LOCUS       NM_001017468            1202 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Rattus norvegicus MHC class I polypeptide-related sequence B
            (Micb), mRNA.
ACCESSION   NM_001017468 XM_574378
VERSION     NM_001017468.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1202)
  AUTHORS   Watanabe,Y., Maruoka,T., Walter,L. and Kasahara,M.
  TITLE     Comparative genomics of the Mill family: a rapidly evolving MHC
            class I gene family
  JOURNAL   Eur J Immunol 34 (6), 1597-1607 (2004)
   PUBMED   15162429
REFERENCE   2  (bases 1 to 1202)
  AUTHORS   Dunn,C., Chalupny,N.J., Sutherland,C.L., Dosch,S., Sivakumar,P.V.,
            Johnson,D.C. and Cosman,D.
  TITLE     Human cytomegalovirus glycoprotein UL16 causes intracellular
            sequestration of NKG2D ligands, protecting against natural killer
            cell cytotoxicity
  JOURNAL   J Exp Med 197 (11), 1427-1439 (2003)
   PUBMED   12782710
REFERENCE   3  (bases 1 to 1202)
  AUTHORS   Jinushi,M., Takehara,T., Tatsumi,T., Kanto,T., Groh,V., Spies,T.,
            Kimura,R., Miyagi,T., Mochizuki,K., Sasaki,Y. and Hayashi,N.
  TITLE     Expression and role of MICA and MICB in human hepatocellular
            carcinomas and their regulation by retinoic acid
  JOURNAL   Int J Cancer 104 (3), 354-361 (2003)
   PUBMED   12569559
REFERENCE   4  (bases 1 to 1202)
  AUTHORS   Steinle,A., Li,P., Morris,D.L., Groh,V., Lanier,L.L., Strong,R.K.
            and Spies,T.
  TITLE     Interactions of human NKG2D with its ligands MICA, MICB, and
            homologs of the mouse RAE-1 protein family
  JOURNAL   Immunogenetics 53 (4), 279-287 (2001)
   PUBMED   11491531
REFERENCE   5  (bases 1 to 1202)
  AUTHORS   Yamamoto,K., Fujiyama,Y., Andoh,A., Bamba,T. and Okabe,H.
  TITLE     Oxidative stress increases MICA and MICB gene expression in the
            human colon carcinoma cell line (CaCo-2)
  JOURNAL   Biochim Biophys Acta 1526 (1), 10-12 (2001)
   PUBMED   11287116
REFERENCE   6  (bases 1 to 1202)
  AUTHORS   Cosman,D., Mullberg,J., Sutherland,C.L., Chin,W., Armitage,R.,
            Fanslow,W., Kubin,M. and Chalupny,N.J.
  TITLE     ULBPs, novel MHC class I-related molecules, bind to CMV
            glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D
            receptor
  JOURNAL   Immunity 14 (2), 123-133 (2001)
   PUBMED   11239445
REFERENCE   7  (bases 1 to 1202)
  AUTHORS   Groh,V., Steinle,A., Bauer,S. and Spies,T.
  TITLE     Recognition of stress-induced MHC molecules by intestinal
            epithelial gammadelta T cells
  JOURNAL   Science 279 (5357), 1737-1740 (1998)
   PUBMED   9497295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB113961.1.
            
            [WARNING] On Aug 27, 2024 this sequence was replaced by
            NM_001017468.3.
            
            On Apr 5, 2007 this sequence version replaced NM_001017468.1.
            
