LOCUS       NM_001007709            2150 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mitochondrial elongation factor 1 (Mief1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001007709 XM_235489
VERSION     NM_001007709.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2150)
  AUTHORS   Rathore,A., Chu,Q., Tan,D., Martinez,T.F., Donaldson,C.J.,
            Diedrich,J.K., Yates,J.R. 3rd and Saghatelian,A.
  TITLE     MIEF1 Microprotein Regulates Mitochondrial Translation
  JOURNAL   Biochemistry 57 (38), 5564-5575 (2018)
   PUBMED   30215512
REFERENCE   2  (bases 1 to 2150)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   3  (bases 1 to 2150)
  AUTHORS   Zhao,L., Li,S., Wang,S., Yu,N. and Liu,J.
  TITLE     The effect of mitochondrial calcium uniporter on mitochondrial
            fission in hippocampus cells ischemia/reperfusion injury
  JOURNAL   Biochem Biophys Res Commun 461 (3), 537-542 (2015)
   PUBMED   25911325
REFERENCE   4  (bases 1 to 2150)
  AUTHORS   Andreev,D.E., O'Connor,P.B., Zhdanov,A.V., Dmitriev,R.I.,
            Shatsky,I.N., Papkovsky,D.B. and Baranov,P.V.
  TITLE     Oxygen and glucose deprivation induces widespread alterations in
            mRNA translation within 20 minutes
  JOURNAL   Genome Biol 16 (1), 90 (2015)
   PUBMED   25943107
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2150)
  AUTHORS   Richter,V., Palmer,C.S., Osellame,L.D., Singh,A.P., Elgass,K.,
            Stroud,D.A., Sesaki,H., Kvansakul,M. and Ryan,M.T.
  TITLE     Structural and functional analysis of MiD51, a dynamin receptor
            required for mitochondrial fission
  JOURNAL   J Cell Biol 204 (4), 477-486 (2014)
   PUBMED   24515348
REFERENCE   6  (bases 1 to 2150)
  AUTHORS   Koirala,S., Guo,Q., Kalia,R., Bui,H.T., Eckert,D.M., Frost,A. and
            Shaw,J.M.
  TITLE     Interchangeable adaptors regulate mitochondrial dynamin assembly
            for membrane scission
  JOURNAL   Proc Natl Acad Sci U S A 110 (15), E1342-E1351 (2013)
   PUBMED   23530241
REFERENCE   7  (bases 1 to 2150)
  AUTHORS   Loson,O.C., Song,Z., Chen,H. and Chan,D.C.
  TITLE     Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in
            mitochondrial fission
  JOURNAL   Mol Biol Cell 24 (5), 659-667 (2013)
   PUBMED   23283981
REFERENCE   8  (bases 1 to 2150)
  AUTHORS   Palmer,C.S., Osellame,L.D., Stojanovski,D. and Ryan,M.T.
  TITLE     The regulation of mitochondrial morphology: intricate mechanisms
            and dynamic machinery
  JOURNAL   Cell Signal 23 (10), 1534-1545 (2011)
   PUBMED   21683788
  REMARK    Review article
REFERENCE   9  (bases 1 to 2150)
  AUTHORS   Zhao,J., Liu,T., Jin,S., Wang,X., Qu,M., Uhlen,P., Tomilin,N.,
            Shupliakov,O., Lendahl,U. and Nister,M.
  TITLE     Human MIEF1 recruits Drp1 to mitochondrial outer membranes and
            promotes mitochondrial fusion rather than fission
  JOURNAL   EMBO J 30 (14), 2762-2778 (2011)
   PUBMED   21701560
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2150)
  AUTHORS   Palmer,C.S., Osellame,L.D., Laine,D., Koutsopoulos,O.S.,
            Frazier,A.E. and Ryan,M.T.
  TITLE     MiD49 and MiD51, new components of the mitochondrial fission
            machinery
  JOURNAL   EMBO Rep 12 (6), 565-573 (2011)
   PUBMED   21508961
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083593.1.
