LOCUS       NM_001114181            1053 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus methyltransferase 5, N6-adenosine (Mettl5), mRNA.
ACCESSION   NM_001114181 XM_578126
VERSION     NM_001114181.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1053)
  AUTHORS   Richard,E.M., Polla,D.L., Assir,M.Z., Contreras,M., Shahzad,M.,
            Khan,A.A., Razzaq,A., Akram,J., Tarar,M.N., Blanpied,T.A.,
            Ahmed,Z.M., Abou Jamra,R., Wieczorek,D., van Bokhoven,H.,
            Riazuddin,S. and Riazuddin,S.
  TITLE     Bi-allelic Variants in METTL5 Cause Autosomal-Recessive
            Intellectual Disability and Microcephaly
  JOURNAL   Am J Hum Genet 105 (4), 869-878 (2019)
   PUBMED   31564433
REFERENCE   2  (bases 1 to 1053)
  AUTHORS   van Tran,N., Ernst,F.G.M., Hawley,B.R., Zorbas,C., Ulryck,N.,
            Hackert,P., Bohnsack,K.E., Bohnsack,M.T., Jaffrey,S.R., Graille,M.
            and Lafontaine,D.L.J.
  TITLE     The human 18S rRNA m6A methyltransferase METTL5 is stabilized by
            TRMT112
  JOURNAL   Nucleic Acids Res 47 (15), 7719-7733 (2019)
   PUBMED   31328227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC158754.1 and CH473949.1.
            
            On May 14, 2008 this sequence version replaced XM_578126.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158754.1, BQ206740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1053              BC158754.1         1-1053
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..1053
                     /gene="Mettl5"
                     /gene_synonym="RGD1566062"
                     /note="methyltransferase 5, N6-adenosine"
                     /db_xref="GeneID:502632"
                     /db_xref="RGD:1566062"
     exon            1..327
                     /gene="Mettl5"
                     /gene_synonym="RGD1566062"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..848
                     /gene="Mettl5"
                     /gene_synonym="RGD1566062"
                     /note="methyltransferase-like protein 5; methyltransferase
                     like 5"
                     /codon_start=1
                     /product="rRNA N6-adenosine-methyltransferase METTL5"
                     /protein_id="NP_001107653.1"
                     /db_xref="GeneID:502632"
                     /db_xref="RGD:1566062"
                     /translation="MKKLKLKELESRLQEVDGFEKPKLLLEQYPTRPHIAACMLYTIH
                     NTYDDIESKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNV
                     DMIQCDVYSLSSRMSKLFDTVIMNPPFGTKNNKGTDMAFLKTALGMARTAVYSLHKSS
                     TREHIQKKAAEWKVKTEIIAELRYDLPALYNFHKKKSVDIEVDLIRFSF"
     exon            328..442
                     /gene="Mettl5"
                     /gene_synonym="RGD1566062"
                     /inference="alignment:Splign:2.1.0"
     exon            443..624
                     /gene="Mettl5"
                     /gene_synonym="RGD1566062"
                     /inference="alignment:Splign:2.1.0"
     exon            625..707
                     /gene="Mettl5"
                     /gene_synonym="RGD1566062"
                     /inference="alignment:Splign:2.1.0"
     exon            708..759
                     /gene="Mettl5"
                     /gene_synonym="RGD1566062"
                     /inference="alignment:Splign:2.1.0"
     exon            760..809
                     /gene="Mettl5"
                     /gene_synonym="RGD1566062"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1030
                     /gene="Mettl5"
                     /gene_synonym="RGD1566062"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagctagca gcttcggtgt gctttcttgg cgctcctagg ttccacgggc ggcaatcccc
       61 gcgaggccca tgggattccc tcgctgagtc cttagtagtc cgtcccggat cctactccct
      121 accctcgctt gcaccgctgt ggagtttcgg gttaggtagt cttccctgca ggtcctgtgc
      181 tgttaagccc caggagccca aactttaatg agaaaacgat gaagaagtta aagcttaagg
      241 aactagagag tcgtctgcaa gaagtggatg gattcgaaaa gcccaagtta cttctagaac
      301 agtatcccac taggccgcac attgcagcat gcatgcttta tacaatccac aatacatacg
      361 acgacattga gagtaaagca gttgcagatc taggatgtgg ttgtggagta ctcagtattg
      421 gagccgcaat gttaggagca gggttgtgtg ttggatttga catagatgaa gatgcactgg
      481 aaatatttaa taaaaatgtg gaagagtttg agttaacaaa tgtcgatatg attcagtgtg
      541 atgtgtactc attatctagc agaatgtcca agttatttga cacagtaatt atgaatcctc
      601 cctttgggac caaaaataat aaagggacag atatggcttt tctgaagact gctttgggaa
      661 tggcaagaac agcagtgtat tctttacaca agtcctcaac tagagaacat attcagaaga
      721 aagctgccga gtggaaagtg aagacagaga ttatcgcaga gcttcgatat gacctaccag
      781 cattatacaa ctttcataaa aagaaatcag tggacattga agtggaccta attcgctttt
      841 ctttttaaaa gcttctgaag acaaaaagca gcttaaaacc taactaagga ataaaaacac
      901 tgcttactaa ataaactact tgtctctagc accattctct cttttcttat gctttgatgc
      961 gggttcttct ctgtctcttc cgtctcttcc tcttttcact ggtcctatta caacaaagaa
     1021 ttttgttaaa aaaaaaaaaa aaaaaaaaaa aaa
//
