LOCUS       NM_001398684            6286 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus MIA SH3 domain ER export factor 3 (Mia3),
            transcript variant 1, mRNA.
ACCESSION   NM_001398684 XM_039091492
VERSION     NM_001398684.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6286)
  AUTHORS   Maeda,M., Katada,T. and Saito,K.
  TITLE     TANGO1 recruits Sec16 to coordinately organize ER exit sites for
            efficient secretion
  JOURNAL   J Cell Biol 216 (6), 1731-1743 (2017)
   PUBMED   28442536
REFERENCE   2  (bases 1 to 6286)
  AUTHORS   Luo,C., Wang,F., Ren,X., Ke,T., Xu,C., Tang,B., Qin,S., Yao,Y.,
            Chen,Q. and Wang,Q.K.
  TITLE     Identification of a molecular signaling gene-gene regulatory
            network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for
            coronary artery disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (6), 1640-1653 (2017)
   PUBMED   28341552
REFERENCE   3  (bases 1 to 6286)
  AUTHORS   Santos,A.J., Nogueira,C., Ortega-Bellido,M. and Malhotra,V.
  TITLE     TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky
            pre-chylomicrons/VLDLs from the endoplasmic reticulum
  JOURNAL   J Cell Biol 213 (3), 343-354 (2016)
   PUBMED   27138255
REFERENCE   4  (bases 1 to 6286)
  AUTHORS   Saito,K., Yamashiro,K., Shimazu,N., Tanabe,T., Kontani,K. and
            Katada,T.
  TITLE     Concentration of Sec12 at ER exit sites via interaction with cTAGE5
            is required for collagen export
  JOURNAL   J Cell Biol 206 (6), 751-762 (2014)
   PUBMED   25202031
REFERENCE   5  (bases 1 to 6286)
  AUTHORS   Saito,K., Yamashiro,K., Ichikawa,Y., Erlmann,P., Kontani,K.,
            Malhotra,V. and Katada,T.
  TITLE     cTAGE5 mediates collagen secretion through interaction with TANGO1
            at endoplasmic reticulum exit sites
  JOURNAL   Mol Biol Cell 22 (13), 2301-2308 (2011)
   PUBMED   21525241
REFERENCE   6  (bases 1 to 6286)
  AUTHORS   Wilson,D.G., Phamluong,K., Li,L., Sun,M., Cao,T.C., Liu,P.S.,
            Modrusan,Z., Sandoval,W.N., Rangell,L., Carano,R.A., Peterson,A.S.
            and Solloway,M.J.
  TITLE     Global defects in collagen secretion in a Mia3/TANGO1 knockout
            mouse
  JOURNAL   J Cell Biol 193 (5), 935-951 (2011)
   PUBMED   21606205
  REMARK    Erratum:[J Cell Biol. 2011 Jul 25;194(2):347]
REFERENCE   7  (bases 1 to 6286)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 6286)
  AUTHORS   Saito,K., Chen,M., Bard,F., Chen,S., Zhou,H., Woodley,D.,
            Polischuk,R., Schekman,R. and Malhotra,V.
  TITLE     TANGO1 facilitates cargo loading at endoplasmic reticulum exit
            sites
  JOURNAL   Cell 136 (5), 891-902 (2009)
   PUBMED   19269366
REFERENCE   9  (bases 1 to 6286)
  AUTHORS   Arndt,S., Melle,C., Mondal,K., Klein,G., von Eggeling,F. and
            Bosserhoff,A.K.
  TITLE     Interactions of TANGO and leukocyte integrin CD11c/CD18 regulate
            the migration of human monocytes
  JOURNAL   J Leukoc Biol 82 (6), 1466-1472 (2007)
   PUBMED   17726152
REFERENCE   10 (bases 1 to 6286)
  AUTHORS   Arndt,S. and Bosserhoff,A.K.
