LOCUS       NM_001106397            3536 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus microtubule associated monooxygenase, calponin
            and LIM domain containing 1 (Mical1), mRNA.
ACCESSION   NM_001106397 XM_001069650 XM_215424
VERSION     NM_001106397.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3536)
  AUTHORS   Fremont,S., Hammich,H., Bai,J., Wioland,H., Klinkert,K.,
            Rocancourt,M., Kikuti,C., Stroebel,D., Romet-Lemonne,G.,
            Pylypenko,O., Houdusse,A. and Echard,A.
  TITLE     Oxidation of F-actin controls the terminal steps of cytokinesis
  JOURNAL   Nat Commun 8, 14528 (2017)
   PUBMED   28230050
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3536)
  AUTHORS   Alqassim,S.S., Urquiza,M., Borgnia,E., Nagib,M., Amzel,L.M. and
            Bianchet,M.A.
  TITLE     Modulation of MICAL Monooxygenase Activity by its Calponin Homology
            Domain: Structural and Mechanistic Insights
  JOURNAL   Sci Rep 6, 22176 (2016)
   PUBMED   26935886
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3536)
  AUTHORS   Vitali,T., Maffioli,E., Tedeschi,G. and Vanoni,M.A.
  TITLE     Properties and catalytic activities of MICAL1, the flavoenzyme
            involved in cytoskeleton dynamics, and modulation by its CH, LIM
            and C-terminal domains
  JOURNAL   Arch Biochem Biophys 593, 24-37 (2016)
   PUBMED   26845023
REFERENCE   4  (bases 1 to 3536)
  AUTHORS   Van Battum,E.Y., Gunput,R.A., Lemstra,S., Groen,E.J., Yu,K.L.,
            Adolfs,Y., Zhou,Y., Hoogenraad,C.C., Yoshida,Y., Schachner,M.,
            Akhmanova,A. and Pasterkamp,R.J.
  TITLE     The intracellular redox protein MICAL-1 regulates the development
            of hippocampal mossy fibre connections
  JOURNAL   Nat Commun 5, 4317 (2014)
   PUBMED   25007825
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3536)
  AUTHORS   Lundquist,M.R., Storaska,A.J., Liu,T.C., Larsen,S.D., Evans,T.,
            Neubig,R.R. and Jaffrey,S.R.
  TITLE     Redox modification of nuclear actin by MICAL-2 regulates SRF
            signaling
  JOURNAL   Cell 156 (3), 563-576 (2014)
   PUBMED   24440334
REFERENCE   6  (bases 1 to 3536)
  AUTHORS   Yamamura,R., Nishimura,N., Nakatsuji,H., Arase,S. and Sasaki,T.
  TITLE     The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates
            the assembly of tight junctions and adherens junctions
  JOURNAL   Mol Biol Cell 19 (3), 971-983 (2008)
   PUBMED   18094055
REFERENCE   7  (bases 1 to 3536)
  AUTHORS   Pasterkamp,R.J., Dai,H.N., Terman,J.R., Wahlin,K.J., Kim,B.,
            Bregman,B.S., Popovich,P.G. and Kolodkin,A.L.
  TITLE     MICAL flavoprotein monooxygenases: expression during neural
            development and following spinal cord injuries in the rat
  JOURNAL   Mol Cell Neurosci 31 (1), 52-69 (2006)
   PUBMED   16230022
  REMARK    GeneRIF: Tesults implicate MICALs in neuronal regeneration and
            support the possibility to attenuate axon repulsion in the injured
            spinal cord.
REFERENCE   8  (bases 1 to 3536)
  AUTHORS   Nadella,M., Bianchet,M.A., Gabelli,S.B., Barrila,J. and Amzel,L.M.
  TITLE     Structure and activity of the axon guidance protein MICAL
  JOURNAL   Proc Natl Acad Sci U S A 102 (46), 16830-16835 (2005)
   PUBMED   16275926
REFERENCE   9  (bases 1 to 3536)
  AUTHORS   Fischer,J., Weide,T. and Barnekow,A.
  TITLE     The MICAL proteins and rab1: a possible link to the cytoskeleton?
  JOURNAL   Biochem Biophys Res Commun 328 (2), 415-423 (2005)
   PUBMED   15694364
  REMARK    GeneRIF: Using the microtubule depolymerizing drug nocodazole we
            detected a link between MICAL-1 and -3, and the microtubule
            cytoskeleton.
REFERENCE   10 (bases 1 to 3536)
  AUTHORS   Suzuki,T., Nakamoto,T., Ogawa,S., Seo,S., Matsumura,T.,
            Tachibana,K., Morimoto,C. and Hirai,H.
