LOCUS       NM_001398597            4238 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Rattus norvegicus monoglyceride lipase (Mgll), transcript variant
            1, mRNA.
ACCESSION   NM_001398597 XM_008763053
VERSION     NM_001398597.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4238)
  AUTHORS   Fan,C., Du,J., Yu,Z., Wang,J., Yao,L., Ji,Z., He,W., Deng,Y.,
            Geng,D., Wu,X. and Mao,H.
  TITLE     Inhibition of MAGL attenuates Intervertebral Disc Degeneration by
            Delaying nucleus pulposus senescence through STING
  JOURNAL   Int Immunopharmacol 131, 111904 (2024)
   PUBMED   38518595
  REMARK    GeneRIF: Inhibition of MAGL attenuates Intervertebral Disc
            Degeneration by Delaying nucleus pulposus senescence through STING.
REFERENCE   2  (bases 1 to 4238)
  AUTHORS   Yang,N., Sun,H., Xue,Y., Zhang,W., Wang,H., Tao,H., Liang,X.,
            Li,M., Xu,Y., Chen,L., Zhang,L., Huang,L. and Geng,D.
  TITLE     Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate
            glucocorticoid-induced osteonecrosis of the femoral head
  JOURNAL   Clin Transl Med 11 (6), e447 (2021)
   PUBMED   34185425
  REMARK    GeneRIF: Inhibition of MAGL activates the Keap1/Nrf2 pathway to
            attenuate glucocorticoid-induced osteonecrosis of the femoral head.
REFERENCE   3  (bases 1 to 4238)
  AUTHORS   Fontenot,J., Loetz,E.C., Ishiki,M. and Bland,S.T.
  TITLE     Monoacylglycerol lipase inhibition alters social behavior in male
            and female rats after post-weaning social isolation
  JOURNAL   Behav Brain Res 341, 146-153 (2018)
   PUBMED   29292159
  REMARK    GeneRIF: 4 weeks of post-weaning social isolation increased
            aggressive grooming of a novel same-sex conspecific in male and
            female rats. Treatment with the MAGL inhibitor MJN110 eliminated
            this increase in aggressive grooming in both males and females,
            without reducing non-aggressive social behavior. Activation of the
            medial prefrontal cortex was increased by social interaction but
            was blunted by MJN110 only in females.
REFERENCE   4  (bases 1 to 4238)
  AUTHORS   Berdan,C.A., Erion,K.A., Burritt,N.E., Corkey,B.E. and Deeney,J.T.
  TITLE     Inhibition of Monoacylglycerol Lipase Activity Decreases
            Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and
            Rat Islets
  JOURNAL   PLoS One 11 (2), e0149008 (2016)
   PUBMED   26867016
  REMARK    GeneRIF: MGL has an important role in insulin secretion
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4238)
  AUTHORS   Kouchi,Z.
  TITLE     Monoacylglycerol lipase promotes Fcgamma receptor-mediated
            phagocytosis in microglia but does not regulate LPS-induced
            upregulation of inflammatory cytokines
  JOURNAL   Biochem Biophys Res Commun 464 (2), 603-610 (2015)
   PUBMED   26166819
  REMARK    GeneRIF: results suggest that MAGL regulates phagocytosis, but not
            LPS-mediated cytokine induction in microglia
REFERENCE   6  (bases 1 to 4238)
  AUTHORS   Ho,W.S. and Randall,M.D.
  TITLE     Endothelium-dependent metabolism by endocannabinoid hydrolases and
            cyclooxygenases limits vasorelaxation to anandamide and
            2-arachidonoylglycerol
  JOURNAL   Br J Pharmacol 150 (5), 641-651 (2007)
   PUBMED   17245358
REFERENCE   7  (bases 1 to 4238)
  AUTHORS   Hinojos,C.A., Boerwinkle,E., Fornage,M. and Doris,P.A.
