LOCUS       NM_001393796            3850 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus major facilitator superfamily domain containing 8
            (Mfsd8), mRNA.
ACCESSION   NM_001393796 XM_017590960
VERSION     NM_001393796.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3850)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   2  (bases 1 to 3850)
  AUTHORS   Brandenstein,L., Schweizer,M., Sedlacik,J., Fiehler,J. and
            Storch,S.
  TITLE     Lysosomal dysfunction and impaired autophagy in a novel mouse model
            deficient for the lysosomal membrane protein Cln7
  JOURNAL   Hum Mol Genet 25 (4), 777-791 (2016)
   PUBMED   26681805
REFERENCE   3  (bases 1 to 3850)
  AUTHORS   Damme,M., Brandenstein,L., Fehr,S., Jankowiak,W., Bartsch,U.,
            Schweizer,M., Hermans-Borgmeyer,I. and Storch,S.
  TITLE     Gene disruption of Mfsd8 in mice provides the first animal model
            for CLN7 disease
  JOURNAL   Neurobiol Dis 65, 12-24 (2014)
   PUBMED   24423645
REFERENCE   4  (bases 1 to 3850)
  AUTHORS   Sharifi,A., Kousi,M., Sagne,C., Bellenchi,G.C., Morel,L.,
            Darmon,M., Hulkova,H., Ruivo,R., Debacker,C., El Mestikawy,S.,
            Elleder,M., Lehesjoki,A.E., Jalanko,A., Gasnier,B. and Kyttala,A.
  TITLE     Expression and lysosomal targeting of CLN7, a major facilitator
            superfamily transporter associated with variant late-infantile
            neuronal ceroid lipofuscinosis
  JOURNAL   Hum Mol Genet 19 (22), 4497-4514 (2010)
   PUBMED   20826447
REFERENCE   5  (bases 1 to 3850)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 12, 2021 this sequence version replaced XM_017590960.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.11898.1,
                                           SRR26643285.8029.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000002.1  125775531-125775756 c
            227-318             JAXUCZ010000002.1  125770451-125770542 c
            319-362             JAXUCZ010000002.1  125768294-125768337 c
            363-603             JAXUCZ010000002.1  125766332-125766572 c
            604-717             JAXUCZ010000002.1  125765068-125765181 c
            718-862             JAXUCZ010000002.1  125763101-125763245 c
            863-918             JAXUCZ010000002.1  125761855-125761910 c
            919-1027            JAXUCZ010000002.1  125758997-125759105 c
            1028-1162           JAXUCZ010000002.1  125755847-125755981 c
            1163-1266           JAXUCZ010000002.1  125754141-125754244 c
            1267-1514           JAXUCZ010000002.1  125753809-125754056 c
            1515-3850           JAXUCZ010000002.1  125749994-125752329 c
FEATURES             Location/Qualifiers
     source          1..3850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..3850
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /note="major facilitator superfamily domain containing 8"
                     /db_xref="GeneID:361939"
                     /db_xref="RGD:1310132"
     exon            1..226
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1721
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /codon_start=1
                     /product="major facilitator superfamily domain-containing
                     protein 8"
                     /protein_id="NP_001380725.1"
