LOCUS       NM_130894               3891 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mitofusin 2 (Mfn2), mRNA.
ACCESSION   NM_130894
VERSION     NM_130894.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3891)
  AUTHORS   Deng,X., Xu,H., Pan,C., Hao,X., Liu,J., Shang,X., Chi,R., Hou,W.
            and Xu,T.
  TITLE     Moderate mechanical strain and exercise reduce inflammation and
            excessive autophagy in osteoarthritis by downregulating mitofusin 2
  JOURNAL   Life Sci 332, 122020 (2023)
   PUBMED   37579836
  REMARK    GeneRIF: Moderate mechanical strain and exercise reduce
            inflammation and excessive autophagy in osteoarthritis by
            downregulating mitofusin 2.
REFERENCE   2  (bases 1 to 3891)
  AUTHORS   Wang,S., Sang,X., Li,S., Yang,W., Wang,S., Chen,H. and Lu,C.
  TITLE     Increased Ca2 + transport across the mitochondria-associated
            membranes by Mfn2 inhibiting endoplasmic reticulum stress in
            ischemia/reperfusion kidney injury
  JOURNAL   Sci Rep 13 (1), 17257 (2023)
   PUBMED   37828353
  REMARK    GeneRIF: Increased Ca2 + transport across the
            mitochondria-associated membranes by Mfn2 inhibiting endoplasmic
            reticulum stress in ischemia/reperfusion kidney injury.
            Erratum:[Sci Rep. 2024 Jan 30;14(1):2478. PMID: 38291111]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3891)
  AUTHORS   Kulkarni,P.G., Balasubramanian,N., Manjrekar,R., Banerjee,T. and
            Sakharkar,A.
  TITLE     DNA Methylation-Mediated Mfn2 Gene Regulation in the Brain: A Role
            in Brain Trauma-Induced Mitochondrial Dysfunction and Memory
            Deficits
  JOURNAL   Cell Mol Neurobiol 43 (7), 3479-3495 (2023)
   PUBMED   37193907
  REMARK    GeneRIF: DNA Methylation-Mediated Mfn2 Gene Regulation in the
            Brain: A Role in Brain Trauma-Induced Mitochondrial Dysfunction and
            Memory Deficits.
REFERENCE   4  (bases 1 to 3891)
  AUTHORS   Zhang,R., Yang,A., Zhang,L., He,L., Gu,X., Yu,C., Lu,Z., Wang,C.,
            Zhou,F., Li,F., Ji,L., Xing,J. and Guo,H.
  TITLE     MFN2 deficiency promotes cardiac response to hypobaric hypoxia by
            reprogramming cardiomyocyte metabolism
  JOURNAL   Acta Physiol (Oxf) 239 (1), e14018 (2023)
   PUBMED   37401731
  REMARK    GeneRIF: MFN2 deficiency promotes cardiac response to hypobaric
            hypoxia by reprogramming cardiomyocyte metabolism.
REFERENCE   5  (bases 1 to 3891)
  AUTHORS   Ghosal,S., Gebara,E., Ramos-Fernandez,E., Chioino,A., Grosse,J.,
            Guillot de Suduiraut,I., Zanoletti,O., Schneider,B., Zorzano,A.,
            Astori,S. and Sandi,C.
  TITLE     Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance
            and neuronal function
  JOURNAL   Cell Rep 42 (7), 112776 (2023)
   PUBMED   37440411
  REMARK    GeneRIF: Mitofusin-2 in nucleus accumbens D2-MSNs regulates social
            dominance and neuronal function.
REFERENCE   6  (bases 1 to 3891)
  AUTHORS   Bach,D., Pich,S., Soriano,F.X., Vega,N., Baumgartner,B., Oriola,J.,
            Daugaard,J.R., Lloberas,J., Camps,M., Zierath,J.R.,
            Rabasa-Lhoret,R., Wallberg-Henriksson,H., Laville,M., Palacin,M.,
            Vidal,H., Rivera,F., Brand,M. and Zorzano,A.
