LOCUS       NM_001395865            5520 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus microtubule associated monooxygenase, calponin
            and LIM domain containing 2 (Mical2), transcript variant 1, mRNA.
ACCESSION   NM_001395865
VERSION     NM_001395865.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5520)
  AUTHORS   Lundquist,M.R., Storaska,A.J., Liu,T.C., Larsen,S.D., Evans,T.,
            Neubig,R.R. and Jaffrey,S.R.
  TITLE     Redox modification of nuclear actin by MICAL-2 regulates SRF
            signaling
  JOURNAL   Cell 156 (3), 563-576 (2014)
   PUBMED   24440334
REFERENCE   2  (bases 1 to 5520)
  AUTHORS   McDonald,C.A., Liu,Y.Y. and Palfey,B.A.
  TITLE     Actin stimulates reduction of the MICAL-2 monooxygenase domain
  JOURNAL   Biochemistry 52 (35), 6076-6084 (2013)
   PUBMED   23927065
REFERENCE   3  (bases 1 to 5520)
  AUTHORS   Lee,B.C., Peterfi,Z., Hoffmann,F.W., Moore,R.E., Kaya,A.,
            Avanesov,A., Tarrago,L., Zhou,Y., Weerapana,E., Fomenko,D.E.,
            Hoffmann,P.R. and Gladyshev,V.N.
  TITLE     MsrB1 and MICALs regulate actin assembly and macrophage function
            via reversible stereoselective methionine oxidation
  JOURNAL   Mol Cell 51 (3), 397-404 (2013)
   PUBMED   23911929
REFERENCE   4  (bases 1 to 5520)
  AUTHORS   Lundby,A., Secher,A., Lage,K., Nordsborg,N.B., Dmytriyev,A.,
            Lundby,C. and Olsen,J.V.
  TITLE     Quantitative maps of protein phosphorylation sites across 14
            different rat organs and tissues
  JOURNAL   Nat Commun 3, 876 (2012)
   PUBMED   22673903
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5520)
  AUTHORS   Miura,K. and Imaki,J.
  TITLE     Molecular cloning of Ebitein1: a novel extracellular
            signal-regulated kinase 2-binding protein in testis
  JOURNAL   Biochem Biophys Res Commun 368 (2), 336-342 (2008)
   PUBMED   18241670
REFERENCE   6  (bases 1 to 5520)
  AUTHORS   Pasterkamp,R.J., Dai,H.N., Terman,J.R., Wahlin,K.J., Kim,B.,
            Bregman,B.S., Popovich,P.G. and Kolodkin,A.L.
  TITLE     MICAL flavoprotein monooxygenases: expression during neural
            development and following spinal cord injuries in the rat
  JOURNAL   Mol Cell Neurosci 31 (1), 52-69 (2006)
   PUBMED   16230022
  REMARK    GeneRIF: Tesults implicate MICALs in neuronal regeneration and
            support the possibility to attenuate axon repulsion in the injured
            spinal cord.
