LOCUS       NM_023095               2623 bp    mRNA    linear   ROD 23-MAR-2024
DEFINITION  Rattus norvegicus alpha-1,6-mannosylglycoprotein
            6-beta-N-acetylglucosaminyltransferase (Mgat5), mRNA.
ACCESSION   NM_023095 XM_001057269
VERSION     NM_023095.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Xi,X., Yang,Y., Chen,Q., Ma,J., Wang,X., Deng,Y., Wang,X. and Li,Y.
  TITLE     GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic
            retinopathy progression
  JOURNAL   Mol Biol Rep 51 (1), 428 (2024)
   PUBMED   38499842
  REMARK    GeneRIF: GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes
            diabetic retinopathy progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Nagae,M., Kizuka,Y., Mihara,E., Kitago,Y., Hanashima,S., Ito,Y.,
            Takagi,J., Taniguchi,N. and Yamaguchi,Y.
  TITLE     Structure and mechanism of cancer-associated
            N-acetylglucosaminyltransferase-V
  JOURNAL   Nat Commun 9 (1), 3380 (2018)
   PUBMED   30140003
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Qi,J., Li,N., Fan,K., Yin,P., Zhao,C., Li,Z., Lin,Y., Wang,L. and
            Zha,X.
  TITLE     beta1,6 GlcNAc branches-modified PTPRT attenuates its activity and
            promotes cell migration by STAT3 pathway
  JOURNAL   PLoS One 9 (5), e98052 (2014)
   PUBMED   24846175
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Kurimoto,A., Kitazume,S., Kizuka,Y., Nakajima,K., Oka,R.,
            Fujinawa,R., Korekane,H., Yamaguchi,Y., Wada,Y. and Taniguchi,N.
  TITLE     The absence of core fucose up-regulates GnT-III and Wnt target
            genes: a possible mechanism for an adaptive response in terms of
            glycan function
  JOURNAL   J Biol Chem 289 (17), 11704-11714 (2014)
   PUBMED   24619415
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Moreno,C., Williams,J.M., Lu,L., Liang,M., Lazar,J., Jacob,H.J.,
            Cowley,A.W. Jr. and Roman,R.J.
  TITLE     Narrowing a region on rat chromosome 13 that protects against
            hypertension in Dahl SS-13BN congenic strains
  JOURNAL   Am J Physiol Heart Circ Physiol 300 (4), H1530-H1535 (2011)
   PUBMED   21257920
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Akiyama,K., Morita,H., Suetsugu,S., Kuraba,S., Numata,Y.,
            Yamamoto,Y., Inui,K., Ideura,T., Wakisaka,N., Nakano,K., Oniki,H.,
            Takenawa,T., Matsuyama,M. and Yoshimura,A.
  TITLE     Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna
            rats
  JOURNAL   Mamm Genome 19 (1), 41-50 (2008)
   PUBMED   18064521
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Inamori,K., Mita,S., Gu,J., Mizuno-Horikawa,Y., Miyoshi,E.,
            Dennis,J.W. and Taniguchi,N.
  TITLE     Demonstration of the expression and the enzymatic activity of
            N-acetylglucosaminyltransferase IX in the mouse brain
  JOURNAL   Biochim Biophys Acta 1760 (4), 678-684 (2006)
   PUBMED   16413118
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Guo,H.B., Lee,I., Kamar,M. and Pierce,M.
  TITLE     N-acetylglucosaminyltransferase V expression levels regulate
            cadherin-associated homotypic cell-cell adhesion and intracellular
            signaling pathways
  JOURNAL   J Biol Chem 278 (52), 52412-52424 (2003)
   PUBMED   14561752
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Park,C., Jin,U.H., Lee,Y.C., Cho,T.J. and Kim,C.H.
  TITLE     Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside
            beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma
            cell line Hep3B
  JOURNAL   Arch Biochem Biophys 367 (2), 281-288 (1999)
   PUBMED   10395745
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Shoreibah,M., Perng,G.S., Adler,B., Weinstein,J., Basu,R.,
            Cupples,R., Wen,D., Browne,J.K., Buckhaults,P., Fregien,N. and
            Pierce,M.