  TITLE     Mitofusin-2 determines mitochondrial network architecture and
            mitochondrial metabolism. A novel regulatory mechanism altered in
            obesity
  JOURNAL   J Biol Chem 278 (19), 17190-17197 (2003)
   PUBMED   12598526
REFERENCE   7  (bases 1 to 3891)
  AUTHORS   Ishihara,N., Jofuku,A., Eura,Y. and Mihara,K.
  TITLE     Regulation of mitochondrial morphology by membrane potential, and
            DRP1-dependent division and FZO1-dependent fusion reaction in
            mammalian cells
  JOURNAL   Biochem Biophys Res Commun 301 (4), 891-898 (2003)
   PUBMED   12589796
REFERENCE   8  (bases 1 to 3891)
  AUTHORS   Chen,H., Detmer,S.A., Ewald,A.J., Griffin,E.E., Fraser,S.E. and
            Chan,D.C.
  TITLE     Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion
            and are essential for embryonic development
  JOURNAL   J Cell Biol 160 (2), 189-200 (2003)
   PUBMED   12527753
REFERENCE   9  (bases 1 to 3891)
  AUTHORS   Rojo,M., Legros,F., Chateau,D. and Lombes,A.
  TITLE     Membrane topology and mitochondrial targeting of mitofusins,
            ubiquitous mammalian homologs of the transmembrane GTPase Fzo
  JOURNAL   J Cell Sci 115 (Pt 8), 1663-1674 (2002)
   PUBMED   11950885
REFERENCE   10 (bases 1 to 3891)
  AUTHORS   Santel,A. and Fuller,M.T.
  TITLE     Control of mitochondrial morphology by a human mitofusin
  JOURNAL   J Cell Sci 114 (Pt 5), 867-874 (2001)
   PUBMED   11181170
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070880.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_130894.5.
            
            On Aug 31, 2012 this sequence version replaced NM_130894.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3891              BC070880.1         5-3895
FEATURES             Location/Qualifiers
     source          1..3891
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3891
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /note="mitofusin 2"
                     /db_xref="GeneID:64476"
                     /db_xref="RGD:628843"
     exon            1..143
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            144..322
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2421
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /note="transmembrane GTPase MFN2; hypertension-related
                     protein; mitochondrial transmembrane GTPase FZO1A;
                     mitofusin-2-like"
                     /codon_start=1
                     /product="mitofusin-2"
                     /protein_id="NP_570964.4"
                     /db_xref="GeneID:64476"
                     /db_xref="RGD:628843"
                     /translation="MSLLFSRCNSIVTVKKDKRHMAEVNASPLKHFVTAKKKINGIFE
                     QLGAYIQESAGFLEDTHRNTELDPVTTEEQVLDVKGYLSKVRGISEVLARRHMKVAFF
                     GRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGTDGHEAFLLTEGSEEKKSVKTV
                     NQLAHALHQDEQLHAGSLVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCL
                     DADVFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWDASASEPEYMEEVRRQ
                     HMERCTSFLVDELGVVDRAQAGDRIFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVR
                     MFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHIAAQEQRVYCLE
