LOCUS       NM_001106430             707 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus microsomal glutathione S-transferase 2 (Mgst2),
            mRNA.
ACCESSION   NM_001106430 XM_001054384 XM_001054438 XM_215562
VERSION     NM_001106430.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 707)
  AUTHORS   Ahmad S, Thulasingam M, Palombo I, Daley DO, Johnson KA,
            Morgenstern R, Haeggstrom JZ and Rinaldo-Matthis A.
  TITLE     Trimeric microsomal glutathione transferase 2 displays one third of
            the sites reactivity
  JOURNAL   Biochim Biophys Acta 1854 (10 Pt A), 1365-1371 (2015)
   PUBMED   26066610
REFERENCE   2  (bases 1 to 707)
  AUTHORS   Ahmad S, Niegowski D, Wetterholm A, Haeggstrom JZ, Morgenstern R
            and Rinaldo-Matthis A.
  TITLE     Catalytic characterization of human microsomal glutathione
            S-transferase 2: identification of rate-limiting steps
  JOURNAL   Biochemistry 52 (10), 1755-1764 (2013)
   PUBMED   23409838
REFERENCE   3  (bases 1 to 707)
  AUTHORS   Ma KF, Yang HY, Chen Z, Qi LY, Zhu DY and Lou YJ.
  TITLE     Enhanced expressions and activations of leukotriene C4 synthesis
            enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant
            hepatic failure model
  JOURNAL   World J Gastroenterol 14 (17), 2748-2756 (2008)
   PUBMED   18461660
  REMARK    GeneRIF: Liver mGST2 was up-regulated in rat model of fulminant
            hepatic failure.
REFERENCE   4  (bases 1 to 707)
  AUTHORS   Yang SL, Chen LJ, Kong Y, Xu D and Lou YJ.
  TITLE     Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis
            enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB
            signaling pathway
  JOURNAL   Pharmacology 80 (1), 11-20 (2007)
   PUBMED   17496435
REFERENCE   5  (bases 1 to 707)
  AUTHORS   Schroder O, Sjostrom M, Qiu H, Stein J, Jakobsson PJ and Haeggstrom
            JZ.
  TITLE     Molecular and catalytic properties of three rat leukotriene C(4)
            synthase homologs
  JOURNAL   Biochem Biophys Res Commun 312 (2), 271-276 (2003)
   PUBMED   14637132
REFERENCE   6  (bases 1 to 707)
  AUTHORS   Townsend DM and Tew KD.
  TITLE     The role of glutathione-S-transferase in anti-cancer drug
            resistance
  JOURNAL   Oncogene 22 (47), 7369-7375 (2003)
   PUBMED   14576844
  REMARK    Review article
REFERENCE   7  (bases 1 to 707)
  AUTHORS   Jakobsson PJ, Mancini JA, Riendeau D and Ford-Hutchinson AW.
  TITLE     Identification and characterization of a novel microsomal enzyme
            with glutathione-dependent transferase and peroxidase activities
  JOURNAL   J Biol Chem 272 (36), 22934-22939 (1997)
   PUBMED   9278457
REFERENCE   8  (bases 1 to 707)
  AUTHORS   Scoggan KA, Jakobsson PJ and Ford-Hutchinson AW.
  TITLE     Production of leukotriene C4 in different human tissues is
            attributable to distinct membrane bound biosynthetic enzymes
  JOURNAL   J Biol Chem 272 (15), 10182-10187 (1997)
   PUBMED   9092565
REFERENCE   9  (bases 1 to 707)
  AUTHORS   Jakobsson PJ, Mancini JA and Ford-Hutchinson AW.
  TITLE     Identification and characterization of a novel human microsomal
            glutathione S-transferase with leukotriene C4 synthase activity and
            significant sequence identity to 5-lipoxygenase-activating protein
            and leukotriene C4 synthase
  JOURNAL   J Biol Chem 271 (36), 22203-22210 (1996)
   PUBMED   8703034
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474003.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215562.3, XM_001054384.1, XM_001054438.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG664314.1, FM106588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132296, SAMD00132299
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..707
                     /gene="Mgst2"
                     /note="microsomal glutathione S-transferase 2"
                     /db_xref="GeneID:295037"
                     /db_xref="RGD:1311218"
     exon            1..224
                     /gene="Mgst2"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..610
                     /gene="Mgst2"
                     /EC_number="2.5.1.18"
                     /codon_start=1
                     /product="microsomal glutathione S-transferase 2"
                     /protein_id="NP_001099900.1"
                     /db_xref="GeneID:295037"
                     /db_xref="RGD:1311218"
                     /translation="MAGDSSLLAAVSLLSACQQSYFALQVGRVRLKYKIAPPAVTGSL
                     EFERIFRAQQNSLEFYSVFIISLWMAGWYFNQVFATCLGLLYIYARHKYFWGYAEAAE
                     KRIIGFRLSLGILALLTVLAVLGVASRFLDEYLDFHVAKKLKRPF"
     exon            225..324
                     /gene="Mgst2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..395
                     /gene="Mgst2"
                     /inference="alignment:Splign:2.1.0"
     exon            396..477
                     /gene="Mgst2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..707
                     /gene="Mgst2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgaatcct gctttttttt ttttttttcc tttcccaact ctgttgactc aactctgttg
       61 cctttataag ggagaagatc agcccatcag ggtcctaaag agccttcgtt cttcagctgg
      121 cttcctacat acagttctgt gaaagagatc agagagtgaa agaaagatgg cgggggattc
      181 aagcctgctg gctgcagtct cccttctctc tgcctgtcag caaagttatt ttgctttgca
      241 agtcggacga gtaagattaa aatacaagat cgcacctcca gcagtcacgg gctctctgga
      301 gtttgagaga atatttcgcg cacagcaaaa ctctttggag ttttattccg tattcatcat
      361 atcgctgtgg atggctggat ggtatttcaa tcaagttttt gcaacctgtc tgggtctcct
      421 gtacatatac gcccgtcaca agtatttctg gggctatgca gaagccgctg aaaaaaggat
      481 cattggtttc cggctgagcc tgggcatttt ggccttgctg actgtcctcg ctgtcctggg
      541 ggtagcaagc agattcctgg acgaatacct ggactttcat gttgccaaga aactgaagcg
      601 gcccttctaa gtttttcttc cctttcatgc ttgtagaggc ctcggcacca ctctgaaaac
      661 aatatgatgt catgtgtgaa ataaaaactt ttatttgtct tgctgtg
//