            Sequence Note: The sequence AB113961.1 is from a chimeric clone.
            Only the MHC class I-like located near the LRC, 2 sequence was
            propagated into this RefSeq record.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB113963.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN09345330, SAMN13663610 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1202              AB113961.1         1-1202
FEATURES             Location/Qualifiers
     source          1..1202
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WKA/Hkm"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1202
                     /gene="Micb"
                     /gene_synonym="Mill2"
                     /note="MHC class I polypeptide-related sequence B"
                     /db_xref="GeneID:365212"
                     /db_xref="RGD:1564508"
     exon            1..118
                     /gene="Micb"
                     /gene_synonym="Mill2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1149
                     /gene="Micb"
                     /gene_synonym="Mill2"
                     /note="MHC class I-like located near the LRC, 2; Mill2
                     gene for MHC class I-like located near the LRC, 2, exon 3,
                     partial cds, strain:LEW.1lm1; MHC I like leukocyte 2; MHC
                     class I-like located near the leukocyte receptor complex
                     2; MHC class I-like protein MILL2"
                     /codon_start=1
                     /product="MHC class I-like protein MILL2 precursor"
                     /protein_id="NP_001017468.1"
                     /db_xref="GeneID:365212"
                     /db_xref="RGD:1564508"
                     /translation="MEASSGTAGPAVLLLILALLLTESQGSRSQGTHTLRYDVTACFL
                     EGSEQTRLLVLIYVDDELFLRYNGDRRSAKPWACWIKGHGGDETCAREVENLPKEEER
                     LREMMAEMINQKGHDKGPYTLQATLGCELQRNGSTRGFWHLGYEGRNLLTFDQKTLTW
                     TMDVPFTQQKKTFWEPRAPKADLVKTFLDETCPARLQRHLASLSNVLPDTGSPVVIVT
                     CRNYPVGRITLTCRAFNLSSHVATLLWLRDGKPVQQDVFGPGTILPSGDGTYQTWVSI
                     RVLPGQEPQFACNLRHSNRTIMQTAVSGESMGWPSASWATRQEAEGPHRTHNDHVVDG
                     GLVTGNANKDSPDASSCATASAISAFPVVVLSVALPRAN"
     exon            119..382
                     /gene="Micb"
                     /gene_synonym="Mill2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..658
                     /gene="Micb"
                     /gene_synonym="Mill2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..1180
                     /gene="Micb"
                     /gene_synonym="Mill2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1202
                     /gene="Micb"
                     /gene_synonym="Mill2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtatgtgc ccacacaaag gaggaaaatg gaagccagtt ctggaacagc aggaccagca
       61 gtcctactgt tgatcttagc gctgctcctg acagagtcac agggatccag gagccaggga
      121 acccacactc tgcgctatga tgtcacagcc tgttttctgg agggctctga gcagaccagg
      181 ctcctggtcc taatatacgt agacgatgag ctcttcctga ggtacaatgg agacaggagg
      241 agtgcaaagc cctgggcatg ctggattaag ggccatgggg gagatgagac gtgtgcaaga
      301 gaggttgaga atctgccgaa ggaggaggag agactcaggg agatgatggc tgagatgata
      361 aaccagaagg gccacgacaa aggcccatac actcttcagg caaccctggg ctgtgagctt
      421 caaagaaacg gaagcactag aggcttctgg cacctgggct acgaagggcg gaacctcctc
      481 accttcgacc agaagactct cacatggaca atggatgtgc ccttcaccca gcagaagaag
      541 acgttctggg agccacgtgc acccaaagct gacctagtta agacgttctt ggatgagaca
      601 tgtcctgctc ggctccagag acacctggct tccttgagta atgttctgcc ggatacaggt
      661 tccccagtgg tgattgtgac ctgcaggaat tatcccgtgg gcaggatcac gctgacatgc
      721 cgggctttta atctgagttc ccatgtggcc accctgctct ggcttcggga cgggaagccg
      781 gtacagcagg atgtctttgg gcctgggacc atcctgccca gtggggacgg gacctaccag
      841 acctgggtgt ccattcgggt tcttcctgga caggaaccac agttcgcctg caacctgagg
      901 catagcaacc gcaccatcat gcagaccgct gtctctggcg agagcatggg atggccatcc
      961 gcctcatggg ctacgaggca agaggcggaa ggaccccata ggacacacaa tgaccacgtg
     1021 gttgatggcg gactggttac ggggaatgct aataaggaca gtccagatgc ttccagctgt
     1081 gctacagcct cagccatatc tgcgttcccc gttgtcgtgt tgtctgtggc actgcccaga
     1141 gccaactgaa tccagagccc aaaggataag aagcttccag ttaggaggga caggacgtga
     1201 gt
//