REFERENCE   7  (bases 1 to 5520)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000001.1  175780446-175780604
            160-237             JAXUCZ010000001.1  175789692-175789769
            238-577             JAXUCZ010000001.1  175825530-175825869
            578-785             JAXUCZ010000001.1  175855296-175855503
            786-902             JAXUCZ010000001.1  175858758-175858874
            903-1004            JAXUCZ010000001.1  175861240-175861341
            1005-1160           JAXUCZ010000001.1  175863059-175863214
            1161-1261           JAXUCZ010000001.1  175867707-175867807
            1262-1519           JAXUCZ010000001.1  175871059-175871316
            1520-1635           JAXUCZ010000001.1  175872364-175872479
            1636-1762           JAXUCZ010000001.1  175873263-175873389
            1763-1853           JAXUCZ010000001.1  175873989-175874079
            1854-2001           JAXUCZ010000001.1  175875130-175875277
            2002-2201           JAXUCZ010000001.1  175876111-175876310
            2202-2308           JAXUCZ010000001.1  175876584-175876690
            2309-2377           JAXUCZ010000001.1  175883302-175883370
            2378-2521           JAXUCZ010000001.1  175886513-175886656
            2522-2711           JAXUCZ010000001.1  175898706-175898895
            2712-2800           JAXUCZ010000001.1  175901058-175901146
            2801-2903           JAXUCZ010000001.1  175902436-175902538
            2904-3078           JAXUCZ010000001.1  175916396-175916570
            3079-3263           JAXUCZ010000001.1  175919797-175919981
            3264-3332           JAXUCZ010000001.1  175927515-175927583
            3333-3475           JAXUCZ010000001.1  175931634-175931776
            3476-4781           JAXUCZ010000001.1  175932281-175933586
            4782-4873           JAXUCZ010000001.1  175941987-175942078
            4874-4954           JAXUCZ010000001.1  175945479-175945559
            4955-5048           JAXUCZ010000001.1  175946559-175946652
            5049-5148           JAXUCZ010000001.1  175958199-175958298
            5149-5222           JAXUCZ010000001.1  175962053-175962126
            5223-5520           JAXUCZ010000001.1  175964860-175965157
FEATURES             Location/Qualifiers
     source          1..5520
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..5520
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /note="microtubule associated monooxygenase, calponin and
                     LIM domain containing 2"
                     /db_xref="GeneID:365352"
                     /db_xref="RGD:1311773"
     exon            1..159
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            160..237
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            238..577
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..5407
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /EC_number="1.14.13.225"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein MICAL-2; molecule interacting with CasL protein 2;
                     protein-methionine sulfoxide oxidase MICAL2;
                     [F-actin]-methionine sulfoxide oxidase MICAL2;
                     [F-actin]-monooxygenase MICAL2; F-actin-monooxygenase
                     MICAL2; MICAL C-terminal like; MICAL C-terminal-like
                     protein; mical-cL; ebitein-1; ERK2-binding testicular
                     protein 1"
                     /codon_start=1
                     /product="[F-actin]-monooxygenase MICAL2 isoform 1"
                     /protein_id="NP_001382794.1"
                     /db_xref="GeneID:365352"
                     /db_xref="RGD:1311773"
                     /translation="MGENEDEKQAQASQVFENFVQATTCKGTLQAFNILTCLLDLDPL
