LOCUS       NM_001013964            2287 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus mahogunin ring finger 1 (Mgrn1), mRNA.
ACCESSION   NM_001013964 XM_220160
VERSION     NM_001013964.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Pusapati,G.V., Kong,J.H., Patel,B.B., Krishnan,A., Sagner,A.,
            Kinnebrew,M., Briscoe,J., Aravind,L. and Rohatgi,R.
  TITLE     CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity
            to the Morphogen Sonic Hedgehog
  JOURNAL   Dev Cell 44 (1), 113-129 (2018)
   PUBMED   29290584
  REMARK    Erratum:[Dev Cell. 2018 Jan 22;44(2):271. doi:
            10.1016/j.devcel.2018.01.002.. PMID: 29401421]
REFERENCE   2  (bases 1 to 2287)
  AUTHORS   Benvegnu,S., Mateo,M.I., Palomer,E., Jurado-Arjona,J. and
            Dotti,C.G.
  TITLE     Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of
            the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal
            Survival
  JOURNAL   Mol Cell 66 (3), 358-372 (2017)
   PUBMED   28475871
  REMARK    GeneRIF: With aging, the neuroprotective e3 ligase MGRN1 relocates
            from the cytosol to the nucleus of neurons, where it associates
            with chromatin and potentiates the cellular response to proteotoxic
            stress. This nuclear shift is due to a proteasome impairment
            dependent increase of a monoubiquitinated form of MGRN1.
REFERENCE   3  (bases 1 to 2287)
  AUTHORS   Guerra,D.D., Pratelli,R., Kraft,E., Callis,J. and Pilot,G.
  TITLE     Functional conservation between mammalian MGRN1 and plant LOG2
            ubiquitin ligases
  JOURNAL   FEBS Lett 587 (21), 3400-3405 (2013)
   PUBMED   24036454
REFERENCE   4  (bases 1 to 2287)
  AUTHORS   Cooray,S.N. and Clark,A.J.
  TITLE     Melanocortin receptors and their accessory proteins
  JOURNAL   Mol Cell Endocrinol 331 (2), 215-221 (2011)
   PUBMED   20654690
  REMARK    Review article
REFERENCE   5  (bases 1 to 2287)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2287)
  AUTHORS   Perez-Oliva,A.B., Olivares,C., Jimenez-Cervantes,C. and
            Garcia-Borron,J.C.
  TITLE     Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits
            signaling from melanocortin receptor by competition with Galphas
  JOURNAL   J Biol Chem 284 (46), 31714-31725 (2009)
   PUBMED   19737927
REFERENCE   7  (bases 1 to 2287)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 2287)
  AUTHORS   Kim,B.Y., Olzmann,J.A., Barsh,G.S., Chin,L.S. and Li,L.
  TITLE     Spongiform neurodegeneration-associated E3 ligase Mahogunin
            ubiquitylates TSG101 and regulates endosomal trafficking
  JOURNAL   Mol Biol Cell 18 (4), 1129-1142 (2007)
   PUBMED   17229889
REFERENCE   9  (bases 1 to 2287)
  AUTHORS   Phan,L.K., Chung,W.K. and Leibel,R.L.
  TITLE     The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in
            mice with mutations in the melanocortin signaling pathway
            independently of effects on adiposity
  JOURNAL   Am J Physiol Endocrinol Metab 291 (3), E611-E620 (2006)
   PUBMED   16638826
REFERENCE   10 (bases 1 to 2287)
  AUTHORS   He,L., Lu,X.Y., Jolly,A.F., Eldridge,A.G., Watson,S.J.,
            Jackson,P.K., Barsh,G.S. and Gunn,T.M.
  TITLE     Spongiform degeneration in mahoganoid mutant mice
  JOURNAL   Science 299 (5607), 710-712 (2003)
   PUBMED   12560552
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083621.1.
