LOCUS       NM_022927               2262 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus midline 1 (Mid1), mRNA.
ACCESSION   NM_022927
VERSION     NM_022927.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2262)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   2  (bases 1 to 2262)
  AUTHORS   Zurek,B., Schoultz,I., Neerincx,A., Napolitano,L.M., Birkner,K.,
            Bennek,E., Sellge,G., Lerm,M., Meroni,G., Soderholm,J.D. and
            Kufer,T.A.
  TITLE     TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal
            degradation
  JOURNAL   PLoS One 7 (7), e41255 (2012)
   PUBMED   22829933
REFERENCE   3  (bases 1 to 2262)
  AUTHORS   Aranda-Orgilles,B., Aigner,J., Kunath,M., Lurz,R., Schneider,R. and
            Schweiger,S.
  TITLE     Active transport of the ubiquitin ligase MID1 along the
            microtubules is regulated by protein phosphatase 2A
  JOURNAL   PLoS One 3 (10), e3507 (2008)
   PUBMED   18949047
REFERENCE   4  (bases 1 to 2262)
  AUTHORS   Winter,J., Kunath,M., Roepcke,S., Krause,S., Schneider,R. and
            Schweiger,S.
  TITLE     Alternative polyadenylation signals and promoters act in concert to
            control tissue-specific expression of the Opitz Syndrome gene MID1
  JOURNAL   BMC Mol Biol 8, 105 (2007)
   PUBMED   18005432
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2262)
  AUTHORS   Prickett,T.D. and Brautigan,D.L.
  TITLE     Cytokine activation of p38 mitogen-activated protein kinase and
            apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A
            for site-specific dephosphorylation of MEK3
  JOURNAL   Mol Cell Biol 27 (12), 4217-4227 (2007)
   PUBMED   17438131
REFERENCE   6  (bases 1 to 2262)
  AUTHORS   Berti,C., Fontanella,B., Ferrentino,R. and Meroni,G.
  TITLE     Mig12, a novel Opitz syndrome gene product partner, is expressed in
            the embryonic ventral midline and co-operates with Mid1 to bundle
            and stabilize microtubules
  JOURNAL   BMC Cell Biol 5, 9 (2004)
   PUBMED   15070402
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2262)
  AUTHORS   Landry,J.R. and Mager,D.L.
  TITLE     Widely spaced alternative promoters, conserved between human and
            rodent, control expression of the Opitz syndrome gene MID1
  JOURNAL   Genomics 80 (5), 499-508 (2002)
   PUBMED   12408967
REFERENCE   8  (bases 1 to 2262)
  AUTHORS   Short,K.M., Hopwood,B., Yi,Z. and Cox,T.C.
  TITLE     MID1 and MID2 homo- and heterodimerise to tether the
            rapamycin-sensitive PP2A regulatory subunit, alpha 4, to
            microtubules: implications for the clinical variability of X-linked
            Opitz GBBB syndrome and other developmental disorders
  JOURNAL   BMC Cell Biol 3, 1 (2002)
   PUBMED   11806752
REFERENCE   9  (bases 1 to 2262)
  AUTHORS   Perry,J. and Ashworth,A.
  TITLE     Evolutionary rate of a gene affected by chromosomal position
  JOURNAL   Curr Biol 9 (17), 987-989 (1999)
   PUBMED   10508587
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF186461.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_022927.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF186461.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2262
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..2262
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /note="midline 1"
                     /db_xref="GeneID:54252"
                     /db_xref="RGD:2640"
     exon            1..176
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /inference="alignment:Splign:2.1.0"
     exon            177..892
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2236
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 18; Finger on X
                     and Y (in rat only on X); RING finger protein Midline-1;
                     midline 1 (Opitz/BBB syndrome); RING-type E3 ubiquitin
                     transferase Midline-1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Midline-1"
                     /protein_id="NP_075216.1"
                     /db_xref="GeneID:54252"
                     /db_xref="RGD:2640"
                     /translation="METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCAT
                     NEPVESINAFQCPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRR
