LOCUS       NM_001034124            1506 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus microfibril associated protein 4 (Mfap4), mRNA.
ACCESSION   NM_001034124 XM_213313
VERSION     NM_001034124.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1506)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 1506)
  AUTHORS   Pilecki,B., Holm,A.T., Schlosser,A., Moeller,J.B., Wohl,A.P.,
            Zuk,A.V., Heumuller,S.E., Wallis,R., Moestrup,S.K., Sengle,G.,
            Holmskov,U. and Sorensen,G.L.
  TITLE     Characterization of Microfibrillar-associated Protein 4 (MFAP4) as
            a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic
            Fiber Formation
  JOURNAL   J Biol Chem 291 (3), 1103-1114 (2016)
   PUBMED   26601954
REFERENCE   3  (bases 1 to 1506)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 1506)
  AUTHORS   Kasamatsu,S., Hachiya,A., Fujimura,T., Sriwiriyanont,P., Haketa,K.,
            Visscher,M.O., Kitzmiller,W.J., Bello,A., Kitahara,T.,
            Kobinger,G.P. and Takema,Y.
  TITLE     Essential role of microfibrillar-associated protein 4 in human
            cutaneous homeostasis and in its photoprotection
  JOURNAL   Sci Rep 1, 164 (2011)
   PUBMED   22355679
REFERENCE   5  (bases 1 to 1506)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   6  (bases 1 to 1506)
  AUTHORS   Toyoshima,T., Ishida,T., Nishi,N., Kobayashi,R., Nakamura,T. and
            Itano,T.
  TITLE     Differential gene expression of 36-kDa microfibril-associated
            glycoprotein (MAGP-36/MFAP4) in rat organs
  JOURNAL   Cell Tissue Res 332 (2), 271-278 (2008)
   PUBMED   18322703
  REMARK    GeneRIF: differential gene expression of microfibril-associated
            glycoprotein (MAGP-36); MAGP-36 was expressed highly in sites rich
            in elastic fibers - aorta, skin & esophagus, but it was also
            expressed highly in other sites containing no elastic fibers.
REFERENCE   7  (bases 1 to 1506)
  AUTHORS   Toyoshima,T., Yamashita,K., Furuichi,H., Shishibori,T., Itano,T.
            and Kobayashi,R.
  TITLE     Ultrastructural distribution of 36-kD microfibril-associated
            glycoprotein (MAGP-36) in human and bovine tissues
  JOURNAL   J Histochem Cytochem 47 (8), 1049-1056 (1999)
   PUBMED   10424889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 5, 2020 this sequence version replaced NM_001034124.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100616.1, SRR22582416.1722613.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                JAXUCZ010000010.1  46666653-46666691
            40-124              JAXUCZ010000010.1  46666915-46666999
            125-279             JAXUCZ010000010.1  46667227-46667381
            280-376             JAXUCZ010000010.1  46667946-46668042
            377-559             JAXUCZ010000010.1  46668115-46668297
            560-1506            JAXUCZ010000010.1  46668667-46669613
FEATURES             Location/Qualifiers
     source          1..1506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1506
                     /gene="Mfap4"
                     /gene_synonym="Magp-36"
                     /note="microfibril associated protein 4"
                     /db_xref="GeneID:287382"
                     /db_xref="RGD:1307841"
     exon            1..39
                     /gene="Mfap4"
                     /gene_synonym="Magp-36"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..807
                     /gene="Mfap4"
                     /gene_synonym="Magp-36"
