LOCUS       NM_019239               2678 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus beta-1,4-mannosyl-glycoprotein
            4-beta-N-acetylglucosaminyltransferase (Mgat3), mRNA.
ACCESSION   NM_019239
VERSION     NM_019239.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2678)
  AUTHORS   Lu,J., Isaji,T., Im,S., Fukuda,T., Kameyama,A. and Gu,J.
  TITLE     Expression of N-Acetylglucosaminyltransferase III Suppresses
            alpha2,3-Sialylation, and Its Distinctive Functions in Cell
            Migration Are Attributed to alpha2,6-Sialylation Levels
  JOURNAL   J Biol Chem 291 (11), 5708-5720 (2016)
   PUBMED   26801611
REFERENCE   2  (bases 1 to 2678)
  AUTHORS   Kizuka,Y., Nakano,M., Kitazume,S., Saito,T., Saido,T.C. and
            Taniguchi,N.
  TITLE     Bisecting GlcNAc modification stabilizes BACE1 protein under
            oxidative stress conditions
  JOURNAL   Biochem J 473 (1), 21-30 (2016)
   PUBMED   26467158
REFERENCE   3  (bases 1 to 2678)
  AUTHORS   Kizuka,Y., Kitazume,S., Fujinawa,R., Saito,T., Iwata,N.,
            Saido,T.C., Nakano,M., Yamaguchi,Y., Hashimoto,Y., Staufenbiel,M.,
            Hatsuta,H., Murayama,S., Manya,H., Endo,T. and Taniguchi,N.
  TITLE     An aberrant sugar modification of BACE1 blocks its lysosomal
            targeting in Alzheimer's disease
  JOURNAL   EMBO Mol Med 7 (2), 175-189 (2015)
   PUBMED   25592972
REFERENCE   4  (bases 1 to 2678)
  AUTHORS   Kurimoto,A., Kitazume,S., Kizuka,Y., Nakajima,K., Oka,R.,
            Fujinawa,R., Korekane,H., Yamaguchi,Y., Wada,Y. and Taniguchi,N.
  TITLE     The absence of core fucose up-regulates GnT-III and Wnt target
            genes: a possible mechanism for an adaptive response in terms of
            glycan function
  JOURNAL   J Biol Chem 289 (17), 11704-11714 (2014)
   PUBMED   24619415
REFERENCE   5  (bases 1 to 2678)
  AUTHORS   Okada,T., Ihara,H., Ito,R., Nakano,M., Matsumoto,K., Yamaguchi,Y.,
            Taniguchi,N. and Ikeda,Y.
  TITLE     N-Glycosylation engineering of lepidopteran insect cells by the
            introduction of the beta1,4-N-acetylglucosaminyltransferase III
            gene
  JOURNAL   Glycobiology 20 (9), 1147-1159 (2010)
   PUBMED   20554946
  REMARK    GeneRIF: GnT-III transfection has the potential to be an effective
            approach in humanizing the N-glycosylation of lepidopteran insect
            cells.
REFERENCE   6  (bases 1 to 2678)
  AUTHORS   Pinho,S.S., Reis,C.A., Paredes,J., Magalhaes,A.M., Ferreira,A.C.,
            Figueiredo,J., Xiaogang,W., Carneiro,F., Gartner,F. and Seruca,R.
  TITLE     The role of N-acetylglucosaminyltransferase III and V in the
            post-transcriptional modifications of E-cadherin
  JOURNAL   Hum Mol Genet 18 (14), 2599-2608 (2009)
   PUBMED   19403558
REFERENCE   7  (bases 1 to 2678)
  AUTHORS   Nishikawa,A., Ihara,Y., Hatakeyama,M., Kangawa,K. and Taniguchi,N.
  TITLE     Purification, cDNA cloning, and expression of
            UDP-N-acetylglucosamine: beta-D-mannoside
            beta-1,4N-acetylglucosaminyltransferase III from rat kidney
  JOURNAL   J Biol Chem 267 (25), 18199-18204 (1992)
   PUBMED   1325461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 17, 2007 this sequence version replaced NM_019239.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10852.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000007.1  113614011-113614060
            51-2678             JAXUCZ010000007.1  113637574-113640201
FEATURES             Location/Qualifiers
     source          1..2678
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2678
                     /gene="Mgat3"
                     /note="beta-1,4-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase"
                     /db_xref="GeneID:29582"
                     /db_xref="RGD:3084"
     exon            1..50
                     /gene="Mgat3"
                     /inference="alignment:Splign:2.1.0"
     exon            51..2678
                     /gene="Mgat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1668
                     /gene="Mgat3"
                     /EC_number="2.4.1.144"
                     /note="GNT-III; glcNAc-T III;
                     N-acetylglucosaminyltransferase III; mannosyl
                     (beta-1,4-)-glycoprotein
                     beta-1,4-N-acetylglucosaminyltransferase;
                     N-glycosyl-oligosaccharide-glycoprotein
                     N-acetylglucosaminyltransferase III; mannoside acetyl
                     glucosaminyltransferase 3"
