LOCUS       NM_001271284            1907 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus mitochondrial fission factor (Mff), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001271284 XM_003750720
VERSION     NM_001271284.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1907)
  AUTHORS   Lee,J., Pappalardo,Z., Chopra,D.G., Hennings,T.G., Vaughn,I.,
            Lan,C., Choe,J.J., Ang,K., Chen,S., Arkin,M., McManus,M.T.,
            German,M.S. and Ku,G.M.
  TITLE     A Genetic Interaction Map of Insulin Production Identifies Mfi as
            an Inhibitor of Mitochondrial Fission
  JOURNAL   Endocrinology 159 (9), 3321-3330 (2018)
   PUBMED   30059978
REFERENCE   2  (bases 1 to 1907)
  AUTHORS   Zhang,X.M., Zhang,L., Wang,G., Niu,W., He,Z., Ding,L. and Jia,J.
  TITLE     Suppression of mitochondrial fission in experimental cerebral
            ischemia: The potential neuroprotective target of p38 MAPK
            inhibition
  JOURNAL   Neurochem Int 90, 1-8 (2015)
   PUBMED   26116440
REFERENCE   3  (bases 1 to 1907)
  AUTHORS   da Silva,A.F., Mariotti,F.R., Maximo,V. and Campello,S.
  TITLE     Mitochondria dynamism: of shape, transport and cell migration
  JOURNAL   Cell Mol Life Sci 71 (12), 2313-2324 (2014)
   PUBMED   24442478
  REMARK    Review article
REFERENCE   4  (bases 1 to 1907)
  AUTHORS   Long,B., Wang,K., Li,N., Murtaza,I., Xiao,J.Y., Fan,Y.Y., Liu,C.Y.,
            Li,W.H., Cheng,Z. and Li,P.
  TITLE     miR-761 regulates the mitochondrial network by targeting
            mitochondrial fission factor
  JOURNAL   Free Radic Biol Med 65, 371-379 (2013)
   PUBMED   23867156
  REMARK    GeneRIF: This study reveals a novel model of mitochondrial fission
            regulation, which is composed of miR-761 and mitochondrial fission
            factor
REFERENCE   5  (bases 1 to 1907)
  AUTHORS   Palmer,C.S., Elgass,K.D., Parton,R.G., Osellame,L.D.,
            Stojanovski,D. and Ryan,M.T.
  TITLE     Adaptor proteins MiD49 and MiD51 can act independently of Mff and
            Fis1 in Drp1 recruitment and are specific for mitochondrial fission
  JOURNAL   J Biol Chem 288 (38), 27584-27593 (2013)
   PUBMED   23921378
REFERENCE   6  (bases 1 to 1907)
  AUTHORS   Loson,O.C., Song,Z., Chen,H. and Chan,D.C.
  TITLE     Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in
            mitochondrial fission
  JOURNAL   Mol Biol Cell 24 (5), 659-667 (2013)
   PUBMED   23283981
REFERENCE   7  (bases 1 to 1907)
  AUTHORS   Palmer,C.S., Osellame,L.D., Stojanovski,D. and Ryan,M.T.
  TITLE     The regulation of mitochondrial morphology: intricate mechanisms
            and dynamic machinery
  JOURNAL   Cell Signal 23 (10), 1534-1545 (2011)
   PUBMED   21683788
  REMARK    Review article
REFERENCE   8  (bases 1 to 1907)
  AUTHORS   Otera,H., Wang,C., Cleland,M.M., Setoguchi,K., Yokota,S.,
            Youle,R.J. and Mihara,K.
  TITLE     Mff is an essential factor for mitochondrial recruitment of Drp1
            during mitochondrial fission in mammalian cells
  JOURNAL   J Cell Biol 191 (6), 1141-1158 (2010)
   PUBMED   21149567
REFERENCE   9  (bases 1 to 1907)
  AUTHORS   Dixit,E., Boulant,S., Zhang,Y., Lee,A.S., Odendall,C., Shum,B.,
            Hacohen,N., Chen,Z.J., Whelan,S.P., Fransen,M., Nibert,M.L.,
            Superti-Furga,G. and Kagan,J.C.
  TITLE     Peroxisomes are signaling platforms for antiviral innate immunity
  JOURNAL   Cell 141 (4), 668-681 (2010)
   PUBMED   20451243
REFERENCE   10 (bases 1 to 1907)
  AUTHORS   Gandre-Babbe,S. and van der Bliek,A.M.
  TITLE     The novel tail-anchored membrane protein Mff controls mitochondrial
            and peroxisomal fission in mammalian cells
  JOURNAL   Mol Biol Cell 19 (6), 2402-2412 (2008)
   PUBMED   18353969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1, FN804971.1, BC098682.1 and FM107137.1.
