LOCUS       NM_001107405            3798 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus MIB E3 ubiquitin protein ligase 1 (Mib1), mRNA.
ACCESSION   NM_001107405 XM_001072091 XM_226175
VERSION     NM_001107405.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3798)
  AUTHORS   Qin,X.F., Shan,Y.G., Gao,J.H., Li,F.X. and Guo,Y.X.
  TITLE     E3 ubiquitin ligase mind bomb 1 overexpression reduces apoptosis
            and inflammation of cardiac microvascular endothelial cells in
            coronary microvascular dysfunction
  JOURNAL   Cell Signal 91, 110223 (2022)
   PUBMED   34954392
  REMARK    GeneRIF: E3 ubiquitin ligase mind bomb 1 overexpression reduces
            apoptosis and inflammation of cardiac microvascular endothelial
            cells in coronary microvascular dysfunction.
REFERENCE   2  (bases 1 to 3798)
  AUTHORS   Mertz,J., Tan,H., Pagala,V., Bai,B., Chen,P.C., Li,Y., Cho,J.H.,
            Shaw,T., Wang,X. and Peng,J.
  TITLE     Sequential Elution Interactome Analysis of the Mind Bomb 1
            Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth
  JOURNAL   Mol Cell Proteomics 14 (7), 1898-1910 (2015)
   PUBMED   25931508
  REMARK    GeneRIF: Mib1 analysis provides a comprehensive interactome for
            investigating its role in signaling networks and neuronal
            development.
REFERENCE   3  (bases 1 to 3798)
  AUTHORS   Kwon,D.Y., Dimitriadi,M., Terzic,B., Cable,C., Hart,A.C.,
            Chitnis,A., Fischbeck,K.H. and Burnett,B.G.
  TITLE     The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the
            degradation of survival of motor neuron protein
  JOURNAL   Mol Biol Cell 24 (12), 1863-1871 (2013)
   PUBMED   23615451
REFERENCE   4  (bases 1 to 3798)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 3798)
  AUTHORS   Choe,E.A., Liao,L., Zhou,J.Y., Cheng,D., Duong,D.M., Jin,P.,
            Tsai,L.H. and Peng,J.
  TITLE     Neuronal morphogenesis is regulated by the interplay between
            cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1
  JOURNAL   J Neurosci 27 (35), 9503-9512 (2007)
   PUBMED   17728463
REFERENCE   6  (bases 1 to 3798)
  AUTHORS   Koo,B.K., Lim,H.S., Song,R., Yoon,M.J., Yoon,K.J., Moon,J.S.,
            Kim,Y.W., Kwon,M.C., Yoo,K.W., Kong,M.P., Lee,J., Chitnis,A.B.,
            Kim,C.H. and Kong,Y.Y.
  TITLE     Mind bomb 1 is essential for generating functional Notch ligands to
            activate Notch
  JOURNAL   Development 132 (15), 3459-3470 (2005)
   PUBMED   16000382
REFERENCE   7  (bases 1 to 3798)
  AUTHORS   Itoh,M., Kim,C.H., Palardy,G., Oda,T., Jiang,Y.J., Maust,D.,
            Yeo,S.Y., Lorick,K., Wright,G.J., Ariza-McNaughton,L.,
            Weissman,A.M., Lewis,J., Chandrasekharappa,S.C. and Chitnis,A.B.