  TITLE     Combined genealogical, mapping, and expression approaches to
            identify spontaneously hypertensive rat hypertension candidate
            genes
  JOURNAL   Hypertension 45 (4), 698-704 (2005)
   PUBMED   15710778
REFERENCE   8  (bases 1 to 4238)
  AUTHORS   Gulyas,A.I., Cravatt,B.F., Bracey,M.H., Dinh,T.P., Piomelli,D.,
            Boscia,F. and Freund,T.F.
  TITLE     Segregation of two endocannabinoid-hydrolyzing enzymes into pre-
            and postsynaptic compartments in the rat hippocampus, cerebellum
            and amygdala
  JOURNAL   Eur J Neurosci 20 (2), 441-458 (2004)
   PUBMED   15233753
REFERENCE   9  (bases 1 to 4238)
  AUTHORS   Dinh,T.P., Carpenter,D., Leslie,F.M., Freund,T.F., Katona,I.,
            Sensi,S.L., Kathuria,S. and Piomelli,D.
  TITLE     Brain monoglyceride lipase participating in endocannabinoid
            inactivation
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10819-10824 (2002)
   PUBMED   12136125
  REMARK    GeneRIF: hydrolysis by means of monoglyceride lipase is a primary
            mechanism for 2-arachidonoylglycerol inactivation in intact neurons
            Erratum:[Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13961]
REFERENCE   10 (bases 1 to 4238)
  AUTHORS   Karlsson,M., Contreras,J.A., Hellman,U., Tornqvist,H. and Holm,C.
  TITLE     cDNA cloning, tissue distribution, and identification of the
            catalytic triad of monoglyceride lipase. Evolutionary relationship
            to esterases, lysophospholipases, and haloperoxidases
  JOURNAL   J Biol Chem 272 (43), 27218-27223 (1997)
   PUBMED   9341166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 20, 2021 this sequence version replaced XM_008763053.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227013.1, SRR26643290.16936.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-738               JAXUCZ010000004.1  122749436-122750173
            739-883             JAXUCZ010000004.1  122750653-122750797
            884-990             JAXUCZ010000004.1  122789121-122789227
            991-1127            JAXUCZ010000004.1  122830223-122830359
            1128-1238           JAXUCZ010000004.1  122831077-122831187
            1239-1328           JAXUCZ010000004.1  122840737-122840826
            1329-1544           JAXUCZ010000004.1  122846288-122846503
            1545-4238           JAXUCZ010000004.1  122848747-122851440
FEATURES             Location/Qualifiers
     source          1..4238
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..4238
                     /gene="Mgll"
                     /gene_synonym="MAGL"
                     /note="monoglyceride lipase"
                     /db_xref="GeneID:29254"
                     /db_xref="RGD:71039"
     exon            1..738
                     /gene="Mgll"
                     /gene_synonym="MAGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             711..1670
                     /gene="Mgll"
                     /gene_synonym="MAGL"
                     /EC_number="3.1.1.23"
                     /note="isoform 1 is encoded by transcript variant 1; MGL;
                     monoacylglycerol lipase"
                     /codon_start=1
                     /product="monoglyceride lipase isoform 1"
                     /protein_id="NP_001385526.1"
                     /db_xref="GeneID:29254"
                     /db_xref="RGD:71039"
