LOCUS       NM_001024794            1933 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus methyltransferase 3,
            N6-adenosine-methyltransferase complex catalytic subunit (Mettl3),
            mRNA.
ACCESSION   NM_001024794 XM_341310
VERSION     NM_001024794.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1933)
  AUTHORS   Wu,L., Ning,P., Liang,Y., Wang,T., Chen,L., Lu,D. and Tang,H.
  TITLE     Methyltransferase METTL3 regulates neuropathic pain through m6A
            methylation modification of SOCS1
  JOURNAL   Neuropharmacology 261, 110176 (2024)
   PUBMED   39357736
  REMARK    GeneRIF: Methyltransferase METTL3 regulates neuropathic pain
            through m6A methylation modification of SOCS1.
REFERENCE   2  (bases 1 to 1933)
  AUTHORS   Bao,T., Liao,T., Cai,X., Lu,B., Dai,G., Pei,S., Zhang,Y., Li,Y. and
            Xu,B.
  TITLE     METTL3 mediated ferroptosis in chondrocytes and promoted pain in
            KOA via HMGB1 m6A modification
  JOURNAL   Cell Biol Int 48 (11), 1755-1765 (2024)
   PUBMED   39129231
  REMARK    GeneRIF: METTL3 mediated ferroptosis in chondrocytes and promoted
            pain in KOA via HMGB1 m6A modification.
REFERENCE   3  (bases 1 to 1933)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1933)
  AUTHORS   Xiao,B., Zhu,Y., Liu,M., Chen,M., Huang,C., Xu,D., Wang,F., Sun,S.,
            Huang,J., Sun,N. and Yang,F.
  TITLE     miR-340-3p-modified bone marrow mesenchymal stem cell-derived
            exosomes inhibit ferroptosis through METTL3-mediated m6A
            modification of HMOX1 to promote recovery of injured rat uterus
  JOURNAL   Stem Cell Res Ther 15 (1), 224 (2024)
   PUBMED   39075530
  REMARK    GeneRIF: miR-340-3p-modified bone marrow mesenchymal stem
            cell-derived exosomes inhibit ferroptosis through METTL3-mediated
            m[6]A modification of HMOX1 to promote recovery of injured rat
            uterus.
            Erratum:[Stem Cell Res Ther. 2024 Oct 10;15(1):357. doi:
            10.1186/s13287-024-03985-w. PMID: 39390524]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1933)
  AUTHORS   Wang,Y., Zhang,G., Gao,Y., Zhang,X. and Qi,H.
  TITLE     METTL3 promotes trophoblast ferroptosis in preeclampsia by
            stabilizing the ACSL4 m6A modification
  JOURNAL   Exp Cell Res 437 (1), 113990 (2024)
   PUBMED   38462207
  REMARK    GeneRIF: METTL3 promotes trophoblast ferroptosis in preeclampsia by
            stabilizing the ACSL4 m[6]A modification.
REFERENCE   6  (bases 1 to 1933)
  AUTHORS   Liu,J., Yue,Y., Han,D., Wang,X., Fu,Y., Zhang,L., Jia,G., Yu,M.,
            Lu,Z., Deng,X., Dai,Q., Chen,W. and He,C.
  TITLE     A METTL3-METTL14 complex mediates mammalian nuclear RNA
            N6-adenosine methylation
  JOURNAL   Nat Chem Biol 10 (2), 93-95 (2014)
   PUBMED   24316715
REFERENCE   7  (bases 1 to 1933)
  AUTHORS   Wang,X., Lu,Z., Gomez,A., Hon,G.C., Yue,Y., Han,D., Fu,Y.,
            Parisien,M., Dai,Q., Jia,G., Ren,B., Pan,T. and He,C.
  TITLE     N6-methyladenosine-dependent regulation of messenger RNA stability
  JOURNAL   Nature 505 (7481), 117-120 (2014)
   PUBMED   24284625
REFERENCE   8  (bases 1 to 1933)
  AUTHORS   Fustin,J.M., Doi,M., Yamaguchi,Y., Hida,H., Nishimura,S.,
            Yoshida,M., Isagawa,T., Morioka,M.S., Kakeya,H., Manabe,I. and
            Okamura,H.
  TITLE     RNA-methylation-dependent RNA processing controls the speed of the
            circadian clock
  JOURNAL   Cell 155 (4), 793-806 (2013)
   PUBMED   24209618
REFERENCE   9  (bases 1 to 1933)
  AUTHORS   Dominissini,D., Moshitch-Moshkovitz,S., Schwartz,S.,
            Salmon-Divon,M., Ungar,L., Osenberg,S., Cesarkas,K.,
            Jacob-Hirsch,J., Amariglio,N., Kupiec,M., Sorek,R. and Rechavi,G.
  TITLE     Topology of the human and mouse m6A RNA methylomes revealed by
            m6A-seq
  JOURNAL   Nature 485 (7397), 201-206 (2012)
   PUBMED   22575960
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1933)
  AUTHORS   Bokar,J.A., Shambaugh,M.E., Polayes,D., Matera,A.G. and
            Rottman,F.M.
  TITLE     Purification and cDNA cloning of the AdoMet-binding subunit of the
            human mRNA (N6-adenosine)-methyltransferase
  JOURNAL   RNA 3 (11), 1233-1247 (1997)
   PUBMED   9409616
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097400.1.
