LOCUS       NM_134349               1081 bp    mRNA    linear   ROD 20-AUG-2024
DEFINITION  Rattus norvegicus microsomal glutathione S-transferase 1 (Mgst1),
            mRNA.
ACCESSION   NM_134349
VERSION     NM_134349.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1081)
  AUTHORS   Kuang,Q., Purhonen,P., Alander,J., Svensson,R., Hoogland,V.,
            Winerdal,J., Spahiu,L., Ottosson-Wadlund,A., Jegerschold,C.,
            Morgenstern,R. and Hebert,H.
  TITLE     Dead-end complex, lipid interactions and catalytic mechanism of
            microsomal glutathione transferase 1, an electron crystallography
            and mutagenesis investigation
  JOURNAL   Sci Rep 7 (1), 7897 (2017)
   PUBMED   28801553
  REMARK    GeneRIF: The functional unit is a homotrimer centered on the
            crystallographic three-fold axes of the unit cell. The GSH
            substrate binds in an extended conformation at the interface
            between two subunits of the trimer supported by new in vitro
            mutagenesis data.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1081)
  AUTHORS   Shimoji,M., Figueroa,R.A., Neve,E., Maksel,D., Imreh,G.,
            Morgenstern,R. and Hallberg,E.
  TITLE     Molecular basis for the dual subcellular distribution of microsomal
            glutathione transferase 1
  JOURNAL   Biochim Biophys Acta Biomembr 1859 (2), 238-244 (2017)
   PUBMED   27913278
REFERENCE   3  (bases 1 to 1081)
  AUTHORS   Sobczak,M., Boczek,T., Kowalski,A., Wiktorska,M., Niewiarowska,J.
            and Zylinska,L.
  TITLE     Downregulation of microsomal glutathione-S-transferase 1 modulates
            protective mechanisms in differentiated PC12 cells
  JOURNAL   J Physiol Biochem 70 (2), 375-383 (2014)
   PUBMED   24419913
  REMARK    GeneRIF: Since Mgst1expression was reported to decline with age,
            our results could represent a putative adaptive process during
            aging. It could also be an early mechanism protecting neuronal
            cells against some neurodegenerative insults
REFERENCE   4  (bases 1 to 1081)
  AUTHORS   Johansson,K., Ito,M., Schophuizen,C.M., Mathew Thengumtharayil,S.,
            Heuser,V.D., Zhang,J., Shimoji,M., Vahter,M., Ang,W.H., Dyson,P.J.,
            Shibata,A., Shuto,S., Ito,Y., Abe,H. and Morgenstern,R.
  TITLE     Characterization of new potential anticancer drugs designed to
            overcome glutathione transferase mediated resistance
  JOURNAL   Mol Pharm 8 (5), 1698-1708 (2011)
   PUBMED   21851097
  REMARK    GeneRIF: Two doxorubicin derivatives/prodrugs (DNS-DOX; MNS-DOX)
            are substrates for MGST1; neoplasm drug resistance can be overcome
            in cell lines over-expressing recombinant MGST1.
REFERENCE   5  (bases 1 to 1081)
  AUTHORS   Li,N., Muthusamy,S., Liang,R., Sarojini,H. and Wang,E.
  TITLE     Increased expression of miR-34a and miR-93 in rat liver during
            aging, and their impact on the expression of Mgst1 and Sirt1
  JOURNAL   Mech Ageing Dev 132 (3), 75-85 (2011)
   PUBMED   21216258
  REMARK    GeneRIF: Increased expression of miR-34a and miR-93 in rat liver
            during aging, and their impact on the expression of Mgst1 and
            Sirt1.
REFERENCE   6  (bases 1 to 1081)
  AUTHORS   Nishino,H. and Ito,A.
  TITLE     Purification and properties of glutathione S-transferase from outer
            mitochondrial membrane of rat liver
  JOURNAL   Biochem Int 20 (6), 1059-1066 (1990)
   PUBMED   2369411
REFERENCE   7  (bases 1 to 1081)
  AUTHORS   DeJong,J.L., Morgenstern,R., Jornvall,H., DePierre,J.W. and Tu,C.P.
  TITLE     Gene expression of rat and human microsomal glutathione
            S-transferases
  JOURNAL   J Biol Chem 263 (17), 8430-8436 (1988)
   PUBMED   3372534
REFERENCE   8  (bases 1 to 1081)
  AUTHORS   Morgenstern,R., DePierre,J.W. and Jornvall,H.
