LOCUS       NM_001106683            2147 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus MFSD2 lysolipid transporter A, lysophospholipid
            (Mfsd2a), mRNA.
ACCESSION   NM_001106683 XM_001054640 XM_216525
VERSION     NM_001106683.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2147)
  AUTHORS   Perego SM, Raquel HA, Candido VB, Masson GS, Martins MM, Ceroni A
            and Michelini LC.
  TITLE     Hypertension depresses but exercise training restores both Mfsd2a
            expression and blood-brain barrier function within PVN capillaries
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 325 (3), R299-R307 (2023)
   PUBMED   37458379
  REMARK    GeneRIF: Hypertension depresses but exercise training restores both
            Mfsd2a expression and blood-brain barrier function within PVN
            capillaries.
REFERENCE   2  (bases 1 to 2147)
  AUTHORS   Lei S, Li J, Yu J, Li F, Pan Y, Chen X, Ma C, Zhao W and Tang X.
  TITLE     Porphyromonas gingivalis bacteremia increases the permeability of
            the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated
            transcytosis pathway
  JOURNAL   Int J Oral Sci 15 (1), 3 (2023)
   PUBMED   36631446
  REMARK    GeneRIF: Porphyromonas gingivalis bacteremia increases the
            permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1
            mediated transcytosis pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2147)
  AUTHORS   Zhao C, Ma J, Wang Z, Li H, Shen H, Li X and Chen G.
  TITLE     Mfsd2a Attenuates Blood-Brain Barrier Disruption After
            Sub-arachnoid Hemorrhage by Inhibiting Caveolae-Mediated
            Transcellular Transport in Rats
  JOURNAL   Transl Stroke Res 11 (5), 1012-1027 (2020)
   PUBMED   31907728
  REMARK    GeneRIF: Mfsd2a Attenuates Blood-Brain Barrier Disruption After
            Sub-arachnoid Hemorrhage by Inhibiting Caveolae-Mediated
            Transcellular Transport in Rats.
REFERENCE   4  (bases 1 to 2147)
  AUTHORS   Chan JP, Wong BH, Chin CF, Galam DLA, Foo JC, Wong LC, Ghosh S,
            Wenk MR, Cazenave-Gassiot A and Silver DL.
  TITLE     The lysolipid transporter Mfsd2a regulates lipogenesis in the
            developing brain
  JOURNAL   PLoS Biol 16 (8), e2006443 (2018)
   PUBMED   30074985
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2147)
  AUTHORS   Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL,
            Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR and Silver
            DL.
  TITLE     Mfsd2a Is a Transporter for the Essential omega-3 Fatty Acid
            Docosahexaenoic Acid (DHA) in Eye and Is Important for
            Photoreceptor Cell Development
  JOURNAL   J Biol Chem 291 (20), 10501-10514 (2016)
   PUBMED   27008858
REFERENCE   6  (bases 1 to 2147)
  AUTHORS   Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T,
            Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Vaux
            KK, Cazenave-Gassiot A, Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M,
            Gabriel S, Chi NC, Silver DL and Gleeson JG.
  TITLE     Inactivating mutations in MFSD2A, required for omega-3 fatty acid
            transport in brain, cause a lethal microcephaly syndrome
  JOURNAL   Nat Genet 47 (7), 809-813 (2015)
   PUBMED   26005868
REFERENCE   7  (bases 1 to 2147)
  AUTHORS   Alakbarzade V, Hameed A, Quek DQ, Chioza BA, Baple EL,
            Cazenave-Gassiot A, Nguyen LN, Wenk MR, Ahmad AQ, Sreekantan-Nair
            A, Weedon MN, Rich P, Patton MA, Warner TT, Silver DL and Crosby
            AH.
  TITLE     A partially inactivating mutation in the sodium-dependent
            lysophosphatidylcholine transporter MFSD2A causes a non-lethal
            microcephaly syndrome
  JOURNAL   Nat Genet 47 (7), 814-817 (2015)
   PUBMED   26005865
REFERENCE   8  (bases 1 to 2147)
  AUTHORS   Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk
            MR, Goh EL and Silver DL.
  TITLE     Mfsd2a is a transporter for the essential omega-3 fatty acid
            docosahexaenoic acid
  JOURNAL   Nature 509 (7501), 503-506 (2014)
   PUBMED   24828044
REFERENCE   9  (bases 1 to 2147)
  AUTHORS   Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H and Gu
            C.
  TITLE     Mfsd2a is critical for the formation and function of the
            blood-brain barrier
  JOURNAL   Nature 509 (7501), 507-511 (2014)
   PUBMED   24828040
REFERENCE   10 (bases 1 to 2147)
  AUTHORS   Berger JH, Charron MJ and Silver DL.