                     MREERQDRLRFIDKQLELLAQDYKLRIKQMTEEVERQVSTAMAEEIRRLSVLVDEYQM
                     DFHPSPVVLKVYKNELHRHIEEGLGRNMSDRCSTAIASSLQTMQQDMIDGLKPLLPVS
                     VRNQIDMLVPRQCFSLSYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRAL
                     LGYNDQVQRPLPLTPANPSMPPLPQGSLTQEELMVSMVTGLASLTSRTSMGILVVGGV
                     VWKAVGWRLIALSFGLYGLLYVYERLTWTTRAKERAFKRQFVEYASEKLQLIISYTGS
                     NCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKKVEALDSLQSKAKLLRNKAGW
                     LDSELNMFIHQYLQPSR"
     exon            323..458
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            459..621
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            622..746
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            747..855
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            856..963
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1117
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1185
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1307
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1434
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1539
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1642
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1863
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2019
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2216
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2351
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..3869
                     /gene="Mfn2"
                     /gene_synonym="HSG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagttcagac aggtggagtc aacaccatca gtagccaatc tggacctgaa tcggcacaga
       61 ggagacctca agttcttttc atctttttga ctccagccat gtccatgatg cccaacctgt
      121 gaaggtccct taccagctag aaacgagatg tccctgctct tttctcgatg caactccatc
      181 gtcaccgtca agaaggataa gcgacacatg gctgaggtga atgcttcccc tctcaagcac
      241 tttgtcactg ccaagaaaaa gatcaatggc atctttgagc agctgggggc ctacatccaa
      301 gagagtgccg gcttccttga agacacccac aggaatacag aactggaccc agttactaca
      361 gaagagcagg tcctggatgt caaagggtac ctgtccaagg tcaggggaat cagcgaggtg
      421 ctggccaggc ggcacatgaa ggtggctttt tttggccgga cgagcaatgg gaagagcacc
      481 gtgatcaatg ccatgctttg ggacaaagtt ctgccatctg ggattggcca caccaccaat
      541 tgcttcctgc gggttggggg cacggatggc cacgaggcct tcctcctcac ggagggctca
      601 gaagagaaga agagtgtcaa gaccgtgaac cagctagccc atgccctcca tcaggatgag
      661 cagctgcatg caggcagcct ggtgagtgtg atgtggccca actccaagtg tccacttctg
      721 aaggatgacc tcgtgctgat ggacagccct gggatcgatg tcaccacgga gctggacagc
      781 tggattgata agttttgcct ggatgctgat gtgtttgtac tggtggccaa ctcagagtcc
      841 acgctgatgc agacggagaa gcagttcttc cacaaagtga gtgagcgtct ctcccggccc
      901 aacatcttca tcctgaacaa ccgctgggat gcgtctgcct cggagcctga gtacatggag
      961 gaggtgcggc ggcagcacat ggaacgctgc accagctttc tggtggatga gctaggcgtg
     1021 gtggatcgag ctcaggccgg ggaccggatc ttctttgtgt ctgccaagga ggtgctcagt
     1081 gccagggtcc agaaagccca gggcatgcca gaaggaggtg gcgctcttgc agaaggtttt
     1141 caagtgagga tgtttgagtt tcagaatttc gagaggcgat ttgaggagtg catttcccag
     1201 tctgcagtaa agaccaaatt tgagcagcac acagtccggg ccaagcagat tgcagaggcc
     1261 gtccgtctca tcatggattc cctgcacatt gcggctcagg agcagcgggt ttattgtctt
