LOCUS       NM_001276401            1858 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Rattus norvegicus mitochondrial fission factor (Mff), transcript
            variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001276401 XM_003750721 XM_003750722 XM_003750723
VERSION     NM_001276401.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Lee,J., Pappalardo,Z., Chopra,D.G., Hennings,T.G., Vaughn,I.,
            Lan,C., Choe,J.J., Ang,K., Chen,S., Arkin,M., McManus,M.T.,
            German,M.S. and Ku,G.M.
  TITLE     A Genetic Interaction Map of Insulin Production Identifies Mfi as
            an Inhibitor of Mitochondrial Fission
  JOURNAL   Endocrinology 159 (9), 3321-3330 (2018)
   PUBMED   30059978
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Zhang,X.M., Zhang,L., Wang,G., Niu,W., He,Z., Ding,L. and Jia,J.
  TITLE     Suppression of mitochondrial fission in experimental cerebral
            ischemia: The potential neuroprotective target of p38 MAPK
            inhibition
  JOURNAL   Neurochem Int 90, 1-8 (2015)
   PUBMED   26116440
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   da Silva,A.F., Mariotti,F.R., Maximo,V. and Campello,S.
  TITLE     Mitochondria dynamism: of shape, transport and cell migration
  JOURNAL   Cell Mol Life Sci 71 (12), 2313-2324 (2014)
   PUBMED   24442478
  REMARK    Review article
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Long,B., Wang,K., Li,N., Murtaza,I., Xiao,J.Y., Fan,Y.Y., Liu,C.Y.,
            Li,W.H., Cheng,Z. and Li,P.
  TITLE     miR-761 regulates the mitochondrial network by targeting
            mitochondrial fission factor
  JOURNAL   Free Radic Biol Med 65, 371-379 (2013)
   PUBMED   23867156
  REMARK    GeneRIF: This study reveals a novel model of mitochondrial fission
            regulation, which is composed of miR-761 and mitochondrial fission
            factor
REFERENCE   5  (bases 1 to 1858)
  AUTHORS   Palmer,C.S., Elgass,K.D., Parton,R.G., Osellame,L.D.,
            Stojanovski,D. and Ryan,M.T.
  TITLE     Adaptor proteins MiD49 and MiD51 can act independently of Mff and
            Fis1 in Drp1 recruitment and are specific for mitochondrial fission
  JOURNAL   J Biol Chem 288 (38), 27584-27593 (2013)
   PUBMED   23921378
REFERENCE   6  (bases 1 to 1858)
  AUTHORS   Loson,O.C., Song,Z., Chen,H. and Chan,D.C.
  TITLE     Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in
            mitochondrial fission
  JOURNAL   Mol Biol Cell 24 (5), 659-667 (2013)
   PUBMED   23283981
REFERENCE   7  (bases 1 to 1858)
  AUTHORS   Palmer,C.S., Osellame,L.D., Stojanovski,D. and Ryan,M.T.
  TITLE     The regulation of mitochondrial morphology: intricate mechanisms
            and dynamic machinery
  JOURNAL   Cell Signal 23 (10), 1534-1545 (2011)
   PUBMED   21683788
  REMARK    Review article
REFERENCE   8  (bases 1 to 1858)
  AUTHORS   Otera,H., Wang,C., Cleland,M.M., Setoguchi,K., Yokota,S.,
            Youle,R.J. and Mihara,K.
  TITLE     Mff is an essential factor for mitochondrial recruitment of Drp1
            during mitochondrial fission in mammalian cells
  JOURNAL   J Cell Biol 191 (6), 1141-1158 (2010)
   PUBMED   21149567
REFERENCE   9  (bases 1 to 1858)
  AUTHORS   Dixit,E., Boulant,S., Zhang,Y., Lee,A.S., Odendall,C., Shum,B.,
            Hacohen,N., Chen,Z.J., Whelan,S.P., Fransen,M., Nibert,M.L.,
            Superti-Furga,G. and Kagan,J.C.
  TITLE     Peroxisomes are signaling platforms for antiviral innate immunity
  JOURNAL   Cell 141 (4), 668-681 (2010)
   PUBMED   20451243
REFERENCE   10 (bases 1 to 1858)
  AUTHORS   Gandre-Babbe,S. and van der Bliek,A.M.
  TITLE     The novel tail-anchored membrane protein Mff controls mitochondrial
            and peroxisomal fission in mammalian cells
  JOURNAL   Mol Biol Cell 19 (6), 2402-2412 (2008)
   PUBMED   18353969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1, FN804971.1 and BC098682.1.