                     /codon_start=1
                     /product="beta-1,4-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase"
                     /protein_id="NP_062112.2"
                     /db_xref="GeneID:29582"
                     /db_xref="RGD:3084"
                     /translation="MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPN
                     LISSFFWNNAPVTPQASPEPGDPDLLRTPLYSHSPLLQPLSPSKATEELHRVDFVLPE
                     DTTEYFVRTKAGGVCFKPGTRMLEKPSPGRTEEKTKVAEGSSVRGPARRPMRHVLSAR
                     ERLGGRGTRRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAINI
                     NHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYV
                     FLDHFPPGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFL
                     KLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTIDMLQAVYGLDGIRLRRRQYYT
                     MPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDY
                     EDKRDLNYIRSLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDQFRYLLENPYRE
                     PKSTVEGGRRNQGSDGRSSAVRGKLDTTEG"
ORIGIN      
        1 ggagacctgg ctagaagttt cttagagagg ctgctctatc cttcaccttg gatgaagatg
       61 agacgctaca agctttttct catgttctgt atggccggcc tgtgcctcat ctccttcctg
      121 cacttcttta agacgttatc ctatgtcacc ttcccgagag aactggcctc cctcagccct
      181 aacctcatat ccagcttctt ctggaacaat gcccctgtca ctccccaggc cagtccggag
      241 cccggtgacc ccgacttgtt acggactcca ctctactccc actcccccct gctccagcca
      301 ctgtccccta gcaaggccac cgaagaactg caccgggtgg acttcgtgtt gccggaggac
      361 accacagagt attttgtgcg caccaaagct ggcggtgtgt gcttcaaacc aggtaccagg
      421 atgctggaga aaccttctcc agggcggaca gaggagaaga ccaaggtggc tgaggggtcc
      481 tcggtccggg gtcctgctcg gaggcctatg cggcatgtgt tgagtgcacg ggagcgcctg
      541 ggaggccggg gcactaggcg caagtgggtt gagtgtgtgt gcctgccagg ctggcacggg
      601 cccagctgcg gggtgcccac tgtggtccag tattccaacc tgcccaccaa ggagcgcctg
      661 gtacccaggg aggtgccgag gcgggttatc aacgccatca acatcaacca tgagttcgac
      721 ctgctggatg tgcgcttcca tgagctgggc gatgttgtgg acgcctttgt ggtctgcgaa
      781 tccaatttca ccgcctacgg ggagcctcgg ccgctcaagt tccgagagat gctgaccaat
      841 ggcaccttcg agtacatccg ccacaaggtg ctctacgtct tcctggacca cttcccacct
      901 ggtggccgtc aggacggctg gattgcagac gactacctgc gtaccttcct cacccaggat
      961 ggtgtctccc gcctgcgcaa cctgcgacct gatgacgtct ttatcatcga cgacgcggac
     1021 gagatccctg cgcgtgatgg tgtgctgttc ctcaagctct acgatggctg gacagagccc
     1081 ttcgccttcc atatgcgcaa gtccctgtat ggtttctttt ggaagcaacc aggcacactg
     1141 gaggtggtgt caggctgcac cattgacatg ctgcaggctg tgtatgggct ggacggcatc
     1201 cgcctgcgcc gccgtcagta ctacaccatg cccaactttc gacagtatga gaaccgcacc
     1261 ggccacatcc tagtgcagtg gtctctcggc agccccctgc acttcgcggg ctggcactgc
     1321 tcctggtgct tcacacccga gggcatctac ttcaaactcg tgtcggccca gaatggtgac
     1381 ttcccccgct ggggtgacta cgaggacaag agggacctca attacatccg aagcttgatt
     1441 cgcactgggg gatggttcga cggcacgcag caggagtacc ctcctgcaga ccccagtgaa
     1501 cacatgtatg ctcctaagta cctgctcaag aactatgacc agttccgcta cttgctcgaa
     1561 aatccctacc gggagcccaa gagcactgta gagggtgggc gccggaacca gggctcagac
     1621 ggaaggtcat ctgctgtcag gggcaagttg gatacaacgg agggctaggg ctgtgcagtt
     1681 tcacagggct gggctggctg agatgatggc taagccagtg ttatctttgg cctcctcatt
     1741 atcttggggc tcttgagaga gccaggagtc cttggagttg gtcctctggg ctcaagcccc
     1801 ctagaattaa gggtcaggcc ttccatccca aaacaggaaa gaaaaaaata ttttttagta
     1861 aagaagagca agcccagata tctatgcagc actttttgtc cccaagagtg ctgtgggaaa
     1921 gaggtgttcc tggggagcat gcagtcgttt tctgggactg gtactgggag tgctatggaa
     1981 cttcagccta gttaagagaa gcccaccttt gacatcccag attgttgtcc tgtaatggac
     2041 aaggaggtat accatgccag gagttcccag catcctgtaa ataaatgcaa tgggtccagg
     2101 agcaagaaga gacagtaagg agggactaga aagcgtatct gctcccaatc ttggccaaga
     2161 ggctggggaa gcattggaaa atggcaccct ggagagagag cactttgcag cttcctcaga
     2221 catgctggac ccaaggaatg aggtcacaga tggctggaag ggtggagccg gtggctgtca
     2281 gtccctctgc ctctctaagg agacacgcct ggggggctga ggttccaaat ataccttgat
     2341 gactgatcac tttcctgctg ctgtcttgtg ggagctgctt tgatggactc taggagtcta
     2401 gttctcgggg tgggacagga gctggacacc atgtggacag ccagtatagt aggtgggaca
     2461 agagaaggag acgaacagag gccctatatc cttctctccc tccccatcac tgtctgctgg
     2521 catccagtcc catttttacg acatcccctt ccccaggcct gtaagagcaa gctgggggcc
     2581 aggaagggac tacaagttct tccggggtcc aagaaaggac cttaaggtca gtggcattat
     2641 caacccattc ctcttaattt gtcttggggg ggggaagg
//
