LOCUS       NM_199110               1830 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus MFNG O-fucosylpeptide
            3-beta-N-acetylglucosaminyltransferase (Mfng), mRNA.
ACCESSION   NM_199110 XM_235477
VERSION     NM_199110.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Kakuda S and Haltiwanger RS.
  TITLE     Deciphering the Fringe-Mediated Notch Code: Identification of
            Activating and Inhibiting Sites Allowing Discrimination between
            Ligands
  JOURNAL   Dev Cell 40 (2), 193-201 (2017)
   PUBMED   28089369
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Cui W, Dai X, Marcho C, Han Z, Zhang K, Tremblay KD and Mager J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Tan JB, Xu K, Cretegny K, Visan I, Yuan JS, Egan SE and Guidos CJ.
  TITLE     Lunatic and manic fringe cooperatively enhance marginal zone B cell
            precursor competition for delta-like 1 in splenic endothelial
            niches
  JOURNAL   Immunity 30 (2), 254-263 (2009)
   PUBMED   19217325
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Fiuza UM and Arias AM.
  TITLE     Cell and molecular biology of Notch
  JOURNAL   J Endocrinol 194 (3), 459-474 (2007)
   PUBMED   17761886
  REMARK    Review article
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA and Weinmaster G.
  TITLE     Fringe glycosyltransferases differentially modulate Notch1
            proteolysis induced by Delta1 and Jagged1
  JOURNAL   Mol Biol Cell 16 (2), 927-942 (2005)
   PUBMED   15574878
REFERENCE   6  (bases 1 to 1830)
  AUTHORS   Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, Wang
            Y, Stanley P, Irvine KD, Haltiwanger RS and Vogt TF.
  TITLE     Fringe is a glycosyltransferase that modifies Notch
  JOURNAL   Nature 406 (6794), 369-375 (2000)
   PUBMED   10935626
REFERENCE   7  (bases 1 to 1830)
  AUTHORS   Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD and
            Vogt TF.
  TITLE     A family of mammalian Fringe genes implicated in boundary
            determination and the Notch pathway
  JOURNAL   Development 124 (11), 2245-2254 (1997)
   PUBMED   9187150
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061801.1.
            
            On Jan 1, 2004 this sequence version replaced XM_235477.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061801.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1830
                     /gene="Mfng"
                     /note="MFNG O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase"
                     /db_xref="GeneID:315119"
                     /db_xref="RGD:735126"
     exon            1..357
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1068
                     /gene="Mfng"
                     /EC_number="2.4.1.222"
                     /note="manic fringe homolog"
                     /codon_start=1
                     /product="beta-1,3-N-acetylglucosaminyltransferase manic
                     fringe"
                     /protein_id="NP_954541.1"
                     /db_xref="GeneID:315119"
                     /db_xref="RGD:735126"
                     /translation="MHCRVFRGLAGALFTLLCVGLLSLRYHSSLSLRTMQGTLRLNQP
                     NPGHLELQLGDIFIGVKTTWAFHRSRLDLLLDTWVSRTRQQTFIFTDSPDELLQERLG
                     SHLVVTNCSAEHSHPALSCKMAAEFDAFLVSGLRWFCHVDDDNYVNPKALLQLLRTFP
                     QDHDVYVGKPSLNRPIHASELQSKNRTRLVRFWFATGGAGFCINRQLALKMVPWASGS
                     HFVDTSALIRLPDDCTVGYIIECKLGGRLQPSPLFHSHLETLQLLGTAQLLEQVTLSY
                     GVFEGKLNIIKLPGPFSHEEDPSRFRSLHCLLYPDTPWCPLLAVP"
     exon            358..406
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            407..509
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            510..663
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            664..749
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            750..915
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1001
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1770
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgccaga cttttgcctg taccagggcc cccacctgac cagcctccca ccccaggctg
       61 attggggagt cgggggctga actgtctggg ggcccgctcc caatgcactg ccgggtcttt
      121 cggggcctgg cgggagccct ctttaccctc ctgtgcgtgg ggctcctatc tctacgatac
      181 cactcaagct tgtccctgag gacgatgcag ggcacgctca ggctgaacca accgaaccca
      241 gggcacctgg agctgcagct gggggacatc ttcatcggag tcaagactac ctgggccttc
      301 caccgctccc gcctggacct gctgcttgac acatgggtct ccagaaccag gcaacagaca
      361 ttcatcttca ctgacagccc agatgaactc ctccaggaga gattaggctc gcacctcgtg
      421 gtcaccaact gttctgcaga gcacagtcat cctgctctgt cctgcaagat ggctgcagaa
      481 tttgatgcct tcttggtcag tggcctcagg tggttctgcc atgtggatga tgacaactat
      541 gtgaacccca aggctctgct acagctgctg agaacattcc cgcaggacca tgatgtctat
      601 gtgggcaagc ccagcctgaa ccggcccata cacgcctctg agctgcaatc aaaaaaccgc
      661 acgaggctgg tgcggttctg gtttgccaca gggggtgctg gcttttgtat caaccgccaa
      721 ctggctttga agatggtgcc gtgggccagc ggttcccact ttgtggacac ttcagctctc
      781 atccggctcc ccgatgactg cactgtgggc tacatcatcg agtgcaagct ggggggccgc
      841 ctgcagccca gccccctttt ccactcacac ctggaaacct tgcagctgct gggcactgcc
      901 cagcttctgg agcaggtcac cctcagctat ggtgtctttg aagggaaact gaacatcatc
      961 aagctaccgg gccccttctc ccatgaggag gacccttcca gatttcgctc cctccactgt
     1021 ctcctctacc cggacacacc ctggtgtcca ctgctggcag tgccctgagc tctgacctgc
     1081 cccaaaggat gatggatgct tctatctgac cactccccca tctcccaagc agtcctgagg
     1141 gctcttggtc cgtacacact ggcagatggt ccctggcagg gcctctgggt gacagggaag
     1201 gtcgggatgt ggacactgct tggcgttgaa ggtatctcag gcccagacac ctggtcacac
     1261 cacagaggct gcagggacac ttgaattggt gtgtaggagg gggttggggt cctcaccctc
     1321 ctgagggtga catgtgccct gcctggagtc tggcctctgg ctctggcctc agtcattctt
     1381 tagggactag agtcattggg ataaaaccag gtctgtgatc tgcagctatg gggctggcct
     1441 cagccgctcc tggttctgca cagctggcca atggacctag acttcggaac cccagcaggc
     1501 tcaggtgcca atcgcaatgg gcctttggtt cagtgtccca gcctcttttg ctgtgaggag
     1561 ctgccatatg gcccagcaga actgagcaaa gtcaatagag gggtttctgg agtacactcc
     1621 cagcccaaga ccctgccttc ctactgtgaa cgtgggtgtg atggctggat ctggggaagc
     1681 tactttggca ccatgaaaga aaggccgaga caatctaaag ctgctctccc taacacctga
     1741 tctgtaagaa attaaacttt tatttaaggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