                     /translation="MQKPRLMETGPKDPCRMPEASSPRRTPQNVPYQDLPHLVNADGQ
                     YLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGE
                     RMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMIL
                     ISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICH
                     AGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKT
                     LKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP"
     exon            739..883
                     /gene="Mgll"
                     /gene_synonym="MAGL"
                     /inference="alignment:Splign:2.1.0"
     exon            884..990
                     /gene="Mgll"
                     /gene_synonym="MAGL"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1127
                     /gene="Mgll"
                     /gene_synonym="MAGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1238
                     /gene="Mgll"
                     /gene_synonym="MAGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1328
                     /gene="Mgll"
                     /gene_synonym="MAGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1544
                     /gene="Mgll"
                     /gene_synonym="MAGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..4238
                     /gene="Mgll"
                     /gene_synonym="MAGL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataaagtggt ggcgcagacg ccgcgcccta tcgctgcgca gccggccgcg cgcagtagtc
       61 tggctctagc ccgcagcaga cccggacccg cgtggtgctc ggggaacgtg acagcggcgc
      121 tcgtggcccg ggtaactgcc tcccgcccct gcctcaggat aggagccgcc gccaggggtc
      181 ccctgcgcgg gtgtgcgtgc gcacgagtgt gcgcgcgtgt cagcgtgtgc gcgggaacgc
      241 gcccctcgcg ccctcgcacc aacccccaaa cagacttgtg cccgtcaact gcatcttccc
      301 agaccggtgt gggaacaacg gccaggtcca cgtcctgtgt ggcgtgctga tgacagccct
      361 gaggcttcct tccccaaacg gtcgcgggcg ggcaggaggc aaagtttgtc ggagaatcgg
      421 ggtgactttg ctcggggacc cgcatctgcg cgaatgcgcg gtgccgcgga gcgcgtctcg
      481 cagcagctct gggctaggga ccggctgtcc ctcgctcctg gaaccccttc aggggtgtgt
      541 tctggaaaag tggcgacatg aactagagct ggagcagcag gagggagcag ctcgcacccc
      601 tgcagcccag gcggggaggg cgcggacccg gtggtgctgc cctgcggccg cgatgaggga
      661 acagccctcg tttgcctggc gctgatactc gaggctgtgg cggtagtgga atgcaaaagc
      721 caagactaat ggaaacaggg cccaaagacc cctgcaggat gcctgaggca agttcaccca
      781 ggcgaactcc acagaacgtc ccctaccagg accttcctca cctggtcaat gcggatggac
      841 agtacctctt ttgtaggtac tggaagccca gtggcacacc caaggccctc atcttcgtgt
      901 cccatggagc tggggaacac tgtggccgtt atgacgagct ggctcagatg ttgaagaggc
      961 tggacatgct ggtgtttgcc catgaccatg ttggccatgg gcagagcgag ggagagagga
     1021 tggtggtatc ggacttccaa gtttttgtca gagatttgtt gcagcacgtg aacaccgtcc
     1081 agaaggacta ccccgaggtc cccgtcttcc tcctgggcca ctccatgggc ggtgccatct
     1141 ccatcctagc agctgcagag agaccaaccc acttttctgg catgatccta atttcacctc
     1201 tgatccttgc caatccggaa tctgcatcga ctttgaaggt ccttgctgcc aaactgctca
     1261 attttgtcct gccaaacata tccttggggc gcatcgactc cagcgtgctg tctcggaaca
     1321 agtcggaggt tgacctgtac aactccgacc cactcatctg ccacgcaggg gtgaaggtat
     1381 gctttggcat ccagctgctg aacgctgtct cgagggtgga gcgagcaatg cccaggctga
     1441 cactgccgtt cctgctgctg cagggttctg ctgaccggct ttgcgacagc aaaggtgcct
     1501 acctgctcat ggaatcatcc ccgagtcagg acaaaacact caagatgtat gaaggtgcct
