LOCUS       NM_199412               2229 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus mitochondrial calcium uptake 1 (Micu1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_199412 XM_345104
VERSION     NM_199412.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2229)
  AUTHORS   Ji,L., Liu,F., Jing,Z., Huang,Q., Zhao,Y., Cao,H., Li,J., Yin,C.,
            Xing,J. and Li,F.
  TITLE     MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial
            Ca2+-Dependent Antioxidant Response
  JOURNAL   Diabetes 66 (6), 1586-1600 (2017)
   PUBMED   28292968
  REMARK    GeneRIF: In vitro data show that the reconstitution of MICU1
            inhibited the apoptosis of cardiomyocytes, induced by high glucose
            and high fat, through increasing mitochondrial Ca(2+) uptake and
            subsequently activating the antioxidant system.
REFERENCE   2  (bases 1 to 2229)
  AUTHORS   Matesanz-Isabel,J., Arias-del-Val,J., Alvarez-Illera,P.,
            Fonteriz,R.I., Montero,M. and Alvarez,J.
  TITLE     Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake
  JOURNAL   Biochim Biophys Acta 1858 (6), 1110-1117 (2016)
   PUBMED   26903221
REFERENCE   3  (bases 1 to 2229)
  AUTHORS   Hou,T., Jian,C., Xu,J., Huang,A.Y., Xi,J., Hu,K., Wei,L., Cheng,H.
            and Wang,X.
  TITLE     Identification of EFHD1 as a novel Ca(2+) sensor for mitoflash
            activation
  JOURNAL   Cell Calcium 59 (5), 262-270 (2016)
   PUBMED   26975899
REFERENCE   4  (bases 1 to 2229)
  AUTHORS   Tsai,M.F., Phillips,C.B., Ranaghan,M., Tsai,C.W., Wu,Y.,
            Willliams,C. and Miller,C.
  TITLE     Dual functions of a small regulatory subunit in the mitochondrial
            calcium uniporter complex
  JOURNAL   Elife 5, e15545 (2016)
   PUBMED   27099988
  REMARK    Erratum:[Elife. 2017 Mar 02;6:e26228. doi: 10.7554/eLife.26228..
            PMID: 28253172]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2229)
  AUTHORS   Petrungaro,C., Zimmermann,K.M., Kuttner,V., Fischer,M., Dengjel,J.,
            Bogeski,I. and Riemer,J.
  TITLE     The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer
            from MCU Regulates Mitochondrial Ca(2+) Uptake
  JOURNAL   Cell Metab 22 (4), 721-733 (2015)
   PUBMED   26387864
REFERENCE   6  (bases 1 to 2229)
  AUTHORS   Plovanich,M., Bogorad,R.L., Sancak,Y., Kamer,K.J., Strittmatter,L.,
            Li,A.A., Girgis,H.S., Kuchimanchi,S., De Groot,J., Speciner,L.,
            Taneja,N., Oshea,J., Koteliansky,V. and Mootha,V.K.
  TITLE     MICU2, a paralog of MICU1, resides within the mitochondrial
            uniporter complex to regulate calcium handling
  JOURNAL   PLoS One 8 (2), e55785 (2013)
   PUBMED   23409044
REFERENCE   7  (bases 1 to 2229)
  AUTHORS   Mallilankaraman,K., Doonan,P., Cardenas,C., Chandramoorthy,H.C.,
            Muller,M., Miller,R., Hoffman,N.E., Gandhirajan,R.K., Molgo,J.,
            Birnbaum,M.J., Rothberg,B.S., Mak,D.O., Foskett,J.K. and Madesh,M.
  TITLE     MICU1 is an essential gatekeeper for MCU-mediated mitochondrial
            Ca(2+) uptake that regulates cell survival
  JOURNAL   Cell 151 (3), 630-644 (2012)
   PUBMED   23101630
REFERENCE   8  (bases 1 to 2229)
  AUTHORS   Tsai,L.C., Chan,G.C., Nangle,S.N., Shimizu-Albergine,M.,
            Jones,G.L., Storm,D.R., Beavo,J.A. and Zweifel,L.S.
