LOCUS       NM_001107377            3213 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus mex-3 RNA binding family member C (Mex3c), mRNA.
ACCESSION   NM_001107377 XM_001062342 XM_225735
VERSION     NM_001107377.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3213)
  AUTHORS   Jiao Y, George SK, Zhao Q, Hulver MW, Hutson SM, Bishop CE and Lu
            B.
  TITLE     Mex3c mutation reduces adiposity and increases energy expenditure
  JOURNAL   Mol Cell Biol 32 (21), 4350-4362 (2012)
   PUBMED   22927639
REFERENCE   2  (bases 1 to 3213)
  AUTHORS   Cano F, Bye H, Duncan LM, Buchet-Poyau K, Billaud M, Wills MR and
            Lehner PJ.
  TITLE     The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination
            with MHC-I mRNA degradation
  JOURNAL   EMBO J 31 (17), 3596-3606 (2012)
   PUBMED   22863774
REFERENCE   3  (bases 1 to 3213)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3213)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3213)
  AUTHORS   Jiao Y, Bishop CE and Lu B.
  TITLE     Mex3c regulates insulin-like growth factor 1 (IGF1) expression and
            promotes postnatal growth
  JOURNAL   Mol Biol Cell 23 (8), 1404-1413 (2012)
   PUBMED   22357625
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473971.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062342.1, XM_225735.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA924041.1, CB606619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3213
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..3213
                     /gene="Mex3c"
                     /gene_synonym="Rkhd2"
                     /note="mex-3 RNA binding family member C"
                     /db_xref="GeneID:307271"
                     /db_xref="RGD:1309023"
     exon            1..216
                     /gene="Mex3c"
                     /gene_synonym="Rkhd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1442
                     /gene="Mex3c"
                     /gene_synonym="Rkhd2"
                     /EC_number="2.3.2.27"
                     /note="RNA-binding protein MEX3C; ring finger and KH
                     domain containing 2; mex-3 homolog C"
                     /codon_start=1
                     /product="RNA-binding E3 ubiquitin-protein ligase MEX3C"
                     /protein_id="NP_001100847.1"
                     /db_xref="GeneID:307271"
                     /db_xref="RGD:1309023"
                     /translation="MMAAMLSHAYGPGGGGAAAAALNGEQAALLRRKSVNTTECVPVP
                     SSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAA
                     EHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQ
                     THTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTD
                     VSFEGGTLGSAWLSSNPVPPSRARMMSNYRNDSSSSLGSGSTDSYFGSNRLADFSPTS
                     PFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGN
                     MKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSY
                     SSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCP
                     VCQTAVTQAIQIHS"
     exon            217..3213
                     /gene="Mex3c"
                     /gene_synonym="Rkhd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcggc ggcgggggtg ctgtacggag gggacgatgc ccagggcatg atggcggcga
       61 tgctgtccca cgcctacggc cccggcggcg gcggggccgc cgctgccgcc ctgaacggag
      121 agcaagcggc cctgctgaga aggaagagcg tcaacaccac cgagtgcgtc ccggtgccca
      181 gttccgaaca tgtcgctgag attgtcggac gccagggttg taaaattaaa gcactgagag
      241 ccaagacaaa cacgtatatc aagacacctg tccgcggtga agagcccatt tttgttgtca
