LOCUS       NP_001385774             454 aa            linear   ROD 29-MAR-2024
DEFINITION  mitochondrial dynamics protein MID49 [Rattus norvegicus].
ACCESSION   NP_001385774 XP_006246607
VERSION     NP_001385774.1
DBSOURCE    REFSEQ: accession NM_001398845.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 454)
  AUTHORS   Bartsakoulia,M., Pyle,A., Troncoso-Chandia,D., Vial-Brizzi,J.,
            Paz-Fiblas,M.V., Duff,J., Griffin,H., Boczonadi,V., Lochmuller,H.,
            Kleinle,S., Chinnery,P.F., Grunert,S., Kirschner,J., Eisner,V. and
            Horvath,R.
  TITLE     A novel mechanism causing imbalance of mitochondrial fusion and
            fission in human myopathies
  JOURNAL   Hum Mol Genet 27 (7), 1186-1195 (2018)
   PUBMED   29361167
REFERENCE   2  (residues 1 to 454)
  AUTHORS   da Silva,A.F., Mariotti,F.R., Maximo,V. and Campello,S.
  TITLE     Mitochondria dynamism: of shape, transport and cell migration
  JOURNAL   Cell Mol Life Sci 71 (12), 2313-2324 (2014)
   PUBMED   24442478
  REMARK    Review article
REFERENCE   3  (residues 1 to 454)
  AUTHORS   Palmer,C.S., Elgass,K.D., Parton,R.G., Osellame,L.D.,
            Stojanovski,D. and Ryan,M.T.
  TITLE     Adaptor proteins MiD49 and MiD51 can act independently of Mff and
            Fis1 in Drp1 recruitment and are specific for mitochondrial fission
  JOURNAL   J Biol Chem 288 (38), 27584-27593 (2013)
   PUBMED   23921378
REFERENCE   4  (residues 1 to 454)
  AUTHORS   Koirala,S., Guo,Q., Kalia,R., Bui,H.T., Eckert,D.M., Frost,A. and
            Shaw,J.M.
  TITLE     Interchangeable adaptors regulate mitochondrial dynamin assembly
            for membrane scission
  JOURNAL   Proc Natl Acad Sci U S A 110 (15), E1342-E1351 (2013)
   PUBMED   23530241
REFERENCE   5  (residues 1 to 454)
  AUTHORS   Loson,O.C., Song,Z., Chen,H. and Chan,D.C.
  TITLE     Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in
            mitochondrial fission
  JOURNAL   Mol Biol Cell 24 (5), 659-667 (2013)
   PUBMED   23283981
REFERENCE   6  (residues 1 to 454)
  AUTHORS   Palmer,C.S., Osellame,L.D., Stojanovski,D. and Ryan,M.T.
  TITLE     The regulation of mitochondrial morphology: intricate mechanisms
            and dynamic machinery
  JOURNAL   Cell Signal 23 (10), 1534-1545 (2011)
   PUBMED   21683788
  REMARK    Review article
REFERENCE   7  (residues 1 to 454)
  AUTHORS   Palmer,C.S., Osellame,L.D., Laine,D., Koutsopoulos,O.S.,
            Frazier,A.E. and Ryan,M.T.
  TITLE     MiD49 and MiD51, new components of the mitochondrial fission
            machinery
  JOURNAL   EMBO Rep 12 (6), 565-573 (2011)
   PUBMED   21508961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 27, 2021 this sequence version replaced XP_006246607.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.24447.1,
                                           SRR26360186.2198649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     Protein         1..454
                     /product="mitochondrial dynamics protein MID49"
                     /note="mitochondrial dynamic protein MID49; Smith-Magenis
                     syndrome chromosome region, candidate 7 homolog"
                     /calculated_mol_wt=49641
     Region          <392..439
                     /region_name="Mab-21_C"
                     /note="Mab-21 protein HhH/H2TH-like domain; pfam20266"
                     /db_xref="CDD:466416"
     CDS             1..454
                     /gene="Mief2"
                     /gene_synonym="RGD1560728; Smcr7"
                     /coded_by="NM_001398845.1:329..1693"
                     /db_xref="GeneID:497916"
                     /db_xref="RGD:1560728"
ORIGIN      
        1 maefsqkqrk qhggeglgsv vdfllanarl vlgvggaavl giatlavkrl idratnprde
       61 ddtkgdswke lsllratshp kpqpspaafs qpkspvspsp sapvgptpth sqttpklssv
      121 aplcltfqek llafernhvi vpeahvtlvk qlagdiglel qaylrskfse lpfgvlvpsg
      181 plyeglqagt aehvrllvpl elepglwslv pgmdtvarep rcwavrrtql efhprgcspw
      241 drflvggyls prvllellrk alsasvnwpa igsllgcliw pnvasdelll kvhhecleft
      301 lavlmvvpga stddrlllaw pleglasnlw lqdlypveta rlralddqda gtrrrlllll
      361 cgvcrghpvl vrlgwshltq vilrlgeeev awteealger flqaleflvg sleqaslpch
      421 fnpsvnllgs freeeiddig yvlysglqvp eslf
//
