LOCUS       NP_001178506             505 aa            linear   ROD 24-JUN-2024
DEFINITION  midnolin [Rattus norvegicus].
ACCESSION   NP_001178506 XP_002729811
VERSION     NP_001178506.1
DBSOURCE    REFSEQ: accession NM_001191577.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 505)
  AUTHORS   Obara,Y. and Ishii,K.
  TITLE     Transcriptome Analysis Reveals That Midnolin Regulates mRNA
            Expression Levels of Multiple Parkinson's Disease Causative Genes
  JOURNAL   Biol Pharm Bull 41 (1), 20-23 (2018)
   PUBMED   29311479
  REMARK    GeneRIF: These findings indicate that MIDN regulates the expression
            of a wide variety of genes, including multiple Parkinson's Disease
            causative genes and is associated with Parkinson's Disease onset.
REFERENCE   2  (residues 1 to 505)
  AUTHORS   Obara,Y., Imai,T., Sato,H., Takeda,Y., Kato,T. and Ishii,K.
  TITLE     Midnolin is a novel regulator of parkin expression and is
            associated with Parkinson's Disease
  JOURNAL   Sci Rep 7 (1), 5885 (2017)
   PUBMED   28724963
  REMARK    GeneRIF: MIDN promotes the expression of parkin E3 ubiquitin
            ligase, and that MIDN loss can trigger Parkinson's disease-related
            pathogenic mechanisms.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 505)
  AUTHORS   Hofmeister-Brix,A., Kollmann,K., Langer,S., Schultz,J., Lenzen,S.
            and Baltrusch,S.
  TITLE     Identification of the ubiquitin-like domain of midnolin as a new
            glucokinase interaction partner
  JOURNAL   J Biol Chem 288 (50), 35824-35839 (2013)
   PUBMED   24187134
  REMARK    GeneRIF: midnolin plays a role in cellular signaling of adult
            tissues and regulates glucokinase enzyme activity in pancreatic
            beta cells
REFERENCE   4  (residues 1 to 505)
  AUTHORS   Tsukahara,M., Suemori,H., Noguchi,S., Ji,Z.S. and Tsunoo,H.
  TITLE     Novel nucleolar protein, midnolin, is expressed in the
            mesencephalon during mouse development
  JOURNAL   Gene 254 (1-2), 45-55 (2000)
   PUBMED   10974535
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 17, 2010 this sequence version replaced XP_002729811.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.27605.1,
                                           SRR26643290.24867.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     Protein         1..505
                     /product="midnolin"
                     /note="midbrain nucleolar protein"
                     /calculated_mol_wt=53548
     Region          32..101
                     /region_name="Ubl_midnolin"
                     /note="ubiquitin-like (Ubl) domain found in midnolin and
                     similar proteins; cd01804"
                     /db_xref="CDD:340502"
     Region          155..176
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AE48.1)"
     Region          228..305
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AE48.1)"
     Region          440..485
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AE48.1)"
     CDS             1..505
                     /gene="Midn"
                     /coded_by="NM_001191577.1:1..1518"
                     /db_xref="GeneID:314623"
                     /db_xref="RGD:1309629"
ORIGIN      
        1 mepqpggars crrgapggac elsttaesaa pmslaihstt gtrydlsvph detveglrkr
       61 lsqrlkvpke rlallhkdtr lssgklqefg vgdgskltlv ptveaglmsq asrpeqsvmq
      121 alesltetqp patpgpgraa gggfrkyrli lfkrpwhrqg pqspergger pqvsdflsgr
      181 spltlalrvg dhmmfvqlql aaqhaplqhr hvlaaaaaaa aaargdssia tpvsspcrpv
      241 ssaarvppvs sspsspvsps pvtagtfqsh aasttcpeqt dcsppassnt tstpgssptp
      301 rsrkpgavie sfvnhapgvf sgtfsgtlhp ncqdssgrpr rdigtilqil ndllsatrhy
      361 qgmpasltql rchaqcspas papdltpktt sceklatpsl lqgqsqirmc kppgdrlrqt
      421 enratrckve rlqlllqqkr lrrkarrdar gpyhwtpsrk agrsdssssg gggspseatg
      481 lgldfedsvw kpevnpdiqs efvva
//