      301 ctggacggaa agaagatgtt gccatggcca agagagaaat cctttcggct gcagagcact
      361 tctctatgat ccgtgcatct cggaacaaaa atggccccgc gcttggaggg ttatcgtgta
      421 gtcctaatct gcccggtcaa accacagtcc aagtcagggt cccctatcgt gtggtagggc
      481 tagtggttgg accaaaagga gcaacaatta agagaattca gcaacagacc cacacataca
      541 tagttactcc gagcagagat aaggagccag tctttgaagt cacagggatg ccggaaaatg
      601 ttgatcgagc acgagaagaa atagaaatgc atattgccat gcgtacaggg aactatatag
      661 agctcaatga agaaaatgat ttccactata acggtaccga tgtgagcttt gaaggtggca
      721 ctctaggctc tgcgtggctc tcttccaatc cagttcctcc aagccgagca agaatgatgt
      781 ccaactatcg aaatgatagt tctagttctc taggaagtgg ttccactgat tcctattttg
      841 gaagcaatag gctggctgac tttagtccaa caagcccgtt tagcacagga aacttttggt
      901 ttggagatac actaccgtct gtaggctcag aagaccttgc agtagactct cctgcctttg
      961 actctttacc aacatctgct caaactatct ggactccatt tgaaccagtt aacccactct
     1021 ctggctttgg gagtgatcct tctggtaaca tgaagactca gcgtagagga agtcagccat
     1081 caactcctcg tctgtctcct acctttcctg agagcataga acacccactt gctcgaaggg
     1141 ttaggagcga cccacctagt acaggcaacc atgttggcct tccaatatac atccctgctt
     1201 tttctaatgg taccaatagt tattcctctt ccaatggtgg ttccacctct agctcacctc
     1261 cagaatcaag aagaaagcac gactgtgtga tttgctttga gaatgaagtt attgctgccc
     1321 tagttccatg tggccacaac ctcttctgca tggaatgtgc caacaagatc tgtgaaaaga
     1381 gaacgccatc atgtccagtt tgccagacag ctgttactca ggcaatccaa attcactctt
     1441 aactatatat atatacataa atactatatc ttatatggac tcataaaggc atgggtataa
     1501 tggtataccc cagtaaactt cctaatgaat tcttatgact gttatcaggc tttattggga
     1561 ttaggctaaa gttgttagta cacttataaa aggctgctat ggtaacacta aacctaagtg
     1621 gtctcttgtc tattagtttg gtttgaatta ttaatactat cttgtagact cggagacata
     1681 gcttgtatag gaattgttaa agctgaagtt ctacttggct gtgtaaccta tgagcaaaat
     1741 gtatccatct gaggttgtag tcagtgggtc ccaaagccta gccgcattaa gagtttatgg
     1801 aggtgcctgg catcacaaat gactgacact ccagcgctgc cttcttcaca ctgccagttt
     1861 tgacaaaaac aggtttgttt tttattttac aacaacttct gcctaattct gcaggattgc
     1921 aagtaacttt ttaaagcatt gtgattactt actagtaata atagggctga tggcagttta
     1981 ctagatcact ggttataatt tgggacaaaa actgctacat tgactttcat ctcgcccaga
     2041 gtgctcaagg ctggtgtgtt cagtggatca ggagtacaat tgtctttgat tgtgaattcc
     2101 tacccattgc ctctctcagt gaatgtggaa atggccgcct gggttttccc atttctggat
     2161 gggctttggg aaacacctat attggctgaa aatttgagaa tgtgaacatt ccattcatta
     2221 gtctgatcaa gatattaatt aatatttaga ctgtagctca aaatgtgaaa cattttttgt
     2281 tcaatccata tttgtcttgc acattataaa tatattttta ttttttagta atgtagggga
     2341 tggggaggga gacaataatg cccttggcat gattcatgaa agcagctgtg acaacctcca
     2401 atcagtttac ttcatttcaa acctatttcc aatcacaagg aaagatttct ttaagacact
     2461 tgtccatttc acctgtggat gttttaacgt catcctcagt atgtccccaa atttgctggt
     2521 attgagagga taaaacatta tactggtggg tttttctact aattattttt tgaaacgtta
     2581 ttttcccaac acaaaagagc tttttttctc agtataacaa aaattgagat cttatgtgta
     2641 ttcaatagta aatagacaaa attttatttt ttatttccac ttgaagagtt acatttcgta
     2701 taaagtttac aaataacagt ttttattttg atttttttca gtataaaaag ttgccttgat
     2761 ggcacattat gaggtaatgc taatggcttg taggatagtt gattgtctgt attgaatcct
     2821 aatctctagc tgccgtcttg tagatatgga cgaatgtcac ccagcatgtg tttcgtattt
     2881 ttttgcatcg tacactgcaa ctaataagcc aaggaatcga catatattag gtgcgtgtac
     2941 tatttctaaa aaccacaaac taagaatgat aaattatcaa tatagtttag tatttgctaa
     3001 ttttactaca ctcttttgtt atgtatatgt agggaagtca tagggattat aaattcaatt
     3061 tgagtaaagt ttaaaaccat atattttatg ataaagggcc tttaacttaa gatggccaaa
     3121 gcactgatat tatatatttg ctgtaaagag aattataaga gttttatttt tctgatatta
     3181 aaagttactt aataaagact tgtttccatt aac
//
