LOCUS       NM_001009655            2065 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mitochondrial genome maintenance exonuclease 1
            (Mgme1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001009655 XM_230638
VERSION     NM_001009655.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Kornblum,C., Nicholls,T.J., Haack,T.B., Scholer,S., Peeva,V.,
            Danhauser,K., Hallmann,K., Zsurka,G., Rorbach,J., Iuso,A.,
            Wieland,T., Sciacco,M., Ronchi,D., Comi,G.P., Moggio,M.,
            Quinzii,C.M., DiMauro,S., Calvo,S.E., Mootha,V.K., Klopstock,T.,
            Strom,T.M., Meitinger,T., Minczuk,M., Kunz,W.S. and Prokisch,H.
  TITLE     Loss-of-function mutations in MGME1 impair mtDNA replication and
            cause multisystemic mitochondrial disease
  JOURNAL   Nat Genet 45 (2), 214-219 (2013)
   PUBMED   23313956
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087676.1.
            
            [WARNING] On Jul 18, 2024 this sequence was replaced by
            NM_001009655.2.
            
            On Jan 13, 2005 this sequence version replaced XM_230638.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087676.1, SRR8487231.109748.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2065
                     /gene="Mgme1"
                     /gene_synonym="RGD1307465"
                     /note="mitochondrial genome maintenance exonuclease 1"
                     /db_xref="GeneID:296200"
                     /db_xref="RGD:1307465"
     exon            1..68
                     /gene="Mgme1"
                     /gene_synonym="RGD1307465"
                     /inference="alignment:Splign:2.1.0"
     exon            69..636
                     /gene="Mgme1"
                     /gene_synonym="RGD1307465"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1148
                     /gene="Mgme1"
                     /gene_synonym="RGD1307465"
                     /codon_start=1
                     /product="mitochondrial genome maintenance exonuclease 1"
                     /protein_id="NP_001009655.1"
                     /db_xref="GeneID:296200"
                     /db_xref="RGD:1307465"
                     /translation="MKPLLPICRLLRLLNRFPVKPSPPVSFSTSSYLCSQKKKSSYEA
                     VDQAKYCRLVRSVLSRGPVQTPESLFKEDDVLYGPVSKCKVPEQEQQARVPQHWFPIF
                     NEEKNGKPHTNGSSSPLKIPLQRNMIPSVTRILQHTMPSEQSFFLERWKQRMVLELGE
                     DGFAEYTSNVFLQGKQFHEALESILSPQENLKGGEEHPQCGYIKSVQHILKEIGSVQA
                     LESAVQHEALQYVGLLDCVAEYQGKLCVIDWKTSEKPKPFIQNTYDNPLQVVAYMGAV
                     NHDANYSFQVQCGLIVVAYKDGSPAHPHFMDEELCSKYWAKWLLRLEEYTEKQKNQSI
                     PKPE"
     exon            637..853
                     /gene="Mgme1"
                     /gene_synonym="RGD1307465"
                     /inference="alignment:Splign:2.1.0"
     exon            854..986
                     /gene="Mgme1"
                     /gene_synonym="RGD1307465"
                     /inference="alignment:Splign:2.1.0"
     exon            987..2045
                     /gene="Mgme1"
                     /gene_synonym="RGD1307465"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgagacgt gaacgccgcg gtgcatgctg gggccgcctc gctttgggaa agcgcgggac
       61 tgataaaaat aagaacagca cacttttaaa cagtacagac tagagaaaag taagaggggc
      121 gaagtctaaa aatgaaaccg cttctgccca tctgcaggct gcttagactt ttaaacagat
      181 ttcctgtaaa accaagccct cctgtgagtt tctccacttc ctcttatttg tgtagccaaa
      241 agaaaaaaag ctcttacgaa gcagtagacc aagcaaagta ctgtcgttta gtacgttctg
      301 tcttgtccag aggcccagtc cagactccag agtcattgtt caaggaagat gatgtactct
      361 atggtcctgt gagtaagtgt aaagttccag agcaagagca gcaggcaaga gttccacaac
      421 actggtttcc tatcttcaat gaagagaaaa acgggaaacc acacacaaat ggttcttcaa
      481 gtcctttgaa gatccctttg caaagaaaca tgatacccag tgtgacccgc atccttcagc
      541 ataccatgcc atctgaacag agtttctttt tggagaggtg gaaacagcgg atggttctgg
      601 agctgggaga agatggattt gcagaatata cttcaaatgt gtttttacaa ggcaaacagt
      661 tccatgaagc cttggaaagc atactttcac cccaggagaa cttaaaaggg ggagaggagc
      721 acccccagtg tggctacatc aaaagcgtcc agcatattct gaaagaaatc ggtagtgttc
      781 aagctctgga aagtgctgtc caacatgaag ccttgcagta cgtggggcta ctggactgtg
      841 tggctgagta ccagggcaag ctgtgtgtga tcgattggaa gacatcagaa aaaccaaaac
      901 ctttcattca aaatacatat gacaacccac tacaagttgt ggcatacatg ggtgctgtga
      961 accatgatgc caactacagt tttcaggttc aatgtggatt aattgtggtg gcctataagg
     1021 acgggtcccc tgcccaccct catttcatgg atgaagagct ctgttccaag tattgggcca
     1081 agtggcttct tcgactagaa gaatacacag aaaagcagaa gaaccagagc attccaaagc
     1141 cagagtagag ccaggatgac ttggaaatga tgagcatgcc cctctgtttg ggagatgcac
     1201 tgctgcccac cgagttttta gagaggagca ccaagaatct gaggtttaca ctaacacaag
     1261 ctgaaggtgt agtgagttgg gacgtaccta ctaagaagcc agaaagtctg gaggtcagcc
     1321 cttgactcac cagctgcacg acctctggct gtttcttacc tgagaggagg gcactcagat
     1381 tggcagctgc ccagggactc ctggactccc ttgcagaact ttcgtgtccc tggaaggatg
     1441 cccagtcttt gaactgagat cagaaggcca atgaagcatc atgtgccact agtgttcctg
     1501 ggttctcagg gatgggaggg tcctgcaccc ccagggtgta cagagggaaa gcaagcacat
     1561 cagggatcac cactgcagtt tcctatgtgt tttatatact gggactctgt gtctaagggg
     1621 aaatgtctta aattcattgg tattgttatt tggcctgagg aaagctggct gccaagagag
     1681 ctggggcact caccacatca ctggctgggt ccctttcctt accagagaag ccccagcagt
     1741 aggaagcctg agtgtggaag tcaccaccat taaagtttgg gtatctgttt ctggtgtcag
     1801 caggccatgc actacaaaaa atactgttgt ggaacttttt caccgaggaa cactgatata
     1861 acccattggt tttttctgtg tttgataggt aataaaaacc attggctgtt cttgggtttg
     1921 ggagagggtt ttctattgta taaagtaaat ctagtagcat ttaagttaca gctactgact
     1981 taagattgta agtctacaat cacattcagt tttcattagt tattaaaaat atcaaagctg
     2041 tttaaaaaaa aaaaaaaaaa aaaaa
//