     1561 accatgttct ccacaaggag cttccggaag tgaccaactc tgtcctccat gaaataaata
     1621 cgtgggtgtc tcacaggata gcagtggcag gagctaggtg tctaccctga atgtgctgtc
     1681 tagggaacca gctcgtggtc taggggagtc aggaagagga agggcagtgc tgactggctc
     1741 aaaaaaaaat cacaaattgg aagaaaccct agtaccctag tgcaatttac tttgggggaa
     1801 aaaggataat ttgttgtata gatggctact ggccactgat caccttaatt ggtaggcact
     1861 ttatgaaaga gggagtatat tttccacaca aagactgtgg ggaaatatct cttgaattta
     1921 aaaaaaaaaa aagcagcatc tgcccacctc tcccagctcc tatggggttc agggactctc
     1981 tggcagtccc gtatcccagc ctgcaataat cagaggtctc tttcctcctg tcccaagtcc
     2041 tctctgactg gctgtccgct ggcatgtgac gagctatccc cagagctagc tccttagcag
     2101 gctcctgtgc ccctccaggg cacttcctca aaatgggcaa ccaccctatg acctggtcag
     2161 tgacttttca gatggaaacc aggctggggg aagggaaggt ggccctgaat agctcttctt
     2221 ccccacgcaa cttccccctc ccaccctgct ggttacccac agcatgttgt atgtatttag
     2281 agaggcacct tttctcaggt cactgagttc tccatgctga ggaaggtggc tttgaagata
     2341 atcgtttaat atatatggta tattctaaat taaagattat atgggtgggt gggtgaaacc
     2401 tgagcagctt tggaagaact ggtgcccaca cacagggcca gtctgccaag gacccaggcc
     2461 ccaattgagg actagctggc tctccttgca gaaaagacac agggtggagg actgtggccc
     2521 tgggcagtcc ctctgtccag agccactagg agttgctttg ccagtagcac agctacctct
     2581 ggtggcagga gactcccatg gagccatggt gctggctgcc tgcccagggc agcatcgagc
     2641 actcaatgtc gaccccgcag acaaggacca cggctgtctg caccccattc cagactgcag
     2701 caggacggcc cagccaggcc tcatagaggc taccctgaag cagtgaagtc tgagcccctg
     2761 tcctctcagg tgcccgccca aaggcctacg ccaggcctca cttagcgcca gcaataactg
     2821 gggctcactg ctcccttgga gcactttcat ctttacagag ggccttgctg ttacctcagg
     2881 atcatgtcac tgcacataga accctgggga ggggctctgc tgccaaggag aactgcctgg
     2941 ctgctggaag gggggggggg ctccaggaag gtgggatcca ggtatcccgg agttggtgga
     3001 atttattcta gatcttggga gggccctctg ccccctctgg tggccctgac catgcatagc
     3061 agtcagaggc tggccactta ctataggtca taaggtcact gtgcccctca gcagggccca
     3121 agcactgcat gtagggaagg aagggtccag gagctgtcca gagcgccatt tagctctcct
     3181 tctgtttagg aaataaagac agagtgtgca aagagaggca gtcagcactc cctcctgctc
     3241 agggaaccct ggacagctgt ggacaggcat ggggtattac tactcttcat taagtttaaa
     3301 aaaaaaaaaa aaagggagcc cattccagac tactgtgctc agatctgtga ctcctaccag
     3361 gagccactca aggcttatcc caaaagcaca tgctgacaat gccacttttc caaaccaaat
     3421 gccagcaccc gggttggcgg ttttcatgca tgacgtcatt tagagatgca tttgtatctg
     3481 gctaaagaat cagtaacact aaaacacagg agtggggtta tctgagattg agactgtctt
     3541 gtgaaacctg taagagtcat gtccctgcat gacaaagtca ggaccagcac agggctagta
     3601 gagggctagt ccagccttgt acaggctccg cccttggcac cggtggacgc ctgacaagct
     3661 tcacggtcac ccccatcacc aagatgcaga ggaactggag tgtggaaaaa tgctgggata
     3721 cacaggcctg gcctgaagaa ggtggaggcc agcaagggac caccgatgtc ctccccgagt
     3781 gaaggagggg aggaaccaga accgagtacc tgaaagaaca gagcaccttc tgcaacaacc
     3841 atggacttag tgcctgatga gcttttgagg aaaaggtgcc acctgcaggc agtggagcgt
     3901 ctcaaccact aagtcccagt tccttagaga tagggggaca gcctccctcc accaaggccc
     3961 cctcagcttc tgggtatcct gtggaccacc atgagagcag tggaggtgct ctgctcacat
     4021 cctgcctctg ggccacctca cacttccctt tctctcctga ttgctaatgt aactttctat
     4081 ggatcacagt ggctcactgg tttgtcactg tcaccgcgcg cccagtcact ccccatgtgt
     4141 actcctagtg gggaacctgt atcagcttag aattactaaa gaaaccgatg tgcactacag
     4201 ctcaccataa taaaccacgt gcttttggag agccccca
//