  TITLE     TANGO is a tumor suppressor of malignant melanoma
  JOURNAL   Int J Cancer 119 (12), 2812-2820 (2006)
   PUBMED   17044017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Dec 21, 2021 this sequence version replaced XM_039091492.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.42421.1,
                                           SRR26643295.47803.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000013.1  97543431-97543587   c
            158-291             JAXUCZ010000013.1  97539758-97539891   c
            292-378             JAXUCZ010000013.1  97535922-97536008   c
            379-3154            JAXUCZ010000013.1  97530423-97533198   c
            3155-3412           JAXUCZ010000013.1  97528006-97528263   c
            3413-3555           JAXUCZ010000013.1  97525099-97525241   c
            3556-3687           JAXUCZ010000013.1  97518442-97518573   c
            3688-3709           JAXUCZ010000013.1  97514749-97514770   c
            3710-3798           JAXUCZ010000013.1  97513960-97514048   c
            3799-3876           JAXUCZ010000013.1  97513655-97513732   c
            3877-3987           JAXUCZ010000013.1  97513455-97513565   c
            3988-4059           JAXUCZ010000013.1  97511835-97511906   c
            4060-4164           JAXUCZ010000013.1  97511534-97511638   c
            4165-4287           JAXUCZ010000013.1  97510812-97510934   c
            4288-4399           JAXUCZ010000013.1  97510566-97510677   c
            4400-4455           JAXUCZ010000013.1  97509721-97509776   c
            4456-4546           JAXUCZ010000013.1  97509543-97509633   c
            4547-4685           JAXUCZ010000013.1  97509259-97509397   c
            4686-4787           JAXUCZ010000013.1  97508205-97508306   c
            4788-4848           JAXUCZ010000013.1  97507347-97507407   c
            4849-4884           JAXUCZ010000013.1  97507126-97507161   c
            4885-4952           JAXUCZ010000013.1  97506973-97507040   c
            4953-5053           JAXUCZ010000013.1  97506609-97506709   c
            5054-5191           JAXUCZ010000013.1  97506315-97506452   c
            5192-5260           JAXUCZ010000013.1  97505462-97505530   c
            5261-5334           JAXUCZ010000013.1  97505284-97505357   c
            5335-5473           JAXUCZ010000013.1  97503663-97503801   c
            5474-6286           JAXUCZ010000013.1  97502040-97502852   c
FEATURES             Location/Qualifiers
     source          1..6286
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..6286
                     /gene="Mia3"
                     /note="MIA SH3 domain ER export factor 3"
                     /db_xref="GeneID:683007"
                     /db_xref="RGD:1591600"
     exon            1..157
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..5787
                     /gene="Mia3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; melanoma inhibitory activity family, member 3;
                     melanoma inhibitory activity protein 3; MIA family member
                     3, ER export factor; transport and Golgi organization
                     protein 1 homolog"
                     /codon_start=1