  TITLE     Isolation, characterization, and expression of a cDNA encoding
            N-acetylglucosaminyltransferase V
  JOURNAL   J Biol Chem 268 (21), 15381-15385 (1993)
   PUBMED   8340368
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L14284.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001057269.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L14284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q12-q13"
     gene            1..2623
                     /gene="Mgat5"
                     /note="alpha-1,6-mannosylglycoprotein
                     6-beta-N-acetylglucosaminyltransferase"
                     /db_xref="GeneID:65271"
                     /db_xref="RGD:620100"
     exon            1..106
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            107..155
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            156..538
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..2520
                     /gene="Mgat5"
                     /EC_number="2.4.1.155"
                     /note="alpha-1,6-mannosyl-glycoprotein
                     6-beta-N-acetylglucosaminyltransferase; GNT-V; glcNAc-T V;
                     N-acetylglucosaminyl-transferase V; mannosyl
                     (alpha-1,6-)-glycoprotein
                     beta-1,6-N-acetyl-glucosaminyltransferase; alpha-mannoside
                     beta-1,6-N-acetylglucosaminyltransferase; mannoside
                     acetylglucosaminyltransferase 5;
                     N-acetylglucosaminyltransferase V;
                     alpha-1,6-mannosylglycoprotein
                     6-beta-N-acetylglucosaminyltransferase A-like"
                     /codon_start=1
                     /product="alpha-1,6-mannosylglycoprotein
                     6-beta-N-acetylglucosaminyltransferase A"
                     /protein_id="NP_075583.1"
                     /db_xref="GeneID:65271"
                     /db_xref="RGD:620100"
                     /translation="MAFFSPWKLSSQKLGFFLVTFGFIWGMMLLHFTIQQRTQPESSS
                     MLREQILDLSKRYIKALAEENRNVVDGPYAGVMTAYDLKKTLAVLLDNILQRIGKLES
                     KVDNLVNGTGANSTNSTTAVPSLVSLEKINVADIINGVQEKCVLPPMDGYPHCEGKIK
                     WMKDMWRSDPCYADYGVDGTSCSFFIYLSEVENWCPRLPWRAKNPYEEADHNSLAEIR
                     TDFNILYGMMKKHEEFRWMRLRIRRMADAWIQAIKSLAEKQNLEKRKRKKILVHLGLL
                     TKESGFKIAETAFSGGPLGELVQWSDLITSLYLLGHDIRISASLAELKEIMKKVVGNR
                     SGCPTVGDRIVELIYIDIVGLAQFKKTLGPSWVHYQCMLRVLDSFGTEPEFNHASYAQ
                     SKGHKTPWGKWNLNPQQFYTMFPHTPDNSFLGFVVEQHLNSSDIHHINEIKRQNQSLV
                     YGKVDSFWKNKKIYLDIIHTYMEVHATVYGSSTKNIPSYVKNHGILSGRDLQFLLRET
                     KLFVGLGFPYEGPAPLEAIANGCAFLNPKFNPPKSSKNTDFFIGKPTLRELTSQHPYA
                     EVFIGRPHVWTVDLNNREEVEDAVKAILNQKIEPYMPYEFTCEGMLQRINAFIEKQDF
                     CHGQVMWPPLSALQVKLAEPGQSCKQVCQESQLICEPSFFQHLNKEKDLLKYKVICQS
                     SELYKDILVPSFYPKSKHCVFQGDLLLFSCAGAHPTHQRICPCRDFIKGQVALCKDCL
                     "
     exon            539..700
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            701..777
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            778..867
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            868..939
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1101
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1271
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1406
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1540
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1674
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1824
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1971