                     ERAFDANTMSSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHR
                     LIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDK
                     LKQNLESNLTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECDLLIEIIQER
                     RQIIGTKIKEGKVMRLRKLAQQIANCKQCIERSASLISQAEHSLKENDHARFLQTAKN
                     ITERVSMATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYLTAPNPPTIREELC
                     TASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWMIVPNIKQNHYTV
                     HGLQSGTKYIFMVKAINQAGSRSSEPGKLKTNSQPFKLDPKSAHRKLKVSHDNLTVER
                     DESSSKKSHTPERFTSQGSYGVAGNVFIDSGRHYWEVVISGSTWYAIGLAYKSAPKHE
                     WIGKNSASWALCRCNNNWVVRHNSKEIPIEPAPHPRRVGILLDYDNGSIAFYDALNSI
                     HLYTFDVALAQPVCPTFTVWNKCLTIITGLPIPDHLDCTEQLP"
     exon            893..988
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1096
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1245
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1373
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1517
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1679
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1887
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2262
                     /gene="Mid1"
                     /gene_synonym="Fxy; Midline1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccgatttt cctgttgtat ttcactgtcg acgctctcac agacacacac acaggactgt
       61 tccagctctg cctgccaccc accacctggt ctgagtggcc tgtctatcat tttgtggaag
      121 cccatcctct acatacagcg atgtttcttc aaaaagaact agtgtgcagt ccgttgatag
      181 ctgatcagct tccttggatt ttgctgatga ccccggagag ttttgcctga agatggaaac
      241 actggagtcg gagctgacct gtcctatttg tctggagctt tttgaggacc ctctcctgct
      301 tccctgtgca catagcctct gtttcaactg tgcccaccgc atcctggtct ctcactgtgc
      361 caccaacgag cctgtggagt ccatcaacgc cttccagtgc cccacctgcc ggcatgtcat
      421 cacgctcagc cagcgaggtc tagacgggct caagcgcaac gtcaccttac aaaacatcat
      481 tgacaggttt cagaaagcat ccgtgagtgg gcccaattct cccagtgaga cccgcaggga
      541 gcgggccttt gacgccaaca ccatgtcttc tgccgagaaa gttctctgcc agttctgtga
      601 ccaggatcct gcccaggatg ctgtgaagac ctgtgttact tgcgaagtgt cctactgtga
      661 tgagtgcctg aaagccactc atccgaataa gaagcccttt acaggccatc gtctgattga
      721 gccaatcccg gactcgcaca tccgggggct aatgtgcttg gagcatgagg atgagaaggt
      781 gaatatgtac tgtgtgaccg atgaccagtt aatctgtgcc ttgtgtaaac tggttgggcg
      841 gcaccgcgat catcaggtgg cagctttgag tgagcgctat gacaaattga agcaaaattt
      901 ggagagtaat ctcaccaatc ttattaagag aaacacagaa ctggagaccc ttttggctaa
      961 actcatccaa acttgtcaac atgttgaggt caatgcatcc cgtcaagaag ccaagttgac
     1021 agaggaatgt gatcttctca ttgaaattat tcaggaaaga agacaaatta ttggaacaaa
     1081 gattaaagaa ggcaaggtga tgaggctccg caaattagct cagcagattg caaactgtaa
     1141 acaatgcatt gaaaggtctg catcactcat ttcccaagca gaacactcac tgaaggagaa
     1201 tgaccatgcc cgttttctac agacagcaaa gaatatcact gagagagtct ccatggcaac
     1261 tgcatcctcc caggtcctaa ttcctgaaat caacctcaat gacacatttg acacctttgc
     1321 cttagatttt tcccgggaga agaaactgct agaatgtttg gattacctaa cagctcccaa
     1381 ccctcccaca attagagaag agctctgcac ggcttcctat gacaccatca ctgtccactg
     1441 gacttcggat gatgagttca gtgtggtctc ctatgaactc cagtacacca tattcactgg
     1501 acaagccaat gtcgttagtc tttgtaactc ggcagatagc tggatgattg tgcccaacat
     1561 caagcagaac cactatactg tgcatggcct acaaagtggc accaagtata tcttcatggt
     1621 caaggccatc aaccaggcag gcagccgcag cagtgagcct gggaagctga agacaaacag
     1681 tcagccattt aaactggatc ccaaatctgc tcatcgaaaa ctcaaggtgt cccatgacaa
     1741 cctgactgtt gaacgtgatg agtcatcatc caaaaagagt cacacacctg aacgcttcac
     1801 tagccaaggg agctatggcg tggctggaaa tgtgtttatt gacagtggcc gtcattactg
     1861 ggaagtggtc ataagcggaa gcacatggta tgccattggc cttgcgtaca aatcagctcc
     1921 aaaacatgaa tggattggga agaattctgc ttcctgggcc ctttgccgct gcaacaataa
     1981 ctgggtggtg agacataaca gcaaggaaat acccattgaa ccagcccccc acccccggcg
     2041 tgtaggcatc ctgctggact atgataatgg ctcaatcgct ttttatgatg ctttgaactc
     2101 catccacctc tataccttcg atgtggcgct tgcgcagcct gtgtgcccca cctttactgt
     2161 gtggaacaag tgtttgacga ttataactgg tcttcccatc ccagaccatt tggactgtac
     2221 agaacagcta ccttgagcat ctggccccag agcagcccca ag
//