                     /product="transport and Golgi organization protein 1
                     homolog isoform 1 precursor"
                     /protein_id="NP_001385613.1"
                     /db_xref="GeneID:683007"
                     /db_xref="RGD:1591600"
                     /translation="MAAAPGLLFWLFLLGALWWVPGQPDLSPGRRFSDLKVCGDAECS
                     MLMYRGKALEDFTGPDCRFVNFKKGDDVYVYYKLAGGSPEVWAGSVRQSFGYFPKDLI
                     KVLHKYTEEELRVPADETDFVCFEGGRDDFNSYNIEELLGFLELEDSVPEKLEKAAEV
                     SQHREKSPEGSREHELDLASEPEVVRVDSEDGEGAFSESTEELQGQPSAQESHPHPDT
                     AAANAQGVQSSLDTFEDKLKVPGTENRTGNSSPASVEQEKTDAYQVLRTEMSIDLKTK
                     FGSTADALVSDDEATRLVTSLEDGFDEELDAEYYLMDDEEEHTDSSDELPLLTFVDND
                     EKAPGEPTMEKYLTDKDPNLNEEDKVEPSLAPGIRNDNKDVLTTWGDTFFSIVTGGEG
                     KSGVVDLERSLQEEDLLASSSHQRKPRPTPGYPARDDEGGDLLVEEPKTSDVKDSETD
                     PELVNTGEGKDVQESRGGLAHPESEDAKSETASAYRPQNSKLNPLPAAAKGKDFTLKA
                     VFEKKENGLKEPVIHISKETVHEDKTREMKGDGLESELVHRAARSSEVENNKHQPLGV
                     APLVGNNKPDASKDSTEVPDTSVSGSKAGQQEGFREPGLKTQNQPRFSPPEETGLSRE
                     LGGKVPISGRNLSRQQERDVAAVVSKHADEKTGFPEEEGREDLTDAEPPKVTQRTQEA
                     ESPEVLSVQPVKPEVEEEEEEEEEEEEDHDPHEVLLEDENAVSAQQSRENHPSTHGRR
                     PDMNSQVFEKVILGTLNLNTEKNKHPANVILDTGKKSETTSEEAGDMGKESGSVVVDR
                     EESHVADVRAQGPSQVHSLPDKKAAQTPGSKEAVLRENPSDLQKDNPEGPRNTLGLED
                     PGGEEISGGELEDTKKLGDSESQGPDAEDLGDDPSQRATPEIPDIVLKSIREDMPIIN
                     SFFKDDQQSLYRFLKYFDVRELEGLLQDMSIKLRSAHRDSLPYNVEKVLDKVFRASES
                     LILSVAEKMLDTPVSKIRDLDAKENSPLEEAEVLDDIQDLIYFVRYQYSGVETAPLAT
                     PPPPEEGWAGPGEEMQPAQQDRLPQENTGDISVQVSEDRNLLDQPVTSVQLPEEPDLL
                     DQPVTSVQLPEDTDVLNQPMTEYPSASEISQKPSTEKEIDLGFVPEGGPVGADDIEKQ
                     QERTAERPADAPPLESTSGSLYSFILYLSKMLVATLPDSVQPGPDFYGLPWQPVVVTA
                     VLGVVSFAIFSWRTILVVKSRIYQVTEKQISEKLENIKKENAELMQKLSSYEQKIKES
                     KKYVQETKKQNLILSDEAIKYKDKIKVLEETNVSLGDKAKSLRLQLESEREQNVKNQD
                     LILENKKSIEKLKDVISMNASELSEVQVALNEAKLSEENVKSECHRVQEENARLKKKK
                     EQLQQQIEEWSRSHAELTEQIRSFETSQKDLEVALTHKDDNISALTNCITQLNRLECE
                     LESEDADKGGNESDELANGEMGGDRSKKIKDRIKQMMDVSRTQTAVSIVEEDLKLLQL
                     KLRASMSTKCNLEDQIKKLEDDRSSLQTAKAGLEDECKTLRQKVEILNELYQQKEMAL
                     QKKLSQEEYERQDREQKLTAADEKVVLAAEEVKTYKRRIEEMEEELQKTERSFKNQIA
                     AHEKKAHDNWLKARAAERAMAEEKREAANLRHKLLEMTQKMAMRQDEPVIVKPMPGRP
                     NTQNPPRRGLLSQNGSFGPSPVSGGECSPPLPVESPGRPLSATLSRRDTPRSEFGSLD
                     RHLPRPRWPSEASGKHSASDPGPPPVVNSSSRSSSPAKAMDEGKVNMAPKGPPPFPGV
                     PLMGGPVPPPIRYGPPPQLCGPFGPRPLPPPFVPGMRPPLGVREYAPGVLPGKRDLPV
                     DPREFVPGHTPFRPPGSLGPREFFIPGTRLPPPSHGPQDYPPPPPALRDSLPSGPREE
                     AQPASPSSVQDRSQASKPTP"
     exon            158..291
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            292..378
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..3154
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3412