  TITLE     Mind bomb is a ubiquitin ligase that is essential for efficient
            activation of Notch signaling by Delta
  JOURNAL   Dev Cell 4 (1), 67-82 (2003)
   PUBMED   12530964
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001107405.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1556627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-909               JAXUCZ010000018.1  2075309-2076217
            910-1081            JAXUCZ010000018.1  2109581-2109752
            1082-1211           JAXUCZ010000018.1  2111654-2111783
            1212-1316           JAXUCZ010000018.1  2117505-2117609
            1317-1383           JAXUCZ010000018.1  2120855-2120921
            1384-1588           JAXUCZ010000018.1  2123340-2123544
            1589-1772           JAXUCZ010000018.1  2127448-2127631
            1773-1917           JAXUCZ010000018.1  2134569-2134713
            1918-2051           JAXUCZ010000018.1  2137482-2137615
            2052-2159           JAXUCZ010000018.1  2143160-2143267
            2160-2357           JAXUCZ010000018.1  2150216-2150413
            2358-2509           JAXUCZ010000018.1  2153051-2153202
            2510-2642           JAXUCZ010000018.1  2170351-2170483
            2643-2729           JAXUCZ010000018.1  2170874-2170960
            2730-2891           JAXUCZ010000018.1  2173169-2173330
            2892-3073           JAXUCZ010000018.1  2177201-2177382
            3074-3266           JAXUCZ010000018.1  2180211-2180403
            3267-3345           JAXUCZ010000018.1  2182151-2182229
            3346-3459           JAXUCZ010000018.1  2186223-2186336
            3460-3560           JAXUCZ010000018.1  2189484-2189584
            3561-3798           JAXUCZ010000018.1  2193238-2193475
FEATURES             Location/Qualifiers
     source          1..3798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..3798
                     /gene="Mib1"
                     /note="MIB E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:307594"
                     /db_xref="RGD:1307195"
     exon            1..909
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     CDS             681..3701
                     /gene="Mib1"
                     /EC_number="2.3.2.27"
                     /note="mindbomb homolog 1; mindbomb E3 ubiquitin protein
                     ligase 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MIB1"
                     /protein_id="NP_001100875.1"
                     /db_xref="GeneID:307594"
                     /db_xref="RGD:1307195"
                     /translation="MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFES
                     PEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAE
                     CTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRG
                     VDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCV
                     QDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMF
                     ETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQ
                     VGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTY
                     NPAAVSKVAPAGSTISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDL
                     LKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGD
                     EGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTP
                     LHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWI
                     VDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIV
                     RLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIM
                     GLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPSLCKALAKCHKEKVS
                     GQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQ
                     VQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCRAVVERRVPFITCC
                     GGKSSEEPSDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKN
                     MIFLCGHGTCQLCGDRMSECPICRKAIERRILLY"
     exon            910..1081
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1211
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1316
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1383
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1588
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1772
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1917
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2051
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2159
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2357
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2509
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2642
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2729
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2891
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3073
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3266
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3345
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3459