            
            On Nov 29, 2004 this sequence version replaced XM_235489.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2150
                     /gene="Mief1"
                     /gene_synonym="Smcr7l"
                     /note="mitochondrial elongation factor 1"
                     /db_xref="GeneID:315141"
                     /db_xref="RGD:1359173"
     exon            1..126
                     /gene="Mief1"
                     /gene_synonym="Smcr7l"
                     /inference="alignment:Splign:2.1.0"
     exon            127..479
                     /gene="Mief1"
                     /gene_synonym="Smcr7l"
                     /inference="alignment:Splign:2.1.0"
     exon            480..630
                     /gene="Mief1"
                     /gene_synonym="Smcr7l"
                     /inference="alignment:Splign:2.1.0"
     CDS             487..1878
                     /gene="Mief1"
                     /gene_synonym="Smcr7l"
                     /note="mitochondrial dynamic protein of 51 kDa homolog;
                     mitochondrial dynamic protein MID51; Smith-Magenis
                     syndrome chromosome region, candidate 7-like;
                     mitochondrial dynamics protein of 51 kDa homolog"
                     /codon_start=1
                     /product="mitochondrial dynamics protein MID51"
                     /protein_id="NP_001007710.1"
                     /db_xref="GeneID:315141"
                     /db_xref="RGD:1359173"
                     /translation="MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATL
                     AVKRMYDRAISAPTSPTRLSHSGKRSWEEPNWMGSPRLLNRDMKTGLSRSLQTLPTDS
                     SAFDTDTFCPPRPKPLARRGQVDLKKSRLRMSLQEKLLSYYRNRAAIPAGEQARAKQA
                     AVDICAELRSFLRAKLPDMPLRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCI
                     PGEDTIMNIPGFFLVRRENPEYFPRGSSYWDRCVVGGYLSPKTVADTFEKVVAGSINW
                     PAIGSLLDYVIRPAPPPEALTLEVQYERDKHLVIDFLPSVTLGDTVLVARPHRLAQYD
                     NLWRLSLRPAETARLRALDQADSGCRSLCLKILKAICKSTPALGHLTASQLTNVILHL
                     SQEEADWSPDMLADRFLQALRGLISYLEAGVLPSALNPKVNLFAELTPHEIDELGYTL
                     YCSLSEPEVLLQT"
     exon            631..808
                     /gene="Mief1"
                     /gene_synonym="Smcr7l"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1071
                     /gene="Mief1"
                     /gene_synonym="Smcr7l"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..2124
                     /gene="Mief1"
                     /gene_synonym="Smcr7l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggccgacc ggaagtgctt ctgcctcctc ccgcctccgt gctccctgtc gagtctccgt
       61 cggccgggcg agcgaggtcg tgccccggaa gtaaaggggc catgttgatg ggtgaccccg
      121 agagagagtg tgacgcttag tccttgtcag tcccccatgg ccccgtggag ccgagaggcg
      181 gtgctgcgtc tgtaccgggc tctgctgcgc caaggccgag agcttcgcta caccgatcga
      241 gacttctact ttgcttccat ccgccgagaa ttcaggaaaa atcagaaact tgaggatctg
      301 gaggctcgag agaagcagct ggagaagggc ctggtcttcc tccatagcaa actaggaggc
      361 cttatttaga atcctctctt ttcccctcct accctaattc caagacgagg acaaaggtgc
      421 cttcagtaga tactcctggc tcccctaccc cacctcacag atgcattagg aagcctcagg
      481 tgagcaatgg caggcgctgg tgagcgcaaa ggcaagaagg atgacaatgg cattggaacg
      541 gccattgatt ttgtgctctc caatgcccgg ctggtgctgg gcgtgggtgg agcagccatg
      601 ctgggcatcg ccacattggc agttaagcgg atgtacgacc gggcaattag tgcccctacc
      661 agccccaccc gcctaagcca ttcaggaaag aggagctggg aggaaccaaa ctggatgggc
      721 tctcctcgac tattgaacag ggacatgaag acaggtctga gccggtccct gcagaccctt
      781 cccacagact cttctgcctt tgacacagat acattctgcc caccccggcc caaacctttg
      841 gccaggaggg gccaggtaga cttgaagaag tcacgactcc gcatgtccct gcaggagaaa
      901 cttctttctt actaccggaa ccgtgcagcc atccctgctg gagagcaggc tcgagccaag
      961 caagctgcgg tggacatatg tgctgagctg cggagcttcc tgcgggccaa gctgcctgac
     1021 atgccactcc gggacatgta cttgagtggc agcctctatg acgatctgca ggtggtgaca
     1081 gctgaccata tccaactcat tgtccccctc gtgctggagc agaacctgtg gtcgtgcata
     1141 cctggggagg acaccatcat gaatatccct ggtttcttcc tggtccgtcg tgagaaccca
     1201 gagtactttc ctcgtggtag cagttattgg gaccgctgtg ttgtaggtgg ctacctctcc
     1261 ccaaagacag tggcagacac ctttgagaag gtggtggcag gctccatcaa ctggccagcc
     1321 atagggtccc tcttagacta tgtgatccga ccagcaccac ccccagaggc cctgacacta
     1381 gaagtgcagt atgagaggga caaacatctt gtcattgact tcctgccatc agtgaccctt
     1441 ggtgacactg tcttggtggc cagaccacac cggttagctc agtatgacaa cctgtggcgg
     1501 ctgagccttc gtcctgctga gacggcacgc ttacgggctt tggaccaggc ggactccggc
     1561 tgccggtctc tgtgcctcaa gatcctcaag gccatatgca agtccactcc agctctgggc
     1621 cacctcactg ccagccagct aaccaatgtc atcctccact tgtcccagga ggaggctgac
     1681 tggtctccag acatgttggc cgaccgcttt ctacaggccc tgaggggact catcagctac
     1741 ttggaggctg gagtcttgcc cagtgccctg aaccccaagg tgaacctatt tgcagagctc
     1801 acccctcacg agatagatga attggggtac accctctact gctcgttgtc tgagccggag
     1861 gtgctgctgc agacgtaggc aggtgaaggc ccagactctc ttagaaacac ttggctacgt
     1921 ggttggtgcc tcacaggtcc ctaggtgcct cctgttttgt tggtaattgt cctggtcact
     1981 tcatgctgat tagaatgaca tcccttctgt tttcctaccc atccctattt ttgtaaccaa
     2041 acactgtgct ccttgccgcc ttactctagg ctgatttttt tttttttttt ttttggaaac
     2101 aaacagaagg tgtggagtgc tggcaaaaaa aaaaaaaaaa aaaaaaaaaa
//
