LOCUS       NM_001191814            2039 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus methyltransferase 4, N6-adenosine (Mettl4), mRNA.
ACCESSION   NM_001191814 XM_237515
VERSION     NM_001191814.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2039)
  AUTHORS   Feng,Y., Dong,H., Sun,B., Hu,Y., Yang,Y., Jia,Y., Jia,L., Zhong,X.
            and Zhao,R.
  TITLE     METTL3/METTL14 Transactivation and m6A-Dependent TGF-beta1
            Translation in Activated Kupffer Cells
  JOURNAL   Cell Mol Gastroenterol Hepatol 12 (3), 839-856 (2021)
   PUBMED   33992834
  REMARK    GeneRIF: METTL3/METTL14 Transactivation and m(6)A-Dependent
            TGF-beta1 Translation in Activated Kupffer Cells.
REFERENCE   2  (bases 1 to 2039)
  AUTHORS   Chen,H., Gu,L., Orellana,E.A., Wang,Y., Guo,J., Liu,Q., Wang,L.,
            Shen,Z., Wu,H., Gregory,R.I., Xing,Y. and Shi,Y.
  TITLE     METTL4 is an snRNA m6Am methyltransferase that regulates RNA
            splicing
  JOURNAL   Cell Res 30 (6), 544-547 (2020)
   PUBMED   31913360
REFERENCE   3  (bases 1 to 2039)
  AUTHORS   Kweon,S.M., Chen,Y., Moon,E., Kvederaviciute,K., Klimasauskas,S.
            and Feldman,D.E.
  TITLE     An Adversarial DNA N6-Methyladenine-Sensor Network Preserves
            Polycomb Silencing
  JOURNAL   Mol Cell 74 (6), 1138-1147 (2019)
   PUBMED   30982744
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            [WARNING] On Jul 31, 2024 this sequence was replaced by
            NM_001191814.2.
            
            On Jul 17, 2010 this sequence version replaced XM_237515.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               JAXUCZ010000009.1  118889613-118890005
            394-456             JAXUCZ010000009.1  118893443-118893505
            457-830             JAXUCZ010000009.1  118896793-118897166
            831-896             JAXUCZ010000009.1  118897980-118898045
            897-1071            JAXUCZ010000009.1  118904121-118904295
            1072-1178           JAXUCZ010000009.1  118906046-118906152
            1179-1270           JAXUCZ010000009.1  118906517-118906608
            1271-2039           JAXUCZ010000009.1  118910705-118911473
FEATURES             Location/Qualifiers
     source          1..2039
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     gene            1..2039
                     /gene="Mettl4"
                     /gene_synonym="RGD1306451"
                     /note="methyltransferase 4, N6-adenosine"
                     /db_xref="GeneID:316731"
                     /db_xref="RGD:1306451"
     CDS             1..1416
                     /gene="Mettl4"
                     /gene_synonym="RGD1306451"
                     /EC_number="2.1.1.72"
                     /note="methyltransferase-like protein 4; methyltransferase
                     like 4"
                     /codon_start=1
                     /product="N(6)-adenine-specific methyltransferase METTL4"
                     /protein_id="NP_001178743.1"
                     /db_xref="GeneID:316731"
                     /db_xref="RGD:1306451"
                     /translation="MSVVHHLPPGWLLDHLSFINKVNYQLCQHQEPFCSKNKPTSSVY
                     LDSLQPDPVSPFGTPAPCFAPDATTVLDKEDGGSCEVITQKYVFRSELFNVTKPYITP
                     AVHKKDQQSKKDENLVTGEKQEVSVSVGKKRKRCVAFNRGELDAMEYHTKIRELILDG
                     SSQLIQEGLRSGFLFPLVEKHDGSSGRITLPLDACNLSELCEMAKHLPSLNDMELQTL
                     QLMGDDVFVTELDLSSRIIENNSSFSKMITLMGQRYLLPPKSSFLLSDISCMQPLLNC
                     NKTFDVIVIDPPWENKSVKRSNRYNSLSPQQIKRMPVPKLAAPDCLVVTWVTNRQKHL
                     CFVKEELYPSWSVEVIAEWYWVKITNSGEFVFPLDSLHKKPYECLVLGRVKEKTALAL
                     RNEAVRTPPVPDQRLIVSVPCALHSHKPPLAEVLKDYIKPGGQCLELFARNLQPGWMS
                     WGNEVLKFQHMDYFIALESGQ"
     exon            1..393