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3560
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3798
                     /gene="Mib1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcccaccc tgttgtcgct gaggagcacc tcgcagtccc tcacgaggcg ccgctcgggc
       61 ctggacgcgg cggtacccgg atgtggagcc gctctcgccc ggcggggact cggtggcggg
      121 gcggagcgcg gcggcctgcg cgggggctga gggaagcggg ccctggggcc ccggcgccgg
      181 ccgctcgccg gccgctagcg ccgctgccca tctcggagcc ggctcccggg cgtccaggcc
      241 ggagcgagcg gccgggagcc gctgagggtc ggcggctcgc ctggcctacc gctgcgctcg
      301 ccgccgcgcc cgggcgagcc tcccccggcc ctccgcgctc ccggccgggg gagagcgagg
      361 tttgctggcg gccgtcgctg tagcccggcc ggggagtccg gggcaagcgg caaagccccc
      421 gcccacggcc gctcgccctt ggcctgcaac ccgccgcctg cgagcctcct cgggcgaacc
      481 tccagtcagt gtgggagccg cgacggccac ggcccggcct gggcgaaggg ttcctcgggg
      541 accgcgccgc cgccgccccg gtgaatcggc cccacggccc gcggggctcg ctgccgcccc
      601 cgccgacttc cagagtgcgg cccgggccta gctccctcac ggctcccccg ccggcggcgg
      661 cgcccactgt ccgggcccca atgagtaact cccgcaacaa ccgagtgatg gtggaggggg
      721 tcggcgcccg cgtagtgcgc ggcccggact ggaagtgggg caaacaggac ggcggcgagg
      781 gccatgtagg cactgtgcgg agcttcgaga gcccggagga ggtcgtggtg gtgtgggaca
      841 acggcacggc cgccaactac cgctgctcgg gggcctacga cctgcgcatc ctggacagcg
      901 cgcccaccgg catcaagcat gatggaacta tgtgtgacac ctgccgccaa caaccaatca
      961 ttggcattcg atggaaatgt gcagagtgca ccaattatga tctgtgcact gtttgttatc
     1021 atggagataa acaccactta aggcatcgct tctataggat caccacacca ggaagtgaac
     1081 gggttctgtt agagtctcgt agaaaatcta agaagatcac agccagagga atctttgctg
     1141 gtgccagagt ggtgcgagga gtggactggc agtgggaaga tcaagacgga ggcaatgggc
     1201 gtcgaggaaa ggtaacggaa atccaggact ggagtgcatc cagcccacac agtgcagcat
     1261 atgttctctg ggataacggt gctaagaacc tttacagggt cggctttgag ggcatgtctg
     1321 atctgaaatg tgtccaggat gccaaaggag gttctttcta cagagatcat tgccctgtgt
     1381 taggtgagca gaatggcaac aggaatcctg gtggattgca gattggtgac ctggtaaata
     1441 tagaccttga cctagaaatt gtccagtctt tgcagcacgg tcatggagga tggaccgatg
     1501 gcatgtttga gactttaact acaactggaa ctgtctgtgg cattgatgaa gatcatgaca
     1561 ttgtagtaca gtatccaagt ggcaatagat ggaccttcaa tcctgctgtt ctcactaagg
     1621 caaacattgt ccgaagtggg gatgctgcac agggtgcaga aggaggcacc tcacagtttc
     1681 aagtgggtga tcttgtgcaa gtttgttatg atctggaaag aattaaactt ctccaaagag
     1741 gacatggtga atgggctgaa gcaatgcttc caactttagg taaagtgggc agagtacaac
     1801 agatttattc ggacagtgat ttaaaggtgg aagtctgtgg aacatcgtgg acatataacc
     1861 ctgcagcagt ttccaaagtg gcacctgcag gatcaaccat tagcaatgca tctggtgaaa
     1921 gactctccca gcttctgaag aaattatttg aaacccaaga atctggtgac ctcaatgaag
     1981 agttggttaa ggctgctgcc aatggggatg tggctaaagt ggaagatttg ctaaaaagac
     2041 cagatgtgga tgtgaatggg cagtgcgctg gccacacagc aatgcaagct gctagtcaaa
     2101 atggacacgt tgatattttg aagttacttt tgaagcaaaa tgtagatgtt gaagcagagg
     2161 ataaagatgg agatcgagca gttcaccatg cagcctttgg agatgagggt gctgtcatag
     2221 aagtcctgca ccgaggcagt gctgacctga atgctcgtaa taagcgtaga cagacgcctc
     2281 ttcatattgc tgtcaataaa ggtcatcttc aggttgtgaa gactttgttg gactttggct
     2341 gtcatcctag tctccaggat tctgaaggtg acacccctct ccatgatgcc ataagtaaga
     2401 aacgggatga cattctggcg gttcttctgg aagctggagc agatgtgacc atcacaaaca
     2461 ataatggatt caatgctctg catcatgctg ccctgagagg gaatcccagt gcaatgcgtg
     2521 ttttactctc aaaattacca agaccatgga ttgtggatga gaagaaagat gatggttata
     2581 ctgccttgca cctggctgcc ctgaataatc atgtggaagt ggctgagctg ttggtgcatc
     2641 agggaaatgc aaacttggat atccagaacg tgaaccagca gacggcccta caccttgctg
     2701 ttgaacggca gcacacccag attgtcaggc ttttggttcg tgcaggtgct aagctagaca
     2761 ttcaggataa ggatggagat actcctctgc atgaagcttt gagacatcat actttgtctc
     2821 aactacgtca gctacaagac atgcaagatg tgggcaaggt agatgctgcc tgggaacctt
     2881 caaaaaacac attaataatg ggacttggta ctcagggggc cgagaagaag agtgcagcat
     2941 ctattgcgtg tttcttggca gccaatggtg ccgacctcag cattcgaaat aagaagggtc
     3001 agtcaccact ggatctctgt cctgacccaa gtctctgcaa agctctggca aaatgtcata
     3061 aggaaaaagt cagtggccaa gtgggttctc ggagtccttc tatgattagc aatgattctg
     3121 aaaccttaga ggagtgtatg gtgtgctcag acatgaagag agacactctt tttggtccat
     3181 gtggacacat tgcgacgtgt tctttgtgtt ctcctcgtgt caagaaatgc ctcatttgta
     3241 aagaacaggt tcagtccagg acgaagattg aagaatgtgt ggtgtgttct gacaagaaag
     3301 cagccgttct ctttcaacct tgtgggcaca tgtgtgcttg tgagaactgt gctagcctga
     3361 tgaaaaagtg tgtgcagtgc cgggcagtgg ttgagcggag ggtgcctttc atcacatgct
     3421 gcggtggcaa gagctcggaa gagccctctg atgatatctc gagtgggaat atcccagtgc
     3481 tgcagaagga caaagacaac acaaatgtca atgcagacgt gcagaagctg cagcagcagc
     3541 ttcaggacat taaggagcag acaatgtgcc ctgtgtgctt ggatcgcctg aagaacatga
     3601 ttttcctctg tggccacgga acatgccagc tctgtggaga ccgaatgagt gaatgcccga
     3661 tttgtcgcaa ggcaatagaa cgaaggattc ttttgtactg attaagaaac acagagtgtc
     3721 ttgttagcta aagtatgtga tcatgagatc tatctttgta agttctaaag ctagttggga
     3781 gtttaatcta gtgggtta
//