  TITLE     MICAL, a novel CasL interacting molecule, associates with vimentin
  JOURNAL   J Biol Chem 277 (17), 14933-14941 (2002)
   PUBMED   11827972
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474025.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001069650.1, XM_215424.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..3536
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /note="microtubule associated monooxygenase, calponin and
                     LIM domain containing 1"
                     /db_xref="GeneID:294520"
                     /db_xref="RGD:1309386"
     exon            1..204
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            205..509
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..3395
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /EC_number="1.6.3.1"
                     /EC_number="1.14.13.225"
                     /note="NEDD9 interacting protein with calponin homology
                     and LIM domains; molecule interacting with CasL protein 1;
                     protein-methionine sulfoxide oxidase MICAL1;
                     F-actin-monooxygenase MICAL1; microtubule associated
                     monoxygenase, calponin and LIM domain containing 1;
                     [F-actin]-methionine sulfoxide oxidase MICAL1"
                     /codon_start=1
                     /product="[F-actin]-monooxygenase MICAL1"
                     /protein_id="NP_001099867.1"
                     /db_xref="GeneID:294520"
                     /db_xref="RGD:1309386"
                     /translation="MASPTSTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGG
                     LPQYHKIKAQLNYWSAKSLWAKLDKRASQPAYQQGQACTNTKCLVVGAGPCGLRAAVE
                     LALLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQL
                     QLLLLKVALLLGVEIHWGFTFTGLQPPPKKGSGWRARIQPSPPAQLASYEFDVLISAG
                     GGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKA
                     TGIDLENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDLPETDQLLGKANVVPEALQQFA
                     RAAADFATQGKLGKLEFAQDARGRPDVAAFDFTSMMRSESSARIQEKHGARLLLGLVG
                     DCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGTGPLELLAERESLYQLLSQTSPEN
                     MHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDIMDKEHARKKSDETDARKTTTGSA
                     GTEELLHWCQEQTAGFPGVSVTDFSSSWADGRALCALVHRLQPGLLEPSELQGMSALE
                     ATAWALRVAEYELGIIPVLSAQAVVAGSDPLGLIAYLSHFHSAFKNTPHSSGLVSQPH
                     GTPSAILFLGKLQRSLQRTRTKVEEETPCTEEPPVSEPSVPPALPSEHEEAGAEDVCE
                     LCGKRLYILERFCVDGHFFHRGCFCCRTCEATLRPGGYGQYPGDGYFYCLQHLPQEDQ
                     KEADNNGSPENQELPTPGDSTTQSGPSSPVPPVTEASPVPSPSQPARRLIRLSSVERL
                     RLSSLNIIPDSGVEPPPKPPRSCLDLAQESLKSSFMGWGVLRAPQVPEAIEKGEEEEE
                     EEEEEEEEEEELPPPLALEVEQSLLTLAKNSGDMTKYPTWRRTLMRRAKEEEMKRFCK
                     AQAIQRRLNEIEAAMRELETEGMKLEVALRKESSSPEKQKKLWLEQLLQLIQKKNSLV
                     TEEAELMITVQELDLEEKQRQLDHEFRGINREETLKTQADRLSEDRVLRKLLDVVNQR
                     DALIQFQEERRLREMPV"
     exon            510..717
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            718..822
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            823..927
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1083
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1184
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1442
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1558
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1685
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1767
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1912
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2103
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2189
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2273
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2430
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2507
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2781
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2885
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2999
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3093
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3193
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3264
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3536
                     /gene="Mical1"