  TITLE     Major facilitator superfamily domain-containing protein 2a (MFSD2A)
            has roles in body growth, motor function, and lipid metabolism
  JOURNAL   PLoS One 7 (11), e50629 (2012)
   PUBMED   23209793
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001054640.1, XM_216525.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161915.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132267,
                                           SAMD00132279 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2147
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2147
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /note="MFSD2 lysolipid transporter A, lysophospholipid"
                     /db_xref="GeneID:298504"
                     /db_xref="RGD:1310174"
     exon            1..249
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1761
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /note="major facilitator superfamily domain containing 2;
                     major facilitator superfamily domain containing 2A"
                     /codon_start=1
                     /product="sodium-dependent lysophosphatidylcholine
                     symporter 1"
                     /protein_id="NP_001100153.1"
                     /db_xref="GeneID:298504"
                     /db_xref="RGD:1310174"
                     /translation="MAKGEGAESGSAAGLLPTGILQASERPAQVKKEPKKKQQLSICN
                     KLCYAVGGAPYQLTGCALGFFLQIYLLDVAKVEPLPASIILFVGRAWDAFTDPLVGFC
                     ISKSSWTRLGRLMPWIIFSTPLAIIAYFLIWFVPDFPSGTESSHGFLWYLLFYCLFET
                     LVTCFHVPYSALTMFISTEQSERDSATAYRMTVEVLGTVIGTAIQGQIVGQAKAPCLQ
                     DQNGSAVASEVVNRTQSTASLKETQNAYLLAAGIIASIYVICAVILILGVREQREPYE
                     AQQAESMPFFQGLRLVMSHGPYVKLIAGFLFTSLAFMLVEGNFALFCTYTLGFRNEFQ
                     NLLLAIMLSATFTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMKSNLIVTYVVA
                     IAAGVSVAAAFLLPWSMLPDVIDDFHLKHPHSPGTEPIFFSFYVFFTKFASGVSLGVS
                     TLSLDFAKYQTQGCSQPEEVKFTLKMLVTMAPIILILLGLLLFKLYPIDEEKRRQNKK
                     ALQALRDEASSSGCSDTDSTELASIL"
     exon            250..381
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            382..506
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            507..645
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            646..724
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            725..882
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            883..973
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1095
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1179
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1263
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1376
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1520
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1697
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..2147
                     /gene="Mfsd2a"
                     /gene_synonym="Mfsd2; RGD1310174"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttttcctcg ccggcgttgc tggtttgcta agagctagcg aacagagaga gtagtagctg
       61 cggctgcgcc taggaccgga gcctcaggag agtgccggcc ggcagaacac tagagcatcc
      121 cggcgtccgg gtcccaggcg gcgtggcccg cgggtcatgg ccaaaggaga gggcgccgag
      181 agcggttccg cggcggggct gctccccacc ggcatcctcc aagccagcga acgaccagcc
      241 caggtgaaga aggaaccaaa aaagaagcag caactgtcca tttgcaataa gctttgctat
      301 gcggttggag gggccccata ccagttgacc ggctgcgcgc tgggattctt cctgcagatc
      361 tacctgttgg atgtggctaa ggtggagcca ctccctgctt ccattatcct tttcgtgggc
      421 cgagcgtggg atgccttcac tgaccctctc gtgggcttct gcatcagcaa gtcctcctgg
      481 acccgcctgg gccgcctcat gccctggatc atcttctcca ctcctctggc catcattgct
      541 tactttctca tctggtttgt gcctgacttc ccatcaggga cagaaagttc gcacgggttc
      601 ctttggtacc tgcttttcta ttgcctcttt gagacactgg tcacgtgctt ccacgttccc
      661 tactcagcgc tcaccatgtt catcagtacc gagcagagtg agcgtgactc cgccactgcc
      721 tataggatga ctgtggaggt tctgggcaca gtgataggca cagcgatcca aggacaaatt
      781 gtgggccaag ccaaggcacc ttgtctccag gaccagaatg gctctgcagt ggcctcagaa
      841 gttgtcaatc gtacccagag cactgcctcc ctcaaagaaa cgcaaaatgc atacctgctg
      901 gcagcaggga tcatcgcctc catctacgtc atctgtgccg tcattctgat tttaggcgtg
      961 cgggagcaga gagaacccta cgaggcccag caggccgagt caatgccctt ctttcagggc
     1021 ctccggctgg ttatgagtca tggcccctat gtcaagctca ttgccggctt cctttttacc
     1081 tccctggctt tcatgctggt agaaggtaat tttgccttgt tctgcaccta caccttgggc
     1141 ttccggaacg agttccagaa cctcctcctg gccatcatgc tctcggccac attcaccatc
     1201 cccatctggc aatggttcct aacccggttt ggcaagaaga cggctgtata cgttgggatc
     1261 tcttctgcag ttccttttct catcttggtg gccctcatga agagtaatct aatcgtcact
     1321 tacgtggtgg ccatagcagc tggtgtcagt gtagcagctg ccttcttact accatggtcc
     1381 atgctgcctg atgttatcga tgacttccac ctgaaacacc ctcactcccc tggcacggag
     1441 cccatcttct tctccttcta tgtcttcttc accaagtttg cctctggagt ctcactgggt
     1501 gtctctaccc tcagtctcga ctttgctaag taccagacgc aggggtgctc ccagccagaa
     1561 gaggtcaagt ttacactgaa gatgctggtg accatggctc ctatcatcct catcctgctg
     1621 ggcctgctgc tcttcaagct gtaccccatt gatgaggaga agcggcgaca gaacaagaaa
     1681 gctctgcagg ctttacgaga tgaagccagc agctcaggct gctcggatac agactccaca
     1741 gagctggcca gcattctcta ggacttgccg ggttgcctga agccaccgca caaaggacct
     1801 ggggcaccag gtagcattag ggcatgggat ctttttgccc ttgcactgag cagctgttct
     1861 tcctatgtca agacagggac caaggactgg agggtgagca gcccaggaca tctgtgctca
     1921 ctgctgggct ggccgttctg taaactcctc actgcccgcc catgggccaa gccctagggc
     1981 tgctactgtg aatatgccaa ggactgactg ggcctagctc ggaacactaa tgtagaaacg
     2041 ttttatacag agactaatta ataacttaat gactatgtat atagggatgt gtgtatgtat
     2101 atgtctgtga ggtattaatg ttattaattt tcataaaaac tggaaac
//