            
            On Apr 20, 2005 this sequence version replaced XM_220160.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083621.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2287
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /note="mahogunin ring finger 1"
                     /db_xref="GeneID:302938"
                     /db_xref="RGD:1311862"
     exon            1..221
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1735
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /EC_number="2.3.2.27"
                     /note="probable E3 ubiquitin-protein ligase MGRN1;
                     mahogunin RING finger protein 1; mahoganoid; mahogunin
                     ring finger 1, E3 ubiquitin protein ligase; RING-type E3
                     ubiquitin transferase MGRN1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MGRN1"
                     /protein_id="NP_001013986.1"
                     /db_xref="GeneID:302938"
                     /db_xref="RGD:1311862"
                     /translation="MGSILSRRIAGVEDIDIQANSAYRYPPKSAGNYFASHFFMGGEK
                     FDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYK
                     DDTDSPTEDGEKPRVLYSLEFTFDADARVAITIYCQAVEEFVNGMTVYSCKNPSLQSE
                     TVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHA
                     HVLLAAFEKHVDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNS
                     SECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKP
                     GALSPISFSPVLAQSVDHDEHSNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEE
                     ITYSGISDGLSQASCPLAGLDRIIENGIQKGKTQSKSPDSTLRSPSSPIHEEDEEKLS
                     EDPEAPLPPSGVELVLQESSSPESFGTEEVGEPSLKQGSRVPSIDDVLQDGSPQHHGC
                     SQPVPPADIYLPALGPESCSVGIEE"
     exon            222..343
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            344..432
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            433..579
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            580..697
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            698..764
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            765..814
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            815..862
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            863..931
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1091
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1201
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1428
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1552
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1595
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1694
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1739
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..2262
                     /gene="Mgrn1"
                     /gene_synonym="RGD1311862"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggcggcg gcggcggcgg cggcggcggc ggcggtgggt acgcgtcggt gcggcctggt
       61 ctgagccatg tccgtgtgag gacgccgcag ccgtcacccc ctcctctccg gctggtccgc
      121 agaaacccgc accatgggct ccatcctgag tcgccgcatc gcgggcgtgg aggacatcga
      181 cattcaggcc aactcggcct atcgttaccc tccgaagtcc gcaggaaact actttgcttc
      241 gcactttttc atgggaggag agaagtttga cactccccat cctgaaggtt acctctttgg
      301 cgagaacatg gacctgaact tcctgggtag tcgtccagtc cagttcccct atgtcacccc
      361 tgccccccat gagccagtga agacactcag gagcctggta aacattcgca aagactctct
      421 ccggctggtg aggtacaaag atgacacaga cagccccaca gaggacggcg agaagccccg
      481 cgtgctctac agtctggaat tcacctttga tgctgatgcc cgtgtggcta tcaccattta
      541 ttgccaggca gtggaggagt ttgtcaacgg catgacggtg tacagctgta agaacccttc
      601 tctgcaatct gagactgtcc attacaagag aggcgttagc cagcagttct ccctgccttc
      661 tttcaagatt gacttctccg agtggaagga tgatgagctg aactttgacc tggaccgggg
      721 tgtgtttcca gtagtcatcc aggctgtggt ggatgaagga gatgttgtgg aagtgactgg
      781 ccacgctcat gtgctcttgg ctgcctttga gaagcacgtg gatggcagct tctccgtgaa
      841 gccattaaag cagaagcaaa ttgtggaccg ggtcagctac ctgctgcaag agatctacgg
      901 cattgagaac aagaacaacc aggagactaa gccttccgac gatgagaaca gtgacaacag
      961 cagtgagtgt gtggtgtgcc tgtcagactt gcgggacacg ctaatcctgc cctgccgcca
     1021 cttgtgcctc tgcacttcct gtgctgacac gctgcggtac caggccaaca actgccccat
     1081 ctgccggctg ccattccgag ctctcctaca gatccgggct gtacggaaga agccaggagc
     1141 tctgtctccc atctccttca gtcctgtctt ggcccaaagt gtggaccacg atgaacactc
     1201 taattctgac agtgtcccac ctggctatga gcccatctcc ttgctcgagg cactcaatgg
     1261 actacgggct gtctccccgg ctatcccatc agctcccctc tatgaggaaa tcacctactc
     1321 aggcatctcg gacggtcttt cccaggccag ttgtcccctt gctggactcg atcgaatcat
     1381 agaaaatgga atacagaagg gcaagacaca gagcaagtct ccagacagca ccctgcggtc
     1441 tccatcatct cccattcatg aggaggatga ggagaagctc tcagaggacc cggaggctcc
     1501 tctcccacca agcggtgtgg agctcgtgct tcaggagagc agctcccctg agagtttcgg
     1561 aacagaggag gtgggtgagc catccctaaa gcaaggaagc cgagtaccct ctattgatga
     1621 tgtcctgcag gatggcagtc cccagcatca tggttgcagc cagccagtcc ctcctgctga
     1681 catctaccta ccagccctgg gtcctgagtc gtgctctgtt ggtatagagg agtaagctgg
     1741 atggtccacc tccatggaga cacacagcct tgccaccacc agctccccct ggcctttgct
     1801 gagtggctct agtcccgaac ctggagcttc tgagctgacc cctctctgag agtatggctc
     1861 agtgggcagc acagagccct cagcatccca aacattgcca ggagactccc tggaccccag
     1921 cgagaccctg gcctctcctg tctgcacgcc tcatgtggcc actgggattt gaggggccac
     1981 agggaacctt gatccaattg cacagtgggt tgttcctccc cacaccctcc ttttttatgg
     2041 tcaatagatt tgtaaatggt acaagatgaa ggacagcagc tgtccccatg ggccacgagc
     2101 cctagaggga ctctccccaa ctgtcaaagc tgatgctttg agcacttagc aaaccagcat
     2161 aagagaatct acccatggac tgaagtgtca tcctcacaaa cactctggaa ggtgggccgc
     2221 ctaggttacg gttatgaagg aaacaatgcc tgtctcatgt gaaaaaaaaa aaaaaaaaaa
     2281 aaaaaaa
//