            
            On or before Feb 8, 2013 this sequence version replaced
            XM_003750721.1, XM_003750722.1, XM_003750723.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            contains an alternate exon in the 5' coding region, and lacks two
            in-frame exons, compared to variant 1. It initiates translation at
            an alternate start codon. The encoded isoform (3) is shorter than
            isoform 1 and has a distinct, longer N-terminus.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223111.1, SRR26643429.34461.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000009.1  91455931-91455995
            66-230              FN804971.1         1-165
            231-301             BC098682.1         26-96
            302-471             JAXUCZ010000009.1  91459114-91459283
            472-1854            BC098682.1         97-1479
            1855-1858           JAXUCZ010000009.1  91484168-91484171
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..1858
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /note="mitochondrial fission factor"
                     /db_xref="GeneID:301563"
                     /db_xref="RGD:1310230"
     exon            1..196
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            197..301
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            302..471
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..1168
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="mitochondrial fission factor isoform 3"
                     /protein_id="NP_001263330.1"
                     /db_xref="GeneID:301563"
                     /db_xref="RGD:1310230"
                     /translation="MSMKTGSETSLGRVSGAAFPSPTAAEMAEISRIQYEMEYTEGIS
                     QRMRVPEKLKVAPPNADLEQGFQDGVPNASVIMQVPERIVVTGNNEDISFSRPADLDL
                     IQSTPFKPLALKTPPRVLTLSERPLDFLDLERPPPTPQSEEIRAVGRLKRERSMSENA
                     VRQNGQLVRNDSMYGISSLDAAVEGASEDMSVVDAASLRRQIIKLNRRLQLLEEENKE
                     RAKREMVMYSITVAFWLLNSWLWFRR"
     exon            472..692
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            693..862
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            863..951
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1036
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1858
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacttccgct acggctcctg gaaggggcca gtcctggccg ttctcgcgtc tgtcccggcc
       61 cgccgcggcc gctccgccgc ttctttgccc gggcgcctcg gtgcgctcgg tcaacggcct
      121 ctgcgagcgc tcgcccgagc gccccggagc cggcgagcgg cggccctctc tccggggact
      181 ctccagcagg cccaggggat aaaggtgact caatctggca catgcgcatt ggagcagtaa
      241 ggagttagta tgaagcccag aagcagatag tgccaagtag caagcctgct gtttctcatt
      301 tctggaaaag cagtgtccgt gttgttatgt acacctccaa aaacagttga gatctgtagg
      361 gaagtgttgt gtaaagtaaa caccacaggg tagcagtgcc catagctatt gtagacgtgt
      421 atgctctgtt aaaatgagta tgaaaacggg cagtgagaca tcactaggaa gggtgagtgg
      481 ggcggcattt ccttctccca ctgctgctga gatggcagaa attagtcgaa ttcagtacga
      541 aatggaatac actgaaggta ttagtcagcg aatgagggtc ccggaaaaat taaaagtagc
      601 accaccaaat gctgacctgg aacaagggtt ccaagatgga gttccaaatg ccagtgtgat
      661 aatgcaagtc ccagagagga tcgtggttac aggaaataat gaagacattt ccttttcaag
      721 accagcagat cttgacctta tccagtccac tccctttaaa cctctggcgc tgaaaacacc
      781 tccacgtgtg ctcacactga gtgagagacc gctagatttc ctggatttag aaagaccacc
      841 tccaactcct caaagcgaag agatccgagc agttggcagg ctaaaaagag aacgctctat
      901 gagtgaaaat gctgttcgcc agaatggaca gttggtcaga aacgattcca tgtatggcat
      961 ttcaagccta gatgcagctg ttgaaggagc gtcagaggac atgtctgtgg tagatgcggc
     1021 ttcattgaga cgtcagataa tcaaattaaa cagacgtcta caacttctgg aagaggagaa
     1081 taaagagcgt gctaaaagag aaatggtcat gtattcaatt actgtagcgt tctggctgct
     1141 taacagctgg ctctggtttc gacgctagag gtaacctcag cattcacaga tattgtctca
     1201 acacctggaa atataaagga tttgcaaact tcattgtttc tgtctttgca tcgtctgccg
     1261 tttttctagt ccaagccctg acaatgtatt tcttgcagaa tgcagggaag gacctgtctg
     1321 tagagtggag agctgacctg tcgctgacgg gcgctcagcc cgctccgcag tggcgcctac
     1381 acacgctcct ttgcatgtgc tgtaaatagg ctccaggttc ctttgtttgt ttctaaagaa
     1441 aataattttt ttggcctcat cagtctgtac agctaattct ctaaacagaa atgacagtca
     1501 taaagagcaa gtttagaaaa ctatgtgtga aagaaaagtg ttctgtcctg tttttcagat
     1561 gattaagcag tttctttgat agatgcttct tgtatccgca tctccacagc aatgcgtttt
     1621 aagtcctagt gtggtgcagg acttaagagc agtcaaacca cctaactcca tcctcccctg
     1681 tgcagacgga gtttaaagct cctaacaagt cagcagttga tctgtgtgca atgtgttgtt
     1741 ttgactttca tcttagtttt ctatgaagta tgtttttacc aagtccatgt gcgaatgatt
     1801 taaaacctaa agaataaggt aaaatgtagt gtatttaata aactgtcaac caaagcaa
//