                     /db_xref="GeneID:361939"
                     /db_xref="RGD:1310132"
                     /translation="MANLGSEAEREPLLGTGSPGSREWGMIETQEHYKSRWKSVRILY
                     LTMFLSSVGFSIVIMSIWPYLQKIDQTADASFLGWVIASYSLGQMVASPLFGLWSNYR
                     PRKEPLIVSIFISVAANCLYAYVHVPAAHNKYYMLIARGLVGFGAGNVAVVRSYIAGA
                     TSLQERTGAMANTSTCQALGFILGPVFQTCFALIGEKGVAWDIIKLQINMYTAPVLLA
                     SFLGILNIILILFILREHRVDDLGRQCKSVNVPEENADELQIPEGSIDQVAVVATNIV
                     FFVVLFIFAVYETILTPLTMDMYAWTQEQAVLYNGIILVAFGVEAVLVFMGVKLLSKK
                     IGERAILLGGFVVVWVGFFILLPWGNQFPKIQWEDLHNSSTPNTTFGEIIIDLWNSPR
                     EDHSEQPTGCPIEQAWCLYTPVIHLAQFLTAAVLVGIGYPACSVMSYTLYSKVLGPKP
                     QGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAVSLVCGIVAFTILLIGAVYKRLV
                     AFSVRYGRIQE"
     exon            227..318
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     exon            319..362
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     exon            363..603
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     exon            604..717
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     exon            718..862
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     exon            863..918
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1027
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1162
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1266
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1514
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..3850
                     /gene="Mfsd8"
                     /gene_synonym="Ab2-276; RGD1310132"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaccacagc ctgctgcgcg gcccctgctt ttcctaggca gctgatccgc ttccggcctc
       61 gcggcgcgca ggcgcagttg ccgagtgttt cgacagctcc ggccaggaag gagcttcggg
      121 cgcgagagtg ggcagcgcgc cgcctagtga gtgctgtcat tatggcgaac ctgggaagcg
      181 aggccgagag ggagcccctc ctgggcactg gctcgcccgg aagcagagaa tggggcatga
      241 tagaaaccca agagcattac aagagtagat ggaagtctgt gaggattctc taccttacta
      301 tgttcctcag cagtgtgggt ttttctattg tgataatgtc catctggcca tatcttcaaa
      361 agattgatca gacagctgat gcaagttttt tgggctgggt tattgcttca tatagtcttg
      421 gccaaatggt agcttcacct ctatttggct tatggtctaa ttataggcca agaaaagaac
      481 ctcttatcgt ctccatcttt atttcggtgg cagccaattg cttgtacgca tatgtccatg
      541 tgccagctgc tcataataaa tactacatgt tgattgctcg tggattggtc ggattcggag
      601 caggaaatgt agctgttgtc cgatcataca ttgccggtgc tacttccctt caggaaagaa
      661 cgggtgccat ggctaatacg agcacatgcc aagccctggg ctttattctg ggtccagttt
      721 ttcagacttg ctttgcactc attggagaaa agggtgtggc atgggacatc atcaagcttc
      781 agatcaacat gtacacagct ccagttttac ttgcatcctt cctgggaatt ctaaacatta
      841 ttctgattct ttttatatta agagagcatc gtgtggatga cttgggacgt cagtgtaaga
      901 gtgtcaatgt tccagaagaa aatgcagatg aacttcagat tcctgaagga agtattgatc
      961 aagttgctgt tgtggccacc aatattgtgt tttttgtggt tttgtttatc tttgctgttt
     1021 atgaaacaat cctcactcca ttaacgatgg acatgtacgc ctggacccag gagcaggctg
     1081 tgctctataa tggaataatc cttgttgctt ttggagttga ggcagttctt gttttcatgg
     1141 gtgttaaatt actttccaaa aagattggcg agcgtgctat tctcctggga ggattcgtgg
     1201 ttgtatgggt cggcttcttt atcttgttac cctggggaaa tcagtttccc aaaatacagt
