LOCUS       NM_001191892            1865 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus mitochondrial calcium uptake family, member 3
            (Micu3), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001191892 XM_344525
VERSION     NM_001191892.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Wang,J., Yang,S., Li,H., Shen,H., Lu,X., Li,X. and Chen,G.
  TITLE     Downregulation of mitochondrial calcium uptake family 3 attenuates
            secondary brain injury after intracerebral hemorrhage in rats
  JOURNAL   Exp Neurol 361, 114302 (2023)
   PUBMED   36549422
  REMARK    GeneRIF: Downregulation of mitochondrial calcium uptake family 3
            attenuates secondary brain injury after intracerebral hemorrhage in
            rats.
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Ashrafi,G., de Juan-Sanz,J., Farrell,R.J. and Ryan,T.A.
  TITLE     Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures
            Metabolic Flexibility of Neurotransmission
  JOURNAL   Neuron 105 (4), 678-687 (2020)
   PUBMED   31862210
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jul 17, 2010 this sequence version replaced XM_344525.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               JAXUCZ010000016.1  58713487-58713846   c
            361-514             JAXUCZ010000016.1  58679958-58680111   c
            515-546             JAXUCZ010000016.1  58675567-58675598   c
            547-625             JAXUCZ010000016.1  58666448-58666526   c
            626-673             JAXUCZ010000016.1  58663919-58663966   c
            674-756             JAXUCZ010000016.1  58658073-58658155   c
            757-795             JAXUCZ010000016.1  58653119-58653157   c
            796-891             JAXUCZ010000016.1  58642017-58642112   c
            892-992             JAXUCZ010000016.1  58636917-58637017   c
            993-1164            JAXUCZ010000016.1  58636281-58636452   c
            1165-1273           JAXUCZ010000016.1  58633508-58633616   c
            1274-1431           JAXUCZ010000016.1  58630593-58630750   c
            1432-1500           JAXUCZ010000016.1  58629208-58629276   c
            1501-1865           JAXUCZ010000016.1  58626718-58627082   c
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..1865
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /note="mitochondrial calcium uptake family, member 3"
                     /db_xref="GeneID:364601"
                     /db_xref="RGD:1563411"
     CDS             1..1500
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /note="EF-hand domain-containing family member A2; EF hand
                     domain family, member A2; mitochondrial uptake family,
                     member 3"
                     /codon_start=1
                     /product="calcium uptake protein 3, mitochondrial"
                     /protein_id="NP_001178821.1"
                     /db_xref="GeneID:364601"
                     /db_xref="RGD:1563411"
                     /translation="MAALRRLLWPPPRLSPTLAPQQPFLSPWGRPAGTAPGMSGRPFS
                     GREEDEGAVAEAAWRRRRWGELSIAAAAGGGLVGLVCYQLYGDPRADPSELVAPELDE
                     SPRGRGLLPIPVAAAKETVATGRAVTEDLDLYATSRERRFRLFASIECEGQLFMTPYD
                     FILAVTTDEPKFAKTWKSLSKQELSQMLSETPPVWKGSSKLFRNLKERGVISYTEYLF
                     LLCILTKPHAGFRIAFNMFDTDGNEMVDKKEFLVRLQLYGYHSPTNSVLKPDAEELVS
                     RSYWDTLRRSTSQALFSDLAERADDITSLVADTTLLVHFFGKKGKAELNFEDFYRFMD
                     NLQTEVLEIEFLSYSNGMNTISEEDFAHILLRYTNVENTSVFLENVRYSIPEEKGITF
                     DEFRSFFQFLNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKLSPHLVNTVFKI
                     FDVDKDDQLSYKEFIGIMKDRLHRGFRGYKTVQKYPTFKSCLKKELHSR"
     exon            1..360
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            361..514
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..546
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..625
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..673
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..756
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            757..795
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..891
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..992
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1164
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1273
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1431
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1500
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1865
                     /gene="Micu3"
                     /gene_synonym="Efha2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctgcgc tgcggaggct tctgtggccg ccgcctcggc tttcgccgac gctcgcccct
       61 cagcagccat tcctctcgcc atgggggcgg cctgcgggga cggctccggg gatgtcgggt
      121 cggcccttct ccggccggga agaggacgag ggggccgtag cggaggcggc gtggcggcgg
      181 cggcgctggg gtgagctgag catcgcggcg gcagcgggcg gggggctggt cggccttgtg
      241 tgctaccagc tgtatgggga ccccagagcc gacccctcgg agctagtggc cccagagctg
      301 gacgaatcgc cccgcggcag ggggctgctg cccatcccgg tggctgctgc caaggagacg
      361 gttgctactg gcagagccgt tactgaagac ttggacctct atgctacatc tcgagagaga
      421 cggtttcgtt tatttgcatc tatagaatgt gaaggacagt tattcatgac tccatatgat
      481 tttattctgg ctgttacaac agatgagccc aaatttgcta aaacgtggaa gtcactttct
      541 aaacaggaat taagtcagat gctttcagaa actccaccag tttggaaggg atcatcaaag
      601 ctttttcgaa atcttaaaga aagaggtgtg atttcttaca cggaatatct ttttctttta
      661 tgtattttaa caaagcccca tgcaggtttt agaatagctt tcaacatgtt tgacactgac
      721 ggaaacgaga tggtggataa aaaagaattt ttggtgcgtc ttcaacttta tggataccat
      781 tctcctacta atagtgtact taaaccagat gctgaggaac ttgtctccag aagctactgg
      841 gataccctga gacgtagcac aagccaggcg ctcttctcag accttgcaga gcgtgctgat
      901 gacatcacaa gcttagtagc agatactaca cttcttgtac acttttttgg aaagaaagga
      961 aaagctgagc tcaactttga agatttttat agatttatgg ataatctaca aacagaagtt
     1021 ctagaaatag aatttctttc ctactctaat ggaatgaata ctatcagtga agaagatttt
     1081 gcccatattc ttctacggta tactaatgtg gaaaatacat cagtgttttt ggaaaatgtg
     1141 cgctacagta tacctgaaga aaagggtatc acatttgatg aattcaggtc atttttccag
     1201 tttctaaaca acttagaaga ctttgcaata gctctcaata tgtataactt tgcaagccgt
     1261 tctataggac aagatgaatt taaacgtgct gtatacgtag ctacgggact gaaactttca
     1321 ccacatttgg tgaacactgt cttcaagatt ttcgatgttg acaaagatga ccaattaagt
     1381 tataaagaat ttattgggat tatgaaagac agactccaca gagggttccg gggttataaa
     1441 acagtccaga agtatccgac tttcaaatcc tgcctgaaaa aggaacttca tagcagataa
     1501 atcctcctaa acaagaattg gaagaatata atctatgtga ctaggcaagg agcaagattt
     1561 tgagtggatc caatataaag tcagagcatg cagaaaataa aaggaatgtg gaatgctctg
     1621 aaatgtacat ctttttcctt gaacggagtt tatcaacatc agaggaaaac ttcgtcttgt
     1681 aactacaagc attaacgggg actgagcccg agcaccacca gagaaacctg ctgcaaacac
     1741 tgagtgtaat cactgagctt tcgccttgac tgactgctct gaactcttca ttccctaaca
     1801 tgggtagtcc cgatgaccat ctgagaatat ttagattgtt tatttattag aaacgtcctt
     1861 tattt
//
