff,J., Griffin,H., Boczonadi,V., Lochmuller,H.,
            Kleinle,S., Chinnery,P.F., Grunert,S., Kirschner,J., Eisner,V. and
            Horvath,R.
  TITLE     A novel mechanism causing imbalance of mitochondrial fusion and
            fission in human myopathies
  JOURNAL   Hum Mol Genet 27 (7), 1186-1195 (2018)
   PUBMED   29361167
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   da Silva,A.F., Mariotti,F.R., Maximo,V. and Campello,S.
  TITLE     Mitochondria dynamism: of shape, transport and cell migration
  JOURNAL   Cell Mol Life Sci 71 (12), 2313-2324 (2014)
   PUBMED   24442478
  REMARK    Review article
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Palmer,C.S., Elgass,K.D., Parton,R.G., Osellame,L.D.,
            Stojanovski,D. and Ryan,M.T.
  TITLE     Adaptor proteins MiD49 and MiD51 can act independently of Mff and
            Fis1 in Drp1 recruitment and are specific for mitochondrial fission
  JOURNAL   J Biol Chem 288 (38), 27584-27593 (2013)
   PUBMED   23921378
REFERENCE   4  (bases 1 to 2657)
  AUTHORS   Koirala,S., Guo,Q., Kalia,R., Bui,H.T., Eckert,D.M., Frost,A. and
            Shaw,J.M.
  TITLE     Interchangeable adaptors regulate mitochondrial dynamin assembly
            for membrane scission
  JOURNAL   Proc Natl Acad Sci U S A 110 (15), E1342-E1351 (2013)
   PUBMED   23530241
REFERENCE   5  (bases 1 to 2657)
  AUTHORS   Loson,O.C., Song,Z., Chen,H. and Chan,D.C.
  TITLE     Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in
            mitochondrial fission
  JOURNAL   Mol Biol Cell 24 (5), 659-667 (2013)
   PUBMED   23283981
REFERENCE   6  (bases 1 to 2657)
  AUTHORS   Palmer,C.S., Osellame,L.D., Stojanovski,D. and Ryan,M.T.
  TITLE     The regulation of mitochondrial morphology: intricate mechanisms
            and dynamic machinery
  JOURNAL   Cell Signal 23 (10), 1534-1545 (2011)
   PUBMED   21683788
  REMARK    Review article
REFERENCE   7  (bases 1 to 2657)
  AUTHORS   Palmer,C.S., Osellame,L.D., Laine,D., Koutsopoulos,O.S.,
            Frazier,A.E. and Ryan,M.T.
  TITLE     MiD49 and MiD51, new components of the mitochondrial fission
            machinery
  JOURNAL   EMBO Rep 12 (6), 565-573 (2011)
   PUBMED   21508961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 27, 2021 this sequence version replaced XM_006246545.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.24447.1,
                                           SRR26360186.2198649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               JAXUCZ010000010.1  45907595-45907916
            323-475             JAXUCZ010000010.1  45910563-45910715
            476-638             JAXUCZ010000010.1  45910942-45911104
            639-2657            JAXUCZ010000010.1  45911640-45913658
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2657
                     /gene="Mief2"
                     /gene_synonym="RGD1560728; Smcr7"
                     /note="mitochondrial elongation factor 2"
                     /db_xref="GeneID:497916"
                     /db_xref="RGD:1560728"
     exon            1..322
                     /gene="Mief2"
                     /gene_synonym="RGD1560728; Smcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            323..475
                     /gene="Mief2"
                     /gene_synonym="RGD1560728; Smcr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..1693
                     /gene="Mief2"
                     /gene_synonym="RGD1560728; Smcr7"
                     /note="mitochondrial dynamic protein MID49; Smith-Magenis
                     syndrome chromosome region, candidate 7 homolog"
                     /codon_start=1
                     /product="mitochondrial dynamics protein MID49"
                     /protein_id="NP_001385774.1"
                     /db_xref="GeneID:497916"
                     /db_xref="RGD:1560728"
                     /translation="MAEFSQKQRKQHGGEGLGSVVDFLLANARLVLGVGGAAVLGIAT
                     LAVKRLIDRATNPRDEDDTKGDSWKELSLLRATSHPKPQPSPAAFSQPKSPVSPSPSA
                     PVGPTPTHSQTTPKLSSVAPLCLTFQEKLLAFERNHVIVPEAHVTLVKQLAGDIGLEL