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2088
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2163
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2321
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2623
                     /gene="Mgat5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccccgctc ctggctgtgc ctgggacccc agttcccagg agcacggttg caggagagtg
       61 accccgactg ctactgatgg tgcttctgct gctcctctac tagcaggagt gactcctacc
      121 cagaagtgga cttggaggag ggtccgttag accatcagaa tggaagcccg acaagcaagt
      181 cagctgactc aggaaccaga gtgagggcca cgcactctcc gccccagcct gcaccatgaa
      241 cttgccttcc ccttctgctt gttgagagcc aagggaatgg tacattacta gagagagatg
      301 gctttctttt ctccctggaa gttgtcctct cagaagctgg gctttttctt ggtgactttt
      361 ggcttcatat gggggatgat gcttctacac ttcaccatcc agcagcgaac tcagcctgag
      421 agcagctcca tgttgcggga gcaaatcctt gacctcagca aaaggtacat taaggcactg
      481 gcagaagaga acaggaacgt ggtggatggc ccgtatgccg gtgtcatgac agcctatgat
      541 ctgaagaaaa cgctcgccgt gctgctggat aacatcttgc agcgcatcgg caagctggag
      601 tccaaggtgg acaatcttgt caacggcaca ggagcgaatt ctaccaactc caccacggct
      661 gtccccagct tggtgtcact ggagaaaatt aatgtggcag atatcattaa tggagttcaa
      721 gaaaaatgtg tattgcctcc tatggatggc tacccccact gcgaggggaa aatcaagtgg
      781 atgaaagaca tgtggcggtc agacccctgc tacgcagact atggagtgga cgggacctcc
      841 tgctcctttt ttatttacct cagtgaggtt gaaaattggt gtcctcgttt accttggaga
      901 gcaaaaaatc cctatgaaga agctgaccat aactcattgg cagaaatccg cacggatttt
      961 aacattctct acggcatgat gaagaagcat gaggagttcc ggtggatgag acttcggatc
     1021 cggcgaatgg ctgatgcatg gatccaagca atcaagtctc tggcagagaa acaaaaccta
     1081 gagaagagga aacggaagaa aatccttgtt cacctggggc tcctgaccaa ggaatcaggc
     1141 ttcaagattg cagagacagc attcagcggt ggccctctcg gcgagctcgt tcagtggagt
     1201 gacttaatca catctctgta cctgctgggc catgacatcc gcatctcagc ctcgctggct
     1261 gagctcaagg agattatgaa gaaggttgtt ggaaaccggt ctggctgtcc aactgtagga
     1321 gacagaatcg ttgagcttat ttatatcgat attgtgggac ttgctcaatt caagaaaacg
     1381 ctaggaccat cctgggttca ttaccagtgc atgctccggg tgctggactc ctttggaaca
     1441 gaacctgagt tcaatcacgc aagttacgcc cagtcgaaag gccacaagac cccctgggga
     1501 aagtggaatc tgaacccgca acagttttac accatgttcc ctcatacccc agacaacagc
     1561 tttctgggct tcgtggtcga gcagcacctg aactccagcg acatccacca cattaacgag
     1621 atcaaaaggc agaaccagtc ccttgtgtat ggcaaagtgg atagtttctg gaagaataag
     1681 aagatctact tggacatcat tcacacgtac atggaagtgc acgccactgt ttacggctcc
     1741 agtaccaaga acatccccag ttacgtgaaa aaccatggca ttctcagcgg ccgtgaccta
     1801 cagtttcttc tccgggaaac caagcttttt gttgggcttg gattccctta tgaaggtcca
     1861 gctcccctgg aagccatcgc gaatggatgt gctttcctga accccaagtt caaccctcct
     1921 aaaagcagca aaaacacaga cttcttcatt ggcaagccaa cactgagaga gctcacatcc
     1981 cagcacccgt acgcagaagt cttcatcggc cggccacacg tctggaccgt ggacctcaat
     2041 aaccgagagg aagtagaaga cgcagtaaaa gccatcttaa accagaagat tgagccgtat
     2101 atgccatatg agttcacatg tgaaggcatg ctgcagagaa tcaacgcttt catcgagaaa
     2161 caggacttct gccacggcca agtgatgtgg ccgcccctta gcgccctgca ggtgaagctg
     2221 gctgagcccg ggcagtcctg caaacaggtg tgccaggaga gccagctcat ctgcgagccg
     2281 tccttcttcc agcacctcaa caaggaaaag gacctgctga agtataaggt aatctgccaa
     2341 agctcagaac tatacaagga catcctggtg ccctccttct accccaagag caagcactgt
     2401 gtgttccaag gggatctcct gctcttcagt tgtgccgggg cccaccccac acaccagcgg
     2461 atctgcccct gccgggactt catcaagggc caagtggccc tctgcaaaga ctgcctatag
     2521 catagccacc ctggattcat tcagatggga aagacgtggc tccgctgggc agggccgagg
     2581 ggctgaaaga cagtcaggga ctctgaccag agcctgaaat ctt
//
