LOCUS       NM_030852                588 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus MIA SH3 domain containing (Mia), mRNA.
ACCESSION   NM_030852 XM_001077720
VERSION     NM_030852.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 588)
  AUTHORS   Kerachian,M.A., Cournoyer,D., Harvey,E.J., Chow,T.Y., Begin,L.R.,
            Nahal,A. and Seguin,C.
  TITLE     New insights into the pathogenesis of glucocorticoid-induced
            avascular necrosis: microarray analysis of gene expression in a rat
            model
  JOURNAL   Arthritis Res Ther 12 (3), R124 (2010)
   PUBMED   20579363
REFERENCE   2  (bases 1 to 588)
  AUTHORS   Imamura,T., Imamura,C., Iwamoto,Y. and Sandell,L.J.
  TITLE     Transcriptional Co-activators CREB-binding protein/p300 increase
            chondrocyte Cd-rap gene expression by multiple mechanisms including
            sequestration of the repressor CCAAT/enhancer-binding protein
  JOURNAL   J Biol Chem 280 (17), 16625-16634 (2005)
   PUBMED   15722556
  REMARK    GeneRIF: CREB-binding protein/p300 increase chondrocyte Cd-rap gene
            expression by multiple mechanisms including sequestration of the
            repressor CCAAT/enhancer-binding protein
REFERENCE   3  (bases 1 to 588)
  AUTHORS   Boeda,B., El-Amraoui,A., Bahloul,A., Goodyear,R., Daviet,L.,
            Blanchard,S., Perfettini,I., Fath,K.R., Shorte,S., Reiners,J.,
            Houdusse,A., Legrain,P., Wolfrum,U., Richardson,G. and Petit,C.
  TITLE     Myosin VIIa, harmonin and cadherin 23, three Usher I gene products
            that cooperate to shape the sensory hair cell bundle
  JOURNAL   EMBO J 21 (24), 6689-6699 (2002)
   PUBMED   12485990
REFERENCE   4  (bases 1 to 588)
  AUTHORS   Moser,M., Bosserhoff,A.K., Hunziker,E.B., Sandell,L., Fassler,R.
            and Buettner,R.
  TITLE     Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient
            mice
  JOURNAL   Mol Cell Biol 22 (5), 1438-1445 (2002)
   PUBMED   11839810
REFERENCE   5  (bases 1 to 588)
  AUTHORS   Lu,J., Pei,H., Kaeck,M. and Thompson,H.J.
  TITLE     Gene expression changes associated with chemically induced rat
            mammary carcinogenesis
  JOURNAL   Mol Carcinog 20 (2), 204-215 (1997)
   PUBMED   9364210
REFERENCE   6  (bases 1 to 588)
  AUTHORS   Dietz,U.H. and Sandell,L.J.
  TITLE     Cloning of a retinoic acid-sensitive mRNA expressed in cartilage
            and during chondrogenesis
  JOURNAL   J Biol Chem 271 (6), 3311-3316 (1996)
   PUBMED   8621736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U67884.1 and CA509768.1.
            
            On Aug 4, 2012 this sequence version replaced NM_030852.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U67884.1, CB796570.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132308, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-545               U67884.1           1-545
            546-588             CA509768.1         1-43                c
FEATURES             Location/Qualifiers
     source          1..588
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..588
                     /gene="Mia"
                     /gene_synonym="Cdrap; Mia1"
                     /note="MIA SH3 domain containing"
                     /db_xref="GeneID:81510"
                     /db_xref="RGD:620883"
     exon            1..136
                     /gene="Mia"
                     /gene_synonym="Cdrap; Mia1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..405
                     /gene="Mia"
                     /gene_synonym="Cdrap; Mia1"
                     /note="melanoma-derived growth regulatory protein; CD-RAP;
                     cartilage-derived retinoic acid-sensitive protein;
                     melanoma inhibitory activity protein; melanoma inhibitory
                     activity/condrocyte-derived retinoic acid sensitive
                     protein homolog (MIA/CD-RAP); melanoma inhibitory activity
                     1; melanoma-derived growth regulatory protein-like"
                     /codon_start=1
                     /product="melanoma-derived growth regulatory protein
                     precursor"
                     /protein_id="NP_110479.1"
                     /db_xref="GeneID:81510"
                     /db_xref="RGD:620883"
                     /translation="MVCSPVLLGIVILSVFSGLSRADRAMPKLADRKLCADEECSHPI
                     SMAVALQDYVAPDCRFLTIYRGQVVYVFSKLKGRGRLFWGGSVQGDYYGDLAAHLGYF
                     PSSIVREDLTLKPGKVDMKTDEWDFYCQ"
     exon            137..270
                     /gene="Mia"
                     /gene_synonym="Cdrap; Mia1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..381
                     /gene="Mia"
                     /gene_synonym="Cdrap; Mia1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..571
                     /gene="Mia"
                     /gene_synonym="Cdrap; Mia1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgaagtcca tgatggtgtg ctccccagtg ctccttggta ttgtcatctt gtctgttttt
       61 tcaggcctca gcagggctga tcgagccatg cccaagctgg ctgaccggaa gctgtgtgca
      121 gatgaggagt gtagccatcc tatctccatg gctgtggccc ttcaggacta cgtggcccct
      181 gattgccgct tcttgactat atacaggggc caagtggtat atgtcttctc caagttgaaa
      241 ggccgtggac ggcttttctg gggaggcagt gtgcagggag attactatgg agacctggca
      301 gcccacctgg gctatttccc cagtagcatt gtccgggagg acctgactct gaaacctggc
      361 aaagtcgata tgaagacaga tgaatgggat ttctactgtc aatgagctca acccaccgat
      421 gttatccctg cagttaccct tccggtttgg gcaaatacag cggccaactg caaagtgttt
      481 tgtccctttg gtttttgggg tgggcatgta caaagaatgt ttcacgggtt cctgaaccta
      541 gccaattaaa gccctgaatg ttgtaacgtc aaaaaaaaaa aaaaaaaa
//
