LOCUS       NM_001108137            2296 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus membrane frizzled-related protein (Mfrp), mRNA.
ACCESSION   NM_001108137 XM_001060224 XM_001060288 XM_236179
VERSION     NM_001108137.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2296)
  AUTHORS   Xu,Y., Guan,L., Xiao,X., Zhang,J., Li,S., Jiang,H., Jia,X., Yin,Y.,
            Guo,X., Yang,Z. and Zhang,Q.
  TITLE     Identification of MFRP Mutations in Chinese Families with High
            Hyperopia
  JOURNAL   Optom Vis Sci 93 (1), 19-26 (2016)
   PUBMED   26583794
REFERENCE   2  (bases 1 to 2296)
  AUTHORS   Wasmann,R.A., Wassink-Ruiter,J.S., Sundin,O.H., Morales,E.,
            Verheij,J.B. and Pott,J.W.
  TITLE     Novel membrane frizzled-related protein gene mutation as cause of
            posterior microphthalmia resulting in high hyperopia with macular
            folds
  JOURNAL   Acta Ophthalmol 92 (3), 276-281 (2014)
   PUBMED   23742260
REFERENCE   3  (bases 1 to 2296)
  AUTHORS   Dinculescu,A., Estreicher,J., Zenteno,J.C., Aleman,T.S.,
            Schwartz,S.B., Huang,W.C., Roman,A.J., Sumaroka,A., Li,Q.,
            Deng,W.T., Min,S.H., Chiodo,V.A., Neeley,A., Liu,X., Shu,X.,
            Matias-Florentino,M., Buentello-Volante,B., Boye,S.L.,
            Cideciyan,A.V., Hauswirth,W.W. and Jacobson,S.G.
  TITLE     Gene therapy for retinitis pigmentosa caused by MFRP mutations:
            human phenotype and preliminary proof of concept
  JOURNAL   Hum Gene Ther 23 (4), 367-376 (2012)
   PUBMED   22142163
REFERENCE   4  (bases 1 to 2296)
  AUTHORS   Kannabiran,C., Singh,H., Sahini,N., Jalali,S. and Mohan,G.
  TITLE     Mutations in TULP1, NR2E3, and MFRP genes in Indian families with
            autosomal recessive retinitis pigmentosa
  JOURNAL   Mol Vis 18, 1165-1174 (2012)
   PUBMED   22605927
REFERENCE   5  (bases 1 to 2296)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   6  (bases 1 to 2296)
  AUTHORS   Zenteno,J.C., Buentello-Volante,B., Quiroz-Gonzalez,M.A. and
            Quiroz-Reyes,M.A.
  TITLE     Compound heterozygosity for a novel and a recurrent MFRP gene
            mutation in a family with the nanophthalmos-retinitis pigmentosa
            complex
  JOURNAL   Mol Vis 15, 1794-1798 (2009)
   PUBMED   19753314
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2296)
  AUTHORS   Bailey,M.J., Coon,S.L., Carter,D.A., Humphries,A., Kim,J.S.,
            Shi,Q., Gaildrat,P., Morin,F., Ganguly,S., Hogenesch,J.B.,
            Weller,J.L., Rath,M.F., Moller,M., Baler,R., Sugden,D.,
            Rangel,Z.G., Munson,P.J. and Klein,D.C.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: Mfrp expression increases at night in the rat pineal gland
            over 10-fold.
REFERENCE   8  (bases 1 to 2296)
  AUTHORS   Kameya,S., Hawes,N.L., Chang,B., Heckenlively,J.R., Naggert,J.K.
            and Nishina,P.M.
  TITLE     Mfrp, a gene encoding a frizzled related protein, is mutated in the
            mouse retinal degeneration 6
  JOURNAL   Hum Mol Genet 11 (16), 1879-1886 (2002)
   PUBMED   12140190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jun 23, 2009 this sequence version replaced NM_001108137.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2418696.1,
                                           SRR26360176.2414796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000008.1  53342534-53342737
            205-307             JAXUCZ010000008.1  53342823-53342925
            308-421             JAXUCZ010000008.1  53343036-53343149
            422-595             JAXUCZ010000008.1  53343252-53343425
            596-809             JAXUCZ010000008.1  53343555-53343768
            810-940             JAXUCZ010000008.1  53343983-53344113
            941-1066            JAXUCZ010000008.1  53344223-53344348
            1067-1143           JAXUCZ010000008.1  53344475-53344551
            1144-1292           JAXUCZ010000008.1  53345413-53345561
            1293-1441           JAXUCZ010000008.1  53346002-53346150
            1442-1570           JAXUCZ010000008.1  53346238-53346366
            1571-1698           JAXUCZ010000008.1  53346887-53347014
            1699-2296           JAXUCZ010000008.1  53347099-53347696
FEATURES             Location/Qualifiers
     source          1..2296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2296
                     /gene="Mfrp"
                     /note="membrane frizzled-related protein"
                     /db_xref="GeneID:315597"
                     /db_xref="RGD:1307477"
     exon            1..204
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1923
                     /gene="Mfrp"
                     /codon_start=1
                     /product="membrane frizzled-related protein"