                     /gene="Mettl4"
                     /gene_synonym="RGD1306451"
                     /inference="alignment:Splign:2.1.0"
     exon            394..456
                     /gene="Mettl4"
                     /gene_synonym="RGD1306451"
                     /inference="alignment:Splign:2.1.0"
     exon            457..830
                     /gene="Mettl4"
                     /gene_synonym="RGD1306451"
                     /inference="alignment:Splign:2.1.0"
     exon            831..896
                     /gene="Mettl4"
                     /gene_synonym="RGD1306451"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1071
                     /gene="Mettl4"
                     /gene_synonym="RGD1306451"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1178
                     /gene="Mettl4"
                     /gene_synonym="RGD1306451"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1270
                     /gene="Mettl4"
                     /gene_synonym="RGD1306451"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..2039
                     /gene="Mettl4"
                     /gene_synonym="RGD1306451"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtccgtgg tgcatcattt gccacctgga tggttactgg atcatctttc tttcattaac
       61 aaagtcaact atcaactttg ccagcatcaa gagccttttt gtagcaaaaa caagcccact
      121 tcttctgtct acttggattc tcttcagcca gatcccgtgt ctccttttgg aactcctgct
      181 ccgtgctttg ctcctgacgc cactactgtg ttagacaagg aggatggtgg aagttgtgaa
      241 gtgatcaccc aaaaatatgt ttttcggtcc gaactattta atgtcaccaa accttacata
      301 actccagccg ttcacaaaaa ggaccaacaa agtaagaaag atgaaaatct agtgaccggt
      361 gaaaaacaag aggtctctgt ttctgttggg aagaaacgta aaagatgcgt tgctttcaat
      421 cgaggtgaat tggatgctat ggaatatcat acaaagatca gagagctgat tttggatgga
      481 tcttctcagt taatccaaga aggtctcaga agtggtttcc ttttcccact tgttgaaaaa
      541 catgatggca gtagtggacg catcacttta ccgcttgatg cctgcaattt gtcagagtta
      601 tgcgagatgg caaagcattt gccttccttg aatgacatgg agcttcaaac gctacagttg
      661 atgggagatg atgtgtttgt tacagagctg gacttatctt cacggatcat tgaaaacaac
      721 tctagctttt ccaaaatgat cactttaatg ggacagagat atctgctgcc accaaaaagc
      781 agctttcttt tgtctgacat ttcttgtatg cagccacttc ttaactgtaa taagacattc
      841 gatgtgattg tgattgatcc accatgggag aacaaatcgg ttaaaagaag taacaggtac
      901 aatagtttat ccccacagca gataaagaga atgcctgtcc ctaagctggc tgctcctgac
      961 tgtcttgtcg ttacttgggt gaccaacagg cagaagcatc tgtgctttgt gaaggaggaa
     1021 ctgtaccctt catggtctgt ggaagtcatt gcagagtggt actgggtaaa aatcacaaat
     1081 tcaggggagt ttgtgttccc attggattct ctacacaaaa agccttatga atgtcttgtt
     1141 ctggggagag ttaaagaaaa aactgcttta gcattaagga atgaagctgt aagaacgccc
     1201 ccggttccag atcagaggtt gatcgtcagt gtgccctgtg ctctgcactc acacaagccg
     1261 cctctcgccg aagttctgaa agactacatc aagccaggtg gccagtgttt ggaattgttt
     1321 gctcgaaatt tacagccagg ttggatgagt tggggcaacg aagtcctcaa gtttcagcac
     1381 atggattatt tcattgctct ggagtctgga cagtgactga aaaggtgtgc tgcctttacc
     1441 ccagctcgtt tctctgaact catttcccct tgtaccaggc agtgtgttag acgtatgaac
     1501 ttttatagca atcagtgtgc gtagaaatgt atatacgtcc cccacagccc tttgcagtga
     1561 gtctctccct tcgctccctg atctctggca aacagtggtt tgttttctca cgttagtgtt
     1621 agtgtttcct gtttagaaac ctctggatgt ggagccatgt ggtgcagaaa cccttgagtc
     1681 tggctccttc cacttagtat tcaggaaaac cactagcacc atttataagc cgctccctgc
     1741 gtacttagga gatggttaga ctgaaagcac ttggacaagc tcacttcacc tactcacttt
     1801 ttcaccagac attaattctg aggtttgttc atcttttgag ggcgtaaggc taatgccttt
     1861 tattattact ttaaactgcc agttgaatac acgactcatt gaattattaa gtatattcct
     1921 ttaagctttc tatggagttt tcctgtctaa attttttttg ttcgtttgtt tccgtgcacc
     1981 ggatatcctg acccacacct gactttctgc cttaaaaata aaaccaaggc cacacctca
//