     1321 gaaatgcggg aagagcggca agaccggctg agattcattg acaagcagct ggagctcctg
     1381 gctcaagact ataagctacg gattaagcag atgacagagg aagtggaaag gcaggtgtcc
     1441 acagccatgg ctgaagagat caggcgcctc tctgtgctgg ttgacgagta ccagatggac
     1501 tttcacccat ccccagttgt cctcaaggtt tataagaatg aactgcaccg ccatatagag
     1561 gaaggcctgg gacgaaacat gtctgaccgc tgctccacag ccattgccag ttcactgcag
     1621 actatgcagc aagacatgat agacggcttg aagccccttc ttcctgtgtc tgtgcggaat
     1681 cagatagaca tgctggtccc tcgacagtgt ttctccctca gctatgacct gaactgtgac
     1741 aagctgtgcg ctgactttca ggaggacatc gaattccatt tctcccttgg atggactatg
     1801 ctagtgaata ggttcctggg ccctaagaat agccggcggg ccttgctggg ctacaatgat
     1861 caggttcagc gtcctctccc tctgacacct gccaacccca gcatgccacc cttgccacag
     1921 ggctccctca cccaggagga gctcatggtc tccatggtta ctggcctggc ctctctgact
     1981 tccaggacct ctatgggcat tctcgtggtc ggaggagtgg tgtggaaggc agtgggctgg
     2041 agactcatcg ccctctcctt tggactgtat ggcctcctgt acgtgtatga gcggctgacc
     2101 tggaccacca gagccaagga gagggccttc aagcgccagt ttgtggagta tgccagtgag
     2161 aagctgcagc tcattatcag ttataccggc tctaactgca gccaccaagt tcagcaagaa
     2221 ttgtctggga catttgctca tctgtgccag caagttgaca tcacccggga taatctggag
     2281 caggaaattg ctgccatgaa caagaaagtt gaggctctgg attcacttca gagcaaagcc
     2341 aaattgctca ggaataaagc tggctggttg gacagcgaac tcaacatgtt catacaccag
     2401 tacctgcagc ccagcagata gtgggcagcc agggcggacc tgcaccgaga agagacaggg
     2461 ccgcacctcc catcagctct agtccttggc tgctgcagag agaaggaaag cacccactgt
     2521 cttgtaccag ttactcccta ccccctgcag gaagaccccc agctcatacc cagtggagac
     2581 caacaaggac tggacagctc agccccaagg agtcatgcat gtgtctgtgt ctgctcatca
     2641 tgctcagtcg gttggaagtc actgtgcatt tgataaggtc ttcctcagga tgccatcctg
     2701 cagaacgact gatgggcgcc ttcacaggca tcaggcaggc actcctttca gcccgagtac
     2761 acctacagag agagaatgtt gggggtgact ggactcccca gaaaagttca gggtactgaa
     2821 gaacttgtgt cttgcatttg gccctcagct ttagcacttt ttcccacttg cagagtcttt
     2881 cagttgtgct tggtggccag gctcacacac cctgggcttt agactcaacc agcttatagg
     2941 gaaagctgga gacccttgcc agccagagca aagtaagagc tcaggggacg gtatgtgaac
     3001 tagggtgtcc gatgtggtag tgaggttggt gtctggcatt gtgatgacaa gggactcgcc
     3061 tcccttcttg caagtttgct ccaggtggtt aaaggatgtt gcaggaggaa tggtggaaga
     3121 tgggagctgc ccgggttagt acagaagagg tctctctatc tgacctagca ctgagtggct
     3181 cacaaacctg taaggctcac cttgctaatt tgagctcatc cctgccttgc tacaagctcc
     3241 ctgtggccac cgttctctgg actggattgt gccgatgact gcagctggtt acaaaacgac
     3301 aggagaagcc tggcggctgt tctccttctg ccccaaccct caagcctcct cctcttctgc
     3361 tcctgaagcc tcctgctgct tgcttcgcct catgtcaacg ctgaacttct tactgttaag
     3421 tgttgaaatt gttaatggtc aaaacaggga ggatttcagt caccaaggtt gattgtcttg
     3481 gaagagcagt tttagagtga tgaatccttt gtaggacagg tagagttaga gataaagcac
     3541 tgggctccag cccctcccag aagcccacaa ccaggagctc tctgtgggac ccatgggcca
     3601 tgtcctctcc tgcccatgtc tgtgtgtcac ttcccctcag tctacccttt ttgctgggac
     3661 agtgctggtc ttggccaagg tcagcgtgaa tggaaagaca tagtgcattg ccaggctgga
     3721 cggggtcatc tcacagtggg tcattgccag gctggacggg gtcatctcac agtgggtcag
     3781 gacacatcag tgtcgtgtaa tcccaatgag tgttatgtgc tttttttttg gggggggggt
     3841 agaataaact caaattcttt ttctgtataa aaaaaaaaaa aaaaaaaaaa a
//