                     /protein_id="NP_001101607.1"
                     /db_xref="GeneID:315597"
                     /db_xref="RGD:1307477"
                     /translation="MKEYADVTLCPEAAELSKTEFCNPAFDLEAGPSCPPPALQKNVS
                     SSLQGPWHVQRLRGLQPDCHFSGLCILLLSGLLLLLLGLLVAVILAQLQATSLPRTTK
                     NPLPTRGGLTPTGVIPSTTPNTTTTTTTTPAITGRQEAAMSPTHQTTCGGLLPGPSGF
                     FSSPNYPDLYPPHSHCVWHIQVATGQTIQLKIQVLSTESMLACLFDRLEISPAPTGPL
                     LRMCGKTPPATVNTNTSHLRVSFVSDNDVEGSGFQAWYQAVAPGHWSCTHYEFHCDLL
                     LCLKQDSVCDGIKDCIDGSDEANCSAKTLGCGGNLTELSGVFSTPNYPQHYPHQQLCT
                     WYIKVPVGYRIRLEFHNFSLEEQTECKFDYVEVYEASNSGTFSSLGRFCGAEPPSHLV
                     SSQHQLTVIFKTDLGISSGGFLATYQAINTTESGCPWADLCGPREFCQSRVRRELQRI
                     CDLWKDCANDSNDNCNSHLSPQLDLTCEPVQVEMCLGLSYNTTAFPNIWVGLATQMEV
                     TDILRGYKSLTSLPCYQTFRRFLCGLLEPRCTSLGTILPPCRSVCQEAEQQCQSSLAL
                     LGIPWPFNCNRLPVPASLEACSQP"
     exon            205..307
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            308..421
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            422..595
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            596..809
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            810..940
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1066
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1143
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1292
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1441
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1570
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1698
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..2296
                     /gene="Mfrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggcagcca gagaaccagt gtctcctgac agcctggtcc ctcaagagca aagttcgctt
       61 ctttgattgg tggcttgtga ccggggagtg gaccctcggg ggtcttaggc tatcactgga
      121 actccagaaa gccatgcaga gccttgagcc atgaaggaat atgccgatgt caccctctgt
      181 ccagaggcag ctgagctgag caagacagag ttctgcaatc ctgctttcga cctggaagcc
      241 gggccttctt gccctccacc agcattacag aaaaatgtca gcagcagcct ccaaggtccc
      301 tggcatgtcc agcgtctccg ggggctacaa ccagactgcc acttctccgg gctctgtatc
      361 ctgctgctca gcggcctgct gctactactg ctggggctgc tggtggctgt catcctggct
      421 cagttgcagg ctacatctct ccccaggact accaagaacc cactgcccac ccgaggaggc
      481 ctcaccccca cgggtgtcat tcccagcacc acccctaaca ccaccaccac caccaccacc
      541 accccagcaa tcacagggcg gcaagaggca gccatgagcc ctacacacca aaccacctgt
      601 ggaggcctcc ttcctggtcc cagtggtttc ttcagcagtc ccaactaccc agacctttac
      661 ccaccccaca gccactgcgt ctggcatatc caggtagcca caggccagac aatacagctc
      721 aagattcaag tgctcagcac agaaagcatg ctcgcctgtc tttttgatcg cttggaaatt
      781 agcccagcgc ctacaggccc tctgctcaga atgtgtggta aaacacctcc tgccacagtt
      841 aacaccaaca ccagtcacct ccgtgtgtcc ttcgtctctg ataacgatgt agaagggtct
      901 ggtttccagg cctggtacca agcagtggcc cctggacatt ggagctgtac ccactacgag
      961 ttccactgtg acctgctcct ctgcctgaag caagactctg tgtgtgacgg cattaaggac
     1021 tgcatcgatg gcagtgatga ggccaactgc agtgccaaga cgttggggtg tggagggaac
     1081 ctgactgagc tctctggggt gttctctacc ccaaactacc cacagcacta ccctcaccaa
     1141 cagctttgta cctggtatat caaagtgccc gtgggataca ggataagact agagttccac
     1201 aacttcagcc tggaagaaca aactgaatgc aagtttgact acgtggaggt gtatgaggcc
     1261 agcaactcag gaacattcag ctccctgggc aggttctgtg gagcagagcc accatcccac
     1321 ctcgtctcct cgcagcacca gctgactgta atcttcaaga ctgatcttgg tatcagcagt
     1381 gggggctttt tagcaaccta ccaggccatc aatacgacag agagtgggtg cccctgggca
     1441 gacctttgtg gacccagaga gttctgccag agcagagtac gtagagaact gcaacggatt
     1501 tgtgacttat ggaaagactg tgcaaatgac agcaatgaca actgcaacag ccacttgtcc
     1561 ccacaactgg acctgacctg tgaacctgtc caggtggaga tgtgccttgg actaagctac
     1621 aataccacag ccttccctaa catctgggtg ggcctggcca cacagatgga ggtgacagat
     1681 atcctcagag gctacaagag cctgacaagt ctaccctgct accagacttt ccggaggttc
     1741 ctctgtgggc tgcttgaacc tcgatgcacc tcactgggca ctatcctacc cccttgtcgt
     1801 tctgtctgcc aggaggcaga acaacagtgc cagtctagcc tggcattact gggcatcccc
     1861 tggcctttca actgcaacag gctgcctgtg ccggctagcc tggaagcttg ctcccagccc
     1921 tgaccccaag ccagccccca ccctctgtct gcccatcctc ctctcccaag atgggtgggc
     1981 aaggcaggca gaaaacaagg gtggcctgga catgggactc tgcccatcct ctctggagct
     2041 tctcaaagag gaaaaagaac agttattact ctgatcctgc ccaggactaa cgggactgtc
     2101 ccatcatctt tcccctaccg tcctcgagct cttatttgcc aagacagccc tggtaccatt
     2161 ggacggccta gcagacttcc tatccaagtc tctgaccctg attccctgtc ttctgcctcc
     2221 ccccttttca tttaagttca ccatcagctg accttcaagc tttttcatgt agtcaataaa
     2281 actgttttga gtgatg
//