  TITLE     Inactivation of Pde8b enhances memory, motor performance, and
            protects against age-induced motor coordination decay
  JOURNAL   Genes Brain Behav 11 (7), 837-847 (2012)
   PUBMED   22925203
REFERENCE   9  (bases 1 to 2229)
  AUTHORS   Perocchi,F., Gohil,V.M., Girgis,H.S., Bao,X.R., McCombs,J.E.,
            Palmer,A.E. and Mootha,V.K.
  TITLE     MICU1 encodes a mitochondrial EF hand protein required for Ca(2+)
            uptake
  JOURNAL   Nature 467 (7313), 291-296 (2010)
   PUBMED   20693986
REFERENCE   10 (bases 1 to 2229)
  AUTHORS   Natter,S., Seiberler,S., Hufnagl,P., Binder,B.R., Hirschl,A.M.,
            Ring,J., Abeck,D., Schmidt,T., Valent,P. and Valenta,R.
  TITLE     Isolation of cDNA clones coding for IgE autoantigens with serum IgE
            from atopic dermatitis patients
  JOURNAL   FASEB J 12 (14), 1559-1569 (1998)
   PUBMED   9806765
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 27, 2020 this sequence version replaced NM_199412.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062075.1, SRR26360172.1541412.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                JAXUCZ010000020.1  28211774-28211807
            35-196              JAXUCZ010000020.1  28238265-28238426
            197-371             JAXUCZ010000020.1  28241341-28241515
            372-534             JAXUCZ010000020.1  28248330-28248492
            535-578             JAXUCZ010000020.1  28256569-28256612
            579-693             JAXUCZ010000020.1  28273562-28273676
            694-776             JAXUCZ010000020.1  28291673-28291755
            777-974             JAXUCZ010000020.1  28292592-28292789
            975-1112            JAXUCZ010000020.1  28326554-28326691
            1113-1221           JAXUCZ010000020.1  28336939-28337047
            1222-1311           JAXUCZ010000020.1  28354869-28354958
            1312-2229           JAXUCZ010000020.1  28357011-28357928
FEATURES             Location/Qualifiers
     source          1..2229
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..2229
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /note="mitochondrial calcium uptake 1"
                     /db_xref="GeneID:365567"
                     /db_xref="RGD:735033"
     exon            1..34
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            35..196
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1469
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /note="calcium-binding atopy-related autoantigen 1
                     homolog; calcium binding atopy-related autoantigen 1;
                     calcium-binding atopy-related autoantigen 1-like"
                     /codon_start=1
                     /product="calcium uptake protein 1, mitochondrial"
                     /protein_id="NP_955444.2"
                     /db_xref="GeneID:365567"
                     /db_xref="RGD:735033"
                     /translation="MFRLNALSALAELAMGSRWYHGTSQPTQTKRRLMLVAFLGASAV
                     TASTGLLWKKAHAESPPSVNSKKTDAGDKGKSKDTREVSSHEGSAADTAAEPYPEEKK
                     KKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITP
                     NEKQPEHLGLDQYIIKRFDGKKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVL
                     STPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGL
                     CSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLL
                     AYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGAS
                     LDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKP
