LOCUS       NP_001101607             590 aa            linear   ROD 28-MAR-2024
DEFINITION  membrane frizzled-related protein [Rattus norvegicus].
ACCESSION   NP_001101607 XP_001060224 XP_001060288 XP_236179
VERSION     NP_001101607.1
DBSOURCE    REFSEQ: accession NM_001108137.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 590)
  AUTHORS   Xu,Y., Guan,L., Xiao,X., Zhang,J., Li,S., Jiang,H., Jia,X., Yin,Y.,
            Guo,X., Yang,Z. and Zhang,Q.
  TITLE     Identification of MFRP Mutations in Chinese Families with High
            Hyperopia
  JOURNAL   Optom Vis Sci 93 (1), 19-26 (2016)
   PUBMED   26583794
REFERENCE   2  (residues 1 to 590)
  AUTHORS   Wasmann,R.A., Wassink-Ruiter,J.S., Sundin,O.H., Morales,E.,
            Verheij,J.B. and Pott,J.W.
  TITLE     Novel membrane frizzled-related protein gene mutation as cause of
            posterior microphthalmia resulting in high hyperopia with macular
            folds
  JOURNAL   Acta Ophthalmol 92 (3), 276-281 (2014)
   PUBMED   23742260
REFERENCE   3  (residues 1 to 590)
  AUTHORS   Dinculescu,A., Estreicher,J., Zenteno,J.C., Aleman,T.S.,
            Schwartz,S.B., Huang,W.C., Roman,A.J., Sumaroka,A., Li,Q.,
            Deng,W.T., Min,S.H., Chiodo,V.A., Neeley,A., Liu,X., Shu,X.,
            Matias-Florentino,M., Buentello-Volante,B., Boye,S.L.,
            Cideciyan,A.V., Hauswirth,W.W. and Jacobson,S.G.
  TITLE     Gene therapy for retinitis pigmentosa caused by MFRP mutations:
            human phenotype and preliminary proof of concept
  JOURNAL   Hum Gene Ther 23 (4), 367-376 (2012)
   PUBMED   22142163
REFERENCE   4  (residues 1 to 590)
  AUTHORS   Kannabiran,C., Singh,H., Sahini,N., Jalali,S. and Mohan,G.
  TITLE     Mutations in TULP1, NR2E3, and MFRP genes in Indian families with
            autosomal recessive retinitis pigmentosa
  JOURNAL   Mol Vis 18, 1165-1174 (2012)
   PUBMED   22605927
REFERENCE   5  (residues 1 to 590)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   6  (residues 1 to 590)
  AUTHORS   Zenteno,J.C., Buentello-Volante,B., Quiroz-Gonzalez,M.A. and
            Quiroz-Reyes,M.A.
  TITLE     Compound heterozygosity for a novel and a recurrent MFRP gene
            mutation in a family with the nanophthalmos-retinitis pigmentosa
            complex
  JOURNAL   Mol Vis 15, 1794-1798 (2009)
   PUBMED   19753314
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 590)
  AUTHORS   Bailey,M.J., Coon,S.L., Carter,D.A., Humphries,A., Kim,J.S.,
            Shi,Q., Gaildrat,P., Morin,F., Ganguly,S., Hogenesch,J.B.,
            Weller,J.L., Rath,M.F., Moller,M., Baler,R., Sugden,D.,
            Rangel,Z.G., Munson,P.J. and Klein,D.C.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: Mfrp expression increases at night in the rat pineal gland
            over 10-fold.
REFERENCE   8  (residues 1 to 590)
  AUTHORS   Kameya,S., Hawes,N.L., Chang,B., Heckenlively,J.R., Naggert,J.K.
            and Nishina,P.M.
  TITLE     Mfrp, a gene encoding a frizzled related protein, is mutated in the
            mouse retinal degeneration 6
  JOURNAL   Hum Mol Genet 11 (16), 1879-1886 (2002)
   PUBMED   12140190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001060224.1, XP_001060288.1, XP_236179.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2418696.1,
                                           SRR26360176.2414796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..590
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     Protein         1..590
                     /product="membrane frizzled-related protein"
                     /calculated_mol_wt=64315
     Region          150..258
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(158,160,162,189,194,229,253,255,257..258)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          266..300
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(271,279,290..291)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(283,286,290,296..297)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            293..297
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          307..419
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(315,317,319,346,351,390,414,416,418..419)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          476..590
                     /region_name="CRD_FZ"
                     /note="CRD_domain cysteine-rich domain, also known as Fz
                     (frizzled) domain; cd07066"
                     /db_xref="CDD:143549"
     Site            order(484,486..487,490..492)
                     /site_type="other"
                     /note="putative Wnt binding site [polypeptide binding]"
                     /db_xref="CDD:143549"
     CDS             1..590
                     /gene="Mfrp"
                     /coded_by="NM_001108137.2:151..1923"
                     /db_xref="GeneID:315597"
                     /db_xref="RGD:1307477"
ORIGIN      
        1 mkeyadvtlc peaaelskte fcnpafdlea gpscpppalq knvssslqgp whvqrlrglq
       61 pdchfsglci lllsglllll lgllvavila qlqatslprt tknplptrgg ltptgvipst
      121 tpnttttttt tpaitgrqea amspthqttc ggllpgpsgf fsspnypdly pphshcvwhi
      181 qvatgqtiql kiqvlstesm laclfdrlei spaptgpllr mcgktppatv ntntshlrvs
      241 fvsdndvegs gfqawyqava pghwscthye fhcdlllclk qdsvcdgikd cidgsdeanc
      301 saktlgcggn ltelsgvfst pnypqhyphq qlctwyikvp vgyrirlefh nfsleeqtec
      361 kfdyvevyea snsgtfsslg rfcgaeppsh lvssqhqltv ifktdlgiss ggflatyqai
      421 nttesgcpwa dlcgprefcq srvrrelqri cdlwkdcand sndncnshls pqldltcepv
      481 qvemclglsy nttafpniwv glatqmevtd ilrgykslts lpcyqtfrrf lcglleprct
      541 slgtilppcr svcqeaeqqc qsslallgip wpfncnrlpv pasleacsqp
//