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3555
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3687
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3709
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3798
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..3876
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..3987
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3988..4059
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4164
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4165..4287
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4399
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4400..4455
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4546
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4547..4685
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4686..4787
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4788..4848
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4849..4884
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4885..4952
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            4953..5053
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            5054..5191
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5260
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            5261..5334
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            5335..5473
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
     exon            5474..6286
                     /gene="Mia3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accggcgccc gcggtggcca caacatggct gcggcgccgg ggctgctatt ctggctgttc
       61 ctgctcgggg cgctctggtg ggtcccgggc cagccggacc tcagccccgg acggcgtttc
      121 tcggacctca aagtgtgcgg ggacgcagag tgcagcatgt taatgtaccg tggtaaagct
      181 cttgaagact tcacgggccc agattgtcgt tttgtgaatt ttaagaaagg tgacgatgta
      241 tatgtctact acaaactggc agggggatcc cctgaagttt gggctggaag tgtcagacag
      301 agttttggat attttccaaa agatctgatc aaagtccttc ataaatacac agaggaagag
      361 ctgcgcgtcc cggcagacga gacagatttt gtctgctttg aaggaggaag agacgatttt
      421 aacagttata atatagaaga gcttttagga tttttggaac tggaggactc tgtacctgaa
      481 aagttggaga aagctgcaga agtttctcag cacagagaga aatctcctga agggtctcgg
      541 gagcatgaac ttgaccttgc atctgagccc gaggtggtca gagttgattc agaggatgga
      601 gaaggtgctt tctcagagag cactgaggaa ctgcagggac agccctcagc tcaggagagc
      661 cacccccatc ccgacactgc agcggctaat gctcagggag tgcagtcttc attggacact
      721 tttgaagata aattaaaagt gccaggaact gaaaacagaa ctggcaatag ttcccctgcc
      781 tcagtggagc aggagaagac agatgcttac caagtcctga gaacagaaat gagtattgac
      841 ctgaaaacca agtttggctc aactgctgat gcccttgtgt ctgatgatga ggcaaccaga
      901 ctggtcactt cattggagga cggcttcgat gaagaactgg acgctgagta ttatctaatg
      961 gatgatgaag aggagcacac agacagctct gacgagctac cattactcac ttttgtggac
     1021 aacgatgaga aagcccctgg cgagcccaca atggagaaat atttaacaga taaagatccg
     1081 aacttgaatg aggaggataa agttgaaccc tctctggctc ctggcatcag aaatgacaat
     1141 aaagatgtat tgaccacctg gggggatact ttcttttcca ttgtcacagg aggtgaagga
     1201 aaatcaggtg tggtggattt agagagatct ctccaggagg aggacctgtt agcttcatct
