LOCUS       NM_012862                524 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus matrix Gla protein (Mgp), mRNA.
ACCESSION   NM_012862
VERSION     NM_012862.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Fu,M.H., Wang,C.Y., Hsieh,Y.T., Fang,K.M. and Tzeng,S.F.
  TITLE     Functional Role of Matrix gla Protein in Glioma Cell Migration
  JOURNAL   Mol Neurobiol 55 (6), 4624-4636 (2018)
   PUBMED   28707070
  REMARK    GeneRIF: high proliferative glioma cells expressing a high level of
            MGP may exist and contribute to tumor infiltration and recurrence.
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   3  (bases 1 to 524)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 524)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   5  (bases 1 to 524)
  AUTHORS   Lu,X., Gao,B., Yasui,T., Li,Y., Liu,T., Mao,X., Hirose,M., Wu,Y.,
            Yu,D., Zhu,Q., Kohri,K. and Xiao,C.
  TITLE     Matrix Gla protein is involved in crystal formation in kidney of
            hyperoxaluric rats
  JOURNAL   Kidney Blood Press Res 37 (1), 15-23 (2013)
   PUBMED   23445897
  REMARK    GeneRIF: Contiuous expression of Matrix Gla protein contributes to
            crystal formation in kidney of hyperoxaluric animals.
REFERENCE   6  (bases 1 to 524)
  AUTHORS   Shanahan,C.M., Cary,N.R., Metcalfe,J.C. and Weissberg,P.L.
  TITLE     High expression of genes for calcification-regulating proteins in
            human atherosclerotic plaques
  JOURNAL   J Clin Invest 93 (6), 2393-2402 (1994)
   PUBMED   8200973
REFERENCE   7  (bases 1 to 524)
  AUTHORS   Price,P.A., Rice,J.S. and Williamson,M.K.
  TITLE     Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P)
            sequences of the vitamin K-dependent matrix Gla protein from shark,
            lamb, rat, cow, and human
  JOURNAL   Protein Sci 3 (5), 822-830 (1994)
   PUBMED   8061611
REFERENCE   8  (bases 1 to 524)
  AUTHORS   Levedakou,E.N., Strohmeyer,T.G., Effert,P.J. and Liu,E.T.
  TITLE     Expression of the matrix Gla protein in urogenital malignancies
  JOURNAL   Int J Cancer 52 (4), 534-537 (1992)
   PUBMED   1399132
REFERENCE   9  (bases 1 to 524)
  AUTHORS   Barone,L.M., Owen,T.A., Tassinari,M.S., Bortell,R., Stein,G.S. and
            Lian,J.B.
  TITLE     Developmental expression and hormonal regulation of the rat matrix
            Gla protein (MGP) gene in chondrogenesis and osteogenesis
  JOURNAL   J Cell Biochem 46 (4), 351-365 (1991)
   PUBMED   1757478
REFERENCE   10 (bases 1 to 524)
  AUTHORS   Price,P.A., Fraser,J.D. and Metz-Virca,G.
  TITLE     Molecular cloning of matrix Gla protein: implications for substrate
            recognition by the vitamin K-dependent gamma-carboxylase
  JOURNAL   Proc Natl Acad Sci U S A 84 (23), 8335-8339 (1987)
   PUBMED   3317405
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012862.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03026.1, CB323340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000004.1  171500730-171500804 c
            76-108              JAXUCZ010000004.1  171499288-171499320 c
            109-184             JAXUCZ010000004.1  171498228-171498303 c
            185-524             JAXUCZ010000004.1  171497482-171497821 c
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..524
                     /gene="Mgp"
                     /gene_synonym="Mglap"
                     /note="matrix Gla protein"
                     /db_xref="GeneID:25333"
                     /db_xref="RGD:3088"
     exon            1..75
                     /gene="Mgp"
                     /gene_synonym="Mglap"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..326
                     /gene="Mgp"
                     /gene_synonym="Mglap"
                     /codon_start=1
                     /product="matrix Gla protein precursor"
                     /protein_id="NP_036994.2"
                     /db_xref="GeneID:25333"
                     /db_xref="RGD:3088"
                     /translation="MKSLLPLAILAALAVAALCYESHESMESYEVSPFTNRRNANTFI
                     SPQQRWHAKAQERVRELNKPAQEINREACDDYKLCERYALIYGYNAAYNRYFRQRRGA
                     K"
     exon            76..108
                     /gene="Mgp"
                     /gene_synonym="Mglap"
                     /inference="alignment:Splign:2.1.0"
     exon            109..184
                     /gene="Mgp"
                     /gene_synonym="Mglap"
                     /inference="alignment:Splign:2.1.0"
     exon            185..524
                     /gene="Mgp"
                     /gene_synonym="Mglap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacccgaga catcatgaag agcctgctcc ctctggccat cctggctgcg ctggccgtgg
       61 cagccctgtg ctatgaatct cacgaaagca tggaatccta tgaagtcagt cccttcacca
      121 accggagaaa tgccaacacc tttatatccc ctcagcagag atggcacgct aaagcccagg
      181 aaagagtccg ggaactcaac aagcctgccc aggagatcaa cagggaggcc tgtgatgact
      241 acaagctgtg tgagcgctac gccctgatct acgggtacaa cgccgcctac aaccgctact
      301 tcaggcagcg ccgaggagcc aaataagagc gcaaggaaac agtcgctttg ttacggagtc
      361 tggtttcata ttcccctgca gtagcattac cgatacacag attcgtgtgc gttgcttgtt
      421 cctcacatga tcttctgtct ggctgggcca ctccttcctt ccgcgggttg aaagtaatga
      481 aagagcagta ttaagaaatg tgtttatata taataaaatt ctgg
//