            
            On Sep 12, 2012 this sequence version replaced XM_003750720.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225115.1, SRR22399489.3377902.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000009.1  91455931-91455995
            66-205              FN804971.1         1-140
            206-781             BC098682.1         1-576
            782-1000            FM107137.1         363-581
            1001-1903           BC098682.1         577-1479
            1904-1907           JAXUCZ010000009.1  91484168-91484171
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..1907
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /note="mitochondrial fission factor"
                     /db_xref="GeneID:301563"
                     /db_xref="RGD:1310230"
     exon            1..196
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            197..301
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            302..522
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..1217
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="mitochondrial fission factor isoform 1"
                     /protein_id="NP_001258213.1"
                     /db_xref="GeneID:301563"
                     /db_xref="RGD:1310230"
                     /translation="MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQDGV
                     PNASVIMQVPERIVVTGNNEDISFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLD
                     FLDLERPPPTPQSEEIRAVGRLKRERSMSENAVRQNGQLVRNDSIVTPSPPQARVCPP
                     HMLPEDGASLSSARGILSLIQSSTRRAYQQILDVLDENRRPVLRGGSAAATSNPHHDN
                     VRYGISSLDAAVEGASEDMSVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSI
                     TVAFWLLNSWLWFRR"
     exon            523..692
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            693..781
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            782..940
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1000
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1085
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1907
                     /gene="Mff"
                     /gene_synonym="RGD1310230"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacttccgct acggctcctg gaaggggcca gtcctggccg ttctcgcgtc tgtcccggcc
       61 cgccgcggcc gctccgccgc ttctttgccc gggcgcctcg gtgcgctcgg tcaacggcct
      121 ctgcgagcgc tcgcccgagc gccccggagc cggcgagcgg cggccctctc tccggggact
      181 ctccagcagg cccaggggat aaaggtgact caatctggca catgcgcatt ggagcagtaa
      241 ggagttagta tgaagcccag aagcagatag tgccaagtag caagcctgct gtttctcatt
      301 tggtgagtgg ggcggcattt ccttctccca ctgctgctga gatggcagaa attagtcgaa
      361 ttcagtacga aatggaatac actgaaggta ttagtcagcg aatgagggtc ccggaaaaat
      421 taaaagtagc accaccaaat gctgacctgg aacaagggtt ccaagatgga gttccaaatg
      481 ccagtgtgat aatgcaagtc ccagagagga tcgtggttac aggaaataat gaagacattt
      541 ccttttcaag accagcagat cttgacctta tccagtccac tccctttaaa cctctggcgc
      601 tgaaaacacc tccacgtgtg ctcacactga gtgagagacc gctagatttc ctggatttag
      661 aaagaccacc tccaactcct caaagcgaag agatccgagc agttggcagg ctaaaaagag
      721 aacgctctat gagtgaaaat gctgttcgcc agaatggaca gttggtcaga aacgattcca
      781 ttgtgacacc atcaccgcca caggctcggg tctgtcctcc ccatatgcta cctgaagatg
      841 gagctagtct ctcctctgcc cgtggcattt tgtcgcttat ccagtcttct actcgtaggg
      901 cttaccagca gatcttggat gtgctggatg aaaaccgcag acctgtgttg cgtggtgggt
      961 cagctgccgc cacttctaat cctcatcatg acaacgtcag gtatggcatt tcaagcctag
     1021 atgcagctgt tgaaggagcg tcagaggaca tgtctgtggt agatgcggct tcattgagac
     1081 gtcagataat caaattaaac agacgtctac aacttctgga agaggagaat aaagagcgtg
     1141 ctaaaagaga aatggtcatg tattcaatta ctgtagcgtt ctggctgctt aacagctggc
     1201 tctggtttcg acgctagagg taacctcagc attcacagat attgtctcaa cacctggaaa
     1261 tataaaggat ttgcaaactt cattgtttct gtctttgcat cgtctgccgt ttttctagtc
     1321 caagccctga caatgtattt cttgcagaat gcagggaagg acctgtctgt agagtggaga
     1381 gctgacctgt cgctgacggg cgctcagccc gctccgcagt ggcgcctaca cacgctcctt
     1441 tgcatgtgct gtaaataggc tccaggttcc tttgtttgtt tctaaagaaa ataatttttt
     1501 tggcctcatc agtctgtaca gctaattctc taaacagaaa tgacagtcat aaagagcaag
     1561 tttagaaaac tatgtgtgaa agaaaagtgt tctgtcctgt ttttcagatg attaagcagt
     1621 ttctttgata gatgcttctt gtatccgcat ctccacagca atgcgtttta agtcctagtg
     1681 tggtgcagga cttaagagca gtcaaaccac ctaactccat cctcccctgt gcagacggag
     1741 tttaaagctc ctaacaagtc agcagttgat ctgtgtgcaa tgtgttgttt tgactttcat
     1801 cttagttttc tatgaagtat gtttttacca agtccatgtg cgaatgattt aaaacctaaa
     1861 gaataaggta aaatgtagtg tatttaataa actgtcaacc aaagcaa
//