                     DHRNFYTQLKSKVNTWKAKALWHKLDKRGSHKEYKRGKACSNTKCLIVGGGPCGLRTA
                     IELAYLGAKVVVVEKRDTFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIR
                     QLQLILFKVALMLGVEIHVNVEFVRVREPPKDQENRKIGWRAEFLPADHALSNFEFDV
                     IIGADGHRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQ
                     DLKEETGIDLENIVYYKDSTHYFVMTAKKQSLLDKGVILNDYIDTEMLLCAENVNQDN
                     LLSYAREAADFATNYQLPSLDFAINHNGQPDVAMFDFTSMYASENAALMRERQAHQLL
                     VALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWDQGTPPLEVLAERESLYRLLPQ
                     TTPENINKNFEQYTLDPATRYPNLNVHCVRPHQVKHLYITKEMDRFPLERWGSVRRSA
                     SLSRRESDIRPNKLLTWCQQQTKGYQHVRVTDLTTSWRSGLALCAIIHSFRPELINFD
                     SLNENDVVENNQLAFDVAKREFGILPVTTGKEMASTQEPDKLSMVMYLSKFYELFRGT
                     PLRPMDSRRKNYGENADFGLGKTFFQNNYLNLTLPRKRTPRVDAQTEENDVNKRRRQG
                     FNNLEELPAFSSRSLGSSQEYAKESGNQNKVKYMANQLLAKFEENTRNPSALKQESLR
                     KAEFPLSLGGRDTCYFCKKRVYVMERLSAEGHFFHRECFRCSVCAAILRVAAYAFDCD
                     EGKFYCKLHFAHCKTSSKQRKRRAELNQQREEEGTWPEQEAARRDVPAESSCAVAAIS
                     TPEGSPPDEPISPKKSKSVPKPNSRPMEVEATSPRPSEWTSVRIGPGQDGQDVLAVRV
                     LVTSEDSSSDTESDSGSIIGPCTEACEERPRLPESPPLSQPLTRHISLRETLTQPVSL
                     LLHHKEPQAVPGLQRAYSLQSPSKYQNWRRKFQSNSTPMNQRALSPPKEPPPSSSSSS
                     PSLPSSFSSASVPGHTTDDSSSPQVPAYNLHSPQISRDDVSPTPIYLRRARAQGITKE
                     IPLYLPHSPMLESTEHCLVSPDGEELRSPEEISASDGCQKALALGNSESTHKDSYPVS
                     GKDPYLPNQMLALGAAGNTGDLSEESRMGQTGGAELSKERKLGLKKLVLTEEQKTMLL
                     DWNDYTQEHKAGERLAQEKAENGRGNSLKPICSSTLSQAVKEKLLSQKKALGETRTPA
                     AKAPREREVPPPKSPLRLIANAIFRSLLPSSEAGKKTSSKPETKTLPRGQPHAFTRSF
                     SFRKLGSSKDGDQQSPGRHMAKKASAFFSLASPTSKAAQASDLSPPNPILRSRSLPNR
                     PSKMFFATTSLPPSSKVEDVPTLLEKVSLQDAAQGPKKGASHISPLGLKDKSFESFLQ
                     ECKERKDIGDFFNSPKEKGPPGNRVPSLEKLVQPVDSTSMGQVAHPSSTGQDARPGAP
                     VTEDTSSPTSSSAEEDVETQLSSRLKEKIPRRRRKLEKQMAKQEELKRLHKAQAIQRQ
                     LEEVEERQRTSEIQGVRLEKVLRGETDSGTQDEAQLLQEWFKLVLEKNKLMRYESELL
                     IMAQELELEDHQSRLEQKLRQKMLKDEGQKDENDLKEEQEIFEEMMQVIEQRNKLVDS
                     LEEQRIKERTQDQHFENFVLSRGCQLSRT"
     exon            578..785
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            786..902
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1004
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1160
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1261
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1519
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1635
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1762
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1853
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2001
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2201
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2308
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2377
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2521
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2711
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2800
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2903
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3078
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3263
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3332
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3475
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..4781
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            4782..4873
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            4874..4954