                     /note="microfibril-associated glycoprotein 4;
                     microfibrillar-associated protein 4;
                     microfibril-associated glycoprotein 4-like"
                     /codon_start=1
                     /product="microfibril-associated glycoprotein 4 precursor"
                     /protein_id="NP_001029296.2"
                     /db_xref="GeneID:287382"
                     /db_xref="RGD:1307841"
                     /translation="MKTLSGLPLLLLLLSTPPPCAPQASGIRGDALEKSCLQQPLDCD
                     DIYMQGYQEDGVYLIYPYGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWNDYK
                     LGFGRADGEYWLGLQNLHLLTLKQKYELRVDLEDFENNTAYAKYVDFSISPNAVSAEE
                     DGYTLYVAGFEDGGAGDSLSYHSGQKFSTFDRDQDLFVQNCAALSSGAFWFRSCHFAN
                     LNGFYLGGSHLSYANGINWAQWKGFYYSLKRTEMKIRRA"
     exon            40..124
                     /gene="Mfap4"
                     /gene_synonym="Magp-36"
                     /inference="alignment:Splign:2.1.0"
     exon            125..279
                     /gene="Mfap4"
                     /gene_synonym="Magp-36"
                     /inference="alignment:Splign:2.1.0"
     exon            280..376
                     /gene="Mfap4"
                     /gene_synonym="Magp-36"
                     /inference="alignment:Splign:2.1.0"
     exon            377..559
                     /gene="Mfap4"
                     /gene_synonym="Magp-36"
                     /inference="alignment:Splign:2.1.0"
     exon            560..1506
                     /gene="Mfap4"
                     /gene_synonym="Magp-36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagccag cctctctcaa ctgagctaac agcatgaaga ccctctcagg cctgccactg
       61 ctgctgctgc tgctctccac gcctcctccc tgcgccccac aagcctccgg gatccgggga
      121 gatgctctgg agaagtcctg ccttcagcaa cccctggact gtgatgatat ctacatgcag
      181 ggctatcagg aagatggggt gtacctcatc tacccctatg gccccagtgt gccggtccct
      241 gtcttctgtg acatgacaac cgagggtggc aagtggacgg ttttccagaa aagattcaac
      301 ggctcagtga gtttcttccg gggttggaac gactacaagc tgggcttcgg ccgtgctgac
      361 ggggagtact ggctggggct gcagaacctg cacctcctga cactgaagca gaagtatgag
      421 ttgcgcgtgg acttggaaga ctttgagaac aacacagcct atgctaagta tgttgacttc
      481 tccatctccc ccaatgcggt cagtgcggag gaggatggct ataccctcta cgtggctggc
      541 ttcgaggatg gcggggcagg tgactcactg tcctaccaca gtggccagaa gttctccacc
      601 tttgatcgag accaggacct ctttgtgcag aactgtgcag ccctctcctc aggagccttc
      661 tggttcagaa gctgccattt tgccaacctc aacggcttct acctgggtgg gtcccacctc
      721 tcctatgcca atggcatcaa ctgggcccag tggaaaggct tctactactc cctcaagcgc
      781 actgagatga aaattcgtcg tgcctgaagg gctggcccaa gcaggcccca tctctcccct
      841 ggaagcccca agtctccatg ttctccctcc atgctctacc cacaaatcct gagcaccagc
      901 tatgccctgg caaatccctg ccccacatac aggcaggctc tgtagcactc tacctgaggt
      961 taggctgtca gcgccctcca ggcttttctg tggccaaacc attccagcct ggatctagct
     1021 gaaatccata aaactccaag ttgcttctac cctttcacga cagctgaaag ccagaagcta
     1081 ccttctagct gccagcttat acatcccacc tcagccaatt ccttactgca gacccatctg
     1141 tgtagggcta ccctcgacag agaaatacag cacctatggc attgccaatc agctcaggca
     1201 tggccacagt cacaccccag cactcccaca gctctcctca gaatacttcc taccttggtc
     1261 tcatcaacta actcccttaa gtgagcatca tggagcccaa acccatctgc cttcactcat
     1321 ccctcaaaat tcaacaccaa gaccacactc accacagctg ctgcccatcg actctgaagg
     1381 agccacggca aagcagctta atttggtccc ctacttccct agggattgtc atgagagagg
     1441 cagcagagaa ctctgggggc tgggagtggt gggaagtaga ggtctcaata aaccttcagg
     1501 atctga
//