                     QAYLRSKFSELPFGVLVPSGPLYEGLQAGTAEHVRLLVPLELEPGLWSLVPGMDTVAR
                     EPRCWAVRRTQLEFHPRGCSPWDRFLVGGYLSPRVLLELLRKALSASVNWPAIGSLLG
                     CLIWPNVASDELLLKVHHECLEFTLAVLMVVPGASTDDRLLLAWPLEGLASNLWLQDL
                     YPVETARLRALDDQDAGTRRRLLLLLCGVCRGHPVLVRLGWSHLTQVILRLGEEEVAW
                     TEEALGERFLQALEFLVGSLEQASLPCHFNPSVNLLGSFREEEIDDIGYVLYSGLQVP
                     ESLF"
     exon            476..638
                     /gene="Mief2"
                     /gene_synonym="RGD1560728; Smcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            639..2657
                     /gene="Mief2"
                     /gene_synonym="RGD1560728; Smcr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctaggc gactcccaga gcttcaggcc tcgagttgtg ggactggaga ggcctgcggg
       61 ggtcctgctg gagacgatca ccacttccag tctccagtcg caacgtggag ggtcgggtcc
      121 aggcattgtt gcttgggctg ctgtagaccc tgagctggcc gtgatcccgg agagatttcg
      181 gtaccaacgt cagggacaca ggcagtctct gcgtgaggga cccgtggtgg tggtgagact
      241 tccgggtctt tgggcctagc tcttcatctt tggactcaac tttgctcgtg tgtaacatgc
      301 ttcccaaaat tgtcagaacc aagtgaccat ggcagagttc tcacagaagc agaggaagca
      361 gcatggtggc gagggcctgg gcagtgtggt ggacttcctc ttggctaacg ctcgtttggt
      421 gctaggtgtg ggcggggctg cagtgctggg cattgccacc ctggccgtaa agcggctcat
      481 cgacagggca actaaccctc gtgatgagga tgacaccaag ggggacagct ggaaggaact
      541 gagcctgctg agagccactt cacaccccaa gccccagccc tctcctgctg ccttcagcca
      601 gcccaaatct cctgtgtccc cctccccctc tgccccagtg gggcccacac ccactcactc
      661 tcagacgaca cccaagctca gctctgtagc acccttgtgc ctgacgttcc aggagaagct
      721 gctggcattc gagcgcaacc atgtgattgt cccagaagcc cacgtgactt tggtgaaaca
      781 gctggctgga gacattggct tggagctgca ggcctacttg aggagcaagt tctcagaact
      841 gccctttggt gtacttgtgc ccagtgggcc tctctacgaa gggctacagg cggggactgc
      901 tgagcacgtg cgcctgctag tgcctctgga gttggagccc gggctatgga gcctggtacc
      961 tggcatggac actgtggcca gggaacctcg atgctgggct gttcgtagga cccagcttga
     1021 gttccatccc cgtgggtgta gcccatggga ccgcttcctg gtggggggct acctttctcc
     1081 ccgtgtcttg ctggagctgc tacggaaggc cctgtcagcc tctgtcaact ggccagccat
     1141 tggcagcctg cttgggtgtc tgatctggcc caatgtggct tcggatgagc tgctgctgaa
     1201 agtgcatcat gagtgtctgg agttcacttt agctgtgctc atggtggtcc ctggggccag
     1261 cactgatgac cgccttctgc tggcttggcc cctagagggg ctggccagca atctctggct
     1321 acaggatcta tatccagtag aaaccgcccg tttgcgggcc ctggatgacc aggatgctgg
     1381 cactcgacgg aggttattgc tgctcctgtg cggtgtgtgt cgtggccatc cggttctggt
     1441 gcggctgggc tggagccacc tgactcaggt gattctgcgt ctgggtgaag aggaagtggc
     1501 ctggactgag gaggcattgg gggaacggtt tctgcaagct ctggagttct tggtgggcag
     1561 cttggagcag gctagcctgc cgtgtcactt caaccccagc gtgaacctct tgggtagctt
     1621 tcgggaagag gagattgatg acattggcta cgtgctgtac agtggtctcc aggttcctga
     1681 gagcctgttc taggtgaatg aggactgtgg ttgacttatt ttctaatgct ggagagccgc
     1741 agccacctcc ctcccaggac accgcagtgt ggtttgcttt attttagcca gagtggagga
     1801 gggatgacat tacctaagcc cacatgtggg cttgtgcctg ggtgacggtg atcaagagtc
     1861 ccaaacccag agagtctggg gtgctgacat ctgaatgtgg ctggcctgcc ctggctgact
     1921 gctttcagtg ccagccacac tgatgcccct tagccctctg gggttaattt aggaacttgg
     1981 gctcaggcca ccgtcaccag caatgaactc acaaagaatg agatgtggct tttgatttcc
     2041 taggcttcac ctgggcaaag gctggttcca acatttgtca agaaaggaga atgttcttgg
     2101 gtgggttaag agccctaggt atctggaggc acttacaggg agtcagctgg tgccctggag
     2161 gatagcttcg cagctgtgga gggatggtgg tttcctgatg gtggtgcatt tttctgactg
     2221 agtcctcagg ccttgaggct gacgttgact cccttgctgc ctgccttata ccccagggga
     2281 ggaaggaagg tcttgttctc tcctgcttgg tttttctcta taggccataa attacctctg
     2341 ggagaacccc ttcctcactg gggagccgag ctctgtgctg cctatgcaag gctgtcccat
     2401 cgtggctgct cctagactgc agggtagagg acatgcccct cccagaggcc tgtgtgcagc
     2461 cctggcctct gcagcgtgcc aaaatattct gatagatgtc tgggtcctca ccttgcaccc
     2521 tggccaaggt gcatggctgg agaagggaga ctatctccct gccaggggaa cctttctatt
     2581 ttaggtacct cccccctaaa cacacattga tacaaaatca tgctttgaag atgtgaataa
     2641 aaggagaaag aattgta
//