            
            On Jun 10, 2005 this sequence version replaced XM_341310.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097400.1, SRR8487226.213014.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1933
                     /gene="Mettl3"
                     /note="methyltransferase 3, N6-adenosine-methyltransferase
                     complex catalytic subunit"
                     /db_xref="GeneID:361035"
                     /db_xref="RGD:1311750"
     exon            1..166
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1809
                     /gene="Mettl3"
                     /EC_number="2.1.1.62"
                     /note="N6-adenosine-methyltransferase 70 kDa subunit;
                     methyltransferase-like 3"
                     /codon_start=1
                     /product="N6-adenosine-methyltransferase catalytic
                     subunit"
                     /protein_id="NP_001019965.1"
                     /db_xref="GeneID:361035"
                     /db_xref="RGD:1311750"
                     /translation="MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSP
                     TFRSDSPVPTAPTSSGPKPSTTSIVPELATDPELEKKLLHHLSDLALTLPTDAVSIRL
                     AISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAV
                     AEKKGLGEAAGTITGQKRRAEQDLTTVATFTSSLASGLGSSTSEPAKEPAKKSRKHAA
                     SDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFC
                     DYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEID
                     ACVDSESPGSKEHMPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVV
                     MADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYE
                     RVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVR
                     STSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFK
                     HRYPDGVISKPKNL"
     exon            167..384
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
     exon            385..789
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
     exon            790..965
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1182
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1370
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1409
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1518
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1584
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1697
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1909
                     /gene="Mettl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgtgaga attagatgta tcttcgttct aggctgggga tgtgctagtc cgcgctagga
       61 actaggatgt cggacacgtg gagctctatc caggcccata agaaacaact ggactcgctt
      121 cgcgagagac tgcagcggcg gcggaagcag gactctgggc acttggactt aaggaatcca
      181 gaagcagcac tgtccccaac cttccgtagt gatagcccag tgcctactgc ccctacctct
      241 agtggcccta agcccagcac aacgtctata gtccctgaat tagctacaga ccctgagtta
      301 gagaagaagt tgctacacca cctctcagat ctcgccttaa ccttgcccac tgatgctgta
      361 tccatccgtc ttgccatctc tacgccagat gcacctgcca ctcaagatgg ggtagaaagc
      421 cttctacaga aatttgctgc ccaggagttg attgaggtaa agcgaggtct cctacaagat
      481 gacgcacatc ccactctcgt aacctatgct gaccactcca agctgtctgc catgatgggg
      541 gctgtggcag aaaagaaagg ccttggagag gcagcaggga ctatcacagg gcagaaacgg
      601 cgtgcagagc aggacttgac tacagtggct acctttacca gctctttagc atctggtctg
      661 ggctcttcaa catcagaacc agctaaggag ccagctaaga aatcaaggaa gcacgctgcc
      721 tcagatgttg acctggagat agaaagtctt ttgaaccaac agtcaactaa ggaacagcag
      781 agcaagaagg tcagtcagga gatcctagag ctattaaata ccacaacagc caaggaacag
      841 tccattgttg aaaagttccg ctctcgaggt cgggcccagg tgcaagaatt ttgtgactat
      901 gggaccaagg aagagtgcat gaaagccagt gacgctgatc ggccttgtcg caagctgcac
      961 ttcagacgga ttatcaacaa gcacactgat gagtctttag gtgattgctc tttcctgaac
     1021 acctgcttcc acatggacac ctgcaagtat gtccactatg aaattgacgc ctgtgtggat
     1081 tctgagagtc ctggcagcaa ggagcacatg ccgagccagg agcttgctct tacacagagc
     1141 gttgggggcg actccagtgc agaccgactc tttccacccc agtggatctg ttgtgatatc
     1201 cgctacctgg acgtcagtat cttgggcaaa tttgcagttg tgatggctga cccaccttgg
     1261 gatattcaca tggagctacc gtatgggacg ttaacagatg acgagatgcg caggctcaat
     1321 ataccagtac tacaggatga tggctttctt ttcctctggg tcacaggcag ggccatggaa
     1381 ttgggcagag aatgtctgaa cctctggggt tacgagcggg tggacgagat catctgggtg
     1441 aagaccaatc agctgcagcg catcatcagg acaggccgga caggccactg gctgaaccac
     1501 gggaaggagc actgcttggt tggtgtcaaa ggaaatcccc aaggcttcaa ccagggtctg
     1561 gattgcgatg tgattgtagc tgaggttcgt tccaccagtc acaaaccaga tgaaatatat
     1621 ggcatgattg agagactgtc ccctggcacc cgaaagattg agttatttgg acgaccacac
     1681 aatgtgcagc ccaactggat tactcttgga aaccaactgg atgggataca ccttctggac
     1741 ccagatgtgg ttgcccggtt taagcacagg tatccagatg gtgtcatctc taaacctaag
     1801 aacttatagg agacattgag agccgtggct ccacaggctg cctgaagaga agtgcttatg
     1861 cagtgtcccc caccctgtac ataaataaaa gtctgtatta taattggcaa aaaaaaaaaa
     1921 aaaaaaaaaa aaa
//