     1261 gggaagattt acataacagc tcaaccccta atactacatt tggggaaatt attattgatc
     1321 tttggaattc tccaagagaa gatcacagtg aacagccaac tggatgccca attgaacagg
     1381 cctggtgcct atacacccca gtgattcatc tggcccagtt cctgacagct gctgtgctag
     1441 ttggaatagg ctatccagcc tgcagtgtca tgtcctatac attatactca aaagttctag
     1501 gacccaaacc tcagggtata tacatgggct ggttaaccac ttctggaagt gcagcacgga
     1561 ttcttgggcc tgtgttcatc agccatgtgt acacttactt gggcccacga tgggcagtca
     1621 gccttgtgtg tggaatagta gcgttcacca tcttgctaat aggagctgtt tacaaaagac
     1681 tcgttgcctt ttctgtcaga tatgggagga tccaggagta agttagcagt ctatgctggg
     1741 tacttgctgc ctactgtctt caactgaaca ttgaataatt tgactttgaa tagtaggatg
     1801 tgtaaaaaca ttctcggtca taatctcctt atcaaaggta aactgttttc atatcatacc
     1861 ttactggagt cccatgaacg agtcccatga actcaacagt gaatggataa tggtctgtag
     1921 gtatgaaact acactcaata ttaactgtac aaagttctat attaattaac cagacacaac
     1981 atttagttta aaaaaatgtt tcattttttt aaacaaaaat attttttcat gaaagttttt
     2041 taagataaaa atgcattatt attaagcttc cgaatgaaat aaaatgagcc ttaaattgtt
     2101 acagcctgct cacaaccaga ttaggcttta ggttttcttt cctgcccagg gtgaatctag
     2161 tttattacct ccccctcaaa acttgtaatt cacacattga cctttgtcta tttttttttt
     2221 tttttttcgg agctggggac cgaacccagg gccttgcgct tgctaggcaa gcgctctacc
     2281 actgagctaa atccccaacc ccaacctttg tctattttta ttttgataat taacctgagc
     2341 aagcatgatg ctaatgtttg aggagtaaaa aggtgaacga gacaaggtgg tttttactcc
     2401 cttcagaagg tctaccttct gaagtgctag tttcatatta ataatcatat ttaaaaaaca
     2461 ctaacttatg tttctaatag caagtggatt cttaaaatta ctatttttca agttctttaa
     2521 actctagtgc aaactctgac ctttgaatgc cccttgtcag taatgacaga gaagaatagc
     2581 agtttgcaac ctacctgtag acccagtcac agcagcagag ctgaagttgg accatgattg
     2641 ctctcgggca gtctcatctc atcaggtgag acttgaagca gaatggccaa aggtgactac
     2701 tgatcaaact agtttctacc tctgtgtgaa tggaacactg gtatgtgtac gggaatctgt
     2761 aaaacatgca gaagtgcttt cctgtcttgt tatcatggtt tcaaatctga gtgtgaacat
     2821 aatattctcc acctcatact ctggtctgct gaagctatta gcaccacgtg atggcagcat
     2881 tttgcttcag tttgttttgt catgccctgg acgtcctctt gtcctcttac ctgctgttct
     2941 gtatttcctt tcctcttttg ggtcactgct gactttaaat tccacctttg tgtggtatgc
     3001 ccagagataa aagaatgata acctgaaaga acaagagcac tccacgttcc tgtgtaatac
     3061 acagaagttc ctcacagcaa gcttagagct gaagataaga gcctcacagc aagcttagag
     3121 ctgaagataa gagcccgacc catgatgtat atgaaggata caagtcactt gtcttcaagg
     3181 ctatctcgtg actgctgcac ttcctcagaa caagaaaatt ggcctgaaca ctaacagttg
     3241 cttaactgtg aggaaccatt tccacttgtg actcagattt gcagaaatag ttgggaaaaa
     3301 aattaagagt gcactgagtg aagaaggctt tatcttagca tatatgttct cagcaagaac
     3361 atgacagaca tttcccagcc ctataatttt aatactgcag ttcagaagac tacaacccag
     3421 caaaatgact gcactgtctt ttttaccaag gcactcgctt cctgggagat tagactaaca
     3481 tcacctcatc accaaagtga gggcactgag aggtacaggg aaagcagctg agaggtaaac
     3541 actgttaata atgtacatta aaggagtaaa aaaagagtaa aagaggaagg tggctttatt
     3601 tttgaaaacc taacaaggga ttatttcctt attttgaatg tactgtcact tcataaagca
     3661 tctctagcca ttatacttcc ctatttaaaa caagttcttt tctcttatga aaataaaata
     3721 aacttgtgat ttttaattta atgaagagaa attactattt ggatctggct accatttatt
     3781 gttgaagatt tatttgtaac tttattgcat tgtgagtatt catttcaaat aaagcaagac
     3841 tgtaagcatt
//