                     KDMGFTRLMQAMWKCAQETAWDFALPK"
     exon            197..371
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..534
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..578
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..693
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..776
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..974
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1112
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1221
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1311
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..2229
                     /gene="Micu1"
                     /gene_synonym="Cbara1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgagttg ctgctaaagc tggagcgcgg acgggatgtt tcgtcttaat gccctctctg
       61 cgttggcaga actggccatg ggctcccgct ggtaccatgg aacatctcag cccacacaga
      121 ctaagcggag actgatgttg gtggcgttcc ttggagcatc cgcggtgact gcaagtaccg
      181 gtctcctgtg gaagaaggct cacgcagaat ctccaccgag cgtcaacagc aagaagactg
      241 acgctggaga taaggggaag agcaaggaca cccgggaagt gtccagccat gaaggaagcg
      301 ctgcagacac tgcggccgag ccttacccag aggagaagaa gaagaagcgt tctggattca
      361 gagacagaaa agtaatggag tatgagaata ggatccgagc ctactccaca ccagacaaaa
      421 tcttccggta ttttgccacc ttgaaagtaa tcaacgaacc tggtgaaact gaagtgttca
      481 tgaccccaca ggactttgtg cgctccataa cacccaatga gaagcagcca gaacacttgg
      541 gcctggatca gtacataata aagcgcttcg atggaaagaa aattgcccag gaacgagaaa
      601 agtttgctga cgaaggcagc atcttctata cccttggaga gtgtggactc atctccttct
      661 ctgactacat cttcctcaca acggtgctct ccactcctca gagaaatttc gaaattgcct
      721 tcaagatgtt tgacttgaat ggagatggag aagtagacat ggaggagttt gagcaggttc
      781 aaagcatcat tcgctcccag accagcatgg gcatgcgtca cagagatcgt ccaactactg
      841 ggaacaccct caagtctggc ttatgttccg ccctcacgac ctactttttt ggagctgatc
      901 tcaaagggaa actgaccatt aaaaacttcc tggaatttca gcgtaaactg cagcatgacg
      961 ttctaaagct ggagtttgaa cgccatgacc cggtagacgg gagaatctct gagaggcagt
     1021 tcggtggcat gctgctggcc tacagtggag tgcagtccaa gaagctgacc gccatgcaga
     1081 ggcagctgaa gaagcacttc aaggatggga agggcctgac tttccaggag gtggagaact
     1141 tcttcacttt cctgaagaac attaatgacg tggacactgc gttaagcttt taccacatgg
     1201 ctggagcatc cctcgataaa gtgaccatgc agcaagtggc caggacagtg gcgaaagtcg
     1261 agctgtcgga ccacgtgtgt gacgtggtgt ttgcactctt tgactgcgac ggcaatgggg
     1321 agctgagcaa taaggagttt gtctccatca tgaagcagag gctgatgaga ggcctggaga
     1381 agcccaagga catgggcttt acccgtctca tgcaggccat gtggaaatgt gcccaagaaa
     1441 ccgcctggga ctttgctcta cccaaatagt accccacctc ctgcacctta gcaccccgca
     1501 atcctggagt ggccttcatg ctgctgatgc ttctgggagt agtgcccaca tccccatctt
     1561 tctggaagtg acctctggcc tcagctggct gacctctcca tcctcccctg acccagtcag
     1621 tgttccgcta ggctctgaat ctgcagtcag atcaaaggtc taagacagga acaagtcttc
     1681 aaaacagaga ccatagctcc cttaaccagt gccccgtggg taaatgcggg gagccctccc
     1741 acactggcag ccccaggagg catctctgca gtctctcact gtggatttaa gtaacacaaa
     1801 cgtccctgcc atcttcctcc cactgtttta aagctgcaag tttggaaata ctctggcagg
     1861 caaagggaag tctgtgatga acggtaatgc agatgaccct ggtaccctga tctggcaggg
     1921 cacctggtca ggggaagggt ctgcgtcaga caccagcggc accaggaagg ctctttgcca
     1981 ccagcacagc tcccgattca aagtcgctgc tttgagcggc tctccagaac ctcctgctct
     2041 tttttttttt cctcccgggc tccctgcgat gcctcctctg ggactctgct tcactagagc
     2101 cagggctgag cccctgttcc ttgtgtcttg tcccctctct atagacctgc agagcgcagc
     2161 tcagagcctg tctgccctct gtctaataca ctcgtaaata tcactttaat tatagcactt
     2221 tgcaggaaa
//