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            4955..5048
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            5049..5148
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            5149..5222
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
     exon            5223..5520
                     /gene="Mical2"
                     /gene_synonym="Mical-2; Micalcl; RGD1311773; RSB-11-77"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaaccac aggcacccgg ccggctcagc ctgcgccggg ccgcctcgct agctccgggc
       61 tcggcaggcg gcccgcgggg ttccgaatct ctgcgccctc agacaggggc caagcaaggc
      121 aggcgctgac ctgaagcccg gaggcccgcg agaccttcgg ccatttttag gagaggaaat
      181 gtggacatag agggacctga ccccagaaac agaccaggag gctcctgctt gcctgtggtg
      241 taatacttag ccttcccttt atgctgactc ctgctgatcc ctccacacca ctgttccaca
      301 cagctcctga accatgggag agaatgaaga tgagaagcag gcacaggcca gccaggtctt
      361 cgagaacttt gtacaagcta ccacatgcaa agggaccctc caggccttca acatccttac
      421 ctgcctcctg gacctagatc cgctggacca tagaaacttc tacacccagc tcaagtccaa
      481 ggtgaacacc tggaaggcca aagctctgtg gcacaaactg gataagcgtg gctcccacaa
      541 ggagtacaag cgaggaaaag cctgctcgaa cactaagtgt ctcatcgtcg gaggaggacc
      601 atgtggcctg cgcactgcca ttgaactcgc ctacctggga gccaaggtgg ttgtggtgga
      661 gaagagggac accttctccc ggaacaatgt gttgcacctc tggcctttca ctatccatga
      721 ccttcggggc ctgggggcca agaagtttta tgggaaattc tgtgctggct ccatcgacca
      781 catcagtatc cgacaactgc agctcatcct gttcaaggtg gccctgatgc tgggagtgga
      841 aatccatgtg aatgtggagt ttgtgagggt ccgagagcct cctaaagacc aagaaaatcg
      901 aaagattgga tggcgggcag agttcctccc tgcagaccac gccctgtcta actttgagtt
      961 tgatgtcatc atcggtgcag atggccacag gaacacgcta gaagggttca ggaggaaaga
     1021 gttccgaggg aaactggcca ttgccatcac tgccaacttc ataaacagga atagcacagc
     1081 tgaggccaag gtggaggaga tcagtggcgt ggccttcatc ttcaaccaga agttcttcca
     1141 ggacctgaag gaagaaacag ggatcgatct tgagaacatt gtttactaca aggacagtac
     1201 ccactacttt gtcatgacag ccaagaagca gagcctgctg gacaaaggcg tcatcctaaa
     1261 tgactacatc gacacagaga tgctgctgtg tgccgagaat gtgaaccagg acaacctgct
     1321 ctcctatgcc agagaagccg ctgattttgc caccaattac cagctgccat ccttagactt
     1381 tgccataaat cacaacgggc agcctgacgt ggccatgttc gacttcacct ccatgtatgc
     1441 ctcggagaac gcagccctga tgcgtgagcg ccaggcacac cagctgcttg tggcccttgt
     1501 aggcgacagc ctgcttgagc cgttttggcc catgggcaca ggctgcgccc gaggcttcct
     1561 ggcagccttt gacacggcat ggatggtaaa gagctgggac cagggcaccc ctcccctgga
     1621 ggtgctagct gaaagagaga gtctttaccg gctgttacct cagacaaccc ctgagaacat
     1681 caacaaaaat tttgagcagt acacattgga cccagccaca cggtacccaa acctcaacgt
     1741 gcactgtgtc aggcctcacc aggtgaagca tttgtacatc actaaggaga tggaccgctt
     1801 ccctctcgag agatggggct cagtgaggag atctgccagc ctctccaggc gggagtcaga
     1861 catccggcct aacaagctct taacctggtg ccagcagcag accaagggtt accagcatgt
     1921 cagagtcact gacctgacca catcctggcg cagcggcttg gccctgtgtg ccatcatcca
     1981 cagcttccgg ccagagctga tcaacttcga ctctctgaat gagaatgacg ttgtggagaa
     2041 caaccaactg gcatttgatg tggccaagcg tgagtttggg atcctgcctg tgaccacggg
     2101 caaagagatg gcatctaccc aggagcccga caagctcagc atggtcatgt acctctccaa
     2161 gttctatgag ctcttccggg gtactcccct gagacccatg gattcccggc gtaaaaacta
     2221 cggagaaaat gctgactttg gcttgggcaa aacattcttt cagaataact atctcaacct
     2281 cacattgccc agaaagagaa ccccacgggt agacgcccag actgaagaga atgacgtgaa
     2341 caagaggagg cggcaaggct tcaacaacct ggaagagctg ccagccttct ccagccggag
     2401 cttgggctcc agccaagagt atgctaaaga aagtggcaat cagaacaaag tcaagtacat
     2461 ggccaatcag ctgctagcca agtttgagga gaacactcgg aacccttcag ccttgaaaca
     2521 ggaatccctg cgaaaggcgg aattccccct gagcctgggt ggcagggaca cctgctactt