     1261 agccatcaga ggaagccacg gccaacacct ggctatccag cccgtgatga cgaaggtggt
     1321 gatcttcttg tagaagagcc caaaacaagt gatgtaaagg actcagaaac agacccagaa
     1381 cttgtcaata caggagaagg aaaggacgta caggaatcca ggggaggcct ggcacatcct
     1441 gagtcagagg atgccaaatc agaaacggcg agtgcttatc gtcctcagaa tagcaagctc
     1501 aaccctttgc cagctgctgc aaagggcaaa gactttacac tgaaagctgt ctttgaaaaa
     1561 aaagaaaatg gcctaaagga accagttatc catatctcca aggaaacagt ccatgaagac
     1621 aagaccagag agatgaaggg agacggcttg gagagtgaat tagtacacag agctgccagg
     1681 agttcagagg tggaaaataa caagcaccaa cccttgggtg ttgcaccact cgtggggaat
     1741 aataagcctg atgcatccaa agacagtaca gaggtcccag acacttctgt cagtggatca
     1801 aaagcaggcc aacaggaggg atttcgagaa ccaggtctta aaactcagaa tcaacctaga
     1861 ttctcccctc cagaggaaac tggtctctca agagaactgg gggggaaagt tcctatttcg
     1921 ggaagaaatc tttctcggca gcaagagcga gacgtagctg ctgtagtcag taagcatgca
     1981 gatgagaaga caggatttcc agaggaggag ggcagggaag acctaacaga tgcagagcca
     2041 cccaaggtca cacaaaggac gcaggaggct gagagcccgg aagttctgag tgtccaacct
     2101 gttaagccag aagtggagga ggaggaggag gaggaggagg aggaggagga ggaccacgat
     2161 ccccatgagg tactgctgga ggatgaaaat gctgtgagtg cacagcagtc tagagaaaat
     2221 caccccagca ctcacggcag aaggccagat atgaattctc aagtttttga aaaagtaatt
     2281 ttggggaccc ttaatcttaa cactgaaaaa aacaaacacc cagctaatgt gattttggat
     2341 acgggaaaaa agagtgaaac cacatctgaa gaggcaggtg atatgggcaa ggagtcaggt
     2401 agtgtggtgg tggacagaga agaaagccat gtggcagatg tgagagccca ggggccctct
     2461 caggtccaca gccttccaga caagaaagca gctcagactc caggctccaa ggaagctgtt
     2521 ctgagggaaa atcctagtga tttacaaaaa gacaacccgg aggggccacg caataccttg
     2581 ggacttgaag accctggggg agaagaaatc tcaggagggg aactggaaga taccaagaag
     2641 cttggagact cagaaagtca ggggcctgat gctgaagacc ttggggatga cccgtcccag
     2701 cgagctacac ccgaaattcc tgacatagtg ctcaagagta taagggaaga catgcctatc
     2761 ataaacagtt tcttcaagga cgaccaacag tccctgtatc gtttcctgaa gtacttcgat
     2821 gttcgtgagc tggagggctt gctccaagac atgtcaataa agctgagatc agcacatcgg
     2881 gacagcctgc cttacaacgt ggagaaagtc ctagataaag tcttccgtgc ctccgagtca
     2941 ctaattctga gtgtggcgga gaaaatgctt gatacaccag tgtccaaaat tagggacctg
     3001 gacgcaaaag agaacagtcc gttggaagaa gctgaggtgt tggatgacat acaagacctg
     3061 atctattttg tcaggtatca atactctgga gtggagactg ccccattagc cacacctcca
     3121 cctccggagg aaggctgggc tggaccagga gaagagatgc agccagccca gcaagacaga
     3181 ttaccacaag aaaacacagg agacatcagt gtgcaggttt cggaggaccg taatctctta
     3241 gatcaaccag tgaccagcgt gcagcttcca gaggagcccg atctcttgga tcaacctgtg
     3301 accagcgtgc agctgccaga ggacaccgat gtcttgaatc aacccatgac tgagtaccca
     3361 agtgcctccg agatatcaca gaagccaagt accgagaaag aaatagatct aggttttgta
     3421 cccgaaggtg gtcctgtcgg ggctgatgat atagaaaagc aacaagagag aactgcagag
     3481 cggccagcag atgccccgcc tctggaaagt acatctggtt ccctgtactc cttcatcctc
     3541 tacttaagta agatgctagt tgccacgctg cctgacagtg ttcagcccgg gcctgacttc
     3601 tatggactac cgtggcagcc tgtggtcgtc actgcagttc tgggagttgt ttcctttgcg
     3661 attttctcct ggagaactat tcttgttgta aagagtagaa tatatcaagt tactgagaaa
     3721 caaatttctg aaaagttgga gaacatcaag aaagaaaatg cagaacttat gcaaaaattg