  TITLE     Microsomal glutathione transferase. Primary structure
  JOURNAL   J Biol Chem 260 (26), 13976-13983 (1985)
   PUBMED   3932348
REFERENCE   9  (bases 1 to 1081)
  AUTHORS   Morgenstern,R., Lundqvist,G., Andersson,G., Balk,L. and
            DePierre,J.W.
  TITLE     The distribution of microsomal glutathione transferase among
            different organelles, different organs, and different organisms
  JOURNAL   Biochem Pharmacol 33 (22), 3609-3614 (1984)
   PUBMED   6439207
REFERENCE   10 (bases 1 to 1081)
  AUTHORS   Morgenstern,R., Guthenberg,C. and Depierre,J.W.
  TITLE     Microsomal glutathione S-transferase. Purification, initial
            characterization and demonstration that it is not identical to the
            cytosolic glutathione S-transferases A, B and C
  JOURNAL   Eur J Biochem 128 (1), 243-248 (1982)
   PUBMED   7173206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB711033.1, BC063150.1 and BP494884.1.
            
            On Apr 28, 2007 this sequence version replaced NM_134349.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063150.1, CF110942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               CB711033.1         17-257
            242-304             BC063150.1         240-302
            305-325             BP494884.1         304-324
            326-1081            BC063150.1         324-1079
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..1081
                     /gene="Mgst1"
                     /note="microsomal glutathione S-transferase 1"
                     /db_xref="GeneID:171341"
                     /db_xref="RGD:70927"
     exon            1..40
                     /gene="Mgst1"
                     /inference="alignment:Splign:2.1.0"
     exon            41..197
                     /gene="Mgst1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..539
                     /gene="Mgst1"
                     /EC_number="2.5.1.18"
                     /note="microsomal GST-1; microsomal GST-I"
                     /codon_start=1
                     /product="microsomal glutathione S-transferase 1"
                     /protein_id="NP_599176.1"
                     /db_xref="GeneID:171341"
                     /db_xref="RGD:70927"
                     /translation="MADLKQLMDNEVLMAFTSYATIILAKMMFLSSATAFQRLTNKVF
                     ANPEDCAGFGKGENAKKFLRTDEKVERVRRAHLNDLENIVPFLGIGLLYSLSGPDLST
                     ALIHFRIFVGARIYHTIAYLTPLPQPNRGLAFFVGYGVTLSMAYRLLRSRLYL"
     exon            198..292
                     /gene="Mgst1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..901
                     /gene="Mgst1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgcagga cagctagcag cgcttcctcc tgggattcag tcatttaaag attgagacca
       61 agattgaaag catggctgac ctcaagcagc tcatggacaa cgaggtgttg atggccttta
      121 cctcctatgc aacgatcatt cttgccaaga tgatgttcct gagctccgcg actgcattcc
      181 agaggctaac caacaaggtt tttgccaacc cggaagactg tgctggcttc ggcaaggggg
      241 agaatgccaa gaagttcctt cggactgacg agaaggtgga acgcgtgcga agagcccacc
      301 tgaacgacct tgaaaacatc gttccctttc tcggtatcgg cctcctgtac tccctgagcg
      361 gaccggatct ctctacagcc ctcattcact tcagaatctt tgtgggcgct cggatctacc
      421 acaccattgc ttacttgact ccccttcctc agccaaacag gggcttggca ttttttgttg
      481 gctacggagt tactttgtca atggcttaca ggctgctcag gagcagactg tacttgtaaa
      541 gagatttgtg accgtcaccc tctgattgat ttaaaaaaat aaaggattct atatttctag
      601 tgtattaaaa aactttctaa ggttttatgt atgaaaggag cagagaaatc aggaatcagg
      661 gaaaattctg tttgaagact accatccaca ggctctaccc ttttgtacct gggttagaca
      721 tttaacatga ccggccttag ctatgctgtc taactcctaa agtactttgt cctaagtctt
      781 gagtgcctta taaattgtaa cattccttct acatttcctg tggtgcatct ataaaagagt
      841 gctcacacct gtgtgaagcc tgggtttcat tggcacctga attaaaaaca ttacaaatga
      901 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      961 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1021 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1081 a
//