     2581 ttgtaagaag cgcgtgtacg tgatggagcg actgagcgcc gagggccact ttttccaccg
     2641 agagtgcttc cgatgcagcg tctgcgcagc catcctacgt gtggctgcct atgcctttga
     2701 ctgtgatgaa ggcaaatttt actgcaagct ccattttgct cactgtaaaa ccagcagcaa
     2761 acagcggaag agacgggcag agctgaatca gcaaagagag gaggaaggga catggccgga
     2821 gcaggaagca gctcggagag atgttccagc agaaagctct tgtgcagtgg cggccatcag
     2881 cacgccagaa ggcagccccc cagatgagcc catctctcct aagaagtcaa agagtgtccc
     2941 taagcccaac tccagaccca tggaagttga agccacctct cctcggccgt ctgaatggac
     3001 ttcagtaagg atcggcccag ggcaggatgg gcaggatgtg ctggctgtac gggtcctagt
     3061 caccagtgag gacagcagct ctgatacaga atccgactct ggcagcatca taggcccctg
     3121 cacagaggcc tgtgaagaga gaccccgcct tccagaatcc ccacctctat cacagcctct
     3181 aacccggcac atctccctgc gggagaccct gacccaacca gtctctctac tactacacca
     3241 caaggagcca caagctgtgc ctggtctgca gcgggcctac agcctccagt ctccaagcaa
     3301 ataccagaac tggaggagaa aattccagtc caattcaaca cccatgaacc aaagagcact
     3361 gtcgcctcca aaggagcctc ctccttcatc ttcgtcgtct tcaccttccc tgccatcttc
     3421 attttcttca gctagtgtac ctgggcacac tacagatgat tcctcctctc ctcaggtgcc
     3481 agcatacaac ctccactccc cacagatctc cagagacgat gtcagcccca ctccaatcta
     3541 cctcagacgt gccagggctc aaggaattac gaaggaaatc cccctctatc tgcctcatag
     3601 ccccatgctg gagagcacgg aacactgcct ggttagccct gatggagaag aactcagaag
     3661 ccctgaggag atctcggctt cagacggctg ccagaaagca ctggctcttg gaaacagcga
     3721 aagcacacac aaagattcct accccgtttc agggaaggac ccgtatttgc ccaatcaaat
     3781 gctagctctt ggtgcggcag ggaacacagg agacttgagt gaggaatcca ggatgggaca
     3841 gacaggtgga gcagagctgt ccaaagaaag gaagttgggc ttgaagaaat tagtcctcac
     3901 tgaggagcag aagaccatgt tgctagactg gaatgactac acccaggagc acaaggctgg
     3961 ggagcggctc gcgcaggaaa aggctgagaa tggcagaggc aatagcctga agccaatctg
     4021 ctcttctacc ctctctcagg cggtgaaaga gaaattgcta tcccagaaaa aagccctggg
     4081 ggagacacgt accccagctg ccaaggcacc ccgggaacga gaagttcctc cacccaagtc
     4141 ccccttaagg ctcatagcaa acgccatctt taggtctctg ctccccagtt ctgaagctgg
     4201 aaaaaagaca agctctaaac cagagaccaa aactttgcct aggggtcagc cgcatgcttt
     4261 cactcgttcc tttagcttcc ggaaactggg ttccagtaaa gatggggacc agcagtctcc
     4321 agggagacac atggccaaga aggcttcagc cttcttctct ctggcttctc caacatctaa
     4381 ggctgcccag gcctcagacc ttagccctcc caaccccatc ctccgaagcc ggagtttgcc
     4441 caatcgtcca tccaagatgt tctttgcaac cacatcccta ccacccagca gcaaggttga
     4501 agatgtcccc accctcctag agaaagtgag tttgcaggat gccgctcaag gtccaaagaa
     4561 aggagcctca catatttctc cccttggcct caaagataaa tcctttgaga gttttctcca
     4621 ggaatgcaaa gaaagaaagg acattgggga cttctttaat agccccaagg agaaggggcc
     4681 accagggaac agagtcccat ccttggagaa gctggtgcag cctgttgaca gcacctccat
     4741 ggggcaggtg gcacatcctt cttccacagg gcaagatgca cgccctggag ctccagtgac
     4801 agaggacacc tcttctccta cctcgtcctc tgcagaggaa gatgttgaga ctcagctttc
     4861 ctcaaggtta aaggagaaga taccaagaag gaggaggaag ctggagaagc agatggctaa
     4921 gcaagaagaa ttgaaaagac tccataaggc tcaggccatc cagagacaac tagaggaggt
     4981 ggaagagcgg cagaggacgt cagagatcca gggtgtgagg ctggagaagg tgctgagagg
     5041 agaaacagat tcagggacac aggacgaagc ccagcttttg caggaatggt ttaagctggt
     5101 tctggagaag aataaattaa tgcgatatga gtcggagcta ctgatcatgg cccaagaact
     5161 agaactagaa gatcatcaga gcagactgga gcagaaacta cgacagaaaa tgctcaagga
     5221 tgagggccag aaagatgaga atgatctaaa ggaggagcaa gaaatattcg aggagatgat
     5281 gcaggtgatt gagcaaagaa acaagcttgt ggattcccta gaggaacagc gcatcaaaga
     5341 aagaacccag gatcaacact ttgaaaactt tgttctctcc agaggctgtc agctcagcag
     5401 gacttgaggt gcccttccct gctgaagcca gaaagccaag aacacaacga gttcccaccc
     5461 aagcactgaa tttagacccc actacttaag aaataataaa gataataata acgcctctca
//