     3781 tcaagttatg agcaaaagat caaggagtca aagaaatatg ttcaagaaac caagaaacaa
     3841 aatctgattc tctctgatga agctattaag tacaaggata aaatcaaggt acttgaagaa
     3901 actaatgtaa gtttgggtga caaagccaaa agccttcgtc ttcagttaga gtctgagaga
     3961 gagcagaacg tcaagaacca ggacttgata ctggaaaaca agaagtccat tgagaagttg
     4021 aaggatgtca tttcgatgaa tgcgtcagaa ctttcagagg ttcaagttgc ccttaatgaa
     4081 gccaagctca gtgaagagaa tgtaaagtct gaatgccatc gggttcaaga agaaaatgcc
     4141 aggcttaaga agaagaaaga gcagttgcag cagcagattg aagagtggag cagatcacat
     4201 gctgagctca ctgaacagat caggtcgttt gagacgtccc agaaagactt ggaagtggct
     4261 cttactcaca aggacgacaa catcagtgct ctgactaatt gcatcacaca gttgaatcgg
     4321 ttagaatgtg aacttgaatc tgaggatgca gataaaggag gaaatgagtc agatgagctg
     4381 gccaatggag aaatgggagg tgaccggagc aagaagataa aagacagaat aaagcagatg
     4441 atggacgtct ctcggacaca aactgcagtc tcgatagttg aagaggatct aaaactttta
     4501 caacttaagc taagagcatc gatgtccact aaatgtaacc tggaagacca aatcaagaaa
     4561 ttggaagatg accgcagctc gctgcagact gctaaagctg ggttggaaga cgagtgcaaa
     4621 actctgaggc agaaagtgga gatcctgaat gagctctacc agcagaagga gatggcactg
     4681 cagaagaaac tgagtcaaga agagtatgaa cggcaagaca gagagcagaa actaacggca
     4741 gccgatgaaa aggtggttct ggctgcagag gaagtgaaaa cttacaagcg gcgaattgaa
     4801 gaaatggaag aagaattaca gaaaacagag cgctcattca aaaaccagat tgctgcccat
     4861 gagaagaaag ctcatgataa ctggcttaaa gctcgcgctg cagagagagc catggcagag
     4921 gagaagagag aagctgctaa cttacggcac aaattactgg aaatgactca aaagatggcg
     4981 atgagacaag atgaacctgt gatcgtaaaa ccaatgccag gaagaccaaa cacacagaac
     5041 cctcctcggc gaggtctgct gagccagaat ggctcttttg gcccatcccc tgtgagtggt
     5101 ggagaatgtt cccctcccct accagtagag tcacctggga gacctctctc tgccacactc
     5161 agtcgaagag acactcctag aagtgaattt gggtcactgg acaggcattt acctcgtcct
     5221 cgatggccat cagaggcctc tgggaaacac tctgcttctg acccaggtcc acctcctgtg
     5281 gtgaatagca gctccaggag ctcttctccc gctaaggcca tggatgaggg caaggttaac
     5341 atggctccca aagggccgcc tccatttcca ggggtgcctc tcatgggagg cccagtgcca
     5401 ccacctatac gatatggacc acctcctcag ctatgtgggc cttttgggcc tcgcccactt
     5461 cctccaccat ttgttccagg catgcgtcca ccactaggtg taagagaata tgcaccaggt
     5521 gttctgcctg ggaaacggga cctgcctgtt gaccctcggg aatttgtacc aggacataca
     5581 ccatttagac ctccaggttc acttggtcca agagagttct ttattcctgg tacccgatta
     5641 ccacctccgt cccacggtcc tcaggattat ccaccaccac cacctgcttt aagagactca
     5701 ctgccttcag gcccaagaga ggaagcccaa cctgcctctc caagcagtgt ccaggaccgc
     5761 tcacaggctt caaaacccac cccctaactt tgacctgttg ctgagtcaga gaggaagtgg
     5821 acattactca ttacagcaaa gggtttcatt ggcatcaaaa cctaaaagtt tgttttacaa
     5881 agattgtttt tagtactaag ctgccttggc agtttgcatt tttgagccaa acaaaaatat
     5941 attattttcc cttctaagta aagatcacct cttaagctag aacatcctcc caactttgaa
     6001 atgtgcaata aagaatacct gtgtttagtt catgtagcat atgtaatgat tgctaaatga
     6061 tttagaaata tcataaagta tgaacatttc ctgtggaaat gctttaagaa cacgtatttc
     6121 catggccttg gtttagtgta tgccagctga ttcagagcaa ggtgtttaca gctccacgtg
     6181 tgtctcaaag actgttacgc tacaagacgt ttactcaagg atcacaaact gtcccctgtt
     6241 gctaaagttc tttgtagtaa tagttcataa acttggttta ttaata
//
