LOCUS       NM_001191577            1725 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus midnolin (Midn), mRNA.
ACCESSION   NM_001191577 XM_002729765
VERSION     NM_001191577.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1725)
  AUTHORS   Obara,Y. and Ishii,K.
  TITLE     Transcriptome Analysis Reveals That Midnolin Regulates mRNA
            Expression Levels of Multiple Parkinson's Disease Causative Genes
  JOURNAL   Biol Pharm Bull 41 (1), 20-23 (2018)
   PUBMED   29311479
  REMARK    GeneRIF: These findings indicate that MIDN regulates the expression
            of a wide variety of genes, including multiple Parkinson's Disease
            causative genes and is associated with Parkinson's Disease onset.
REFERENCE   2  (bases 1 to 1725)
  AUTHORS   Obara,Y., Imai,T., Sato,H., Takeda,Y., Kato,T. and Ishii,K.
  TITLE     Midnolin is a novel regulator of parkin expression and is
            associated with Parkinson's Disease
  JOURNAL   Sci Rep 7 (1), 5885 (2017)
   PUBMED   28724963
  REMARK    GeneRIF: MIDN promotes the expression of parkin E3 ubiquitin
            ligase, and that MIDN loss can trigger Parkinson's disease-related
            pathogenic mechanisms.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1725)
  AUTHORS   Hofmeister-Brix,A., Kollmann,K., Langer,S., Schultz,J., Lenzen,S.
            and Baltrusch,S.
  TITLE     Identification of the ubiquitin-like domain of midnolin as a new
            glucokinase interaction partner
  JOURNAL   J Biol Chem 288 (50), 35824-35839 (2013)
   PUBMED   24187134
  REMARK    GeneRIF: midnolin plays a role in cellular signaling of adult
            tissues and regulates glucokinase enzyme activity in pancreatic
            beta cells
REFERENCE   4  (bases 1 to 1725)
  AUTHORS   Tsukahara,M., Suemori,H., Noguchi,S., Ji,Z.S. and Tsunoo,H.
  TITLE     Novel nucleolar protein, midnolin, is expressed in the
            mesencephalon during mouse development
  JOURNAL   Gene 254 (1-2), 45-55 (2000)
   PUBMED   10974535
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 17, 2010 this sequence version replaced XM_002729765.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.27605.1,
                                           SRR26643290.24867.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000007.1  10206769-10207004   c
            237-324             JAXUCZ010000007.1  10205648-10205735   c
            325-387             JAXUCZ010000007.1  10205404-10205466   c
            388-516             JAXUCZ010000007.1  10203344-10203472   c
            517-834             JAXUCZ010000007.1  10202930-10203247   c
            835-976             JAXUCZ010000007.1  10202592-10202733   c
            977-1240            JAXUCZ010000007.1  10201724-10201987   c
            1241-1725           JAXUCZ010000007.1  10200306-10200790   c
FEATURES             Location/Qualifiers
     source          1..1725
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1725
                     /gene="Midn"
                     /note="midnolin"
                     /db_xref="GeneID:314623"
                     /db_xref="RGD:1309629"
     CDS             1..1518
                     /gene="Midn"
                     /note="midbrain nucleolar protein"
                     /codon_start=1
                     /product="midnolin"
                     /protein_id="NP_001178506.1"
                     /db_xref="GeneID:314623"
                     /db_xref="RGD:1309629"
                     /translation="MEPQPGGARSCRRGAPGGACELSTTAESAAPMSLAIHSTTGTRY
                     DLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPT
                     VEAGLMSQASRPEQSVMQALESLTETQPPATPGPGRAAGGGFRKYRLILFKRPWHRQG
                     PQSPERGGERPQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAA
                     AAAAARGDSSIATPVSSPCRPVSSAARVPPVSSSPSSPVSPSPVTAGTFQSHAASTTC
                     PEQTDCSPPASSNTTSTPGSSPTPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQD
                     SSGRPRRDIGTILQILNDLLSATRHYQGMPASLTQLRCHAQCSPASPAPDLTPKTTSC
                     EKLATPSLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRKARRDAR
                     GPYHWTPSRKAGRSDSSSSGGGGSPSEATGLGLDFEDSVWKPEVNPDIQSEFVVA"
     exon            1..236
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            237..324
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            325..387
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            388..516
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            517..834
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            835..976
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1240
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1725
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagccgc agcccggcgg cgcccggagc tgccggcgcg gggcccccgg tggcgcctgc
       61 gagctgagca cgaccgcgga atcggccgca cccatgagcc tggcgatcca cagcactacg
      121 gggacccgct acgacctttc ggtgccccac gacgagaccg tggaggggct gcgcaaaagg
      181 ctgtcccaac gcctcaaagt acccaaggaa cgcctggcgc tgcttcacaa agacacccgg
      241 ctcagttcgg ggaagctgca ggaattcggc gtgggggatg ggagcaagtt gacgctcgtg
      301 cccacggtgg aagctggcct catgtcccag gcctcgaggc cggagcagtc cgttatgcaa
      361 gccctggaaa gtttgactga gacccagccc ccagcgacac ccgggccagg ccgggctgcc
      421 ggaggaggct tccggaaata cagattgatt ttatttaagc gtccgtggca ccgacaggga
      481 ccccagagcc cagagagggg cggcgagagg ccccaggtca gtgacttttt gtcaggccga
      541 tcgcctttga ccctggccct gcgagttggg gatcacatga tgtttgtaca attgcaactg
      601 gcagcccaac acgccccact ccagcaccgc catgtgctgg ccgcggctgc cgcagctgct
      661 gccgctgccc ggggagattc cagcatagct accccagtat cctcaccttg tcggcccgtg
      721 tccagtgccg cccgtgtccc cccagtatcc agcagccctt cttcgcctgt gtccccctca
      781 cctgtcaccg ctggcacctt ccaatcccat gcagcctcca cgacttgtcc tgagcagacg
      841 gactgttctc cacccgccag cagcaacacc acatccaccc caggcagcag ccccaccccc
      901 cgatcccgca aacccggtgc agtcattgag agcttcgtga accacgctcc aggggtcttc
      961 tcagggacct tctctggcac actgcacccc aactgccagg atagtagtgg gcggcctcgg
     1021 cgtgacatcg gcaccattct gcagatactc aatgacctcc taagtgccac aaggcattac
     1081 cagggcatgc cggcctcact gacccagctc cgctgccacg cgcagtgctc acctgcctca
     1141 ccagcccctg acctcacccc caaaactacc tcctgtgaaa agctggcaac cccatcactg
     1201 ctccagggcc agagccagat ccgaatgtgc aagccccctg gagaccgtct gcgacagaca
     1261 gagaaccgtg ccacacgctg caaagtggaa cgcctccagc tcctgctgca gcagaagcgc
     1321 ctgcgaagga aggcacggcg ggacgcccgg ggtccttacc actggacccc aagccgcaaa
     1381 gctggtcgta gtgacagcag cagcagtggg ggtggaggta gccccagcga ggccacaggc
     1441 ttgggcctcg acttcgagga ctccgtttgg aagcctgaag tcaacccaga catccagtcc
     1501 gagtttgtgg tggcttaaag aatccccttg ggcctgaaca tcctctaccc catacacggg
     1561 gcaggaggac gacacagact ggacgctgag cggcccagct ctggggggga ggggcaggag
     1621 gtcacctcca ttgccactta ccagcctttc tgattctttt ttagctcctc ccctggttgt
     1681 ctaccctgca tccctggtca cgtgcccacc tgtctttctt ccctt
//