                     /gene_synonym="MICAL-1; Nical"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaagaggag gactgcggcg taatgaggtg cggataagtc ttcctctgtg ttttgcgctg
       61 gcgccgcggt ccagactcct cggaactccc cggttccaga gccaccaggc cctctcttgc
      121 tttctctgca ccaccccttc ctctgcccta gccctgggat acccttccga caggaagcgg
      181 cttttccagc cccagaaacg ccgggcactg ggtttcccca cagctgctcc tcttgtcagc
      241 aggggcccca tatggcttca ccaacctcca ccaacccagc acatgaccac tttgagacct
      301 ttgtgcaggc acagctgtgc caagatgtac tgagcagttt tcaggggctc tgtagagccc
      361 tgggagtgga gtctggtggg ggattacccc agtaccacaa gatcaaggcc cagctcaact
      421 actggagtgc caagtcactg tgggccaagt tggacaagag agcaagccag cctgcgtacc
      481 agcaaggcca ggcctgtacc aacaccaagt gtctcgtggt aggtgctggg ccttgtggac
      541 ttcgggctgc agtggagctt gcactgttag gtgcccgagt ggtgcttgtg gaaaagcgta
      601 ccaagttctc taggcacaat gtactccatc tctggccctt caccatccat gatctccggg
      661 cacttggggc caagaagttc tacgggcgtt tctgtactgg gaccctggac catatcagca
      721 tccgacagct ccagctgctt ctgctgaagg tggcgttact gttgggggtg gagattcact
      781 ggggcttcac tttcactggc ctgcagcccc ctcccaaaaa agggagtggc tggcgtgccc
      841 ggatccagcc cagtccccca gcccaactgg ccagctacga atttgatgtc ctcatctcag
      901 ctggaggagg caaatttgtc cctgaaggct tcaccatcag agagatgcgc ggcaaactgg
      961 ccatcggcat cacagccaac tttgtgaatg ggcgcacggt ggaggagaca caggtgccag
     1021 aaatcagtgg cgtagctcgg atctacaacc aaaaattctt ccagagcctg ctcaaagcca
     1081 caggtattga tctggagaac attgtgtact acaaggacga cacccactac tttgtcatga
     1141 cagccaagaa gcagtgtctg ctgaggctgg gggtattgcg ccaggacttg ccagagactg
     1201 atcagctgct gggcaaagct aatgtggtgc ctgaggctct gcagcagttt gccagagcag
     1261 cggccgactt cgccacccaa ggcaagcttg ggaaactgga gttcgctcag gatgcacgtg
     1321 ggcggcccga tgtggcagcc ttcgacttca caagcatgat gcggtcagag agttctgctc
     1381 gtatccaaga aaagcatggt gcccgcctac tgctggggct ggtgggggac tgccttgtgg
     1441 agcccttctg gcctttgggc actggagtgg cccgaggctt cttggcagcc ttcgatgcag
     1501 cctggatggt gaagcggtgg gcggagggta ctgggcctct agagctgttg gctgaacgtg
     1561 agagcttgta ccagcttctg tcacaaacat ccccagagaa tatgcatcga aatgtagccc
     1621 agtatgggtt ggaccctgcc acccgatacc ccaacctgaa cctccgggct gtaacgccca
     1681 accaggtaca agacctctat gacataatgg acaaggagca tgctcggaag aagagtgacg
     1741 agacggatgc ccggaagaca accacagggt ctgcaggcac tgaggagctt ctgcactggt
     1801 gccaggagca gacagctggc tttcctggag tctctgtcac tgacttctct tcctcgtggg
     1861 ctgatgggcg agctctgtgt gccctggtac accgcctaca gcctggcctt ctggaaccct
     1921 cagagctgca gggcatgagc gctctggaag ccactgcctg ggcactgagg gtggcagaat
     1981 atgagttggg catcatacca gtgttgtctg cacaggccgt agtggcaggc agtgacccac
     2041 tgggcctcat tgcctacctc agccacttcc acagcgcctt caagaacaca ccccacagct
     2101 caggccttgt cagccagcct cacgggaccc ctagtgccat acttttcctt ggcaaactcc
     2161 agaggagcct acaacggacc cggaccaagg tagaggagga gactccgtgt actgaggagc
     2221 ctcctgtctc tgagcccagt gtgcccccag ctctgccctc cgaacatgag gaggctgggg
     2281 cagaggatgt gtgtgagctc tgtgggaaac gcctctacat cctggaacgc ttctgtgtgg
     2341 atggccattt cttccaccgc ggctgcttct gctgccgtac ctgtgaggcc acattgcggc
     2401 caggtggcta tgggcaatat ccaggagatg gatatttcta ctgtctccag cacctacccc
     2461 aggaggatca gaaggaggca gacaacaatg gaagtccaga gaaccaggag ctcccaacac
     2521 caggagacag taccacacag tcaggcccct cctctcctgt acctcctgtg acggaggcca
     2581 gccctgtccc aagccccagc caacctgcac gtcggctgat ccgcctctcc agcgtagaac
     2641 gcctacggct atcctccctg aacatcatcc ctgactcagg agtggagcct ccacccaagc
     2701 ccccacggag ctgcttggac ttggcccaag agtccctcaa gagcagcttt atgggctggg
     2761 gtgtgctccg ggcaccacag gttcctgagg ccatagagaa gggggaggag gaagaagaag
     2821 aggaggagga agaagaagag gaggaggagg agcttccgcc acctttggcg ctagaagtgg
     2881 aacagtcact gctgaccttg gccaagaact caggcgacat gactaagtac ccaacgtggc
     2941 gtcgaaccct catgcgccgt gccaaagagg aggagatgaa gaggttctgc aaggcccagg
     3001 ccatccagcg gagactaaac gagattgagg ctgctatgag ggaactggag accgaaggca
     3061 tgaagctgga ggtggccttg aggaaagaga gtagctctcc agaaaagcag aagaaactct
     3121 ggctagagca gctgctacag ctcattcaga agaagaacag cctagtgact gaggaagccg
     3181 aactcatgat cacggtgcag gagctggacc tggaagagaa gcagcggcaa ctggaccacg
     3241 agtttcgggg catcaaccgg gaagaaactc tgaagaccca ggccgaccga ctgtctgagg
     3301 accgggtcct aaggaagctg ttggatgtgg tgaaccagcg ggatgctctg atccaattcc
     3361 aggaggagcg aaggctcaga gagatgcccg tatagatggg ggcccggggc tagaagagga
     3421 cgattagagg cctctgagcc ccataagcaa gacaccatca cgagggctgt acccctgcca
     3481 tctggactgc ttagtcaggg gcttcgttgt ttacaataaa agtgtgtgcc acgaac
//
